HUP0003856A2 - 6-Pirrolidin-2-ilpirindin-származékok, eljárás előállításukra és gyógyászati alkalmazásuk - Google Patents
6-Pirrolidin-2-ilpirindin-származékok, eljárás előállításukra és gyógyászati alkalmazásukInfo
- Publication number
- HUP0003856A2 HUP0003856A2 HU0003856A HUP0003856A HUP0003856A2 HU P0003856 A2 HUP0003856 A2 HU P0003856A2 HU 0003856 A HU0003856 A HU 0003856A HU P0003856 A HUP0003856 A HU P0003856A HU P0003856 A2 HUP0003856 A2 HU P0003856A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- ylpyrindine
- pyrrolidin
- therapy
- derivatives
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- -1 cyano, hydroxy Chemical group 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány tárgya (I) általános képletű vegyület tiszta optikaiizomer vagy ilyen izomerek keveréke formájában, ahol R1 jelentésehidrogénatom, 1-4 szénatomos alkil- vagy fenil-(1-4 szénatomos alkil)-csoport, R2 jelentése hidrogénatom vagy 1-4 szénatomos alkilcsoport ésR3, R4 és R5 jelentése egymástól függetlenül hidrogén- vagyhalogénatom, vagy trifluormetil-, ciano-, hidroxi-, 1-6 szénatomosalkil- vagy 1-6 szénatomos alkoxicsoport, szabad bázis vagysavaddíciós só állapotban. A találmány a vegyületek előállításáraszolgáló eljárásra és a vegyületeket tartalmazógyógyszerkészítményekre is vonatkozik, melyek a nikotin receptorokműködészavaraival kapcsolatos rendellenességek kezelésére vagymegelőzésére használhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9708706A FR2765874B1 (fr) | 1997-07-09 | 1997-07-09 | Derives de 6-pyrrolidin-2-ylpyrindines, leur preparation et leur application en therapeutique |
| PCT/FR1998/001446 WO1999002517A1 (fr) | 1997-07-09 | 1998-07-07 | Derives de 6-pyrrolidin-2-ylpyrindines, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0003856A2 true HUP0003856A2 (hu) | 2001-10-28 |
Family
ID=9509040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003856A HUP0003856A2 (hu) | 1997-07-09 | 1998-07-07 | 6-Pirrolidin-2-ilpirindin-származékok, eljárás előállításukra és gyógyászati alkalmazásuk |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6184229B1 (hu) |
| EP (1) | EP1000056A1 (hu) |
| JP (1) | JP2002508004A (hu) |
| KR (1) | KR20010021617A (hu) |
| CN (1) | CN1262680A (hu) |
| AR (1) | AR013192A1 (hu) |
| AU (1) | AU8544498A (hu) |
| BG (1) | BG104037A (hu) |
| BR (1) | BR9811672A (hu) |
| CA (1) | CA2295666A1 (hu) |
| CO (1) | CO4890850A1 (hu) |
| EE (1) | EE200000018A (hu) |
| FR (1) | FR2765874B1 (hu) |
| HU (1) | HUP0003856A2 (hu) |
| IL (1) | IL133536A0 (hu) |
| NO (1) | NO20000066L (hu) |
| PL (1) | PL338123A1 (hu) |
| SK (1) | SK212000A3 (hu) |
| TR (1) | TR200000057T2 (hu) |
| WO (1) | WO1999002517A1 (hu) |
| ZA (1) | ZA986047B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005126340A (ja) * | 2003-10-22 | 2005-05-19 | Kureha Chem Ind Co Ltd | 置換ピリドン類の製造法、その原料化合物及びその製造方法 |
| JP5254616B2 (ja) | 2004-09-13 | 2013-08-07 | クロノ セラピューティクス、インコーポレイテッド | 生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達 |
| ES2521494T3 (es) | 2007-04-02 | 2014-11-12 | Parkinson's Institute | Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos |
| CA2974324A1 (en) | 2015-01-28 | 2016-08-04 | Zita S. Netzel | Drug delivery methods and systems |
| EP3565617A1 (en) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| WO2019232077A1 (en) | 2018-05-29 | 2019-12-05 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5227391A (en) * | 1992-04-10 | 1993-07-13 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| US5232933A (en) * | 1992-05-21 | 1993-08-03 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
-
1997
- 1997-07-09 FR FR9708706A patent/FR2765874B1/fr not_active Expired - Fee Related
-
1998
- 1998-07-07 EP EP98936453A patent/EP1000056A1/fr not_active Withdrawn
- 1998-07-07 SK SK21-2000A patent/SK212000A3/sk unknown
- 1998-07-07 KR KR1020007000175A patent/KR20010021617A/ko not_active Application Discontinuation
- 1998-07-07 TR TR2000/00057T patent/TR200000057T2/xx unknown
- 1998-07-07 AU AU85444/98A patent/AU8544498A/en not_active Abandoned
- 1998-07-07 US US09/462,352 patent/US6184229B1/en not_active Expired - Fee Related
- 1998-07-07 IL IL13353698A patent/IL133536A0/xx unknown
- 1998-07-07 PL PL98338123A patent/PL338123A1/xx unknown
- 1998-07-07 CA CA002295666A patent/CA2295666A1/en not_active Abandoned
- 1998-07-07 BR BR9811672-0A patent/BR9811672A/pt not_active IP Right Cessation
- 1998-07-07 HU HU0003856A patent/HUP0003856A2/hu unknown
- 1998-07-07 WO PCT/FR1998/001446 patent/WO1999002517A1/fr not_active Application Discontinuation
- 1998-07-07 JP JP50824799A patent/JP2002508004A/ja active Pending
- 1998-07-07 CN CN98807003A patent/CN1262680A/zh active Pending
- 1998-07-07 EE EEP200000018A patent/EE200000018A/xx unknown
- 1998-07-08 AR ARP980103305A patent/AR013192A1/es not_active Application Discontinuation
- 1998-07-08 CO CO98038696A patent/CO4890850A1/es unknown
- 1998-07-08 ZA ZA986047A patent/ZA986047B/xx unknown
-
1999
- 1999-12-22 BG BG104037A patent/BG104037A/xx unknown
-
2000
- 2000-01-06 NO NO20000066A patent/NO20000066L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6184229B1 (en) | 2001-02-06 |
| BG104037A (en) | 2001-04-30 |
| FR2765874B1 (fr) | 1999-08-13 |
| NO20000066L (no) | 2000-03-09 |
| TR200000057T2 (tr) | 2000-08-21 |
| ZA986047B (en) | 1999-02-01 |
| AR013192A1 (es) | 2000-12-13 |
| BR9811672A (pt) | 2000-09-19 |
| CA2295666A1 (en) | 1999-01-21 |
| WO1999002517A1 (fr) | 1999-01-21 |
| PL338123A1 (en) | 2000-09-25 |
| KR20010021617A (ko) | 2001-03-15 |
| NO20000066D0 (no) | 2000-01-06 |
| EE200000018A (et) | 2000-08-15 |
| CN1262680A (zh) | 2000-08-09 |
| SK212000A3 (en) | 2000-06-12 |
| FR2765874A1 (fr) | 1999-01-15 |
| JP2002508004A (ja) | 2002-03-12 |
| CO4890850A1 (es) | 2000-02-28 |
| EP1000056A1 (fr) | 2000-05-17 |
| IL133536A0 (en) | 2001-04-30 |
| AU8544498A (en) | 1999-02-08 |
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