DK433884A - 1-heteroaryl-4-((2,5-pyrrolidindion-1-yl)-alkyl)piperazin-derivater og fremgangsmaade til fremstilling deraf - Google Patents

1-heteroaryl-4-((2,5-pyrrolidindion-1-yl)-alkyl)piperazin-derivater og fremgangsmaade til fremstilling deraf Download PDF

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Publication number
DK433884A
DK433884A DK433884A DK433884A DK433884A DK 433884 A DK433884 A DK 433884A DK 433884 A DK433884 A DK 433884A DK 433884 A DK433884 A DK 433884A DK 433884 A DK433884 A DK 433884A
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pyrrolidindion
heteroaryl
alkyl
preparing
procedure
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DK433884A
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DK171990B1 (da
DK433884D0 (da
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James Stewart New
Joseph P Yevich
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Bristol Myers Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK433884A 1983-09-12 1984-09-12 1-Heteroaryl-4-((2,5-pyrrolidindion-1-yl)-alkyl)piperazin-derivater, fremgangsmåder til deres fremstilling samt farmaceutiske midler omfattende disse derivater DK171990B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53151983 1983-09-12
US06/531,519 US4524206A (en) 1983-09-12 1983-09-12 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Publications (3)

Publication Number Publication Date
DK433884D0 DK433884D0 (da) 1984-09-12
DK433884A true DK433884A (da) 1985-03-13
DK171990B1 DK171990B1 (da) 1997-09-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK433884A DK171990B1 (da) 1983-09-12 1984-09-12 1-Heteroaryl-4-((2,5-pyrrolidindion-1-yl)-alkyl)piperazin-derivater, fremgangsmåder til deres fremstilling samt farmaceutiske midler omfattende disse derivater

Country Status (33)

Country Link
US (1) US4524206A (da)
JP (1) JPH0647586B2 (da)
KR (1) KR890000566B1 (da)
AR (1) AR241910A1 (da)
AU (1) AU581858B2 (da)
BE (1) BE900555A (da)
CA (1) CA1285564C (da)
CH (1) CH660484A5 (da)
CS (1) CS258119B2 (da)
CY (1) CY1538A (da)
DD (1) DD224593A5 (da)
DE (1) DE3433327C2 (da)
DK (1) DK171990B1 (da)
ES (1) ES8605797A1 (da)
FI (1) FI83515C (da)
FR (1) FR2555585B1 (da)
GB (1) GB2146333B (da)
GR (1) GR80320B (da)
HK (1) HK84590A (da)
HU (1) HU192439B (da)
IE (1) IE58020B1 (da)
IL (1) IL72854A (da)
IT (1) IT1196250B (da)
LU (1) LU85537A1 (da)
NL (1) NL8402769A (da)
NO (1) NO162384B (da)
NZ (1) NZ209480A (da)
OA (1) OA07809A (da)
PT (1) PT79187B (da)
SE (1) SE463368B (da)
SU (1) SU1384199A3 (da)
YU (2) YU45655B (da)
ZA (1) ZA847065B (da)

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DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4585773A (en) * 1984-07-11 1986-04-29 Bristol-Myers Company Isoindolinyl-alkyl-piperazines
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
JPS61238784A (ja) * 1985-04-17 1986-10-24 Sumitomo Seiyaku Kk コハク酸イミド誘導体及びその酸付加塩
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
NZ216720A (en) * 1985-07-08 1990-09-26 Bristol Myers Co Diazinylpiperidine derivatives and pharmaceutical compositions
US4826843A (en) * 1985-07-08 1989-05-02 Bristol-Myers Cerebral function enhancing diazinylpiperidine derivatives
US4925841A (en) * 1985-07-22 1990-05-15 Temple University Of The Commonwealth System Of Higher Education Mannich bases of spirosuccinimides
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
US4757073A (en) * 1986-09-30 1988-07-12 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1-yl) pyridines, compositions and use
DD263531A5 (de) * 1986-10-21 1989-01-04 ������@���Kk�� Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen
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US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US5077295A (en) * 1988-09-16 1991-12-31 Pfizer Inc. Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
KR0179063B1 (ko) * 1993-02-04 1999-03-20 사사이 아키라 항정신병 작용을 갖는 화합물
US5338738A (en) * 1993-04-19 1994-08-16 Bristol-Myers Squibb Company Cerebral function enhancers: acyclic amide derivatives of pyrimidinylpiperidines
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
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BR112013008063A2 (pt) 2010-10-05 2016-06-14 Syngenta Participations Ag pirrolidin-il-aril-carboxamidas inseticidas
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BR112014007460A2 (pt) 2011-10-03 2017-04-04 Syngenta Participations Ag processos enanciosseletivos para pirrolidinas 3-aril-3-trifluorometil-substituídas inseticidas
EP3896058A3 (en) 2011-10-03 2022-01-12 Syngenta Participations Ag Enantionselective processes to insecticidal 3-aryl-3-trifluoromethyl-substituted pyrrolidines
EP3601280A1 (en) 2017-03-23 2020-02-05 Syngenta Participations AG Insecticidal compounds
WO2018172477A1 (en) 2017-03-23 2018-09-27 Syngenta Participations Ag Insecticidal compounds
WO2019243263A1 (en) 2018-06-19 2019-12-26 Syngenta Participations Ag Insecticidal compounds
EP3856715A1 (en) 2018-09-26 2021-08-04 Syngenta Participations Ag Insecticidal compounds

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DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
IL72854A (en) 1988-03-31
CY1538A (en) 1990-11-16
FI843522L (fi) 1985-03-13
DK171990B1 (da) 1997-09-08
NO843579L (no) 1985-03-13
PT79187A (en) 1984-10-01
NL8402769A (nl) 1985-04-01
YU45655B (sh) 1992-07-20
PT79187B (en) 1986-11-24
AU3287084A (en) 1985-05-30
NZ209480A (en) 1988-01-08
US4524206A (en) 1985-06-18
ZA847065B (en) 1985-04-24
CS258119B2 (en) 1988-07-15
HK84590A (en) 1990-10-25
SE8404552D0 (sv) 1984-09-11
SE8404552L (sv) 1985-03-13
SU1384199A3 (ru) 1988-03-23
FI83515C (fi) 1991-07-25
IE842311L (en) 1985-03-12
DD224593A5 (de) 1985-07-10
OA07809A (fr) 1986-11-20
IL72854A0 (en) 1984-12-31
ES8605797A1 (es) 1986-04-01
GB2146333A (en) 1985-04-17
ES535780A0 (es) 1986-04-01
FI83515B (fi) 1991-04-15
SE463368B (sv) 1990-11-12
GB8422860D0 (en) 1984-10-17
CS672184A2 (en) 1987-12-17
BE900555A (fr) 1985-03-11
CH660484A5 (de) 1987-04-30
IE58020B1 (en) 1993-06-30
LU85537A1 (fr) 1985-04-29
JPH0647586B2 (ja) 1994-06-22
KR850002483A (ko) 1985-05-13
KR890000566B1 (ko) 1989-03-21
FR2555585A1 (fr) 1985-05-31
YU156384A (en) 1987-02-28
CA1285564C (en) 1991-07-02
FR2555585B1 (fr) 1989-01-06
HUT36116A (en) 1985-08-28
GB2146333B (en) 1987-04-01
JPS6084282A (ja) 1985-05-13
AR241910A1 (es) 1993-01-29
AU581858B2 (en) 1989-03-09
GR80320B (en) 1985-01-14
IT8422621A0 (it) 1984-09-11
HU192439B (en) 1987-06-29
YU210386A (en) 1987-12-31
DE3433327C2 (de) 1998-07-16
DE3433327A1 (de) 1985-03-28
DK433884D0 (da) 1984-09-12
NO162384B (no) 1989-09-11
YU45809B (sh) 1992-07-20
IT1196250B (it) 1988-11-16
FI843522A0 (fi) 1984-09-07

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