DE3169160D1 - Amino-acids derivatives and their therapeutic use - Google Patents

Amino-acids derivatives and their therapeutic use

Info

Publication number
DE3169160D1
DE3169160D1 DE8181400621T DE3169160T DE3169160D1 DE 3169160 D1 DE3169160 D1 DE 3169160D1 DE 8181400621 T DE8181400621 T DE 8181400621T DE 3169160 T DE3169160 T DE 3169160T DE 3169160 D1 DE3169160 D1 DE 3169160D1
Authority
DE
Germany
Prior art keywords
amino
therapeutic use
acids derivatives
image
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181400621T
Other languages
English (en)
Inventor
Bernard Roques
Jean-Charles Schwartz
Jeanne-Marie Lecomte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioprojet SC
Original Assignee
Bioprojet SC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet SC filed Critical Bioprojet SC
Application granted granted Critical
Publication of DE3169160D1 publication Critical patent/DE3169160D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8181400621T 1980-04-17 1981-04-17 Amino-acids derivatives and their therapeutic use Expired DE3169160D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8008601A FR2480747A1 (fr) 1980-04-17 1980-04-17 Derives d'acides amines et leur application therapeutique

Publications (1)

Publication Number Publication Date
DE3169160D1 true DE3169160D1 (en) 1985-04-11

Family

ID=9240999

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181400621T Expired DE3169160D1 (en) 1980-04-17 1981-04-17 Amino-acids derivatives and their therapeutic use

Country Status (5)

Country Link
US (1) US4513009A (de)
EP (1) EP0038758B1 (de)
AT (1) ATE12042T1 (de)
DE (1) DE3169160D1 (de)
FR (1) FR2480747A1 (de)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4611002A (en) * 1977-07-14 1986-09-09 E. R. Squibb And Sons, Inc. Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors
US4372974A (en) * 1980-06-25 1983-02-08 New York University Anticonvulsive compositions and method of treating convulsive disorders
US4906615A (en) * 1980-12-18 1990-03-06 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4610816A (en) * 1980-12-18 1986-09-09 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4329495A (en) * 1981-05-18 1982-05-11 Pfizer Inc. Enkephalinase enzyme inhibiting compounds
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4766110A (en) * 1981-08-21 1988-08-23 Ryan James W Novel complex amido and imido derivatives of carboxyalkyl peptides
AU8866882A (en) * 1981-09-25 1983-03-31 Wellcome Foundation Limited, The 2-(n-hydroxycarbamoyl)phenylpropanoyl amino acids
ZA827002B (en) * 1981-09-25 1984-05-30 Wellcome Found Pharmaceutical amides,and preparation,formulations and use thereof
US4474799A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4474795A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
NZ202232A (en) * 1981-11-06 1985-08-16 Smithkline Beckman Corp N-carboxyalkylproline-containing tripeptides and pharmaceutical compositions
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
JPS58188847A (ja) * 1982-04-26 1983-11-04 Takeda Chem Ind Ltd ペプチド誘導体
EP0103077B1 (de) * 1982-06-17 1988-05-18 Schering Corporation Substituierte Dipeptide, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Zusammensetzungen und Verfahren zur Herstellung dieser pharmazeutischen Zusammensetzungen
IL69136A0 (en) * 1982-07-19 1983-10-31 Squibb & Sons Inc Substituted peptide compounds
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
US4587234A (en) * 1982-11-18 1986-05-06 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4496540A (en) * 1982-12-30 1985-01-29 Biomeasure, Inc. Therapeutic compounds
FR2540495B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
US4798904A (en) * 1983-10-03 1989-01-17 E. R. Squibb & Sons, Inc. Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase
US4774256A (en) * 1983-10-03 1988-09-27 E. R. Squibb & Sons, Inc. Use of enkephalinase inhibitors as analgesic agents
US4722810A (en) * 1984-08-16 1988-02-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
CA1298307C (en) * 1984-04-02 1992-03-31 Norma G. Delaney Enkephalinase inhibitors
US4939261A (en) * 1984-06-08 1990-07-03 Ciba-Geigy Corporation N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase
US4636560A (en) * 1984-11-16 1987-01-13 E. R. Squibb & Sons, Inc. Amino thiol peptides
US5654301A (en) * 1985-02-15 1997-08-05 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
CA1340902C (en) * 1985-02-15 2000-02-22 Harold L. Kohn Amino acid derivative anticonvulsant
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
IT1188206B (it) * 1985-11-28 1988-01-07 Eniricerche Spa Procedimento per la sintesi in fase solida di peptidi in cui almeno un legame ammidico e' retroinvertito
EP0225292A3 (de) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Einige N-substituierte Buttersäureamidderivate
US5166212A (en) * 1985-12-06 1992-11-24 Ciba-Geigy Corporation Certain n-substituted butyramide derivatives
DK77487A (da) * 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
EP0254032A3 (de) * 1986-06-20 1990-09-05 Schering Corporation Hemmer der neutralen Metallendopeptidase zur Behandlung von Hypertension
US4801609B1 (en) * 1987-03-27 1993-11-09 Mercapto-acylamino acid antihypertensives
US4929641B1 (en) * 1988-05-11 1994-08-30 Schering Corp Mercapto-acylamino acid antihypertensives
EP0566157A1 (de) 1986-06-20 1993-10-20 Schering Corporation Hemmer der neutralen Metalloendopeptidase zur Behandlung von Hypertension
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
US5192800A (en) * 1986-12-11 1993-03-09 Pfizer Inc. Glutaramide diuretic agents
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
EP0286595B1 (de) * 1987-04-08 1993-08-11 Ciba-Geigy Ag Schwefelhaltige Verbindungen als Antioxidantien für Schmiermittel und Elastomere
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
FR2623498B1 (fr) * 1987-11-24 1990-04-06 Bioprojet Soc Civ Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques
EP0322633B1 (de) * 1987-12-16 1991-05-22 Schering Corporation Mercapto-acylaminosäure-Antihypertensiver
EP0429537A4 (en) * 1988-08-18 1991-08-21 California Biotechnology, Inc. Atrial natriuretic peptide clearance inhibitors
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives
JP2733511B2 (ja) * 1988-10-22 1998-03-30 日本臓器製薬株式会社 新規アミノアルカン誘導体
IT1228451B (it) * 1989-02-22 1991-06-19 Sclavo S P A Siena Nuovi derivati diamminici geminali e loro impiego nelle sintesi di peptidi retro-inversi
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
US5599951A (en) * 1989-09-15 1997-02-04 Societe Civile Bioprojet Amino acid derivatives, the process for their preparation and their applications to therapy
JPH05501247A (ja) * 1989-10-13 1993-03-11 シェリング・コーポレーション エンドペプチダーゼのカルボキシアルキルジペプチド阻害剤
CA2069112A1 (en) * 1989-11-21 1991-05-22 Bernard R. Neustadt Carboxyalkylcarbonyl aminoacid endopeptidase inhibitors
AU7168091A (en) * 1989-12-22 1991-07-24 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
US5075302A (en) * 1990-03-09 1991-12-24 Schering Corporation Mercaptoacyl aminolactam endopeptidase inhibitors
US5223516A (en) * 1990-03-22 1993-06-29 E. R. Squibb & Sons, Inc. 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
CA2038379C (en) * 1990-03-22 2002-11-05 Norma G. Delaney Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
DE4011171A1 (de) * 1990-04-06 1991-10-10 Degussa Herstellung von (alpha)-aminosaeure-2,2,2,-trifluorethylester
US5173506A (en) * 1990-08-16 1992-12-22 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
US5252601A (en) * 1991-05-03 1993-10-12 Merrell Dow Pharmaceuticals Inc. 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors
FI922867A (fi) * 1991-06-21 1992-12-22 Tanabe Seiyaku Co Dikarbonsyraderivat och foerfarande foer framstaellning av dem
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
CA2091194A1 (en) * 1992-04-08 1993-10-09 Richard D. Connell 2-oxo-ethyl derivatives as immunosuppressants
JPH06199850A (ja) * 1992-12-28 1994-07-19 Tanabe Seiyaku Co Ltd インドール含有ペプチド及びその製法
AU3494093A (en) * 1993-01-22 1994-08-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-lipophilic aliphatic carbonyl {n-mercaptoacyl-(amino acid or peptide)} compounds as antihypertensive agents
GB9306886D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
GB9306899D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
FR2707638B1 (fr) * 1993-07-16 1995-08-18 Bioprojet Soc Civ Nouveaux dérivés d'amino-acides, leurs procédés de préparation et leur application thérapeutique.
IT1266570B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari
US5455262A (en) * 1993-10-06 1995-10-03 Florida State University Mercaptosulfide metalloproteinase inhibitors
FR2712286B1 (fr) * 1993-11-12 1995-12-22 Oreal Nouveaux N-mercaptoalkyl alcanediamines et leur utilisation.
US5760241A (en) * 1995-12-28 1998-06-02 Zambon Group S.P.A. Thiol derivatives with metallopeptidase inhibitory activity
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
JP3973748B2 (ja) * 1998-01-14 2007-09-12 花王株式会社 発毛抑制剤
EP1090625B1 (de) * 1999-10-05 2004-12-22 Kao Corporation Topische Zusammensetzung für die Haut und deren Anwendung
GB0015490D0 (en) * 2000-06-23 2000-08-16 Smithkline Beecham Lab Novel formulations
CA2415957C (en) * 2000-06-23 2010-08-10 Bioprojet Dry powder formulation comprising racecadotril
JP2004530647A (ja) * 2001-01-30 2004-10-07 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧治療用眼薬組成物
EP1243262B1 (de) * 2001-03-20 2006-05-31 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz
PT1243263E (pt) * 2001-03-21 2003-03-31 Sanol Arznei Schwarz Gmbh Nova utilizacao de uma classe peptidica de composto para o tratamento de alodinia ou de outros tipos diferentes de dor cronica ou fantasma
US6428822B1 (en) 2001-04-03 2002-08-06 Chengzhi Life Science Company, Ltd. Extracts of mixed arctium lappa L., carrot and whole radish for treating hypertension, constipation and detoxification
FR2823212B1 (fr) * 2001-04-10 2005-12-02 Inst Nat Sante Rech Med Inhibiteurs de la toxine botulique de type b
IL160523A0 (en) * 2001-09-03 2004-07-25 Newron Pharm Spa PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE
EP1438956A1 (de) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-Aminoamidderivate die als Antimigränemittel nützlich sind
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
AU2005232395B2 (en) 2004-04-16 2010-09-09 Schwarz Pharma Ag Use of peptidic compounds for the prophylaxis and treatment of chronic headache
EP1588704A1 (de) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamidderivate zur Behandlung des Restless-Leg-Syndroms und der Suchterkrankungen
EP1604656A1 (de) 2004-06-09 2005-12-14 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen zur Behandlung von amyotropher Lateralsklerose (ALS)
KR20070045271A (ko) * 2004-08-27 2007-05-02 쉬바르츠파르마에이지 골암 통증, 화학요법- 및 뉴클레오시드- 유도 통증의치료를 위한 펩티드 화합물의 용도
NZ553970A (en) * 2004-09-10 2010-01-29 Newron Pharm Spa Use of (halobenzyloxy)benzylamino-propanamides for the manufacture of medicaments active as sodium and/or calcium channel selective modulators
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
US20070048372A1 (en) * 2005-08-18 2007-03-01 Srz Properties, Inc. Method for treating non-inflammatory osteoarthritic pain
EP1754476A1 (de) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamid (SPM 927) zur Behandlung von Myalgien, z.B. Fibromyalgie
BRPI0713594A2 (pt) 2006-06-15 2012-10-30 Sanol Arznei Schwarz Gmbh composição farmacêutica com efeito anticonsulsivante sinérgico
EP1870097A1 (de) * 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamidederivate zur Behandlung von kognitiven Störungen
TW200838501A (en) * 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
TWI406850B (zh) * 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
EP2200975A1 (de) 2007-09-07 2010-06-30 Theravance, Inc. Blutdrucksenkende mittel mit dualer wirkung
ATE555099T1 (de) 2007-12-11 2012-05-15 Theravance Inc Dual wirkende benzimidazol-derivate und deren verwendung als blutdrucksenkende mittel
EP2297113A1 (de) 2008-04-29 2011-03-23 Theravance, Inc. Blutdrucksenkende mittel mit dualer wirkung
FR2931151A1 (fr) * 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
WO2010011821A2 (en) 2008-07-24 2010-01-28 Theravance, Inc. Dual-acting antihypertensive agents
EP2451782B1 (de) 2009-07-07 2016-11-09 Theravance Biopharma R&D IP, LLC Blutdrucksenkende mittel auf pyrazolbasis mit doppelwirkung
US8372984B2 (en) 2009-07-22 2013-02-12 Theravance, Inc. Dual-acting oxazole antihypertensive agents
JP2013517295A (ja) 2010-01-19 2013-05-16 セラヴァンス， インコーポレーテッド 二重に作用するチオフェン、ピロール、チアゾールおよびフラン抗高血圧症薬
WO2011116490A1 (zh) * 2010-03-22 2011-09-29 北京世纪迈劲生物科技有限公司 制备消旋卡多曲的方法
EP2462922A1 (de) 2010-12-10 2012-06-13 Bioprojet Neue Darreichungsform für Enkephalinasehemmer
NZ611528A (en) 2010-12-15 2015-06-26 Theravance Biopharma R & D Ip Llc Neprilysin inhibitors
DK2651896T3 (en) 2010-12-15 2015-10-05 Theravance Biopharma R & D Ip Llc Neprilysininhibitorer
KR101854874B1 (ko) 2011-02-17 2018-05-04 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제로서 치환된 아미노부티릭 유도체
WO2012154249A1 (en) 2011-02-17 2012-11-15 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
ES2642883T3 (es) 2011-05-31 2017-11-20 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina
JP5959075B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
CA2835216A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
WO2013181332A1 (en) 2012-05-31 2013-12-05 Theravance, Inc. Nitric oxide donor neprilysin inhibitors
ES2710932T3 (es) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
SI2864292T1 (sl) 2012-06-08 2017-07-31 Theravance Biopharma R&D Ip, Llc Inhibitorji neprilizina
MX2015000217A (es) 2012-06-28 2015-04-10 Mcneil Ppc Inc Composiciones lipidicas de racecadotrilo.
US9801819B2 (en) 2012-06-28 2017-10-31 Johnson & Johnson Consumer Inc. Racecadotril compositions
NZ704741A (en) 2012-08-08 2017-10-27 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
ES2634218T3 (es) 2013-03-05 2017-09-27 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina
MX2016009759A (es) 2014-01-30 2016-11-17 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
MX2016009760A (es) 2014-01-30 2016-11-08 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
ES2549127T1 (es) 2014-03-10 2015-10-23 Galenicum Health S.L. Composiciones farmacéuticas que comprenden un principio activo
EP2949318A1 (de) 2014-05-26 2015-12-02 Galenicum Health S.L. Pharmazeutische Racecadotril Zusammensetzungen
MA40859A (fr) 2014-10-29 2017-09-05 Johnson & Johnson Consumer Inc Particules de cadotril
JP6766055B2 (ja) 2015-02-11 2020-10-07 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての（２ｓ，４ｒ）−５−（５’−クロロ−２’−フルオロビフェニル−４−イル）−４−（エトキシオキサリルアミノ）−２−ヒドロキシメチル−２−メチルペンタン酸
ES2857101T3 (es) 2015-02-19 2021-09-28 Theravance Biopharma R&D Ip Llc Acido (2R,4R)-5-(5’-cloro-2’-fluorobifenil-4-il)-2-hidroxi-4-[(5-metiloxazol-2-carbonil)amino]pentanoico
PT3408260T (pt) 2016-03-08 2021-07-23 Theravance Biopharma R&D Ip Llc Ácido (2s,4r)-5-(5¿-cloro-2¿-fluoro-[1,1¿-bifenil]-4-il)-2- (etoximetil)-4-(3-hidroxi-isoxazole-5-carboxamido)-2- metilpentanoico cristalino e suas utilizações
RU2749949C2 (ru) 2017-03-06 2021-06-21 Атена Фармасьютикс Сас Фармацевтическая композиция, содержащая рацекадотрил, и способ ее получения
CN107088189B (zh) * 2017-05-05 2019-10-25 珠海赛隆药业股份有限公司 卡多曲衍生物和血管紧张素受体拮抗剂的复合物及其用途
CN107129450B (zh) * 2017-06-05 2019-05-03 山东裕欣药业有限公司 一种消旋卡多曲晶体化合物及其制备方法
EP4056171A1 (de) 2021-03-12 2022-09-14 Athena Pharmaceutiques SAS Geschmacksmaskierte racecadotril-tablettenzusammensetzung und verfahren zu ihrer herstellung

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB850479A (en) * 1956-09-05 1960-10-05 Takeda Pharmaceutical Acylated amino-acids and amino-sugars
DE1062705B (de) * 1957-07-15 1959-08-06 Fulvio Bracco Dr Verfahren zur Herstellung strahlenschutzwirksamer Cysteamin-Derivate
CH451186A (de) * 1961-11-02 1968-05-15 Santen Phamarceutical Co Ltd Verfahren zur Herstellung von N-Mercaptopropionylglycin und dessen Derivaten
FR1491204A (fr) * 1962-08-10 1967-08-11 Santen Pharmaceutical Co Ltd Procédés pour la préparation des alpha-et beta mercaptopropionylglycocolle et de leurs dérivés
US3700770A (en) * 1966-10-21 1972-10-24 Parke Davis & Co Phenylalanine derivatives for treatment of measles infections
CA1009252A (en) * 1972-10-03 1977-04-26 Santen Pharmaceutical Co. N-(mercaptoacyl) aminoacids
US4025644A (en) * 1974-12-18 1977-05-24 Daiichi Seiyaku Co., Ltd. Tyrosine derivatives and use
JPS535112A (en) * 1976-03-08 1978-01-18 Santen Pharmaceutical Co Ltd New cysteine derivatives
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4228184A (en) * 1976-05-10 1980-10-14 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
US4091024A (en) * 1976-12-03 1978-05-23 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
GB1585061A (en) * 1977-03-15 1981-02-25 Nat Res Dev Synthesis of peptides
PH14064A (en) * 1977-05-06 1981-01-26 Pfizer Phenylgycine derivatives,pharmaceutical compositions and method of use
GB2000783B (en) * 1977-07-12 1982-01-27 Hudson D Enkephalin analogues
CA1180006A (en) * 1978-01-11 1984-12-27 John A. Yankeelov, Jr. Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use
FR2427821A1 (fr) * 1978-06-05 1980-01-04 Proter Spa Acide (2-mercapto propionamido)-acetique, utile notamment comme agent mucolytique
GR73585B (de) * 1978-09-11 1984-03-26 Univ Miami
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
EP0036713B1 (de) * 1980-03-05 1984-01-18 University Of Miami Inhibitoren für Angiotensin umwandelnde Enzyme
IT1148006B (it) * 1980-04-11 1986-11-26 Wellcome Found Ammidi dotate di proprieta' farmaceutiche e loro preparazione
EP0048159A3 (de) * 1980-09-17 1982-05-12 University Of Miami Carboxyalkyl-Peptide und Thioäther und Äther von Peptiden als antihypertensive Mittel
IT1149848B (it) * 1980-11-11 1986-12-10 Ausonia Farma Srl Derivato della glicina,metodo per la sua preparazione e composizioni farmaceutiche che lo contengono
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists

Also Published As

Publication number Publication date
FR2480747A1 (fr) 1981-10-23
US4513009A (en) 1985-04-23
EP0038758B1 (de) 1985-03-06
EP0038758A1 (de) 1981-10-28
ATE12042T1 (de) 1985-03-15

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