YU63392A - Bis(oksi) jedinjenja i postupak za njihovo dobijanje - Google Patents

Bis(oksi) jedinjenja i postupak za njihovo dobijanje

Info

Publication number
YU63392A
YU63392A YU63392A YU63392A YU63392A YU 63392 A YU63392 A YU 63392A YU 63392 A YU63392 A YU 63392A YU 63392 A YU63392 A YU 63392A YU 63392 A YU63392 A YU 63392A
Authority
YU
Yugoslavia
Prior art keywords
compounds
oxy
bis
value
groups
Prior art date
Application number
YU63392A
Other languages
English (en)
Inventor
V.M. Girijavallabhan
A.K. Ganguly
R.W. Versace
A.K. Saksena
P.A. Pinto
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Priority to HRP-633/92A priority Critical patent/HRP920365A2/hr
Publication of YU63392A publication Critical patent/YU63392A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Dental Preparations (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

BIS(OKSI) JEDINJENJA I POSTUPAK ZA NJIHOVO DOBIJANJE, pronalazak se odnosi na bis(oksi) jedinjenja formule Ar1-O-M-O-Ar2 (I), u kojoj Ar1 i Ar2 nezavisno predstavljaju supstituisani fenil ili supstituisani piridil, pri čemu su supstituenti nezavisno odabrani od jednog, dva ili tri halogena ili C1-10alkil, C1-10perhaloalkil, C1-10alkoksi, karbamil, di(C1-10)alkilkarbamil, C1-10alkoksikarbonil, oksazolinil grupa, ili C1-10alkil grupa supstituisanih sa C1-10alkoksi, hidroksi ili C1-10alkoksikarbonil; M predstavlja: C4-8alkilen, C4-8alkenilen ili C4-8alkinilen; O je kiseonik; R' je C1-3alkil ili vodonik; A je kiseonik ili sumpor; Q je odabrano od vodonika, halogena i grupa nitro, C1-6alkil, C1-6perhaloalkil, C1-6alkiltio i C1-6alkilsulfonil; isprekidane linije u M-3 i M-4, izmedju ugljenikovih atoma u položaju 2 i 3, 3 i 4 i 4 i 5 označavaju da veze izmedju ugljenikovih atoma u položaju 2 i 3, 3 i 4 ili 5 i 6 mogu da budu proste ili dvogube; n ima vrednost 1 ili 2; m ima vrednost 1 ili 2; p. ima vrednost 0 ili 1; i njihove farmaceutski prihvatljive soli. Jedinjenja iz sadašnjeg pronalaska su korisna kao sredstva za tretiranje i prevenciju virusnih, a naročito pikornavirusnih infekcija. Pronalazak obuhvata i postupak za dobijanje jedinjenja formule (I).
YU63392A 1991-06-19 1992-06-17 Bis(oksi) jedinjenja i postupak za njihovo dobijanje YU63392A (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HRP-633/92A HRP920365A2 (en) 1991-06-19 1992-09-21 Bis(oxy) compounds and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71745191A 1991-06-19 1991-06-19

Publications (1)

Publication Number Publication Date
YU63392A true YU63392A (sh) 1994-11-15

Family

ID=24882086

Family Applications (1)

Application Number Title Priority Date Filing Date
YU63392A YU63392A (sh) 1991-06-19 1992-06-17 Bis(oksi) jedinjenja i postupak za njihovo dobijanje

Country Status (23)

Country Link
US (4) US5559133A (sh)
EP (2) EP0519702A1 (sh)
JP (1) JP2625258B2 (sh)
KR (1) KR960004887B1 (sh)
AT (1) ATE182874T1 (sh)
AU (1) AU674657B2 (sh)
CA (1) CA2111854C (sh)
CZ (1) CZ279793A3 (sh)
DE (1) DE69229733T2 (sh)
ES (1) ES2134808T3 (sh)
FI (1) FI935690A (sh)
IE (1) IE921971A1 (sh)
IL (1) IL102241A0 (sh)
MX (1) MX9203068A (sh)
MY (1) MY107993A (sh)
NZ (1) NZ243180A (sh)
OA (1) OA09828A (sh)
PL (1) PL169699B1 (sh)
SK (1) SK144293A3 (sh)
TW (1) TW260658B (sh)
WO (1) WO1992022520A1 (sh)
YU (1) YU63392A (sh)
ZA (1) ZA924445B (sh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU674657B2 (en) * 1991-06-19 1997-01-09 Schering Corporation Orally active antiviral compounds
JPH08507062A (ja) * 1993-02-26 1996-07-30 シェリング・コーポレーション ヒトにおけるエンテロウイルス感染症の選択的処置のための２−クロロ−１−［［４−［（２，６−ジクロロフェノキシ）メチル］フェニル］メトキシ］−４−メトキシベンゼンの使用
AU6783698A (en) * 1997-04-10 1998-10-30 Pharmacia & Upjohn Company Polyaromatic antiviral compositions
AU6462500A (en) * 1999-07-29 2001-02-19 Patrick T. Prendergast Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418571A1 (de) * 1973-04-18 1974-11-14 Ciba Geigy Ag Phenyl-aralkyl-aether, diphenyle und benzophenone, verfahren zu ihrer herstellung und ihre verwendung
JPS509785A (sh) * 1973-05-31 1975-01-31
JPS5922697B2 (ja) * 1976-01-13 1984-05-28 エーザイ株式会社 ビス−（メタ−アミジノフエノキシ）−化合物
JPS5651423A (en) * 1979-09-13 1981-05-09 Wellcome Found Antiviral agent
WO1983002609A1 (fr) * 1982-01-29 1983-08-04 Inoue, Toshihide PROCEDE DE PREPARATION DE L'ACIDE 'alpha', 'omega'-BIS(2-CHLOROPHENOXY)-ALCANE-4,4'-DICARBOXYLIQUE OU SON ESTER D'ALKYLE INFERIEUR
US4851423A (en) * 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
JPH0621083B2 (ja) * 1986-12-22 1994-03-23 株式会社三光開発科学研究所 ジ（アリ−ルオキシ）アルカンの製造方法
US4891449A (en) * 1988-06-30 1990-01-02 Great Lakes Chemical Corporation Halogenated unsymmetrical higher alkyl phenoxy alkanes
KR920701167A (ko) * 1989-07-07 1992-08-11 에릭 에스. 딕커 약제학적 활성 화합물
AU674657B2 (en) * 1991-06-19 1997-01-09 Schering Corporation Orally active antiviral compounds

Also Published As

Publication number Publication date
CA2111854A1 (en) 1992-12-23
EP0519702A1 (en) 1992-12-23
CZ279793A3 (en) 1994-05-18
NZ243180A (en) 1995-08-28
EP0590026B1 (en) 1999-08-04
CA2111854C (en) 2001-01-09
MY107993A (en) 1996-07-15
ZA924445B (en) 1993-02-24
FI935690A0 (fi) 1993-12-17
JP2625258B2 (ja) 1997-07-02
DE69229733D1 (de) 1999-09-09
IE921971A1 (en) 1992-12-30
JPH06503839A (ja) 1994-04-28
PL169699B1 (en) 1996-08-30
IL102241A0 (en) 1993-01-14
ES2134808T3 (es) 1999-10-16
US5350772A (en) 1994-09-27
KR960004887B1 (ko) 1996-04-16
US5618849A (en) 1997-04-08
AU2221392A (en) 1993-01-12
US5449782A (en) 1995-09-12
OA09828A (en) 1994-04-15
MX9203068A (es) 1993-07-01
TW260658B (sh) 1995-10-21
US5559133A (en) 1996-09-24
WO1992022520A1 (en) 1992-12-23
DE69229733T2 (de) 1999-12-02
FI935690A (fi) 1993-12-17
ATE182874T1 (de) 1999-08-15
AU674657B2 (en) 1997-01-09
SK144293A3 (en) 1994-06-08
EP0590026A1 (en) 1994-04-06

Similar Documents

Publication Publication Date Title
SE8201145L (sv) Nya aminometyl-5 oxazolidiniska derivat, deras framstellningssett och derasterapeutiska anvendning
ATE131479T1 (de) 1,3-dihydro-2h-imidano 4,5-b-quinolin-2-ein derivate als phosphodiestenase hemmer
YU5493A (sh) Antibiotska jedinjenja
YU48105B (sh) Derivati triazola i postupak za njihovo dobijanje
ME00558A (en) Pyrazole derivatives for treating hiv
ME00870B (me) Derivati hinolina
HN1998000074A (es) Derivados de macrolidos c-4 sustituidos
ATE60605T1 (de) 7-substituierte bicyclische pyrazolidinone.
AR019496A1 (es) Azalidas de 13 miembros, composiciones farmaceuticas, uso en la preparacion de medicamentos y preparacion de los mismos
YU109092A (sh) Fungicidni derivati 2-imidazolin-5-ona i 2-imidazolin-5-tiona
YU63392A (sh) Bis(oksi) jedinjenja i postupak za njihovo dobijanje
FI923759A0 (fi) Terapeutiska bensazapinfoereningar.
DK0720598T3 (da) Phenoxyphenylcyclopentenyl-hydroxyurinstoffer
ATE325109T1 (de) Benzofuranderivate und pharmazeutische zusammensetzungen, die diese enthalten
ES2062426T3 (es) Derivados de benzonaftiridina-1,8, su preparacion y las composiciones que les contienen.
FI935867A (fi) Tetrahydrobensazepinderivat som inhibiterar lipoxigenas
DK0625140T3 (da) Cyclopropyl-N-hydroxyurinstof og -N-hydroxyacetamider, som inhiberer lipoxygenase
ES8203828A1 (es) Procedimiento para la obtencion de bis (fenoxiacetatos sus- tituidos)de n-alcohil-dialcanolaminas
YU153590A (sh) Derivati indola