DE69327380T2 - Antibiotische Pyrrolidinylthiopenemderivate - Google Patents
Antibiotische PyrrolidinylthiopenemderivateInfo
- Publication number
- DE69327380T2 DE69327380T2 DE69327380T DE69327380T DE69327380T2 DE 69327380 T2 DE69327380 T2 DE 69327380T2 DE 69327380 T DE69327380 T DE 69327380T DE 69327380 T DE69327380 T DE 69327380T DE 69327380 T2 DE69327380 T2 DE 69327380T2
- Authority
- DE
- Germany
- Prior art keywords
- pyrrolidinylthiopenem
- antibiotic
- derivatives
- 4alkyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- OPWKVJSODSSZDG-MRVPVSSYSA-N (5R)-3-pyrrolidin-1-yl-4-thia-1-azabicyclo[3.2.0]hept-2-ene-7-thione Chemical class N1(CCCC1)C=1S[C@H]2N(C=1)C(C2)=S OPWKVJSODSSZDG-MRVPVSSYSA-N 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004776 1-fluoroethyl group Chemical group [H]C([H])([H])C([H])(F)* 0.000 abstract 1
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92402733 | 1992-10-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69327380D1 DE69327380D1 (de) | 2000-01-27 |
| DE69327380T2 true DE69327380T2 (de) | 2000-05-11 |
Family
ID=8211717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69327380T Expired - Fee Related DE69327380T2 (de) | 1992-10-07 | 1993-10-01 | Antibiotische Pyrrolidinylthiopenemderivate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5538962A (de) |
| EP (1) | EP0592167B1 (de) |
| JP (1) | JPH06211871A (de) |
| KR (1) | KR100292395B1 (de) |
| AT (1) | ATE187968T1 (de) |
| CA (1) | CA2106330A1 (de) |
| DE (1) | DE69327380T2 (de) |
| ES (1) | ES2140445T3 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9515975D0 (en) | 1995-08-04 | 1995-10-04 | Zeneca Ltd | Chemical compounds |
| ATE265209T1 (de) | 1996-07-17 | 2004-05-15 | Merck & Co Inc | Änderung des zirkadischen rhythmus mit nicht- peptidischen neurokinin-1 rezeptor antagonisten |
| JP2001500118A (ja) | 1996-08-17 | 2001-01-09 | ゼネカ・リミテッド | ファルネシルタンパク質トランスフェラーゼ阻害剤としての３―メルカプトピロリジン |
| GB9930317D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| GB9930318D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| NZ237191A (en) * | 1990-02-23 | 1992-12-23 | Sankyo Co | 2-((substituted amide) substituted heterocyclylthio) carbpen-2-em derivatives and pharmaceutical compositions |
| GB9107341D0 (en) * | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| GB9304156D0 (en) * | 1992-03-26 | 1993-04-21 | Zeneca Ltd | Antibiotic compounds |
-
1993
- 1993-09-16 CA CA002106330A patent/CA2106330A1/en not_active Abandoned
- 1993-10-01 EP EP93307843A patent/EP0592167B1/de not_active Expired - Lifetime
- 1993-10-01 AT AT93307843T patent/ATE187968T1/de not_active IP Right Cessation
- 1993-10-01 DE DE69327380T patent/DE69327380T2/de not_active Expired - Fee Related
- 1993-10-01 ES ES93307843T patent/ES2140445T3/es not_active Expired - Lifetime
- 1993-10-06 US US08/132,256 patent/US5538962A/en not_active Expired - Fee Related
- 1993-10-06 KR KR1019930020870A patent/KR100292395B1/ko not_active IP Right Cessation
- 1993-10-06 JP JP5250437A patent/JPH06211871A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE187968T1 (de) | 2000-01-15 |
| CA2106330A1 (en) | 1994-04-08 |
| US5538962A (en) | 1996-07-23 |
| JPH06211871A (ja) | 1994-08-02 |
| KR100292395B1 (ko) | 2001-09-17 |
| ES2140445T3 (es) | 2000-03-01 |
| KR940009189A (ko) | 1994-05-20 |
| EP0592167B1 (de) | 1999-12-22 |
| EP0592167A1 (de) | 1994-04-13 |
| DE69327380D1 (de) | 2000-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |