YU13197A - Novi 2,3-benzodiazepinski derivati, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže - Google Patents
Novi 2,3-benzodiazepinski derivati, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadržeInfo
- Publication number
- YU13197A YU13197A YU13197A YU13197A YU13197A YU 13197 A YU13197 A YU 13197A YU 13197 A YU13197 A YU 13197A YU 13197 A YU13197 A YU 13197A YU 13197 A YU13197 A YU 13197A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- hydrogen
- formula
- independently
- alkyl group
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 150000002431 hydrogen Chemical class 0.000 abstract 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 abstract 1
- RPBDCDQMCRHNLM-UHFFFAOYSA-N C1=NNC=C2C=CC=CC2=C1 Chemical class C1=NNC=C2C=CC=CC2=C1 RPBDCDQMCRHNLM-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000036963 noncompetitive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Pronalazak se odnosi na nove 2,3-benzodiazepinske derivate koji su nekonkurentska AMPA antagonistička jedinjenja formule I, gde R1 i R2 predstavljaju, nezavisno, vodonik, halo, C1-4 alkil grupu, C1-4-alkoksi grupu, nitro grupu, trifluorometil grupu ili grupu formule -NR8R9, gde R8 i R9, označavaju, nezavisno, vodonik, C1-4 alkil grupu ili grupu formule -COR10, gde R10 je vodonik, C1-6 alkil grupa koja može biti supstituisana, C6-10 aril grupa, C1-4 alkoksi grupa, C3-5 cikloalkil grupa, C2-6 alkenil grupa, C3-5 cikloalkoksi grupa ili grupa formule-NR11R12, gde R11 i R12 označavaju, nezavisno, vodonik, C1-4 alkil grupu, C3-5 cikloalkil grupu ili C6-10 aril grupu; R3 predstavlja C1-4 alkil grupu, C3-5 cikloalkil grupu ili grupu formule -CO-R13, gde R13 ima istu definiciju datu za R10; R4 i R5 predstavljaju, nezavisno, vodonik ili C1-3 alkil grupu; R6 i R7 predstavljaju, nezavisno, vodonik, hloro ili bromo uz predpostavku da ako jedan od R6 i R7 označava vodonik, drugi nije vodonik, kao i na njihove izomere i kiselinske adicione soli jedinjenja ili izomera, na postupak za njihovo dobijanje i dalje na farmaceutske preparate dobijene od ovih. Pronalazak se odnosi takodje na polazna jedinjenja formule II, gde R1, R2, R4, R5, R6 i R7 su kao što je dato za jedinjenje formule
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9600871A HU9600871D0 (en) | 1996-04-04 | 1996-04-04 | New 2,3-benzodiazepine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
YU13197A true YU13197A (sh) | 1999-09-27 |
Family
ID=89993864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU13197A YU13197A (sh) | 1996-04-04 | 1997-04-03 | Novi 2,3-benzodiazepinski derivati, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže |
Country Status (11)
Country | Link |
---|---|
KR (1) | KR970069997A (sh) |
AT (1) | ATE254608T1 (sh) |
AU (1) | AU720745B2 (sh) |
BE (1) | BE1010962A4 (sh) |
DE (1) | DE59711013D1 (sh) |
ES (1) | ES2127699B1 (sh) |
IT (1) | IT1290453B1 (sh) |
NZ (1) | NZ314517A (sh) |
UA (1) | UA45358C2 (sh) |
YU (1) | YU13197A (sh) |
ZA (1) | ZA972746B (sh) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU179018B (en) * | 1978-10-19 | 1982-08-28 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivatives |
HU186760B (en) * | 1981-03-12 | 1985-09-30 | Gyogyszerkutato Intezet | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives |
HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
HU208429B (en) * | 1991-05-03 | 1993-10-28 | Gyogyszerkutato Intezet | Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity |
DK1157992T3 (da) * | 1994-08-31 | 2005-10-24 | Lilly Co Eli | Dihydro-2,3-benzodiazepinederivativer |
-
1997
- 1997-04-01 ZA ZA972746A patent/ZA972746B/xx unknown
- 1997-04-03 NZ NZ314517A patent/NZ314517A/xx unknown
- 1997-04-03 YU YU13197A patent/YU13197A/sh unknown
- 1997-04-03 BE BE9700308A patent/BE1010962A4/fr not_active IP Right Cessation
- 1997-04-03 KR KR1019970012301A patent/KR970069997A/ko not_active Application Discontinuation
- 1997-04-03 UA UA97041584A patent/UA45358C2/uk unknown
- 1997-04-04 AT AT97105591T patent/ATE254608T1/de not_active IP Right Cessation
- 1997-04-04 DE DE59711013T patent/DE59711013D1/de not_active Expired - Fee Related
- 1997-04-04 ES ES009700703A patent/ES2127699B1/es not_active Expired - Fee Related
- 1997-04-04 IT IT000776 patent/IT1290453B1/it active IP Right Grant
- 1997-04-04 AU AU17734/97A patent/AU720745B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
ES2127699B1 (es) | 2000-01-16 |
KR970069997A (ko) | 1997-11-07 |
ITMI970776A1 (it) | 1998-10-04 |
AU720745B2 (en) | 2000-06-08 |
DE59711013D1 (de) | 2003-12-24 |
BE1010962A4 (fr) | 1999-03-02 |
ES2127699A1 (es) | 1999-04-16 |
UA45358C2 (uk) | 2002-04-15 |
ATE254608T1 (de) | 2003-12-15 |
AU1773497A (en) | 1997-10-09 |
IT1290453B1 (it) | 1998-12-03 |
ZA972746B (en) | 1998-10-09 |
NZ314517A (en) | 2000-03-27 |
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