YU45809B - Postupak za dobijanje 1-heteroaril-4-/(2,5-pirolidindion-1-il)-alkil/-pipe raz kih derivata - Google Patents

Postupak za dobijanje 1-heteroaril-4-/(2,5-pirolidindion-1-il)-alkil/-pipe raz kih derivata

Info

Publication number
YU45809B
YU45809B YU210386A YU210386A YU45809B YU 45809 B YU45809 B YU 45809B YU 210386 A YU210386 A YU 210386A YU 210386 A YU210386 A YU 210386A YU 45809 B YU45809 B YU 45809B
Authority
YU
Yugoslavia
Prior art keywords
defined above
hydrogen
formula
substituted phenyl
forms
Prior art date
Application number
YU210386A
Other languages
English (en)
Other versions
YU210386A (en
Inventor
J.S. New
J.P. Vevich
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Priority to YU210386A priority Critical patent/YU45809B/sh
Publication of YU210386A publication Critical patent/YU210386A/xx
Publication of YU45809B publication Critical patent/YU45809B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE 1-HETEROARIL-4-/(2,5-PIROLIDINDION-1-IL)-ALKIL/-PIPE RAZ KIH DERIVATA, formule: i njihovih farmaceutski prihvatljivih adicionih soli sa kiselinama, gde R1 predstavlja C1-4alkil, trifluorometil ili Z-supstituisani fenil, pri cemu je Z vodonik ili halogen; ili R1 sa R2 gradi C4-5 alkilenski most koji inkorporira kondenzovani Z-supstituisani fenil, pri cemu je Z kao sto je definisano gore; ili R1, zajedno sa R3, obrazuje kondenzovani cikloheksenil prsten ili X1-X4 tetra-supstituisani fenil, pri cemu su X1-X4 nezavisno odabrani od vodonika, halogena ili nitro; R2 je C1-4 alkil ili Z-supstituisani fenil, gde je Z kao sto je definisano gore, ili R2, zajedno sa R1, gradi alkilenski most kao sto je definisano ranije; ili je R2 odsutno, a R1 i R3 grade kondenzovani prstenasti sistem kao sto je definisano gore; R3 je vodonik ili, zajedno sa R1, obrazuje kondenzovani prstenasti sistem kao sto je definisano gore; B predstavlja R4, R5-disupstituisani heterociklicni prstenasto sistem odabran iz grupe koja se sastoji od benzoizotiazola, piridina i pirimidina, pri cemu su R4 i R5 nezavisno odabrani od C1-4alkil, C1-4alkoksi, C1-4alkiltio, cijano, halogena i vodonika; i n je 2-4; naz nacen time, sto jedinjenje formule: u kojoj su R1, R2, R3 i n kao sto je definisano ranije, reaguje sa jedinjenjem formule: Q ---- B (VII) u kojoj je B kao sto je definisano gore a Q je pogodna odlazeca grupa, kao sto je hloro, bromo, jodo, sulfat, fosfat, tozilat ili mezilat, u rastvaracu kao sto je benzol, dimetilformamid, etanol, acetonitril, toluol ili n-butil alkohol, na temperaturi refluksa reakcione smese, da bi se dobilo zeljeno jedinjenje formule (I) koje se, po potrebi, nakon toga prevodi u svoju farmaceutski prihvatljivu adicionu so, reakcijom sa pogodnom kiselinom. Prijava sadrzi jos 4 patentna zahteva.
YU210386A 1983-09-12 1986-12-09 Postupak za dobijanje 1-heteroaril-4-/(2,5-pirolidindion-1-il)-alkil/-pipe raz kih derivata YU45809B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YU210386A YU45809B (sh) 1983-09-12 1986-12-09 Postupak za dobijanje 1-heteroaril-4-/(2,5-pirolidindion-1-il)-alkil/-pipe raz kih derivata

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/531,519 US4524206A (en) 1983-09-12 1983-09-12 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
YU156384A YU45655B (sh) 1983-09-12 1984-09-10 Postupak za dobijanje 1-heteroaril-4-/(2,5 pirolidindion-1-il) alkil/piperazinskih derivata
YU210386A YU45809B (sh) 1983-09-12 1986-12-09 Postupak za dobijanje 1-heteroaril-4-/(2,5-pirolidindion-1-il)-alkil/-pipe raz kih derivata

Publications (2)

Publication Number Publication Date
YU210386A YU210386A (en) 1987-12-31
YU45809B true YU45809B (sh) 1992-07-20

Family

ID=24117966

Family Applications (2)

Application Number Title Priority Date Filing Date
YU156384A YU45655B (sh) 1983-09-12 1984-09-10 Postupak za dobijanje 1-heteroaril-4-/(2,5 pirolidindion-1-il) alkil/piperazinskih derivata
YU210386A YU45809B (sh) 1983-09-12 1986-12-09 Postupak za dobijanje 1-heteroaril-4-/(2,5-pirolidindion-1-il)-alkil/-pipe raz kih derivata

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU156384A YU45655B (sh) 1983-09-12 1984-09-10 Postupak za dobijanje 1-heteroaril-4-/(2,5 pirolidindion-1-il) alkil/piperazinskih derivata

Country Status (33)

Country Link
US (1) US4524206A (sh)
JP (1) JPH0647586B2 (sh)
KR (1) KR890000566B1 (sh)
AR (1) AR241910A1 (sh)
AU (1) AU581858B2 (sh)
BE (1) BE900555A (sh)
CA (1) CA1285564C (sh)
CH (1) CH660484A5 (sh)
CS (1) CS258119B2 (sh)
CY (1) CY1538A (sh)
DD (1) DD224593A5 (sh)
DE (1) DE3433327C2 (sh)
DK (1) DK171990B1 (sh)
ES (1) ES8605797A1 (sh)
FI (1) FI83515C (sh)
FR (1) FR2555585B1 (sh)
GB (1) GB2146333B (sh)
GR (1) GR80320B (sh)
HK (1) HK84590A (sh)
HU (1) HU192439B (sh)
IE (1) IE58020B1 (sh)
IL (1) IL72854A (sh)
IT (1) IT1196250B (sh)
LU (1) LU85537A1 (sh)
NL (1) NL8402769A (sh)
NO (1) NO162384B (sh)
NZ (1) NZ209480A (sh)
OA (1) OA07809A (sh)
PT (1) PT79187B (sh)
SE (1) SE463368B (sh)
SU (1) SU1384199A3 (sh)
YU (2) YU45655B (sh)
ZA (1) ZA847065B (sh)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4585773A (en) * 1984-07-11 1986-04-29 Bristol-Myers Company Isoindolinyl-alkyl-piperazines
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
JPS61238784A (ja) * 1985-04-17 1986-10-24 Sumitomo Seiyaku Kk コハク酸イミド誘導体及びその酸付加塩
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
US4826843A (en) * 1985-07-08 1989-05-02 Bristol-Myers Cerebral function enhancing diazinylpiperidine derivatives
NZ216720A (en) * 1985-07-08 1990-09-26 Bristol Myers Co Diazinylpiperidine derivatives and pharmaceutical compositions
US4925841A (en) * 1985-07-22 1990-05-15 Temple University Of The Commonwealth System Of Higher Education Mannich bases of spirosuccinimides
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
US4757073A (en) * 1986-09-30 1988-07-12 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1-yl) pyridines, compositions and use
DD263531A5 (de) * 1986-10-21 1989-01-04 ������@���Kk�� Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen
US4777254A (en) * 1986-12-02 1988-10-11 American Home Products Corp. Cyclic imides as H1 -antagonists
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
US4855430A (en) * 1987-11-12 1989-08-08 American Home Products Corporation Polycyclicamine with psychotropic activity
AU2717288A (en) * 1987-11-12 1989-06-01 American Home Products Corporation Polycyclicamines with psychotropic activity
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
NZ230045A (en) 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US5077295A (en) * 1988-09-16 1991-12-31 Pfizer Inc. Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
CN1050604C (zh) * 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
US5338738A (en) * 1993-04-19 1994-08-16 Bristol-Myers Squibb Company Cerebral function enhancers: acyclic amide derivatives of pyrimidinylpiperidines
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
US5538985A (en) * 1994-01-27 1996-07-23 Mitsui Toatsu Chemicals, Inc. Pyrrolidinone derivatives
US5521313A (en) * 1994-05-05 1996-05-28 Bristol-Myers Squibb Company Process for preparing certain azapirones
US6084097A (en) * 1997-10-20 2000-07-04 Council Of Scientific & Industrial Research Methods for preparing 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl] propanes
US6083950A (en) * 1997-11-13 2000-07-04 Ranbaxy Laboratories Limited 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers
WO2001048055A1 (en) * 1999-12-27 2001-07-05 Idemitsu Kosan Co., Ltd. Succinimide compounds and use thereof
CN1230423C (zh) * 2000-11-30 2005-12-07 兰贝克赛实验室有限公司 可有效用作尿－选择性α1－肾上腺素能受体封阻剂的1,4－双取代的哌嗪衍生物
US6660736B2 (en) * 2002-03-27 2003-12-09 Hoffmann-La Roche Inc. Phthalimido derivatives and a process for their preparation
CN1787995A (zh) * 2002-04-08 2006-06-14 兰贝克赛实验室有限公司 用作尿－选择性α－1A肾上腺素受体阻滞剂的α,w－二羧酰亚胺衍生物
ATE411027T1 (de) * 2003-10-23 2008-10-15 Hoffmann La Roche Benzazepin-derivate als mao-b-hemmer
US20090312344A1 (en) * 2004-05-31 2009-12-17 Mohammad Salman Arylpiperazine derivatives as adrenergic receptor antagonists
US20060247249A1 (en) * 2005-11-16 2006-11-02 Mohammad Salman Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers
US8003660B2 (en) 2006-02-22 2011-08-23 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
WO2008005295A2 (en) 2006-06-29 2008-01-10 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
CA2686525C (en) * 2007-03-29 2012-05-29 Obschestvo S Ogranishennoi Otvetstvennostu "Farmving" An antihistamine antiallergic agent and a method of deriving it
EP2625165B1 (en) 2010-10-05 2018-07-04 Syngenta Participations AG Insecticidal pyrrolidin-yl-aryl-carboxamides
AR086587A1 (es) 2011-05-31 2014-01-08 Syngenta Participations Ag Compuestos insecticidas
CN109438316A (zh) 2011-10-03 2019-03-08 先正达参股股份有限公司 杀虫的3-芳基-3-三氟甲基-取代的吡咯烷的对映选择性方法
EP3896058A3 (en) 2011-10-03 2022-01-12 Syngenta Participations Ag Enantionselective processes to insecticidal 3-aryl-3-trifluoromethyl-substituted pyrrolidines
WO2018172480A1 (en) 2017-03-23 2018-09-27 Syngenta Participations Ag Insecticidal compounds
US11104671B2 (en) 2017-03-23 2021-08-31 Syngenta Participations Ag Insecticidal compounds
WO2019243263A1 (en) 2018-06-19 2019-12-26 Syngenta Participations Ag Insecticidal compounds
US20220048876A1 (en) 2018-09-26 2022-02-17 Syngenta Participations Ag Insecticidal compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
US3558777A (en) * 1968-06-21 1971-01-26 Mead Johnson & Co Pharmacologic processes and compositions containing azaspirodecanediones and azaspiroundecanediones
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
US4305944A (en) * 1980-09-08 1981-12-15 Mead Johnson & Company N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines
JPS5976059A (ja) * 1982-10-21 1984-04-28 Sumitomo Chem Co Ltd 環状イミド誘導体及びその酸付加塩
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
HK84590A (en) 1990-10-25
FI83515C (fi) 1991-07-25
ZA847065B (en) 1985-04-24
LU85537A1 (fr) 1985-04-29
IT8422621A0 (it) 1984-09-11
NL8402769A (nl) 1985-04-01
IT1196250B (it) 1988-11-16
YU210386A (en) 1987-12-31
KR890000566B1 (ko) 1989-03-21
PT79187A (en) 1984-10-01
DE3433327A1 (de) 1985-03-28
IL72854A (en) 1988-03-31
US4524206A (en) 1985-06-18
IE58020B1 (en) 1993-06-30
FI843522L (fi) 1985-03-13
FR2555585B1 (fr) 1989-01-06
CY1538A (en) 1990-11-16
FR2555585A1 (fr) 1985-05-31
CS672184A2 (en) 1987-12-17
BE900555A (fr) 1985-03-11
DK433884D0 (da) 1984-09-12
IL72854A0 (en) 1984-12-31
NO843579L (no) 1985-03-13
SE463368B (sv) 1990-11-12
GB2146333A (en) 1985-04-17
FI843522A0 (fi) 1984-09-07
KR850002483A (ko) 1985-05-13
AU581858B2 (en) 1989-03-09
CS258119B2 (en) 1988-07-15
AU3287084A (en) 1985-05-30
FI83515B (fi) 1991-04-15
HU192439B (en) 1987-06-29
OA07809A (fr) 1986-11-20
GB2146333B (en) 1987-04-01
YU156384A (en) 1987-02-28
CH660484A5 (de) 1987-04-30
IE842311L (en) 1985-03-12
IT8422621A1 (it) 1986-03-11
AR241910A1 (es) 1993-01-29
PT79187B (en) 1986-11-24
GB8422860D0 (en) 1984-10-17
YU45655B (sh) 1992-07-20
DE3433327C2 (de) 1998-07-16
DK171990B1 (da) 1997-09-08
GR80320B (en) 1985-01-14
CA1285564C (en) 1991-07-02
DK433884A (da) 1985-03-13
HUT36116A (en) 1985-08-28
NO162384B (no) 1989-09-11
NZ209480A (en) 1988-01-08
JPH0647586B2 (ja) 1994-06-22
ES535780A0 (es) 1986-04-01
SE8404552L (sv) 1985-03-13
SU1384199A3 (ru) 1988-03-23
SE8404552D0 (sv) 1984-09-11
ES8605797A1 (es) 1986-04-01
DD224593A5 (de) 1985-07-10
JPS6084282A (ja) 1985-05-13

Similar Documents

Publication Publication Date Title
YU45809B (sh) Postupak za dobijanje 1-heteroaril-4-/(2,5-pirolidindion-1-il)-alkil/-pipe raz kih derivata
YU46541B (sh) Postupak za dobijanje antiaritmičkih agenasa
YU47790B (sr) Postupak za dobijanje novih farmakološki aktivnih kateholnih derivata
YU46079B (sh) Postupak za dobijanje 1-tercijarnih-alkil-supstituisanih naftiridin-i hinolin-karboksilnih kiselina
YU175585A (en) Process for making new dihydropiridines
DK157861C (da) Analogifremgangsmaade til fremstilling af 4-substituerede fenylalkylimidazolderivater eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf
YU45667B (sh) Postupak za dobijanje 1,2,4-triazolon jedinjenja
ES8307760A1 (es) Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina.
YU27691A (sh) Poboljšanja vezana za leukotrienske antagoniste
YU45757B (sh) Postupak za dobijanje cikličnih imidnih derivata 2-(4-butilpiperazin-1-il)-piridina
GB1441859A (en) Pyrazole derivatives process for tbeir preparation and their use as medicaments
ES8700857A1 (es) Un procedimiento para la produccion de dihidropiridinas
YU47605B (sh) Postupak za dobijanje supstituisanih derivata stirena
YU45867B (sh) Postupak za dobijanje derivata 3,7-diazabiciklo (3,3,1) nonana
YU238990A (sh) Imidazo (4,5-c) piridini kao antiostereoporozna sredstva
ES478485A1 (es) Procedimiento para la preparacion de 1-oxo-1h-pirimido (6-1-b) benzotiazoles.
US4012387A (en) Benzo-[g]pyrido[2,1-b]quinazolinones
HUT37756A (en) Process for preparing 1,4-dihydro-pyridina derivatives
HRP20000027B1 (en) Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds
SU419034A3 (ru) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ХИНАЗОЛИНА1Изобретение относитс к способу получени новых производных хиназолина, которые обладают улучшенными лекарственными свойствами и могут найти нрименение в фармацевтической промышленности.Предлагаетс основанный на известной реакции алкилировани хиназолннов способ получени производных хиназолина общей формулы ICnH,n--R.Примером галоида в формуле I могут служить атомы хлора, брома, фтора и йода; Ci—С4-алкилов — метил, этил, н-пропил, изо- пропил, н-бутил, изобутил и т/?ет-бутил; 5 Ci—С4-алкоксильных групп — метокси-, эток- СИ-, н-пропокси-, изопронокси-, н-бутокси-, изо- бутокси- и грег-бутоксигруппы; Сз—Се-цикло- алкилов — циклопропил, циклобутил, цикло- пентил, циклогексил, метилциклопропил, ди- 10 метилциклопронил и т. п. группы. Когда СпН2п группа — алкилен с 1—3 атомами углерода, она может быть представлена такими группами, как метиленова , этиленова , 1-метилэти- ленова , 2-метилэтиленова и триметиленова .где D — группаСпособ получени соединений формулы 1 заключаетс в том, что 1-незамеш,енное производное хиназолина общей формулы П15Нг; , :- ;-О "^ О ."^ -'.RI, R2 и Rs каждый — водород, галоид, нит- рогруппа, Ci—С4-алкил, Ci—Сгалкоксил, С\—С4-алкилтиогруП'Па, Ci—С^алкилсульфо- группа, Ci—С4-алкилсульфинильна группа, грифторметил;R4 — Сз—Сб-циклоалг-'ил;W — кислород или сера;п — О или целое число от 1 до 3.2025где RI, Ra, D и W имеют вышеуказанные зна- 30 чени .
BE879727A (fr) Derives de 1,2,4-triazole, leur preparation et leur utilisation
DK394483A (da) Fremgangsmaade til fremstilling af 1,7-dihydropyrrol(3,4-e)-(1,4)diazepin-2(3h)-on-derivater
YU13197A (sh) Novi 2,3-benzodiazepinski derivati, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže
EP0035285A3 (en) Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters
YU108992A (sh) Nova jedinjenja