ES2133358T3 - Compuestos de carbapenem como antibioticos. - Google Patents

Compuestos de carbapenem como antibioticos.

Info

Publication number
ES2133358T3
ES2133358T3 ES93302296T ES93302296T ES2133358T3 ES 2133358 T3 ES2133358 T3 ES 2133358T3 ES 93302296 T ES93302296 T ES 93302296T ES 93302296 T ES93302296 T ES 93302296T ES 2133358 T3 ES2133358 T3 ES 2133358T3
Authority
ES
Spain
Prior art keywords
formula
4alkyl
hydroxyisoxazol
carboxy
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93302296T
Other languages
English (en)
Inventor
Frederic Henri Jung
Alain Michel Bertrandie
Ronald Hilson Begg Galt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca SAS
Syngenta Ltd
Original Assignee
Zeneca Pharma SA
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Pharma SA, Zeneca Ltd filed Critical Zeneca Pharma SA
Application granted granted Critical
Publication of ES2133358T3 publication Critical patent/ES2133358T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A CARBAPENEMOS Y SUMINISTRA UN COMPUESTO DE LA FORMULA (I) DONDE: R1 ES 1 IL, 1 QUIL; R3 ES HIDROGENO O C1 (IB) P (IC) Y EN LA FORMULA (IB) EL GRUPO NAFTIL PUEDE ESTAR UNIDO AL NITROGENO O AL ENLACE DEL GRUPO CARBAMOIL EN ORO ANILLO; Z ES CARBOXI, ACIDO SULFONICO, ACIDO SULFINICO, C1 ANAMIDO SULFONIL ( C1 LSULFONILCARBAMOIL, C1 SULFOAMINO, N OSULFAMOIL, TETRAZOL UIDO CON LA CONDICION DE QUE CUANDO P ES DE LA FORMULA (IA) O (IC), Z NO ES CARBOXI; O UNA SAL ACEPTABLE FARMACEUTICAMENTE O ESTER DE ELLA HIDROLIZABLE IN VIVO. SE DESCRIBEN TAMBIEN PROCESOS PARA SU PREPARACION, PRODUCTOS INTERMEDIOS EN SU PREPARACION, SU UTILIZACION COMO AGENTES TERAPEUTICOS Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES93302296T 1992-03-26 1993-03-25 Compuestos de carbapenem como antibioticos. Expired - Lifetime ES2133358T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP92400837 1992-03-26
EP92400839 1992-03-26
EP92402700 1992-10-02

Publications (1)

Publication Number Publication Date
ES2133358T3 true ES2133358T3 (es) 1999-09-16

Family

ID=27234858

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93302296T Expired - Lifetime ES2133358T3 (es) 1992-03-26 1993-03-25 Compuestos de carbapenem como antibioticos.

Country Status (8)

Country Link
US (1) US5571805A (es)
EP (1) EP0562855B1 (es)
JP (1) JPH0625244A (es)
KR (1) KR100287040B1 (es)
AT (1) ATE179978T1 (es)
CA (1) CA2091309A1 (es)
DE (1) DE69324846T2 (es)
ES (1) ES2133358T3 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
AU680736B2 (en) * 1994-02-25 1997-08-07 Banyu Pharmaceutical Co., Ltd. Carbapenem derivative
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
HRP970281B1 (en) * 1996-05-28 2002-04-30 Merck & Co Inc Carbapenem antibiotic, composition and method of preparation
WO1998007692A1 (en) 1996-08-17 1998-02-26 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
KR100881472B1 (ko) 1999-02-04 2009-02-05 어플라이드 머티어리얼스, 인코포레이티드 소정 기판 상에 놓여져 있는 패턴화된 마스크 표면 위로 적층 구조물을 증착하기 위한 방법
GB9930317D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
AR035728A1 (es) * 2001-01-16 2004-07-07 Merck & Co Inc Proceso perfeccionado para la sintesis de carbapenem
GB2376313A (en) * 2001-06-04 2002-12-11 Hewlett Packard Co Indicating to a user if they are connected to a trusted computer platform
CN101367815B (zh) * 2007-06-28 2012-07-04 山东轩竹医药科技有限公司 六元环甲酰胺取代的巯基吡咯烷碳青霉烯化合物
CN101362757A (zh) * 2007-08-09 2009-02-11 山东轩竹医药科技有限公司 磺酰基取代的碳青霉烯类化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082133A3 (en) * 1979-04-19 1983-07-20 Merck & Co. Inc. A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
DE3579888D1 (de) * 1984-11-08 1990-10-31 Sumitomo Pharma Carbapenemverbindungen und deren herstellung.
GB9107341D0 (en) * 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds

Also Published As

Publication number Publication date
EP0562855B1 (en) 1999-05-12
KR100287040B1 (ko) 2001-05-02
CA2091309A1 (en) 1993-09-27
DE69324846D1 (de) 1999-06-17
EP0562855A1 (en) 1993-09-29
KR940005626A (ko) 1994-03-22
ATE179978T1 (de) 1999-05-15
JPH0625244A (ja) 1994-02-01
US5571805A (en) 1996-11-05
DE69324846T2 (de) 1999-09-16

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