ATE60605T1 - 7-substituierte bicyclische pyrazolidinone. - Google Patents
7-substituierte bicyclische pyrazolidinone.Info
- Publication number
- ATE60605T1 ATE60605T1 AT86303174T AT86303174T ATE60605T1 AT E60605 T1 ATE60605 T1 AT E60605T1 AT 86303174 T AT86303174 T AT 86303174T AT 86303174 T AT86303174 T AT 86303174T AT E60605 T1 ATE60605 T1 AT E60605T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- group
- alkyl
- arylalkyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72902185A | 1985-04-30 | 1985-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE60605T1 true ATE60605T1 (de) | 1991-02-15 |
Family
ID=24929253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT86303174T ATE60605T1 (de) | 1985-04-30 | 1986-04-28 | 7-substituierte bicyclische pyrazolidinone. |
Country Status (16)
Country | Link |
---|---|
US (4) | US4734504A (de) |
EP (1) | EP0202046B1 (de) |
JP (2) | JPH0759582B2 (de) |
KR (1) | KR880001092B1 (de) |
CN (1) | CN86103619A (de) |
AT (1) | ATE60605T1 (de) |
AU (1) | AU5675586A (de) |
CA (1) | CA1274832A (de) |
DE (1) | DE3677253D1 (de) |
DK (1) | DK193086A (de) |
ES (1) | ES8801833A1 (de) |
GR (1) | GR861118B (de) |
HU (1) | HUT40660A (de) |
IL (1) | IL78634A0 (de) |
PT (1) | PT82468B (de) |
ZA (2) | ZA863170B (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4940718A (en) * | 1985-04-30 | 1990-07-10 | Eli Lilly And Company | 7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use |
KR880001092B1 (ko) * | 1985-04-30 | 1988-06-23 | 일라이 릴리 앤드 캄파니 | 7-치환된 바이시클릭 피라졸리디논 및 그의 제조방법 |
US4935536A (en) * | 1987-05-21 | 1990-06-19 | Millipore Corporation | Protecting groups for asparagine and glutamine in peptide synthesis |
IL86095A0 (de) * | 1987-09-30 | 1988-09-30 | Lilly Co Eli | |
US5011938A (en) * | 1989-10-02 | 1991-04-30 | Eli Lilly And Company | 7-substituted bicyclic pyrazolidinones |
US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5308841A (en) * | 1990-12-21 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
DE69220744T2 (de) * | 1991-09-27 | 1997-11-13 | Merrell Pharma Inc | 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung |
US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
NZ246811A (en) * | 1992-02-14 | 1996-02-27 | Merrell Dow Pharma | N-[pyrido (and oxazino and thiazino) benzazepine] 1-benzyl-1-(heterocyclyl(alkyl)carbonylthio) acetamide derivatives and pharmaceutical compositions |
WO1993023403A1 (en) * | 1992-05-15 | 1993-11-25 | Merrell Dow Pharmaceuticals Inc. | NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE |
US5420271A (en) * | 1992-08-24 | 1995-05-30 | Merrell Dow Pharmaceuticals, Inc. | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
US5470845A (en) * | 1992-10-28 | 1995-11-28 | Bristol-Myers Squibb Company | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia |
CA2107644A1 (en) * | 1992-10-28 | 1994-04-29 | David R. Magnin | .alpha.-phosphonosulfonae squalene synthetase inhibitors and methd |
WO1994010193A1 (en) * | 1992-10-30 | 1994-05-11 | Merrell Dow Pharmaceuticals Inc. | Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace |
DK0745080T3 (da) * | 1994-02-14 | 1999-09-27 | Merrell Pharma Inc | Nye mercaptoacetylamiddisulfidderivater, der er anvendelige som inhibitorer af enkephalinase og ACE. |
ES2145267T3 (es) * | 1994-02-14 | 2000-07-01 | Merrell Pharma Inc | Nuevos derivados bisulfuro de mercaptoacetilamido de 1,3,4,5-tetrahidro-benzo(c)azepin-3-ona utiles como inhibidores de la encefalinasa y del enzima de conversion de la angiotensina. |
US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
HUT76479A (en) * | 1994-02-14 | 1997-09-29 | Merrell Pharma Inc | Novel fused benzazepinone derivatives, process for preparation thereof and pharmaceutical composition containing them |
ES2168355T3 (es) * | 1994-02-14 | 2002-06-16 | Merrell Pharma Inc | Derivados de bisulfuro de indano-2-mercaptoacetilamida utiles como inhibidores de la encefalinasa. |
US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
CA2184692C (en) * | 1994-03-24 | 2001-01-02 | Gary A. Flynn | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives |
ES2141923T3 (es) * | 1994-03-24 | 2000-04-01 | Merrell Pharma Inc | Uso hipocolesterolemico, antiaterosclerotico e hipotrigliceridemico de derivados aminoacetilmercapto. |
US5447922A (en) * | 1994-08-24 | 1995-09-05 | Bristol-Myers Squibb Company | α-phosphonosulfinic squalene synthetase inhibitors |
US5786448A (en) * | 1996-11-07 | 1998-07-28 | Trega Biosciences, Inc. | Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein |
GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
TW201109335A (en) | 2009-08-04 | 2011-03-16 | Takeda Pharmaceutical | Heterocyclic compounds |
CN106883236B (zh) * | 2017-03-17 | 2018-12-04 | 浙江大学 | 一种制备含硫的n,n-双环吡唑烷酮类衍生物的方法 |
CN115286635B (zh) * | 2022-08-22 | 2023-10-24 | 河南师范大学 | 一种手性并环吡唑啉酮类化合物的合成方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3065224A (en) | 1955-06-24 | 1962-11-20 | Bayer Ag | Process for the production of addition products of organic isocyanates and organic carbodiimides |
US2938892A (en) | 1958-10-10 | 1960-05-31 | Little Inc A | Amides and process of preparing same with a monocarbodhmide |
AR206201A1 (es) | 1972-06-29 | 1976-07-07 | Ciba Geigy Ag | Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos |
GB1415910A (en) * | 1973-03-21 | 1975-12-03 | Kyowa Hakko Kogyo Kk | Benzothiazoles |
DD110868A1 (de) * | 1974-04-03 | 1975-01-12 | ||
GB1472052A (en) * | 1975-02-14 | 1977-04-27 | Pliva Pharm & Chem Works | Preparation of d-penicillamine and substituted 3-pyrazoline- 5-ones |
GB1591439A (en) | 1976-10-01 | 1981-06-24 | Glaxo Operations Ltd | 7-syn (oxyimino -acylamido) cephalosporins |
DE2714880A1 (de) | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
US4128425A (en) * | 1977-05-06 | 1978-12-05 | Polaroid Corporation | Photographic developers |
DD143617A1 (de) | 1979-05-14 | 1980-09-03 | Helmut Dorn | Verfahren zur herstellung von 2-nitro-und 2-amino-5-oxo-perhydro-pyrazolo eckige klammer auf 1,2-a eckige klammer zu pyrazolen |
DE2931673A1 (de) * | 1979-08-04 | 1981-02-26 | Basf Ag | Pyrazolin-5-on-yl-methyl-(di)thiophosphorsaeureester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen |
GB2073740A (en) * | 1980-03-03 | 1981-10-21 | Wellcome Found | Pyrazolidinones |
US4396619A (en) | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin betaines |
GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
US4465679A (en) * | 1983-01-31 | 1984-08-14 | Usv Pharmaceutical Corporation | 1,2-Diaza-3-one compounds, their use in treating hypertension and pharmaceutical compositions thereof |
AU575854B2 (en) | 1983-10-04 | 1988-08-11 | Shionogi & Co., Ltd. | 7beta-(carboxyalkenamido) cephalosporins |
HU198298B (en) | 1985-04-30 | 1989-09-28 | Lilly Co Eli | Process for producing 4-substituted pyrazolidinones |
HU198186B (en) | 1985-04-30 | 1989-08-28 | Lilly Co Eli | Process for producing pyrazolidinium-ilides |
KR880001092B1 (ko) * | 1985-04-30 | 1988-06-23 | 일라이 릴리 앤드 캄파니 | 7-치환된 바이시클릭 피라졸리디논 및 그의 제조방법 |
-
1986
- 1986-04-28 KR KR1019860003251A patent/KR880001092B1/ko not_active IP Right Cessation
- 1986-04-28 CA CA000507777A patent/CA1274832A/en not_active Expired - Lifetime
- 1986-04-28 AT AT86303174T patent/ATE60605T1/de not_active IP Right Cessation
- 1986-04-28 PT PT82468A patent/PT82468B/pt unknown
- 1986-04-28 EP EP86303174A patent/EP0202046B1/de not_active Expired - Lifetime
- 1986-04-28 HU HU861763A patent/HUT40660A/hu unknown
- 1986-04-28 CN CN198686103619A patent/CN86103619A/zh active Pending
- 1986-04-28 AU AU56755/86A patent/AU5675586A/en not_active Abandoned
- 1986-04-28 DE DE8686303174T patent/DE3677253D1/de not_active Expired - Lifetime
- 1986-04-28 ZA ZA863170A patent/ZA863170B/xx unknown
- 1986-04-28 ES ES554463A patent/ES8801833A1/es not_active Expired
- 1986-04-28 IL IL78634A patent/IL78634A0/xx unknown
- 1986-04-28 DK DK193086A patent/DK193086A/da not_active Application Discontinuation
- 1986-04-28 GR GR861118A patent/GR861118B/el unknown
- 1986-04-30 JP JP61100817A patent/JPH0759582B2/ja not_active Expired - Lifetime
- 1986-05-14 US US06/862,918 patent/US4734504A/en not_active Expired - Lifetime
- 1986-05-14 US US06/862,909 patent/US4734505A/en not_active Expired - Lifetime
- 1986-05-14 US US06/862,913 patent/US4716232A/en not_active Expired - Fee Related
- 1986-10-28 JP JP61258084A patent/JPS63112583A/ja active Pending
-
1987
- 1987-10-29 US US07/114,897 patent/US4795815A/en not_active Expired - Lifetime
-
1988
- 1988-04-13 ZA ZA882604A patent/ZA882604B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR880001092B1 (ko) | 1988-06-23 |
CA1274832A (en) | 1990-10-02 |
EP0202046B1 (de) | 1991-01-30 |
US4734505A (en) | 1988-03-29 |
JPS63112583A (ja) | 1988-05-17 |
GR861118B (en) | 1986-08-18 |
IL78634A0 (en) | 1986-08-31 |
CN86103619A (zh) | 1986-10-29 |
PT82468B (en) | 1988-03-23 |
DK193086A (da) | 1987-01-20 |
ES554463A0 (es) | 1988-02-16 |
JPH0759582B2 (ja) | 1995-06-28 |
US4716232A (en) | 1987-12-29 |
KR860008181A (ko) | 1986-11-12 |
ZA882604B (en) | 1989-12-27 |
ES8801833A1 (es) | 1988-02-16 |
DK193086D0 (da) | 1986-04-28 |
DE3677253D1 (de) | 1991-03-07 |
EP0202046A1 (de) | 1986-11-20 |
US4795815A (en) | 1989-01-03 |
ZA863170B (en) | 1987-12-30 |
AU5675586A (en) | 1986-11-13 |
PT82468A (en) | 1986-05-01 |
HUT40660A (en) | 1987-01-28 |
JPS61254589A (ja) | 1986-11-12 |
US4734504A (en) | 1988-03-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |