GR861118B - 7-substituted bicyclic pyrazolidinones - Google Patents
7-substituted bicyclic pyrazolidinonesInfo
- Publication number
- GR861118B GR861118B GR861118A GR860101118A GR861118B GR 861118 B GR861118 B GR 861118B GR 861118 A GR861118 A GR 861118A GR 860101118 A GR860101118 A GR 860101118A GR 861118 B GR861118 B GR 861118B
- Authority
- GR
- Greece
- Prior art keywords
- substituted
- group
- alkyl
- arylalkyl
- phenyl
- Prior art date
Links
- -1 bicyclic pyrazolidinones Chemical class 0.000 title abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 17
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 10
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 9
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 8
- 150000002431 hydrogen Chemical group 0.000 abstract 8
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 8
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 150000001767 cationic compounds Chemical class 0.000 abstract 3
- 229910001411 inorganic cation Inorganic materials 0.000 abstract 3
- 150000002892 organic cations Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000005544 phthalimido group Chemical group 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- NDGRWYRVNANFNB-UHFFFAOYSA-N pyrazolidin-3-one Chemical class O=C1CCNN1 NDGRWYRVNANFNB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72902185A | 1985-04-30 | 1985-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR861118B true GR861118B (en) | 1986-08-18 |
Family
ID=24929253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR861118A GR861118B (en) | 1985-04-30 | 1986-04-28 | 7-substituted bicyclic pyrazolidinones |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US4716232A (el) |
| EP (1) | EP0202046B1 (el) |
| JP (2) | JPH0759582B2 (el) |
| KR (1) | KR880001092B1 (el) |
| CN (1) | CN86103619A (el) |
| AT (1) | ATE60605T1 (el) |
| AU (1) | AU5675586A (el) |
| CA (1) | CA1274832A (el) |
| DE (1) | DE3677253D1 (el) |
| DK (1) | DK193086A (el) |
| ES (1) | ES8801833A1 (el) |
| GR (1) | GR861118B (el) |
| HU (1) | HUT40660A (el) |
| IL (1) | IL78634A0 (el) |
| PT (1) | PT82468B (el) |
| ZA (2) | ZA863170B (el) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK193086A (da) * | 1985-04-30 | 1987-01-20 | Lilly Co Eli | 7-substituerede bicycliske pyrazolidinoner, fremgangsmaade til fremstilling heraf og mellemprodukter til brug ved fremgangsmaaden |
| US4940718A (en) * | 1985-04-30 | 1990-07-10 | Eli Lilly And Company | 7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use |
| US4935536A (en) * | 1987-05-21 | 1990-06-19 | Millipore Corporation | Protecting groups for asparagine and glutamine in peptide synthesis |
| IL86095A0 (el) * | 1987-09-30 | 1988-09-30 | Lilly Co Eli | |
| US5011938A (en) * | 1989-10-02 | 1991-04-30 | Eli Lilly And Company | 7-substituted bicyclic pyrazolidinones |
| US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5308841A (en) * | 1990-12-21 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| EP0534363B1 (en) * | 1991-09-27 | 1997-07-09 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| NZ246811A (en) * | 1992-02-14 | 1996-02-27 | Merrell Dow Pharma | N-[pyrido (and oxazino and thiazino) benzazepine] 1-benzyl-1-(heterocyclyl(alkyl)carbonylthio) acetamide derivatives and pharmaceutical compositions |
| JP3360079B2 (ja) * | 1992-05-15 | 2002-12-24 | メレルダウファーマスーティカルズ インコーポレイテッド | エンケファリナーゼ及びＡＣＥの阻害剤として有用な新規なメルカプトアセチルアミドピリダゾ［１，２］ピリダジン、ピラゾロ［１，２］ピリダジン、ピリダゾ［１，２‐ａ］［１，２］ジアゼピン、及びピラゾロ［１，２‐ａ］［１，２］ジアゼピン誘導体類 |
| US5420271A (en) * | 1992-08-24 | 1995-05-30 | Merrell Dow Pharmaceuticals, Inc. | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| US5470845A (en) * | 1992-10-28 | 1995-11-28 | Bristol-Myers Squibb Company | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia |
| CA2107644A1 (en) * | 1992-10-28 | 1994-04-29 | David R. Magnin | .alpha.-phosphonosulfonae squalene synthetase inhibitors and methd |
| DE69329701T2 (de) * | 1992-10-30 | 2001-05-10 | Merrell Pharma Inc | Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace-hemmer |
| AU687507B2 (en) * | 1994-02-14 | 1998-02-26 | Merrell Pharmaceuticals Inc. | Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| WO1995021854A1 (en) * | 1994-02-14 | 1995-08-17 | Merrell Pharmaceuticals Inc. | Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace |
| CA2183314C (en) * | 1994-02-14 | 1999-08-31 | Gary A. Flynn | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
| KR100348949B1 (ko) * | 1994-02-14 | 2003-01-24 | 메렐 파마슈티칼스 인크. | 엔케팔리나제의억제제로서유용한신규의인단-2-머캅토아세틸아미드디술파이드유도체 |
| US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
| JPH10503468A (ja) * | 1994-03-24 | 1998-03-31 | メリル・フアーマシユウテイカルズ・インコーポレイテツド | 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のメルカプトアセチルアミドジスルフィド誘導体 |
| ES2141923T3 (es) * | 1994-03-24 | 2000-04-01 | Merrell Pharma Inc | Uso hipocolesterolemico, antiaterosclerotico e hipotrigliceridemico de derivados aminoacetilmercapto. |
| US5447922A (en) * | 1994-08-24 | 1995-09-05 | Bristol-Myers Squibb Company | α-phosphonosulfinic squalene synthetase inhibitors |
| US5786448A (en) * | 1996-11-07 | 1998-07-28 | Trega Biosciences, Inc. | Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
| AR077688A1 (es) | 2009-08-04 | 2011-09-14 | Takeda Pharmaceutical | Compuestos heterociclicos, utiles en el tratamiento de cancer |
| CN106883236B (zh) * | 2017-03-17 | 2018-12-04 | 浙江大学 | 一种制备含硫的n，n-双环吡唑烷酮类衍生物的方法 |
| CN115286635B (zh) * | 2022-08-22 | 2023-10-24 | 河南师范大学 | 一种手性并环吡唑啉酮类化合物的合成方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065224A (en) | 1955-06-24 | 1962-11-20 | Bayer Ag | Process for the production of addition products of organic isocyanates and organic carbodiimides |
| US2938892A (en) | 1958-10-10 | 1960-05-31 | Little Inc A | Amides and process of preparing same with a monocarbodhmide |
| AR206201A1 (es) | 1972-06-29 | 1976-07-07 | Ciba Geigy Ag | Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos |
| GB1415910A (en) * | 1973-03-21 | 1975-12-03 | Kyowa Hakko Kogyo Kk | Benzothiazoles |
| DD110868A1 (el) * | 1974-04-03 | 1975-01-12 | ||
| GB1472052A (en) * | 1975-02-14 | 1977-04-27 | Pliva Pharm & Chem Works | Preparation of d-penicillamine and substituted 3-pyrazoline- 5-ones |
| GB1591439A (en) | 1976-10-01 | 1981-06-24 | Glaxo Operations Ltd | 7-syn (oxyimino -acylamido) cephalosporins |
| DE2714880A1 (de) | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
| US4128425A (en) * | 1977-05-06 | 1978-12-05 | Polaroid Corporation | Photographic developers |
| DD143617A1 (de) | 1979-05-14 | 1980-09-03 | Helmut Dorn | Verfahren zur herstellung von 2-nitro-und 2-amino-5-oxo-perhydro-pyrazolo eckige klammer auf 1,2-a eckige klammer zu pyrazolen |
| DE2931673A1 (de) * | 1979-08-04 | 1981-02-26 | Basf Ag | Pyrazolin-5-on-yl-methyl-(di)thiophosphorsaeureester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen |
| GB2073740A (en) * | 1980-03-03 | 1981-10-21 | Wellcome Found | Pyrazolidinones |
| US4396619A (en) | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin betaines |
| GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
| US4465679A (en) * | 1983-01-31 | 1984-08-14 | Usv Pharmaceutical Corporation | 1,2-Diaza-3-one compounds, their use in treating hypertension and pharmaceutical compositions thereof |
| AU575854B2 (en) | 1983-10-04 | 1988-08-11 | Shionogi & Co., Ltd. | 7beta-(carboxyalkenamido) cephalosporins |
| HU198186B (en) | 1985-04-30 | 1989-08-28 | Lilly Co Eli | Process for producing pyrazolidinium-ilides |
| IL78629A0 (en) | 1985-04-30 | 1986-08-31 | Lilly Co Eli | 4-substituted diazolidinones |
| DK193086A (da) * | 1985-04-30 | 1987-01-20 | Lilly Co Eli | 7-substituerede bicycliske pyrazolidinoner, fremgangsmaade til fremstilling heraf og mellemprodukter til brug ved fremgangsmaaden |
-
1986
- 1986-04-28 DK DK193086A patent/DK193086A/da not_active Application Discontinuation
- 1986-04-28 HU HU861763A patent/HUT40660A/hu unknown
- 1986-04-28 AU AU56755/86A patent/AU5675586A/en not_active Abandoned
- 1986-04-28 EP EP86303174A patent/EP0202046B1/en not_active Expired - Lifetime
- 1986-04-28 KR KR1019860003251A patent/KR880001092B1/ko not_active IP Right Cessation
- 1986-04-28 IL IL78634A patent/IL78634A0/xx unknown
- 1986-04-28 GR GR861118A patent/GR861118B/el unknown
- 1986-04-28 CA CA000507777A patent/CA1274832A/en not_active Expired - Lifetime
- 1986-04-28 DE DE8686303174T patent/DE3677253D1/de not_active Expired - Lifetime
- 1986-04-28 CN CN198686103619A patent/CN86103619A/zh active Pending
- 1986-04-28 ZA ZA863170A patent/ZA863170B/xx unknown
- 1986-04-28 ES ES554463A patent/ES8801833A1/es not_active Expired
- 1986-04-28 PT PT82468A patent/PT82468B/pt unknown
- 1986-04-28 AT AT86303174T patent/ATE60605T1/de not_active IP Right Cessation
- 1986-04-30 JP JP61100817A patent/JPH0759582B2/ja not_active Expired - Lifetime
- 1986-05-14 US US06/862,913 patent/US4716232A/en not_active Expired - Fee Related
- 1986-05-14 US US06/862,918 patent/US4734504A/en not_active Expired - Lifetime
- 1986-05-14 US US06/862,909 patent/US4734505A/en not_active Expired - Lifetime
- 1986-10-28 JP JP61258084A patent/JPS63112583A/ja active Pending
-
1987
- 1987-10-29 US US07/114,897 patent/US4795815A/en not_active Expired - Lifetime
-
1988
- 1988-04-13 ZA ZA882604A patent/ZA882604B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0202046A1 (en) | 1986-11-20 |
| ZA863170B (en) | 1987-12-30 |
| ES8801833A1 (es) | 1988-02-16 |
| JPH0759582B2 (ja) | 1995-06-28 |
| KR860008181A (ko) | 1986-11-12 |
| US4734504A (en) | 1988-03-29 |
| DK193086D0 (da) | 1986-04-28 |
| AU5675586A (en) | 1986-11-13 |
| CA1274832A (en) | 1990-10-02 |
| US4734505A (en) | 1988-03-29 |
| US4716232A (en) | 1987-12-29 |
| IL78634A0 (en) | 1986-08-31 |
| DE3677253D1 (de) | 1991-03-07 |
| CN86103619A (zh) | 1986-10-29 |
| DK193086A (da) | 1987-01-20 |
| HUT40660A (en) | 1987-01-28 |
| PT82468A (en) | 1986-05-01 |
| PT82468B (en) | 1988-03-23 |
| ATE60605T1 (de) | 1991-02-15 |
| ZA882604B (en) | 1989-12-27 |
| JPS61254589A (ja) | 1986-11-12 |
| JPS63112583A (ja) | 1988-05-17 |
| EP0202046B1 (en) | 1991-01-30 |
| KR880001092B1 (ko) | 1988-06-23 |
| ES554463A0 (es) | 1988-02-16 |
| US4795815A (en) | 1989-01-03 |
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