ECSP045292A - Proceso para la preparación de piperazines quirales 1,4-disustituidas - Google Patents

Proceso para la preparación de piperazines quirales 1,4-disustituidas

Info

Publication number
ECSP045292A
ECSP045292A EC2004005292A ECSP045292A ECSP045292A EC SP045292 A ECSP045292 A EC SP045292A EC 2004005292 A EC2004005292 A EC 2004005292A EC SP045292 A ECSP045292 A EC SP045292A EC SP045292 A ECSP045292 A EC SP045292A
Authority
EC
Ecuador
Prior art keywords
preparation
disustituted
piperazines
disubstituted piperazines
chiral
Prior art date
Application number
EC2004005292A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ECSP045292A publication Critical patent/ECSP045292A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/06—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing halogen atoms, or nitro or nitroso groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un proceso para la preparación estereoselectiva de novedosos derivados de mostaza de nitrógeno quirales útiles en la síntesis de piperazinas 1,4-disustituidas ópticamente activas de la Fórmula (I), donde R, Ar y Q se definen según se contempla en esta solicitud, y compuestos intermedios de los mismos. Las piperazinas 1,4-disustituidas actúan como agentes de conjugación del receptor 5HT1A útiles en el tratamiento de trastornos del Sistema Nervioso Central (SNC).
EC2004005292A 2002-03-12 2004-09-10 Proceso para la preparación de piperazines quirales 1,4-disustituidas ECSP045292A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36345802P 2002-03-12 2002-03-12

Publications (1)

Publication Number Publication Date
ECSP045292A true ECSP045292A (es) 2004-10-26

Family

ID=28041772

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005292A ECSP045292A (es) 2002-03-12 2004-09-10 Proceso para la preparación de piperazines quirales 1,4-disustituidas

Country Status (20)

Country Link
US (3) US7019137B2 (es)
EP (1) EP1483256A2 (es)
JP (1) JP2005527530A (es)
KR (1) KR20040091119A (es)
CN (2) CN100451014C (es)
AR (1) AR038931A1 (es)
AU (1) AU2003220110B2 (es)
BR (1) BR0308347A (es)
CA (1) CA2477906A1 (es)
CR (1) CR7428A (es)
EC (1) ECSP045292A (es)
IL (1) IL163828A0 (es)
MX (1) MXPA04008730A (es)
NO (1) NO20043988L (es)
NZ (1) NZ535169A (es)
RU (2) RU2315044C2 (es)
TW (1) TW200304825A (es)
UA (1) UA79774C2 (es)
WO (1) WO2003078420A2 (es)
ZA (1) ZA200408205B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7504395B2 (en) * 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
US7361773B2 (en) * 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
MXPA04008730A (es) * 2002-03-12 2004-12-06 Wyeth Corp Proceso para preparacion de piperazinas quirales 1,4-disustituidas.
US20050215561A1 (en) * 2004-03-19 2005-09-29 Krishnendu Ghosh Pharmaceutical dosage forms and compositions
US20070099931A1 (en) * 2004-03-19 2007-05-03 Wyeth Pharmaceutical dosage forms and compositions
US20050209245A1 (en) * 2004-03-19 2005-09-22 Wyeth Process for preparing N-aryl-piperazine derivatives
WO2008117269A2 (en) 2007-03-28 2008-10-02 Atir Holding S.A. Heterotri cyciii c compounds as serotonergic and/or dopaminergic agents and uses thereof
CN108627380B (zh) * 2017-03-15 2020-10-20 中国人民解放军军事医学科学院毒物药物研究所 去除或减少有毒物质的方法以及检测有毒物质的方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE960203C (de) * 1953-12-25 1957-03-21 Yoshitomi Pharmaceutical Verfahren zur Herstellung von N-substituierten Aminocarbonsaeureestern
NZ209876A (en) * 1983-10-17 1988-03-30 Duphar Int Res Piperazines and pharmaceutical compositions
DE3586794T2 (de) 1984-12-21 1993-05-27 Duphar Int Res Arzneimittel mit psychotroper wirkung.
JPH01125357A (ja) 1987-11-06 1989-05-17 Dainippon Pharmaceut Co Ltd トリペプチドの誘導体
IL101722A (en) 1991-05-02 1996-05-14 Wyeth John & Brother Ltd Piperazine derivatives their preparation and pharmaceutical compositions containing them
GB9125900D0 (en) * 1991-12-05 1992-02-05 Wyeth John & Brother Ltd Piperazine derivatives
IL105348A0 (en) * 1992-04-13 1993-08-18 Fujisawa Pharmaceutical Co Azabicyclo derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
GB9208740D0 (en) * 1992-04-23 1992-06-10 Glaxo Group Ltd Chemical compounds
WO1994024115A1 (fr) 1993-04-16 1994-10-27 Santen Pharmaceutical Co., Ltd. Nouveau derive de piperazine
GB9411099D0 (en) 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives
EP0763024B1 (en) 1994-06-03 2002-08-14 JOHN WYETH & BROTHER LIMITED Processes and intermediates for the preparation of piperazine derivatives
GB9413772D0 (en) 1994-07-08 1994-08-24 Wyeth John & Brother Ltd 5-HT1A ligands
DK0775118T3 (da) * 1994-08-05 2003-09-29 Pfizer Benzimidazolderivater, der har dopaminerg aktivitet
US5681958A (en) * 1995-06-07 1997-10-28 Shaman Pharmaceuticals, Inc. Cryptolepine analogs with hypoglycemic activity
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
GB9514901D0 (en) 1995-07-20 1995-09-20 American Home Prod Piperazine derivatives
CA2251017A1 (en) 1996-04-10 1997-10-16 Mark E. Duggan .alpha.v.beta.3 antagonists
US6271234B1 (en) 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
JPH11106381A (ja) * 1997-09-30 1999-04-20 Ss Pharmaceut Co Ltd クロメン誘導体及びその塩並びにこれを含有する医薬
US6469007B2 (en) 2000-11-28 2002-10-22 Wyeth Serotonergic agents
ES2283625T3 (es) * 2001-11-30 2007-11-01 Schering Corporation Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos.
ATE439356T1 (de) * 2002-03-12 2009-08-15 Wyeth Corp Verfahren zur herstellung von chiralen n-aryl piperazinen
MXPA04008730A (es) 2002-03-12 2004-12-06 Wyeth Corp Proceso para preparacion de piperazinas quirales 1,4-disustituidas.
US7091349B2 (en) * 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
US7361773B2 (en) * 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
ATE360002T1 (de) 2002-03-12 2007-05-15 Wyeth Corp Verfahren zur herstellung von n1-(2'-pyridyl)-1,2-propandiaminsulfamidsäure und ihre verwendung zur herstellung von biologisch aktiven piperazinen

Also Published As

Publication number Publication date
CN101492383A (zh) 2009-07-29
WO2003078420A3 (en) 2004-03-11
CN100451014C (zh) 2009-01-14
NZ535169A (en) 2006-03-31
RU2007125687A (ru) 2009-01-20
TW200304825A (en) 2003-10-16
JP2005527530A (ja) 2005-09-15
CR7428A (es) 2008-09-23
US20030208075A1 (en) 2003-11-06
WO2003078420A2 (en) 2003-09-25
CA2477906A1 (en) 2003-09-25
EP1483256A2 (en) 2004-12-08
AU2003220110A1 (en) 2003-09-29
BR0308347A (pt) 2005-01-25
RU2004130313A (ru) 2005-04-10
US20050228181A1 (en) 2005-10-13
AU2003220110B2 (en) 2009-04-09
MXPA04008730A (es) 2004-12-06
IL163828A0 (en) 2005-12-18
UA79774C2 (en) 2007-07-25
US7256289B2 (en) 2007-08-14
NO20043988L (no) 2004-09-23
US7019137B2 (en) 2006-03-28
CN1642937A (zh) 2005-07-20
RU2315044C2 (ru) 2008-01-20
ZA200408205B (en) 2007-03-28
KR20040091119A (ko) 2004-10-27
US20080058543A1 (en) 2008-03-06
AR038931A1 (es) 2005-02-02

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