EA200300619A1 - Серотонинергические средства - Google Patents

Серотонинергические средства

Info

Publication number
EA200300619A1
EA200300619A1 EA200300619A EA200300619A EA200300619A1 EA 200300619 A1 EA200300619 A1 EA 200300619A1 EA 200300619 A EA200300619 A EA 200300619A EA 200300619 A EA200300619 A EA 200300619A EA 200300619 A1 EA200300619 A1 EA 200300619A1
Authority
EA
Eurasian Patent Office
Prior art keywords
serotoninergic
antagonists
trifluoromethyl
receptors
cyano
Prior art date
Application number
EA200300619A
Other languages
English (en)
Other versions
EA005925B1 (ru
Inventor
Уэйн Эверетт Чилдерс
Майкл Джерард Келли
Шэрон Джой Розенцвейг-Липсон
Original Assignee
Уайт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Уайт filed Critical Уайт
Publication of EA200300619A1 publication Critical patent/EA200300619A1/ru
Publication of EA005925B1 publication Critical patent/EA005925B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Предложены новые производные пиперазина, характеризующиеся формулой (III), где Rпредставляет собой циано, нитро, трифторметил или галоген, или его фармацевтически приемлемые кислотно-аддитивные соли, которые могут использоваться в качестве антагонистов 5-HT-рецепторов.Отчет о международном поиске был опубликован 2002.08.08.
EA200300619A 2000-11-28 2001-11-27 Серотонинергические средства EA005925B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25330100P 2000-11-28 2000-11-28
US29781401P 2001-06-13 2001-06-13
PCT/US2001/043160 WO2002044142A2 (en) 2000-11-28 2001-11-27 Piperazine derivatives, their preparation and their use for treating central nervous system (cns) disorders

Publications (2)

Publication Number Publication Date
EA200300619A1 true EA200300619A1 (ru) 2003-10-30
EA005925B1 EA005925B1 (ru) 2005-08-25

Family

ID=26943115

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300619A EA005925B1 (ru) 2000-11-28 2001-11-27 Серотонинергические средства

Country Status (25)

Country Link
US (3) US6469007B2 (ru)
EP (1) EP1339406B1 (ru)
JP (1) JP4198989B2 (ru)
KR (1) KR100835552B1 (ru)
CN (1) CN100352437C (ru)
AR (1) AR035603A1 (ru)
AT (1) ATE269078T1 (ru)
AU (2) AU2002237654B2 (ru)
BR (1) BR0115609A (ru)
CA (1) CA2428039C (ru)
DE (1) DE60103927T2 (ru)
DK (1) DK1339406T3 (ru)
EA (1) EA005925B1 (ru)
ES (1) ES2222401T3 (ru)
HK (1) HK1057864A1 (ru)
HU (1) HUP0400551A2 (ru)
IL (1) IL156098A0 (ru)
MX (1) MXPA03004677A (ru)
NO (1) NO325501B1 (ru)
NZ (1) NZ526150A (ru)
PL (1) PL363219A1 (ru)
PT (1) PT1339406E (ru)
TR (1) TR200401546T4 (ru)
TW (1) TWI224102B (ru)
WO (1) WO2002044142A2 (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432826B1 (en) * 1999-11-29 2002-08-13 Applied Materials, Inc. Planarized Cu cleaning for reduced defects
US20060287335A1 (en) * 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) * 2000-11-28 2006-10-05 Wyeth Serotonergic agents
DK1408976T5 (da) * 2001-07-20 2011-01-10 Psychogenics Inc Behandling af ADHD (Attention deficit hyperactivity disorder)
US7361773B2 (en) 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
US7091349B2 (en) 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
EP1483256A2 (en) 2002-03-12 2004-12-08 Wyeth Process for making chiral 1,4-disubstituted piperazines
ATE439356T1 (de) 2002-03-12 2009-08-15 Wyeth Corp Verfahren zur herstellung von chiralen n-aryl piperazinen
GB0219961D0 (en) * 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US20040192730A1 (en) * 2003-03-13 2004-09-30 Dynogen Pharmaceuticals, Inc. Methods of using compounds with combined 5-HT1A and SSRI activities as-needed to treat sexual dysfunction
US20050209245A1 (en) * 2004-03-19 2005-09-22 Wyeth Process for preparing N-aryl-piperazine derivatives
US20070099931A1 (en) * 2004-03-19 2007-05-03 Wyeth Pharmaceutical dosage forms and compositions
US20050215561A1 (en) * 2004-03-19 2005-09-29 Krishnendu Ghosh Pharmaceutical dosage forms and compositions
KR100646337B1 (ko) * 2004-06-30 2006-11-23 주식회사 롯데기공 보일러의 누수 감지방법
JP5091679B2 (ja) * 2004-10-15 2012-12-05 アメリカ合衆国 マルチドメイン両親媒性ヘリックスペプチドおよびその使用方法
EP1853593A1 (en) * 2005-03-01 2007-11-14 Wyeth Crystalline and amorphous 4-cyano-n{(2r)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-propyl}-n-pyridin-2-yl-benzamide hydrochloride
TW200800959A (en) * 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
US7495111B2 (en) * 2005-06-17 2009-02-24 Wyeth Compounds useful as serotonin inhibitors and 5-HT1A agonists and antagonists
JP2009524680A (ja) * 2006-01-26 2009-07-02 ザ ユニバーシティ オブ ロチェスター 血液脳関門におけるアミロイドβペプチド／ＲＡＧＥ相互作用の阻害
TW200808741A (en) * 2006-06-09 2008-02-16 Wyeth Corp 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
TW200808740A (en) * 2006-06-09 2008-02-16 Wyeth Corp Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof
TW200811144A (en) * 2006-06-09 2008-03-01 Wyeth Corp Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline
US20080262228A1 (en) * 2006-11-28 2008-10-23 Wyeth Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof
TW200901974A (en) * 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them
US8936787B2 (en) * 2008-04-15 2015-01-20 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Peptides promoting lipid efflux

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101722A (en) 1991-05-02 1996-05-14 Wyeth John & Brother Ltd History of piperazine, their preparation and pharmaceutical preparations containing them
GB9514901D0 (en) 1995-07-20 1995-09-20 American Home Prod Piperazine derivatives

Also Published As

Publication number Publication date
JP4198989B2 (ja) 2008-12-17
KR20030051879A (ko) 2003-06-25
US7026320B2 (en) 2006-04-11
KR100835552B1 (ko) 2008-06-09
DE60103927T2 (de) 2005-06-23
AU2002237654B2 (en) 2005-07-28
NO20032390D0 (no) 2003-05-27
DE60103927D1 (de) 2004-07-22
US20030216408A1 (en) 2003-11-20
AR035603A1 (es) 2004-06-16
US6469007B2 (en) 2002-10-22
HUP0400551A2 (en) 2006-02-28
US6586436B2 (en) 2003-07-01
EA005925B1 (ru) 2005-08-25
PT1339406E (pt) 2004-10-29
ES2222401T3 (es) 2005-02-01
WO2002044142A3 (en) 2002-08-08
CA2428039A1 (en) 2002-06-06
AU3765402A (en) 2002-06-11
CA2428039C (en) 2011-08-09
JP2004520289A (ja) 2004-07-08
US20030022901A1 (en) 2003-01-30
EP1339406A2 (en) 2003-09-03
NZ526150A (en) 2004-11-26
EP1339406B1 (en) 2004-06-16
TWI224102B (en) 2004-11-21
US20020107254A1 (en) 2002-08-08
TR200401546T4 (tr) 2004-09-21
IL156098A0 (en) 2003-12-23
DK1339406T3 (da) 2004-09-27
HK1057864A1 (en) 2004-04-23
BR0115609A (pt) 2003-11-11
PL363219A1 (en) 2004-11-15
ATE269078T1 (de) 2004-07-15
NO20032390L (no) 2003-07-22
WO2002044142A2 (en) 2002-06-06
CN1477961A (zh) 2004-02-25
CN100352437C (zh) 2007-12-05
NO325501B1 (no) 2008-05-26
MXPA03004677A (es) 2003-09-05

Similar Documents

Publication Publication Date Title
EA200300619A1 (ru) Серотонинергические средства
EA200201179A1 (ru) Производные 2-аминокарбонил-9h-пурина
EA200600925A1 (ru) Производные триазола в качестве антагонистов вазопрессина
EA200300919A1 (ru) N-замещенные неарильные гетероциклические антагонисты nmda/nr2b
EA200300829A1 (ru) Производные 1-арил- или 1-алкилсульфонилбензазола в качестве лигандов 5-гидрокситриптамина-6
RS50140B (sr) Postupak za dobijanje perkihinina i njegova upotreba
AR088921A2 (es) PROCESO PARA LA PREPARACION DE DERIVADOS DE ACETILENO QUE TIENEN ACTIVIDAD ANTAGONISTA mGluR5, COMPOSICIONES Y USO DE LOS COMPUESTOS
EA200101177A1 (ru) Производные индола в качестве антагонистов прогестерона
EA200100826A1 (ru) 16-галогенопроизводные эпотилона, способ их получения и их применение в фармацевтике
DK1404317T3 (da) 5-Halogentryptaminderivater til anvendelse som ligander af 5-HT6- og/eller 5-HT7-serotoninreceptorer
EA200200873A1 (ru) Новые пиперазиновые производные
ATE297910T1 (de) Retinoid x rezeptormodulatoren
HRP20090162T1 (en) Quinolinone-carboxamide compounds as 5-ht4 receptor agonists
ATE374190T1 (de) Tetrahydrochinazolinderivate als cfr-antagonisten
DE69838662D1 (de) Morphinanderivate und ihre medizinische Anwendung
TR200100698T2 (tr) 5-HT4 alıcı-Antagonistleri olarak Dihidrobenzodioksin Karboksamit ve Keton türevleri
EA200300593A1 (ru) Соединения пиперазинилпиразинов в качестве агонистов или антагонистов серотонин 5-ht2 рецептора
EA200301142A1 (ru) Производные гетероциклилокси-, -тиокси- и -аминобензазола в качестве лигандов 5-гидрокситриптамина-6
EA200000804A1 (ru) Мета-азациклические соединения аминобензойной кислоты и их производные, являющиеся ингибиторами интегрина
EA200300629A1 (ru) Конденсированные производные пурина как антагонисты рецепторов аденозина a
EA200700364A1 (ru) Производные амида кинуреновой кислоты как антагонисты nr2b подтипа рецептора nmda
EA200301143A1 (ru) Производные гетероциклилалкокси-, алкилтио- и -алкиламинобензазола в качестве лигандов 5-гидрокситриптамина-6
EA200301317A1 (ru) Производные аминохинолина и его применение в качестве лигандов аденозина a3
DE60002583D1 (de) Benzofurylpiperazine als serotonin-agonisten
EA200301087A1 (ru) Новые пиперидинкарбоксамидные производные, способ их получения и содержащие их фармацевтические композиции

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU