ATE12042T1 - Aminosaeurederivate und ihre therapeutische verwendung. - Google Patents

Aminosaeurederivate und ihre therapeutische verwendung.

Info

Publication number
ATE12042T1
ATE12042T1 AT81400621T AT81400621T ATE12042T1 AT E12042 T1 ATE12042 T1 AT E12042T1 AT 81400621 T AT81400621 T AT 81400621T AT 81400621 T AT81400621 T AT 81400621T AT E12042 T1 ATE12042 T1 AT E12042T1
Authority
AT
Austria
Prior art keywords
amino acid
acid derivatives
therapeutic use
image
antidiarrhea
Prior art date
Application number
AT81400621T
Other languages
English (en)
Inventor
Bernard Roques
Jean-Charles Schwartz
Jeanne-Marie Lecomte
Original Assignee
Bioprojet Soc Civ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet Soc Civ filed Critical Bioprojet Soc Civ
Application granted granted Critical
Publication of ATE12042T1 publication Critical patent/ATE12042T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT81400621T 1980-04-17 1981-04-17 Aminosaeurederivate und ihre therapeutische verwendung. ATE12042T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8008601A FR2480747A1 (fr) 1980-04-17 1980-04-17 Derives d'acides amines et leur application therapeutique
EP81400621A EP0038758B1 (de) 1980-04-17 1981-04-17 Aminosäurederivate und ihre therapeutische Verwendung

Publications (1)

Publication Number Publication Date
ATE12042T1 true ATE12042T1 (de) 1985-03-15

Family

ID=9240999

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81400621T ATE12042T1 (de) 1980-04-17 1981-04-17 Aminosaeurederivate und ihre therapeutische verwendung.

Country Status (5)

Country Link
US (1) US4513009A (de)
EP (1) EP0038758B1 (de)
AT (1) ATE12042T1 (de)
DE (1) DE3169160D1 (de)
FR (1) FR2480747A1 (de)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4611002A (en) * 1977-07-14 1986-09-09 E. R. Squibb And Sons, Inc. Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors
US4372974A (en) * 1980-06-25 1983-02-08 New York University Anticonvulsive compositions and method of treating convulsive disorders
US4610816A (en) * 1980-12-18 1986-09-09 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4906615A (en) * 1980-12-18 1990-03-06 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4329495A (en) * 1981-05-18 1982-05-11 Pfizer Inc. Enkephalinase enzyme inhibiting compounds
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4766110A (en) * 1981-08-21 1988-08-23 Ryan James W Novel complex amido and imido derivatives of carboxyalkyl peptides
ZA827000B (en) * 1981-09-25 1984-05-30 Wellcome Found Pharmaceutical amides,and preparation,formulations and use thereof
ZA827002B (en) * 1981-09-25 1984-05-30 Wellcome Found Pharmaceutical amides,and preparation,formulations and use thereof
US4474799A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4474795A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
NZ202232A (en) * 1981-11-06 1985-08-16 Smithkline Beckman Corp N-carboxyalkylproline-containing tripeptides and pharmaceutical compositions
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
JPS58188847A (ja) * 1982-04-26 1983-11-04 Takeda Chem Ind Ltd ペプチド誘導体
DE3376649D1 (en) * 1982-06-17 1988-06-23 Schering Corp Substituted dipeptides, methods for their production, pharmaceutical compositions containing them, method for making such pharmaceutical compositions
IL69136A0 (en) * 1982-07-19 1983-10-31 Squibb & Sons Inc Substituted peptide compounds
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
US4587234A (en) * 1982-11-18 1986-05-06 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4496540A (en) * 1982-12-30 1985-01-29 Biomeasure, Inc. Therapeutic compounds
FR2540495B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
US4798904A (en) * 1983-10-03 1989-01-17 E. R. Squibb & Sons, Inc. Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase
US4722810A (en) * 1984-08-16 1988-02-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4774256A (en) * 1983-10-03 1988-09-27 E. R. Squibb & Sons, Inc. Use of enkephalinase inhibitors as analgesic agents
ZA852359B (en) * 1984-04-02 1985-11-27 Squibb & Sons Inc Enkephalinase inhibitors
US4939261A (en) * 1984-06-08 1990-07-03 Ciba-Geigy Corporation N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase
US4636560A (en) * 1984-11-16 1987-01-13 E. R. Squibb & Sons, Inc. Amino thiol peptides
EP0194464B1 (de) * 1985-02-15 1991-04-03 Research Corporation Technologies, Inc. (a Delaware corp.) Aminosäure-Derivate und ihre Anwendung zur Herstellung eines Antikrampfmittels
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US5654301A (en) * 1985-02-15 1997-08-05 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
IT1188206B (it) * 1985-11-28 1988-01-07 Eniricerche Spa Procedimento per la sintesi in fase solida di peptidi in cui almeno un legame ammidico e' retroinvertito
EP0225292A3 (de) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Einige N-substituierte Buttersäureamidderivate
US5166212A (en) * 1985-12-06 1992-11-24 Ciba-Geigy Corporation Certain n-substituted butyramide derivatives
DK77487A (da) * 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
EP0566157A1 (de) 1986-06-20 1993-10-20 Schering Corporation Hemmer der neutralen Metalloendopeptidase zur Behandlung von Hypertension
US4801609B1 (en) * 1987-03-27 1993-11-09 Mercapto-acylamino acid antihypertensives
US4929641B1 (en) * 1988-05-11 1994-08-30 Schering Corp Mercapto-acylamino acid antihypertensives
EP0254032A3 (de) * 1986-06-20 1990-09-05 Schering Corporation Hemmer der neutralen Metallendopeptidase zur Behandlung von Hypertension
US5192800A (en) * 1986-12-11 1993-03-09 Pfizer Inc. Glutaramide diuretic agents
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
ATE92916T1 (de) * 1987-04-08 1993-08-15 Ciba Geigy Ag Schwefelhaltige verbindungen als antioxidantien fuer schmiermittel und elastomere.
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
FR2623498B1 (fr) * 1987-11-24 1990-04-06 Bioprojet Soc Civ Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques
AU615976B2 (en) * 1987-12-16 1991-10-17 Schering Corporation Mercapto-acylamino acid antihypertensives
JP2848411B2 (ja) * 1988-08-18 1999-01-20 サイオス インコーポレイテッド 心房性ナトリウム利尿ペプチドクリアランス阻害剤
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives
JP2733511B2 (ja) * 1988-10-22 1998-03-30 日本臓器製薬株式会社 新規アミノアルカン誘導体
IT1228451B (it) * 1989-02-22 1991-06-19 Sclavo S P A Siena Nuovi derivati diamminici geminali e loro impiego nelle sintesi di peptidi retro-inversi
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
US5599951A (en) * 1989-09-15 1997-02-04 Societe Civile Bioprojet Amino acid derivatives, the process for their preparation and their applications to therapy
AU6503390A (en) * 1989-10-13 1991-05-16 Schering Corporation Carboxyalkyl dipeptide inhibitors of endopeptidases
EP0502075A1 (de) * 1989-11-21 1992-09-09 Schering Corporation Endopeptidase-hemmende carboxyalkylcarboxylaminosäure
US5407960A (en) * 1989-12-22 1995-04-18 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
US5075302A (en) * 1990-03-09 1991-12-24 Schering Corporation Mercaptoacyl aminolactam endopeptidase inhibitors
CA2038379C (en) * 1990-03-22 2002-11-05 Norma G. Delaney Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
US5223516A (en) * 1990-03-22 1993-06-29 E. R. Squibb & Sons, Inc. 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
DE4011171A1 (de) * 1990-04-06 1991-10-10 Degussa Herstellung von (alpha)-aminosaeure-2,2,2,-trifluorethylester
US5173506A (en) * 1990-08-16 1992-12-22 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
US5252601A (en) * 1991-05-03 1993-10-12 Merrell Dow Pharmaceuticals Inc. 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors
FI922867A7 (fi) * 1991-06-21 1992-12-22 Tanabe Seiyaku Co Dikarbonsyraderivat och foerfarande foer framstaellning av dem
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
FR2682952B1 (fr) 1991-10-25 1993-12-03 Institut Nal Sante Recherc Medic Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
CA2091194A1 (en) * 1992-04-08 1993-10-09 Richard D. Connell 2-oxo-ethyl derivatives as immunosuppressants
JPH06199850A (ja) * 1992-12-28 1994-07-19 Tanabe Seiyaku Co Ltd インドール含有ペプチド及びその製法
AU3494093A (en) * 1993-01-22 1994-08-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-lipophilic aliphatic carbonyl {n-mercaptoacyl-(amino acid or peptide)} compounds as antihypertensive agents
GB9306886D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
GB9306899D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
FR2707638B1 (fr) * 1993-07-16 1995-08-18 Bioprojet Soc Civ Nouveaux dérivés d'amino-acides, leurs procédés de préparation et leur application thérapeutique.
IT1266570B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari
US5455262A (en) * 1993-10-06 1995-10-03 Florida State University Mercaptosulfide metalloproteinase inhibitors
FR2712286B1 (fr) * 1993-11-12 1995-12-22 Oreal Nouveaux N-mercaptoalkyl alcanediamines et leur utilisation.
US5760241A (en) * 1995-12-28 1998-06-02 Zambon Group S.P.A. Thiol derivatives with metallopeptidase inhibitory activity
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
JP3973748B2 (ja) * 1998-01-14 2007-09-12 花王株式会社 発毛抑制剤
EP1090625B1 (de) * 1999-10-05 2004-12-22 Kao Corporation Topische Zusammensetzung für die Haut und deren Anwendung
GB0015490D0 (en) * 2000-06-23 2000-08-16 Smithkline Beecham Lab Novel formulations
CN1635884A (zh) * 2000-06-23 2005-07-06 生物计划公司 包含外消旋卡朵曲的干粉制剂
JP2004530647A (ja) * 2001-01-30 2004-10-07 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧治療用眼薬組成物
ES2262567T3 (es) * 2001-03-20 2006-12-01 Schwarz Pharma Ag Nuevo uso de una clase peptidica de compuesto para tratamiento del dolor inflamatorio no neuropatico.
ATE228358T1 (de) * 2001-03-21 2002-12-15 Sanol Arznei Schwarz Gmbh Neue verwendung einer klasse von peptidverbindungen zur behandlung von allodynie oder andere arten von chronischen oder phantomschmerzen
US6428822B1 (en) 2001-04-03 2002-08-06 Chengzhi Life Science Company, Ltd. Extracts of mixed arctium lappa L., carrot and whole radish for treating hypertension, constipation and detoxification
FR2823212B1 (fr) * 2001-04-10 2005-12-02 Inst Nat Sante Rech Med Inhibiteurs de la toxine botulique de type b
EP1423168B1 (de) * 2001-09-03 2006-02-08 Newron Pharmaceuticals S.p.A. Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
EP1438956A1 (de) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-Aminoamidderivate die als Antimigränemittel nützlich sind
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
NZ550482A (en) 2004-04-16 2010-08-27 Sanol Arznei Schwarz Gmbh Use of peptidic compounds for the prophylaxis and treatment of chronic headache
EP1588704A1 (de) * 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamidderivate zur Behandlung des Restless-Leg-Syndroms und der Suchterkrankungen
EP1604656A1 (de) 2004-06-09 2005-12-14 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen zur Behandlung von amyotropher Lateralsklerose (ALS)
DE602005021970D1 (de) * 2004-08-27 2010-08-05 Ucb Pharma Gmbh Verwendung von peptidverbindungen zur behandlung von schmerzen durch knochenkrebs, chemotherapie- und nucleosid-bedingten schmerzen
AU2005282028B2 (en) * 2004-09-10 2011-03-24 Newron Pharmaceuticals S.P.A. (halobenzyloxy) benzylamino-propanamides as sodium and/or calcium channel selective modulators
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
US20070048372A1 (en) * 2005-08-18 2007-03-01 Srz Properties, Inc. Method for treating non-inflammatory osteoarthritic pain
EP1754476A1 (de) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamid (SPM 927) zur Behandlung von Myalgien, z.B. Fibromyalgie
EP1870097A1 (de) * 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamidederivate zur Behandlung von kognitiven Störungen
JP5443981B2 (ja) 2006-06-15 2014-03-19 ウーツェーベー ファルマ ゲーエムベーハー 相乗的抗痙攣効果を有する医薬組成物
TW200838501A (en) 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
TWI406850B (zh) 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
US7834041B2 (en) 2007-09-07 2010-11-16 Theravance, Inc. Dual-acting antihypertensive agents
CN101896470B (zh) 2007-12-11 2013-04-10 施万制药 双重作用的苯并咪唑衍生物和其作为抗高血压药剂的用途
US7989484B2 (en) 2008-04-29 2011-08-02 Theravance, Inc. Dual-acting antihypertensive agents
FR2931151A1 (fr) * 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
JP2011529072A (ja) 2008-07-24 2011-12-01 セラヴァンス， インコーポレーテッド 二重作用血圧降下薬
US7956054B2 (en) 2009-07-07 2011-06-07 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
WO2011011232A1 (en) 2009-07-22 2011-01-27 Theravance, Inc. Dual-acting oxazole antihypertensive agents
EP2526095A1 (de) 2010-01-19 2012-11-28 Theravance, Inc. Doppelt wirkende blutdrucksenkende thiophen-, pyrrol-, thiazol- und furan-mittel
WO2011116490A1 (zh) * 2010-03-22 2011-09-29 北京世纪迈劲生物科技有限公司 制备消旋卡多曲的方法
EP2462922A1 (de) 2010-12-10 2012-06-13 Bioprojet Neue Darreichungsform für Enkephalinasehemmer
CA2819153A1 (en) 2010-12-15 2012-06-21 Theravance, Inc. Neprilysin inhibitors
RU2622288C2 (ru) 2010-12-15 2017-06-14 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи,ЭлЭлСи Ингибиторы неприлизина
EP2675792B1 (de) 2011-02-17 2016-01-06 Theravance Biopharma R&D IP, LLC Substituierte aminobuttersäurederivate als neprilysin-inhibitoren
JP5959065B2 (ja) 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
WO2012166387A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
JP5885832B2 (ja) 2011-05-31 2016-03-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
WO2012166390A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
EP2855464B1 (de) 2012-05-31 2016-10-26 Theravance Biopharma R&D IP, LLC Stickstoffoxiddonor als neprilysin-inhibitoren
CN104350042B (zh) 2012-06-08 2017-05-24 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
US8871792B2 (en) 2012-06-08 2014-10-28 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
WO2014005032A1 (en) 2012-06-28 2014-01-03 Mcneil-Ppc, Inc. Racecadotril lipid compositions
US9801819B2 (en) 2012-06-28 2017-10-31 Johnson & Johnson Consumer Inc. Racecadotril compositions
CA2879697C (en) 2012-08-08 2020-07-07 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
PT2964616T (pt) 2013-03-05 2017-08-08 Theravance Biopharma R&D Ip Llc Inibidores da neprilisina
SG11201606057PA (en) 2014-01-30 2016-08-30 Theravance Biopharma R&D Ip Llc 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors
US9593110B2 (en) 2014-01-30 2017-03-14 Theravence Biopharma R&D IP, LLC Neprilysin inhibitors
ES2549127T1 (es) 2014-03-10 2015-10-23 Galenicum Health S.L. Composiciones farmacéuticas que comprenden un principio activo
ES2555484T1 (es) 2014-05-26 2016-01-04 Galenicum Health S.L. Composiciones farmacéuticas que contienen un agente activo
MA40859A (fr) 2014-10-29 2017-09-05 Johnson & Johnson Consumer Inc Particules de cadotril
EP3256446B1 (de) 2015-02-11 2022-05-18 Theravance Biopharma R&D IP, LLC (2s,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentansaüre als neprilysin-inhibitor
BR112017017783A2 (pt) 2015-02-19 2018-07-17 Theravance Biopharma R&D Ip, Llc Ácido (2r,4r)-5-(5'-cloro-2'-fluorbifenil-4-il)-2-hidróxi- 4-[(5-metiloxazol-2-carbonil)amino]pentanóico.
PL3408260T3 (pl) 2016-03-08 2021-11-08 Theravance Biopharma R&D Ip, Llc Krystaliczny kwas (2S,4R)-5-(5'-chloro-2-fluoro-[1,1'-bifenyl]-4-ilo)-2-(etoksymetylo)-4- (3-hydroksyizoksazolo-5-karboksyamido)-2-metylopentanowy i jego zastosowania
BR112018069973A2 (pt) 2017-03-06 2019-09-17 Athena Drug Delivery Solutions Pvt Ltd uma composição farmacêutica compreendendo racecadotrila e processo para a preparação da mesma
CN107088189B (zh) * 2017-05-05 2019-10-25 珠海赛隆药业股份有限公司 卡多曲衍生物和血管紧张素受体拮抗剂的复合物及其用途
CN107129450B (zh) * 2017-06-05 2019-05-03 山东裕欣药业有限公司 一种消旋卡多曲晶体化合物及其制备方法
EP4056171A1 (de) 2021-03-12 2022-09-14 Athena Pharmaceutiques SAS Geschmacksmaskierte racecadotril-tablettenzusammensetzung und verfahren zu ihrer herstellung

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB850479A (en) * 1956-09-05 1960-10-05 Takeda Pharmaceutical Acylated amino-acids and amino-sugars
DE1062705B (de) * 1957-07-15 1959-08-06 Fulvio Bracco Dr Verfahren zur Herstellung strahlenschutzwirksamer Cysteamin-Derivate
CH451186A (de) * 1961-11-02 1968-05-15 Santen Phamarceutical Co Ltd Verfahren zur Herstellung von N-Mercaptopropionylglycin und dessen Derivaten
FR1491204A (fr) * 1962-08-10 1967-08-11 Santen Pharmaceutical Co Ltd Procédés pour la préparation des alpha-et beta mercaptopropionylglycocolle et de leurs dérivés
US3700770A (en) * 1966-10-21 1972-10-24 Parke Davis & Co Phenylalanine derivatives for treatment of measles infections
CA1009252A (en) * 1972-10-03 1977-04-26 Santen Pharmaceutical Co. N-(mercaptoacyl) aminoacids
US4025644A (en) * 1974-12-18 1977-05-24 Daiichi Seiyaku Co., Ltd. Tyrosine derivatives and use
JPS535112A (en) * 1976-03-08 1978-01-18 Santen Pharmaceutical Co Ltd New cysteine derivatives
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
US4228184A (en) * 1976-05-10 1980-10-14 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
US4091024A (en) * 1976-12-03 1978-05-23 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
GB1585061A (en) * 1977-03-15 1981-02-25 Nat Res Dev Synthesis of peptides
PH14064A (en) * 1977-05-06 1981-01-26 Pfizer Phenylgycine derivatives,pharmaceutical compositions and method of use
GB2000783B (en) * 1977-07-12 1982-01-27 Hudson D Enkephalin analogues
CA1180006A (en) * 1978-01-11 1984-12-27 John A. Yankeelov, Jr. Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use
FR2427821A1 (fr) * 1978-06-05 1980-01-04 Proter Spa Acide (2-mercapto propionamido)-acetique, utile notamment comme agent mucolytique
GR73585B (de) * 1978-09-11 1984-03-26 Univ Miami
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
DE3161915D1 (en) * 1980-03-05 1984-02-23 Univ Miami Angiotensin converting enzyme inhibitors
GB2074571B (en) * 1980-04-11 1984-02-15 Wellcome Found Alpha-benzyl-substituted amides
GR75019B (de) * 1980-09-17 1984-07-12 Univ Miami
IT1149848B (it) * 1980-11-11 1986-12-10 Ausonia Farma Srl Derivato della glicina,metodo per la sua preparazione e composizioni farmaceutiche che lo contengono
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists

Also Published As

Publication number Publication date
US4513009A (en) 1985-04-23
EP0038758A1 (de) 1981-10-28
FR2480747A1 (fr) 1981-10-23
DE3169160D1 (en) 1985-04-11
EP0038758B1 (de) 1985-03-06

Similar Documents

Publication Publication Date Title
ATE12042T1 (de) Aminosaeurederivate und ihre therapeutische verwendung.
SE7906533L (sv) Pyrrolidinderivat
ATE18902T1 (de) Aminosaeurederivate und ihre therapeutischen verwendungen.
FI913478A0 (fi) Diazinderivat.
ATE9475T1 (de) Aminosaeure- und peptid-n-(vinblastinoyl-23)derivate und ihre herstellung.
IT8122675A0 (it) Mercaptoacil derivati di varie proline 4 sostituite e relative composizioni utili per il trattamento dell'ipertensione.
ATE269290T1 (de) Benzoylderivate
DE69021530D1 (de) Neue Derivate von A-nor-3-Carboxysteroiden.
ATE227293T1 (de) 2,3-disubstituierte-(5,6)-heteroarylkondensiert - pyrimidin-4-one
ES529593A0 (es) Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona
GR79463B (de)
NO165921C (no) Fremgangsmaate for fremstilling av disubstituerte prolinderivater.
EA200100516A1 (ru) Производные 3,3-биарилпиперидина и 2,2-биарилморфолина
ES8604922A1 (es) Procedimiento para la preparacion de n-piridilindoles
GR71207B (de)
DK0552765T3 (da) benzimidazoler, farmaceutiske præparater indeholdende disse og fremgangsmåde til deres fremstilling
ZA817265B (en) Novel guanidine derivatives
ATE69220T1 (de) Sechsgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen.
ATE11545T1 (de) Gesaettigte aminocyclitderivate, ihre herstellung und sie enthaltende arzneimittel.
ATE126057T1 (de) Anthelmintische und coccidizide 3-carbamoyl-4- hydroxycumarine, ihre verwendung und zusammensetzungen.
ES2104174T3 (es) Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
DK550584D0 (da) Aralkyl-(arylethynyl) aralkylaminer og fremgangsmaade til fremstilling deraf
DK405884A (da) Spiro(benzofuran-azalkaner), fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
NO842345L (no) Heksahydropyrrolo(2,1-a)isoquinolin-derivater.
JPS57185270A (en) Novel cyclic sulfenamides, manufacture and use as drug

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time