ES2167617T3 - Derivados de 1-bencenosulfonilpirrolidina como antagonistas del receptor de la bradiquinina. - Google Patents
Derivados de 1-bencenosulfonilpirrolidina como antagonistas del receptor de la bradiquinina.Info
- Publication number
- ES2167617T3 ES2167617T3 ES96943182T ES96943182T ES2167617T3 ES 2167617 T3 ES2167617 T3 ES 2167617T3 ES 96943182 T ES96943182 T ES 96943182T ES 96943182 T ES96943182 T ES 96943182T ES 2167617 T3 ES2167617 T3 ES 2167617T3
- Authority
- ES
- Spain
- Prior art keywords
- bencenosulfonilpirrolidina
- bradiquinine
- antagonists
- receptor
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS ELEGIDOS ENTRE EL CONJUNTO FORMADO POR LOS COMPUESTOS DE FORMULA (I), EN LA CUAL X ES UN HALOGENO; R 1 REPRESENTA H O UN ALQUILO EN C 1 C 3 ; R 2 REPRESENTA H U OH; R 3 REPRESENTA (A), (B), (C) O (D); A REPRESENTA UN ENLACE SENCILLO O UN GRUPO - CO (CH 2 ) P - NH -; R 4 REPRESENTA H O C(=NR 5 )NHR 5 ; R 5 Y R 5 REPRESENTAN CADA UNO H O UN GRUPO ALQUILO EN C 1 - C 6 ; R 6 REPRESENTA H O UN GRUPO ALQUILO EN C 1 - C 3 ; M ES 0, 1 O 2; N ES 2, 3 O 4; P ES 1, 2 O 3; Y SUS SALES DE ADICION. SE REFIERE TAMBIEN A SU METODO DE PREPARACION Y SU UTILIZACION TERAPEUTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9515706A FR2743073B1 (fr) | 1995-12-29 | 1995-12-29 | Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2167617T3 true ES2167617T3 (es) | 2002-05-16 |
Family
ID=9486120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96943182T Expired - Lifetime ES2167617T3 (es) | 1995-12-29 | 1996-12-23 | Derivados de 1-bencenosulfonilpirrolidina como antagonistas del receptor de la bradiquinina. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6211181B1 (es) |
EP (1) | EP0874841B1 (es) |
JP (1) | JP2000502693A (es) |
AT (1) | ATE206418T1 (es) |
AU (1) | AU1198897A (es) |
DE (1) | DE69615707T2 (es) |
DK (1) | DK0874841T3 (es) |
ES (1) | ES2167617T3 (es) |
FR (1) | FR2743073B1 (es) |
PT (1) | PT874841E (es) |
WO (1) | WO1997024349A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751650B1 (fr) * | 1996-07-24 | 1998-10-09 | Fournier Ind & Sante | Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique |
IL128666A (en) * | 1996-08-28 | 2005-09-25 | Procter & Gamble | Substituted cyclic amine metalloprotease inhibitors |
US6872742B2 (en) | 1996-08-28 | 2005-03-29 | The Procter & Gamble Company | Substituted cyclic amine metalloprotease inhibitors |
KR100352316B1 (ko) | 1997-07-31 | 2002-09-12 | 더 프록터 앤드 갬블 캄파니 | 메탈로프로테아제억제제로서사용되는술포닐아미노치환히드록삼산유도체 |
FR2790260B1 (fr) * | 1999-02-26 | 2001-05-04 | Fournier Ind & Sante | Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique |
KR20010102486A (ko) | 1999-03-03 | 2001-11-15 | 데이비드 엠 모이어 | 알케닐- 및 알키닐-함유 메탈로프로테아제 저해제 |
JP2003505384A (ja) | 1999-07-15 | 2003-02-12 | ファーマコピーア,インコーポレーティッド | ブラジキニンb1受容体アンタゴニスト |
CA2364178C (en) * | 2000-12-05 | 2006-01-10 | Yasuhiro Katsu | N-benzenesulfonyl l-proline compounds as bradykinin antagonists |
FR2819254B1 (fr) * | 2001-01-08 | 2003-04-18 | Fournier Lab Sa | Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques |
EP1914236A1 (en) | 2002-04-10 | 2008-04-23 | Ortho-McNeil Pharmaceutical, Inc. | Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators |
FR2840897B1 (fr) | 2002-06-14 | 2004-09-10 | Fournier Lab Sa | Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique |
WO2004087700A1 (fr) | 2003-03-25 | 2004-10-14 | Laboratoires Fournier S.A. | Derives du benzenesulfonamide, leur procede de preparation et leur utilisation de la douleur |
AU2013226013B2 (en) * | 2012-02-29 | 2016-08-11 | Baruch S. Blumberg Institute | Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation and Their Method of Use |
WO2016170382A1 (en) | 2015-04-23 | 2016-10-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Pharmaceutical compositions comprising a bradykinin 2 receptor antagonist for prevention or treatment of impaired skin wound healing |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3632329A1 (de) | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
US5288725A (en) * | 1992-10-15 | 1994-02-22 | Merck & Co., Inc. | Pyrroloquinoline Bradykinin antagonist |
AU686115B2 (en) | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
AU680870B2 (en) * | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
-
1995
- 1995-12-29 FR FR9515706A patent/FR2743073B1/fr not_active Expired - Fee Related
-
1996
- 1996-12-23 DE DE69615707T patent/DE69615707T2/de not_active Expired - Fee Related
- 1996-12-23 AT AT96943182T patent/ATE206418T1/de not_active IP Right Cessation
- 1996-12-23 JP JP09524064A patent/JP2000502693A/ja active Pending
- 1996-12-23 PT PT96943182T patent/PT874841E/pt unknown
- 1996-12-23 EP EP96943182A patent/EP0874841B1/fr not_active Expired - Lifetime
- 1996-12-23 AU AU11988/97A patent/AU1198897A/en not_active Abandoned
- 1996-12-23 WO PCT/FR1996/002066 patent/WO1997024349A1/fr active IP Right Grant
- 1996-12-23 DK DK96943182T patent/DK0874841T3/da active
- 1996-12-23 ES ES96943182T patent/ES2167617T3/es not_active Expired - Lifetime
- 1996-12-23 US US09/091,988 patent/US6211181B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1997024349A1 (fr) | 1997-07-10 |
DE69615707T2 (de) | 2002-08-08 |
FR2743073A1 (fr) | 1997-07-04 |
FR2743073B1 (fr) | 1998-02-20 |
EP0874841A1 (fr) | 1998-11-04 |
AU1198897A (en) | 1997-07-28 |
PT874841E (pt) | 2002-03-28 |
DK0874841T3 (da) | 2002-01-28 |
ATE206418T1 (de) | 2001-10-15 |
US6211181B1 (en) | 2001-04-03 |
DE69615707D1 (de) | 2001-11-08 |
EP0874841B1 (fr) | 2001-10-04 |
JP2000502693A (ja) | 2000-03-07 |
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