IT1196250B - Derivati di 1-eteroaril-4-((2,5-pirrolidindion-1-il)alchil) piperazine - Google Patents

Derivati di 1-eteroaril-4-((2,5-pirrolidindion-1-il)alchil) piperazine

Info

Publication number
IT1196250B
IT1196250B IT22621/84A IT2262184A IT1196250B IT 1196250 B IT1196250 B IT 1196250B IT 22621/84 A IT22621/84 A IT 22621/84A IT 2262184 A IT2262184 A IT 2262184A IT 1196250 B IT1196250 B IT 1196250B
Authority
IT
Italy
Prior art keywords
pirrolidindion
eteroaril
alchil
piperazine
derivatives
Prior art date
Application number
IT22621/84A
Other languages
English (en)
Other versions
IT8422621A0 (it
Inventor
James Stewart New
Joseph P Yevich
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT8422621A0 publication Critical patent/IT8422621A0/it
Application granted granted Critical
Publication of IT1196250B publication Critical patent/IT1196250B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
IT22621/84A 1983-09-12 1984-09-11 Derivati di 1-eteroaril-4-((2,5-pirrolidindion-1-il)alchil) piperazine IT1196250B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/531,519 US4524206A (en) 1983-09-12 1983-09-12 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Publications (2)

Publication Number Publication Date
IT8422621A0 IT8422621A0 (it) 1984-09-11
IT1196250B true IT1196250B (it) 1988-11-16

Family

ID=24117966

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22621/84A IT1196250B (it) 1983-09-12 1984-09-11 Derivati di 1-eteroaril-4-((2,5-pirrolidindion-1-il)alchil) piperazine

Country Status (33)

Country Link
US (1) US4524206A (it)
JP (1) JPH0647586B2 (it)
KR (1) KR890000566B1 (it)
AR (1) AR241910A1 (it)
AU (1) AU581858B2 (it)
BE (1) BE900555A (it)
CA (1) CA1285564C (it)
CH (1) CH660484A5 (it)
CS (1) CS258119B2 (it)
CY (1) CY1538A (it)
DD (1) DD224593A5 (it)
DE (1) DE3433327C2 (it)
DK (1) DK171990B1 (it)
ES (1) ES8605797A1 (it)
FI (1) FI83515C (it)
FR (1) FR2555585B1 (it)
GB (1) GB2146333B (it)
GR (1) GR80320B (it)
HK (1) HK84590A (it)
HU (1) HU192439B (it)
IE (1) IE58020B1 (it)
IL (1) IL72854A (it)
IT (1) IT1196250B (it)
LU (1) LU85537A1 (it)
NL (1) NL8402769A (it)
NO (1) NO162384B (it)
NZ (1) NZ209480A (it)
OA (1) OA07809A (it)
PT (1) PT79187B (it)
SE (1) SE463368B (it)
SU (1) SU1384199A3 (it)
YU (2) YU45655B (it)
ZA (1) ZA847065B (it)

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JPS61238784A (ja) * 1985-04-17 1986-10-24 Sumitomo Seiyaku Kk コハク酸イミド誘導体及びその酸付加塩
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US4826843A (en) * 1985-07-08 1989-05-02 Bristol-Myers Cerebral function enhancing diazinylpiperidine derivatives
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JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
US4757073A (en) * 1986-09-30 1988-07-12 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1-yl) pyridines, compositions and use
DD263531A5 (de) * 1986-10-21 1989-01-04 ������@���Kk�� Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen
US4777254A (en) * 1986-12-02 1988-10-11 American Home Products Corp. Cyclic imides as H1 -antagonists
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US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
CN1050604C (zh) * 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
US5338738A (en) * 1993-04-19 1994-08-16 Bristol-Myers Squibb Company Cerebral function enhancers: acyclic amide derivatives of pyrimidinylpiperidines
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
US5538985A (en) * 1994-01-27 1996-07-23 Mitsui Toatsu Chemicals, Inc. Pyrrolidinone derivatives
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US6906191B2 (en) 1999-12-27 2005-06-14 Idemitsu Kosan Co., Ltd. Succinimide compounds and use thereof
JP2004514711A (ja) 2000-11-30 2004-05-20 ランバクシー　ラボラトリーズ　リミテッド 尿選択的アルファ１アドレナリン受容体遮断薬として有用な１，４−２基置換ピペラジン誘導体
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CN1787995A (zh) * 2002-04-08 2006-06-14 兰贝克赛实验室有限公司 用作尿－选择性α－1A肾上腺素受体阻滞剂的α,w－二羧酰亚胺衍生物
CA2543287A1 (en) * 2003-10-23 2005-05-06 F.Hoffmann-La Roche Ag Benzazepine derivatives as mao-b inhibitors
WO2005118537A2 (en) * 2004-05-31 2005-12-15 Ranbaxy Laboratories Limited Arylpiperazine derivatives as adrenergic receptor antagonists
US20060247249A1 (en) * 2005-11-16 2006-11-02 Mohammad Salman Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers
KR20080094964A (ko) 2006-02-22 2008-10-27 버텍스 파마슈티칼스 인코포레이티드 무스카린성 수용체의 조절제
JP2009542670A (ja) 2006-06-29 2009-12-03 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体の調節剤
PT2159226T (pt) * 2007-03-29 2016-12-16 Joint-Stock Company Obninsk Chemical Pharmaceutical Company Agente anti-histamínico e antialérgico e um método para a produção do mesmo
BR112013008063A2 (pt) 2010-10-05 2016-06-14 Syngenta Participations Ag pirrolidin-il-aril-carboxamidas inseticidas
UY34104A (es) 2011-05-31 2013-01-03 Syngenta Participations Ag ?compuestos derivados benzamídicos heterocíclicos, procesos e intermedios para su preparación, composiciones y métodos para su uso?.
CN105017125B (zh) 2011-10-03 2018-12-11 先正达参股股份有限公司 杀虫的3-芳基-3-三氟甲基-取代的吡咯烷的对映选择性方法
EP3896058A3 (en) 2011-10-03 2022-01-12 Syngenta Participations Ag Enantionselective processes to insecticidal 3-aryl-3-trifluoromethyl-substituted pyrrolidines
US11104671B2 (en) 2017-03-23 2021-08-31 Syngenta Participations Ag Insecticidal compounds
US11213032B2 (en) 2017-03-23 2022-01-04 Syngenta Participations Ag Insecticidal compounds
WO2019243263A1 (en) 2018-06-19 2019-12-26 Syngenta Participations Ag Insecticidal compounds
US20220048876A1 (en) 2018-09-26 2022-02-17 Syngenta Participations Ag Insecticidal compounds

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DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
NO843579L (no) 1985-03-13
DK171990B1 (da) 1997-09-08
AU3287084A (en) 1985-05-30
SE463368B (sv) 1990-11-12
ES535780A0 (es) 1986-04-01
NO162384B (no) 1989-09-11
IT8422621A0 (it) 1984-09-11
SE8404552D0 (sv) 1984-09-11
YU45809B (sh) 1992-07-20
HK84590A (en) 1990-10-25
FI843522A0 (fi) 1984-09-07
YU210386A (en) 1987-12-31
GR80320B (en) 1985-01-14
OA07809A (fr) 1986-11-20
SE8404552L (sv) 1985-03-13
SU1384199A3 (ru) 1988-03-23
NL8402769A (nl) 1985-04-01
HUT36116A (en) 1985-08-28
FR2555585A1 (fr) 1985-05-31
DD224593A5 (de) 1985-07-10
FI83515B (fi) 1991-04-15
KR890000566B1 (ko) 1989-03-21
BE900555A (fr) 1985-03-11
LU85537A1 (fr) 1985-04-29
CS672184A2 (en) 1987-12-17
FI843522L (fi) 1985-03-13
JPH0647586B2 (ja) 1994-06-22
FI83515C (fi) 1991-07-25
CS258119B2 (en) 1988-07-15
IE842311L (en) 1985-03-12
AR241910A1 (es) 1993-01-29
DK433884D0 (da) 1984-09-12
IL72854A0 (en) 1984-12-31
PT79187B (en) 1986-11-24
IL72854A (en) 1988-03-31
AU581858B2 (en) 1989-03-09
KR850002483A (ko) 1985-05-13
GB2146333A (en) 1985-04-17
DE3433327C2 (de) 1998-07-16
YU156384A (en) 1987-02-28
CH660484A5 (de) 1987-04-30
NZ209480A (en) 1988-01-08
IE58020B1 (en) 1993-06-30
YU45655B (sh) 1992-07-20
US4524206A (en) 1985-06-18
ZA847065B (en) 1985-04-24
GB2146333B (en) 1987-04-01
CY1538A (en) 1990-11-16
JPS6084282A (ja) 1985-05-13
DE3433327A1 (de) 1985-03-28
ES8605797A1 (es) 1986-04-01
CA1285564C (en) 1991-07-02
HU192439B (en) 1987-06-29
DK433884A (da) 1985-03-13
GB8422860D0 (en) 1984-10-17
PT79187A (en) 1984-10-01
FR2555585B1 (fr) 1989-01-06

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