ATE439356T1 - Verfahren zur herstellung von chiralen n-aryl piperazinen - Google Patents
Verfahren zur herstellung von chiralen n-aryl piperazinenInfo
- Publication number
- ATE439356T1 ATE439356T1 AT03716384T AT03716384T ATE439356T1 AT E439356 T1 ATE439356 T1 AT E439356T1 AT 03716384 T AT03716384 T AT 03716384T AT 03716384 T AT03716384 T AT 03716384T AT E439356 T1 ATE439356 T1 AT E439356T1
- Authority
- AT
- Austria
- Prior art keywords
- producing chiral
- aryl piperazines
- piperazines
- aryl
- chiral
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36343102P | 2002-03-12 | 2002-03-12 | |
| PCT/US2003/007078 WO2003078417A1 (en) | 2002-03-12 | 2003-03-10 | Process for synthesizing chiral n-aryl piperazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE439356T1 true ATE439356T1 (de) | 2009-08-15 |
Family
ID=28041762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03716384T ATE439356T1 (de) | 2002-03-12 | 2003-03-10 | Verfahren zur herstellung von chiralen n-aryl piperazinen |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6713626B2 (de) |
| EP (1) | EP1483255B1 (de) |
| JP (1) | JP4391241B2 (de) |
| KR (1) | KR20040105765A (de) |
| CN (2) | CN1982307A (de) |
| AR (1) | AR038930A1 (de) |
| AT (1) | ATE439356T1 (de) |
| AU (1) | AU2003220094B2 (de) |
| BR (1) | BR0308377A (de) |
| CA (1) | CA2477892C (de) |
| CR (1) | CR7431A (de) |
| DE (1) | DE60328756D1 (de) |
| EC (1) | ECSP045290A (de) |
| ES (1) | ES2329122T3 (de) |
| IL (1) | IL163827A0 (de) |
| MX (1) | MXPA04008729A (de) |
| NO (1) | NO20044050L (de) |
| NZ (1) | NZ535168A (de) |
| RU (1) | RU2315762C2 (de) |
| TW (1) | TW200403231A (de) |
| UA (1) | UA79273C2 (de) |
| WO (1) | WO2003078417A1 (de) |
| ZA (1) | ZA200408202B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060287335A1 (en) * | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
| US20060223824A1 (en) * | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
| US7504395B2 (en) * | 2001-07-20 | 2009-03-17 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder |
| KR20040091720A (ko) * | 2002-03-12 | 2004-10-28 | 와이어쓰 | Ｎ1-(2'-피리딜)-1,2-프로판디아민 설팜산의 제조방법 및생물학적 활성 피페라진 합성시의 이의 용도 |
| US7361773B2 (en) * | 2002-03-12 | 2008-04-22 | Wyeth | Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
| US7091349B2 (en) * | 2002-03-12 | 2006-08-15 | Wyeth | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution |
| CN101492383A (zh) * | 2002-03-12 | 2009-07-29 | 惠氏公司 | 制备手性1,4-二取代哌嗪的方法 |
| US20050215561A1 (en) * | 2004-03-19 | 2005-09-29 | Krishnendu Ghosh | Pharmaceutical dosage forms and compositions |
| US20050209245A1 (en) * | 2004-03-19 | 2005-09-22 | Wyeth | Process for preparing N-aryl-piperazine derivatives |
| US20070099931A1 (en) * | 2004-03-19 | 2007-05-03 | Wyeth | Pharmaceutical dosage forms and compositions |
| KR20070112797A (ko) * | 2005-03-01 | 2007-11-27 | 와이어쓰 | 결정질 및 비결정질4-시아노-ｎ-((2ｒ)-2-[4-(2,3-디히드로-벤조[1,4]디옥신-5-일)-피페라진-1-일]-프로필)-ｎ-피리딘-2-일-벤즈아미드염산염 |
| CN117003693B (zh) * | 2022-05-05 | 2026-01-30 | 四川大学华西医院 | 一类哌啶衍生物及其制备方法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE81975T1 (de) | 1984-12-21 | 1992-11-15 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| JPH01125357A (ja) | 1987-11-06 | 1989-05-17 | Dainippon Pharmaceut Co Ltd | トリペプチドの誘導体 |
| MX9201991A (es) * | 1991-05-02 | 1992-11-01 | Jonh Wyeth & Brother Limited | Derivados de piperazina y procedimiento para su preparacion. |
| GB9125900D0 (en) * | 1991-12-05 | 1992-02-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
| WO1994024115A1 (fr) | 1993-04-16 | 1994-10-27 | Santen Pharmaceutical Co., Ltd. | Nouveau derive de piperazine |
| GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
| CA2191874C (en) | 1994-06-03 | 2008-05-20 | Christopher Ian Brightwell | Novel processes and intermediates for the preparation of piperazine derivatives |
| GB9413772D0 (en) * | 1994-07-08 | 1994-08-24 | Wyeth John & Brother Ltd | 5-HT1A ligands |
| GB9514901D0 (en) * | 1995-07-20 | 1995-09-20 | American Home Prod | Piperazine derivatives |
| ES2185009T3 (es) | 1996-04-10 | 2003-04-16 | Merck & Co Inc | Antagonistas de alfa y beta 3'. |
| US6469007B2 (en) | 2000-11-28 | 2002-10-22 | Wyeth | Serotonergic agents |
-
2003
- 2003-03-10 MX MXPA04008729A patent/MXPA04008729A/es active IP Right Grant
- 2003-03-10 JP JP2003576423A patent/JP4391241B2/ja not_active Expired - Fee Related
- 2003-03-10 WO PCT/US2003/007078 patent/WO2003078417A1/en not_active Ceased
- 2003-03-10 BR BR0308377-2A patent/BR0308377A/pt not_active IP Right Cessation
- 2003-03-10 TW TW092105097A patent/TW200403231A/zh unknown
- 2003-03-10 CN CNA2007100083292A patent/CN1982307A/zh active Pending
- 2003-03-10 NZ NZ535168A patent/NZ535168A/xx unknown
- 2003-03-10 AU AU2003220094A patent/AU2003220094B2/en not_active Expired - Fee Related
- 2003-03-10 RU RU2004130300/04A patent/RU2315762C2/ru not_active IP Right Cessation
- 2003-03-10 AT AT03716384T patent/ATE439356T1/de not_active IP Right Cessation
- 2003-03-10 KR KR10-2004-7014156A patent/KR20040105765A/ko not_active Ceased
- 2003-03-10 ES ES03716384T patent/ES2329122T3/es not_active Expired - Lifetime
- 2003-03-10 IL IL16382703A patent/IL163827A0/xx unknown
- 2003-03-10 DE DE60328756T patent/DE60328756D1/de not_active Expired - Lifetime
- 2003-03-10 EP EP03716384A patent/EP1483255B1/de not_active Expired - Lifetime
- 2003-03-10 CA CA2477892A patent/CA2477892C/en not_active Expired - Fee Related
- 2003-03-10 US US10/384,845 patent/US6713626B2/en not_active Expired - Fee Related
- 2003-03-10 CN CNB038058413A patent/CN1304388C/zh not_active Expired - Fee Related
- 2003-03-11 AR ARP030100831A patent/AR038930A1/es unknown
- 2003-10-03 UA UA20041008211A patent/UA79273C2/uk unknown
-
2004
- 2004-08-24 CR CR7431A patent/CR7431A/es not_active Application Discontinuation
- 2004-09-10 EC EC2004005290A patent/ECSP045290A/es unknown
- 2004-09-24 NO NO20044050A patent/NO20044050L/no not_active Application Discontinuation
- 2004-10-11 ZA ZA200408202A patent/ZA200408202B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200403231A (en) | 2004-03-01 |
| DE60328756D1 (de) | 2009-09-24 |
| ES2329122T3 (es) | 2009-11-23 |
| AR038930A1 (es) | 2005-02-02 |
| EP1483255B1 (de) | 2009-08-12 |
| JP2005526775A (ja) | 2005-09-08 |
| CN1982307A (zh) | 2007-06-20 |
| RU2004130300A (ru) | 2005-04-10 |
| US6713626B2 (en) | 2004-03-30 |
| AU2003220094B2 (en) | 2009-04-23 |
| CA2477892C (en) | 2010-11-23 |
| RU2315762C2 (ru) | 2008-01-27 |
| AU2003220094A1 (en) | 2003-09-29 |
| CA2477892A1 (en) | 2003-09-25 |
| BR0308377A (pt) | 2005-01-11 |
| US20030187265A1 (en) | 2003-10-02 |
| EP1483255A1 (de) | 2004-12-08 |
| IL163827A0 (en) | 2005-12-18 |
| ECSP045290A (es) | 2004-10-26 |
| ZA200408202B (en) | 2007-03-28 |
| UA79273C2 (en) | 2007-06-11 |
| WO2003078417A1 (en) | 2003-09-25 |
| NO20044050L (no) | 2004-09-24 |
| CN1304388C (zh) | 2007-03-14 |
| CR7431A (es) | 2008-07-29 |
| NZ535168A (en) | 2006-03-31 |
| CN1642936A (zh) | 2005-07-20 |
| KR20040105765A (ko) | 2004-12-16 |
| MXPA04008729A (es) | 2005-07-13 |
| JP4391241B2 (ja) | 2009-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |