ECSP045290A - Proceso para la síntesis de piperazinas n-arílicas quirales. - Google Patents
Proceso para la síntesis de piperazinas n-arílicas quirales.Info
- Publication number
- ECSP045290A ECSP045290A EC2004005290A ECSP045290A ECSP045290A EC SP045290 A ECSP045290 A EC SP045290A EC 2004005290 A EC2004005290 A EC 2004005290A EC SP045290 A ECSP045290 A EC SP045290A EC SP045290 A ECSP045290 A EC SP045290A
- Authority
- EC
- Ecuador
- Prior art keywords
- aryl
- chiral
- piperazins
- synthesis
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- -1 2-aminopyridyl Chemical group 0.000 abstract 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Un proceso para la preparación de piperazinas N-arílicas con cadenas laterales quirales que tienen la estructura que se muestra en la fórmula abajo, y para la preparación de compuestos intermedios para las mismas: (Fórmula I). En este proceso, se introduce la quiralidad en el paso de formación del anillo de piperazina y la sustitución de 2-aminopiridilo se incorpora mediante desplazamiento. Las piperazinas N,N'-disustituidas resultantes actúan en el sistema nervioso central en los receptores de 5HT.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36343102P | 2002-03-12 | 2002-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045290A true ECSP045290A (es) | 2004-10-26 |
Family
ID=28041762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2004005290A ECSP045290A (es) | 2002-03-12 | 2004-09-10 | Proceso para la síntesis de piperazinas n-arílicas quirales. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6713626B2 (es) |
| EP (1) | EP1483255B1 (es) |
| JP (1) | JP4391241B2 (es) |
| KR (1) | KR20040105765A (es) |
| CN (2) | CN1304388C (es) |
| AR (1) | AR038930A1 (es) |
| AT (1) | ATE439356T1 (es) |
| AU (1) | AU2003220094B2 (es) |
| BR (1) | BR0308377A (es) |
| CA (1) | CA2477892C (es) |
| CR (1) | CR7431A (es) |
| DE (1) | DE60328756D1 (es) |
| EC (1) | ECSP045290A (es) |
| ES (1) | ES2329122T3 (es) |
| IL (1) | IL163827A0 (es) |
| MX (1) | MXPA04008729A (es) |
| NO (1) | NO20044050L (es) |
| NZ (1) | NZ535168A (es) |
| RU (1) | RU2315762C2 (es) |
| TW (1) | TW200403231A (es) |
| UA (1) | UA79273C2 (es) |
| WO (1) | WO2003078417A1 (es) |
| ZA (1) | ZA200408202B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060287335A1 (en) * | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
| US20060223824A1 (en) | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
| US7504395B2 (en) * | 2001-07-20 | 2009-03-17 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder |
| ATE360002T1 (de) * | 2002-03-12 | 2007-05-15 | Wyeth Corp | Verfahren zur herstellung von n1-(2'-pyridyl)-1,2-propandiaminsulfamidsäure und ihre verwendung zur herstellung von biologisch aktiven piperazinen |
| US7361773B2 (en) | 2002-03-12 | 2008-04-22 | Wyeth | Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines |
| US7091349B2 (en) * | 2002-03-12 | 2006-08-15 | Wyeth | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution |
| MXPA04008730A (es) * | 2002-03-12 | 2004-12-06 | Wyeth Corp | Proceso para preparacion de piperazinas quirales 1,4-disustituidas. |
| US20050215561A1 (en) * | 2004-03-19 | 2005-09-29 | Krishnendu Ghosh | Pharmaceutical dosage forms and compositions |
| US20070099931A1 (en) * | 2004-03-19 | 2007-05-03 | Wyeth | Pharmaceutical dosage forms and compositions |
| US20050209245A1 (en) * | 2004-03-19 | 2005-09-22 | Wyeth | Process for preparing N-aryl-piperazine derivatives |
| CN101137648A (zh) * | 2005-03-01 | 2008-03-05 | 惠氏公司 | 结晶和非晶4－氰基－n－{(2r)－2－[4－(2,3－二氢－苯并[1,4]二氧杂环己烯－5－基)－哌嗪－1－基]－丙基}－n－吡啶－2－基－苯甲酰胺盐酸盐 |
| CN117003693B (zh) * | 2022-05-05 | 2026-01-30 | 四川大学华西医院 | 一类哌啶衍生物及其制备方法和用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3586794T2 (de) | 1984-12-21 | 1993-05-27 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| JPH01125357A (ja) | 1987-11-06 | 1989-05-17 | Dainippon Pharmaceut Co Ltd | トリペプチドの誘導体 |
| IL101722A (en) * | 1991-05-02 | 1996-05-14 | Wyeth John & Brother Ltd | Piperazine derivatives their preparation and pharmaceutical compositions containing them |
| GB9125900D0 (en) * | 1991-12-05 | 1992-02-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
| WO1994024115A1 (fr) | 1993-04-16 | 1994-10-27 | Santen Pharmaceutical Co., Ltd. | Nouveau derive de piperazine |
| GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
| EP0763024B1 (en) | 1994-06-03 | 2002-08-14 | JOHN WYETH & BROTHER LIMITED | Processes and intermediates for the preparation of piperazine derivatives |
| GB9413772D0 (en) * | 1994-07-08 | 1994-08-24 | Wyeth John & Brother Ltd | 5-HT1A ligands |
| GB9514901D0 (en) * | 1995-07-20 | 1995-09-20 | American Home Prod | Piperazine derivatives |
| CA2251017A1 (en) | 1996-04-10 | 1997-10-16 | Mark E. Duggan | .alpha.v.beta.3 antagonists |
| US6469007B2 (en) | 2000-11-28 | 2002-10-22 | Wyeth | Serotonergic agents |
-
2003
- 2003-03-10 AT AT03716384T patent/ATE439356T1/de not_active IP Right Cessation
- 2003-03-10 AU AU2003220094A patent/AU2003220094B2/en not_active Expired - Fee Related
- 2003-03-10 BR BR0308377-2A patent/BR0308377A/pt not_active IP Right Cessation
- 2003-03-10 WO PCT/US2003/007078 patent/WO2003078417A1/en not_active Ceased
- 2003-03-10 MX MXPA04008729A patent/MXPA04008729A/es active IP Right Grant
- 2003-03-10 TW TW092105097A patent/TW200403231A/zh unknown
- 2003-03-10 NZ NZ535168A patent/NZ535168A/xx unknown
- 2003-03-10 CN CNB038058413A patent/CN1304388C/zh not_active Expired - Fee Related
- 2003-03-10 ES ES03716384T patent/ES2329122T3/es not_active Expired - Lifetime
- 2003-03-10 JP JP2003576423A patent/JP4391241B2/ja not_active Expired - Fee Related
- 2003-03-10 EP EP03716384A patent/EP1483255B1/en not_active Expired - Lifetime
- 2003-03-10 CN CNA2007100083292A patent/CN1982307A/zh active Pending
- 2003-03-10 IL IL16382703A patent/IL163827A0/xx unknown
- 2003-03-10 KR KR10-2004-7014156A patent/KR20040105765A/ko not_active Ceased
- 2003-03-10 CA CA2477892A patent/CA2477892C/en not_active Expired - Fee Related
- 2003-03-10 RU RU2004130300/04A patent/RU2315762C2/ru not_active IP Right Cessation
- 2003-03-10 DE DE60328756T patent/DE60328756D1/de not_active Expired - Lifetime
- 2003-03-10 US US10/384,845 patent/US6713626B2/en not_active Expired - Fee Related
- 2003-03-11 AR ARP030100831A patent/AR038930A1/es unknown
- 2003-10-03 UA UA20041008211A patent/UA79273C2/uk unknown
-
2004
- 2004-08-24 CR CR7431A patent/CR7431A/es not_active Application Discontinuation
- 2004-09-10 EC EC2004005290A patent/ECSP045290A/es unknown
- 2004-09-24 NO NO20044050A patent/NO20044050L/no not_active Application Discontinuation
- 2004-10-11 ZA ZA200408202A patent/ZA200408202B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1642936A (zh) | 2005-07-20 |
| ATE439356T1 (de) | 2009-08-15 |
| WO2003078417A1 (en) | 2003-09-25 |
| AU2003220094A1 (en) | 2003-09-29 |
| ZA200408202B (en) | 2007-03-28 |
| CR7431A (es) | 2008-07-29 |
| BR0308377A (pt) | 2005-01-11 |
| RU2004130300A (ru) | 2005-04-10 |
| KR20040105765A (ko) | 2004-12-16 |
| DE60328756D1 (de) | 2009-09-24 |
| CA2477892C (en) | 2010-11-23 |
| IL163827A0 (en) | 2005-12-18 |
| CA2477892A1 (en) | 2003-09-25 |
| NZ535168A (en) | 2006-03-31 |
| CN1304388C (zh) | 2007-03-14 |
| US6713626B2 (en) | 2004-03-30 |
| EP1483255A1 (en) | 2004-12-08 |
| RU2315762C2 (ru) | 2008-01-27 |
| JP4391241B2 (ja) | 2009-12-24 |
| CN1982307A (zh) | 2007-06-20 |
| JP2005526775A (ja) | 2005-09-08 |
| ES2329122T3 (es) | 2009-11-23 |
| AU2003220094B2 (en) | 2009-04-23 |
| NO20044050L (no) | 2004-09-24 |
| TW200403231A (en) | 2004-03-01 |
| MXPA04008729A (es) | 2005-07-13 |
| EP1483255B1 (en) | 2009-08-12 |
| UA79273C2 (en) | 2007-06-11 |
| AR038930A1 (es) | 2005-02-02 |
| US20030187265A1 (en) | 2003-10-02 |
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