HUP0402033A2 - 2-Amino-4-piridil-metil-tiazolin-származékok alkalmazása az indukálható NO-szintetáz inhibitoraként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
2-Amino-4-piridil-metil-tiazolin-származékok alkalmazása az indukálható NO-szintetáz inhibitoraként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0402033A2 HUP0402033A2 HU0402033A HUP0402033A HUP0402033A2 HU P0402033 A2 HUP0402033 A2 HU P0402033A2 HU 0402033 A HU0402033 A HU 0402033A HU P0402033 A HUP0402033 A HU P0402033A HU P0402033 A2 HUP0402033 A2 HU P0402033A2
- Authority
- HU
- Hungary
- Prior art keywords
- inducible
- amino
- preparation
- inhibitors
- pyridylmethyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- IKEKITJRHMNIAR-UHFFFAOYSA-N 4-(4,5-dihydro-1,3-thiazol-2-ylmethyl)pyridin-2-amine Chemical class C1=NC(N)=CC(CC=2SCCN=2)=C1 IKEKITJRHMNIAR-UHFFFAOYSA-N 0.000 title 1
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 title 1
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 2-amino-4-pyridyl-methylthiazoline derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
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Abstract
A találmány tárgyát az (I) általános képletű 2-amino-4-piridil-metil-tiazolin-származékok és ezek gyógyászatilag megfelelő sóinakindukálható NO-szintetáz inhibitorként történő alkalmazása képezi,ahol az (I) általános képletben R1 és R2 jelentése azonosan hidroxil-,1-4 szénatomos alkilcsoport, klóratom vagy 1-4 szénatomosalkoxicsoport, vagy R1 és R2 közül legalább az egyik jelentésehidrogénatom, míg a másik jelentése 1-4 szénatomos alkil-, 1-4szénatomos alkoxi-, hidroxilcsoport vagy klóratom. A találmánykiterjed a vegyületek előállítására és ezeket tartalmazógyógyszerkészítményekre. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0114508A FR2832150B1 (fr) | 2001-11-09 | 2001-11-09 | Utilisation de derives de 2-amino-4-pyridylmethyl-thiazoline comme inhibiteurs de no-synthase inductible |
US35297802P | 2002-01-30 | 2002-01-30 | |
PCT/FR2002/003808 WO2003039446A2 (fr) | 2001-11-09 | 2002-11-07 | Derives de 2-amino-4-pyridylmethyl-thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0402033A2 true HUP0402033A2 (hu) | 2005-02-28 |
Family
ID=26213258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0402033A HUP0402033A2 (hu) | 2001-11-09 | 2002-11-07 | 2-Amino-4-piridil-metil-tiazolin-származékok alkalmazása az indukálható NO-szintetáz inhibitoraként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
Country Status (22)
Country | Link |
---|---|
US (1) | US6762196B2 (hu) |
EP (1) | EP1450750B1 (hu) |
JP (1) | JP4342309B2 (hu) |
CN (1) | CN1288153C (hu) |
AT (1) | ATE446295T1 (hu) |
BR (1) | BR0206368A (hu) |
CA (1) | CA2465877C (hu) |
CY (1) | CY1110284T1 (hu) |
DE (1) | DE60234117D1 (hu) |
DK (1) | DK1450750T3 (hu) |
ES (1) | ES2335090T3 (hu) |
HR (1) | HRP20040402A2 (hu) |
HU (1) | HUP0402033A2 (hu) |
IL (2) | IL161843A0 (hu) |
MA (1) | MA27143A1 (hu) |
MX (1) | MXPA04004213A (hu) |
NO (1) | NO20033131L (hu) |
PL (1) | PL370267A1 (hu) |
PT (1) | PT1450750E (hu) |
RU (1) | RU2004117531A (hu) |
SI (1) | SI1450750T1 (hu) |
WO (1) | WO2003039446A2 (hu) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10240735A1 (de) * | 2002-08-29 | 2004-03-18 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Verwendung von Modulatoren der NO-Signalkaskade und pharmazeutische Zusammensetzung |
EP2612854B1 (en) | 2005-10-25 | 2015-04-29 | Shionogi&Co., Ltd. | Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors |
JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
TW200902526A (en) | 2007-04-24 | 2009-01-16 | Shionogi & Amp Co Ltd | Aminodihydrothiazin derivative substituted with a cyclic group |
NZ589590A (en) | 2008-06-13 | 2012-05-25 | Shionogi & Co | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity |
JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体 |
US8999980B2 (en) | 2009-12-11 | 2015-04-07 | Shionogi & Co., Ltd. | Oxazine derivatives |
EP2634186A4 (en) | 2010-10-29 | 2014-03-26 | Shionogi & Co | naphthyridine |
US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08503940A (ja) * | 1992-11-27 | 1996-04-30 | ザ ウエルカム ファウンデーション リミテッド | 酵素阻害薬 |
KR100342275B1 (ko) * | 1993-10-21 | 2002-12-05 | 지.디. 썰 엘엘씨 | 산화질소신타제저해제로서유용한아미디노유도체 |
WO1996014842A1 (en) * | 1994-11-15 | 1996-05-23 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
FR2810037B1 (fr) * | 2000-06-09 | 2004-04-23 | Aventis Pharma Sa | Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible |
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2002
- 2002-11-07 JP JP2003541738A patent/JP4342309B2/ja not_active Expired - Fee Related
- 2002-11-07 AT AT02793210T patent/ATE446295T1/de active
- 2002-11-07 PT PT02793210T patent/PT1450750E/pt unknown
- 2002-11-07 BR BR0206368-9A patent/BR0206368A/pt not_active Application Discontinuation
- 2002-11-07 CN CNB028246934A patent/CN1288153C/zh not_active Expired - Fee Related
- 2002-11-07 IL IL16184302A patent/IL161843A0/xx unknown
- 2002-11-07 ES ES02793210T patent/ES2335090T3/es not_active Expired - Lifetime
- 2002-11-07 SI SI200230869T patent/SI1450750T1/sl unknown
- 2002-11-07 CA CA002465877A patent/CA2465877C/fr not_active Expired - Fee Related
- 2002-11-07 EP EP02793210A patent/EP1450750B1/fr not_active Expired - Lifetime
- 2002-11-07 DK DK02793210.2T patent/DK1450750T3/da active
- 2002-11-07 RU RU2004117531/04A patent/RU2004117531A/ru not_active Application Discontinuation
- 2002-11-07 MX MXPA04004213A patent/MXPA04004213A/es active IP Right Grant
- 2002-11-07 PL PL02370267A patent/PL370267A1/xx unknown
- 2002-11-07 DE DE60234117T patent/DE60234117D1/de not_active Expired - Lifetime
- 2002-11-07 HU HU0402033A patent/HUP0402033A2/hu unknown
- 2002-11-07 WO PCT/FR2002/003808 patent/WO2003039446A2/fr active Application Filing
- 2002-11-08 US US10/290,624 patent/US6762196B2/en not_active Expired - Fee Related
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2003
- 2003-07-08 NO NO20033131A patent/NO20033131L/no unknown
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2004
- 2004-04-22 MA MA27644A patent/MA27143A1/fr unknown
- 2004-05-06 HR HR20040402A patent/HRP20040402A2/hr not_active Application Discontinuation
- 2004-05-06 IL IL161843A patent/IL161843A/en not_active IP Right Cessation
-
2010
- 2010-01-20 CY CY20101100056T patent/CY1110284T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO20033131D0 (no) | 2003-07-08 |
ES2335090T3 (es) | 2010-03-22 |
NO20033131L (no) | 2003-08-27 |
PT1450750E (pt) | 2010-01-18 |
RU2004117531A (ru) | 2005-04-10 |
US6762196B2 (en) | 2004-07-13 |
MA27143A1 (fr) | 2005-01-03 |
CA2465877C (fr) | 2009-12-29 |
CA2465877A1 (fr) | 2003-05-15 |
US20030153605A1 (en) | 2003-08-14 |
DE60234117D1 (de) | 2009-12-03 |
CN1288153C (zh) | 2006-12-06 |
IL161843A0 (en) | 2005-11-20 |
WO2003039446A3 (fr) | 2003-11-27 |
PL370267A1 (en) | 2005-05-16 |
MXPA04004213A (es) | 2004-07-08 |
JP4342309B2 (ja) | 2009-10-14 |
EP1450750B1 (fr) | 2009-10-21 |
HRP20040402A2 (en) | 2004-10-31 |
CY1110284T1 (el) | 2015-01-14 |
JP2005517634A (ja) | 2005-06-16 |
DK1450750T3 (da) | 2010-03-08 |
WO2003039446A2 (fr) | 2003-05-15 |
ATE446295T1 (de) | 2009-11-15 |
BR0206368A (pt) | 2004-02-10 |
EP1450750A2 (fr) | 2004-09-01 |
IL161843A (en) | 2011-08-31 |
SI1450750T1 (sl) | 2010-02-26 |
CN1602311A (zh) | 2005-03-30 |
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