ES2140445T3 - Derivados de pirrolidinil-tio-penem con propiedades antibioticas. - Google Patents

Derivados de pirrolidinil-tio-penem con propiedades antibioticas.

Info

Publication number
ES2140445T3
ES2140445T3 ES93307843T ES93307843T ES2140445T3 ES 2140445 T3 ES2140445 T3 ES 2140445T3 ES 93307843 T ES93307843 T ES 93307843T ES 93307843 T ES93307843 T ES 93307843T ES 2140445 T3 ES2140445 T3 ES 2140445T3
Authority
ES
Spain
Prior art keywords
pirrolidinil
penem
tio
derivatives
4alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93307843T
Other languages
English (en)
Inventor
Patrice Jean Siret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca SAS
Syngenta Ltd
Original Assignee
Zeneca Pharma SA
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Pharma SA, Zeneca Ltd filed Critical Zeneca Pharma SA
Application granted granted Critical
Publication of ES2140445T3 publication Critical patent/ES2140445T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Abstract

LA PRESENTE INVENCION PROPORCIONA UN COMPUESTO DE LA FORMULA (I) EN LA QUE: R1 ES 1 IDROSIMETILO; R2 ES HIDROGENO O C1 ACIDO SUFONICO, TETRAZOL IL ( Y A ES OPCIONALMENTE DESPIES SUSTITUIDO POR UNO O DOS SUSTITUTIVOS O SAL FARMACEUTICAMENTE ACEPTABLE, O ESTER HIDROLIZABLE IN VIVO. TAMBIEN PROPORCIONA LA INVENCION PROCESOS PARA SU PREPARACION, INTERMEDIOS EN SU PREPARACION, SU USO COMO AGENTES TERAPEUTICOS Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES93307843T 1992-10-07 1993-10-01 Derivados de pirrolidinil-tio-penem con propiedades antibioticas. Expired - Lifetime ES2140445T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92402733 1992-10-07

Publications (1)

Publication Number Publication Date
ES2140445T3 true ES2140445T3 (es) 2000-03-01

Family

ID=8211717

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93307843T Expired - Lifetime ES2140445T3 (es) 1992-10-07 1993-10-01 Derivados de pirrolidinil-tio-penem con propiedades antibioticas.

Country Status (8)

Country Link
US (1) US5538962A (es)
EP (1) EP0592167B1 (es)
JP (1) JPH06211871A (es)
KR (1) KR100292395B1 (es)
AT (1) ATE187968T1 (es)
CA (1) CA2106330A1 (es)
DE (1) DE69327380T2 (es)
ES (1) ES2140445T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
AU3716997A (en) 1996-07-17 1998-02-09 Merck & Co., Inc. Alteration of circadian rhythmicity with a tachykinin antagonist
JP2001500118A (ja) 1996-08-17 2001-01-09 ゼネカ・リミテッド ファルネシルタンパク質トランスフェラーゼ阻害剤としての３―メルカプトピロリジン
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
GB9930317D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
FI96863C (fi) * 1990-02-23 1996-09-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten /2-(1-homopiperatsiinikarbonyyli)pyrrolidin-4-yylitio/-6-(1-hydroksietyyli)-1-karbapen-2-eemi-3-karboksylaattisuolojen valmistamiseksi
GB9107341D0 (en) * 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
GB9304156D0 (en) * 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds

Also Published As

Publication number Publication date
ATE187968T1 (de) 2000-01-15
KR940009189A (ko) 1994-05-20
CA2106330A1 (en) 1994-04-08
EP0592167A1 (en) 1994-04-13
EP0592167B1 (en) 1999-12-22
US5538962A (en) 1996-07-23
KR100292395B1 (ko) 2001-09-17
DE69327380T2 (de) 2000-05-11
DE69327380D1 (de) 2000-01-27
JPH06211871A (ja) 1994-08-02

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