HUP0101112A2 - Piperidinil-aminometil-trifluor-metil-ciklikus-éter típusú vegyületek substance P antagonistaként történő felhasználása és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Piperidinil-aminometil-trifluor-metil-ciklikus-éter típusú vegyületek substance P antagonistaként történő felhasználása és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0101112A2
HUP0101112A2 HU0101112A HUP0101112A HUP0101112A2 HU P0101112 A2 HUP0101112 A2 HU P0101112A2 HU 0101112 A HU0101112 A HU 0101112A HU P0101112 A HUP0101112 A HU P0101112A HU P0101112 A2 HUP0101112 A2 HU P0101112A2
Authority
HU
Hungary
Prior art keywords
alkyl group
compounds
disorders
general formula
hydrogen atom
Prior art date
Application number
HU0101112A
Other languages
English (en)
Inventor
Kunio Satake
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HUP0101112A2 publication Critical patent/HUP0101112A2/hu
Publication of HUP0101112A3 publication Critical patent/HUP0101112A3/hu

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • C07DHETEROCYCLIC COMPOUNDS
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    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76Benzo[c]pyrans
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
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  • Neurology (AREA)
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  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A jelen találmány tárgyát az (I) általános képletű vegyületek és annakgyógyszerészetileg elfogadható sói képezik, ahol az R1 jelentése 1-6szénatomos alkilcsoport; az R2 jelentése hidrogénatom, 1-6 szénatomosalkilcsoport, halogénezett 1-6 szénatomos alkilcsoport, vagyfenilcsoport; az R3 jelentése hidrogénatom, vagy halogénatom; az R4 ésaz R5 jelentése egymástól függetlenül hidrogénatom, 1-6 szénatomosalkilcsoport, vagy halogénezett 1-6 szénatomos alkilcsoport; és az njelentése 1, 2 vagy 3. Ezen vegyületek emlősökben, különösen pedigemberben, mint fájdalomcsillapító vagy gyulladáscsökkentő szerek, vagypéldául az alábbi betegségek, illetve állapotok kezelésérehasználhatók: szív- és érrendszeri megbetegedések, allergiásbetegségek, érképződéssel kapcsolatos rendellenességek,gasztrointesztinális rendellenességek, központi idegrendszeri zavarok,hányás, vizelet-visszatartási zavarok, leégés, a Helicobacter pyloriokozta rendellenességek és kóros állapotok. Ismertetjük továbbá az (I)általános képletű vegyületek előállításához felhasználhatóintermediereket is és az (I) általános képletű vegyületeket tartalmazógyógyszerkészítményeket. Ó
HU0101112A 1997-11-19 1998-10-26 Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance p antagonists and medicaments containing them HUP0101112A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9701466 1997-11-19

Publications (2)

Publication Number Publication Date
HUP0101112A2 true HUP0101112A2 (hu) 2002-05-29
HUP0101112A3 HUP0101112A3 (en) 2002-06-28

Family

ID=11004634

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101112A HUP0101112A3 (en) 1997-11-19 1998-10-26 Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance p antagonists and medicaments containing them

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US (2) US20030208079A1 (hu)
EP (1) EP1032571B1 (hu)
JP (2) JP3394239B2 (hu)
KR (1) KR100366902B1 (hu)
CN (1) CN1173974C (hu)
AP (1) AP909A (hu)
AR (1) AR016422A1 (hu)
AT (1) ATE219078T1 (hu)
AU (1) AU734218B2 (hu)
BG (1) BG63969B1 (hu)
CA (1) CA2310627C (hu)
CO (1) CO4771153A1 (hu)
CZ (1) CZ297315B6 (hu)
DE (1) DE69806045T2 (hu)
DK (1) DK1032571T3 (hu)
DZ (1) DZ2655A1 (hu)
EA (1) EA002621B1 (hu)
ES (1) ES2177058T3 (hu)
HK (1) HK1033313A1 (hu)
HR (1) HRP20000313B1 (hu)
HU (1) HUP0101112A3 (hu)
ID (1) ID24240A (hu)
IL (1) IL135631A0 (hu)
IS (1) IS2202B (hu)
MA (1) MA26567A1 (hu)
MY (1) MY120558A (hu)
NO (2) NO20002544L (hu)
NZ (1) NZ503912A (hu)
OA (1) OA11380A (hu)
PA (1) PA8463001A1 (hu)
PE (1) PE20000021A1 (hu)
PL (1) PL193484B1 (hu)
PT (1) PT1032571E (hu)
RS (1) RS49792B (hu)
SK (1) SK283460B6 (hu)
TN (1) TNSN98210A1 (hu)
TR (1) TR200001463T2 (hu)
TW (1) TW426667B (hu)
UA (1) UA59417C2 (hu)
WO (1) WO1999025714A1 (hu)

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Publication number Priority date Publication date Assignee Title
GB9812662D0 (en) * 1998-06-11 1998-08-12 Merck Sharp & Dohme Therapeutic use
GB9812617D0 (en) * 1998-06-11 1998-08-12 Merck Sharp & Dohme Therapeutic use
EA200101050A1 (ru) * 1999-05-06 2002-04-25 Пфайзер Продактс Инк. Замещенные бензолактамные соединения
RS49964B (sr) 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
ATE234832T1 (de) * 1999-05-21 2003-04-15 Pfizer Prod Inc 1-trifluorotmethyl-4-hydroxy-7-piperidinyl- aminomethylchroman-derivate
AU7557000A (en) * 1999-10-07 2001-05-10 Hisamitsu Pharmaceutical Co. Inc. Piperidine derivatives
PT1095939E (pt) * 1999-10-18 2004-04-30 Pfizer Prod Inc Processo para a preparacao de eteres ciclicos de compostos com piperidinilaminometilo
JP2001172178A (ja) * 1999-10-25 2001-06-26 Pfizer Prod Inc 偏頭痛治療用のnk−1レセプターアンタゴニスト及びエレトリプタン
IL142810A0 (en) * 2000-05-03 2002-03-10 Pfizer Prod Inc Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (en) * 2000-09-28 2003-03-26 Pfizer Products Inc. Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
DK1288208T3 (da) 2001-08-30 2006-10-16 Pfizer Prod Inc Fremgangsmåde til fremstilling af 2-(4-alkyl-1-piperazinyl)-benzaldehyd- og -benzylidenforbindelser ved nucleofil aromatisk substituering af 2-flourbenzaldehyd med 4-alkyl-1-peperazin i vand som oplösningsmiddel
US20040001895A1 (en) * 2002-06-17 2004-01-01 Pfizer Inc. Combination treatment for depression and anxiety
AU2003262773A1 (en) * 2002-08-27 2004-03-19 David T. Harris Amelioration of effects of cigarette smoke
US6911544B2 (en) * 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
US7122700B2 (en) 2004-07-30 2006-10-17 Xerox Corporation Arylamine processes
DE102008000891A1 (de) 2008-03-31 2009-10-01 Robert Bosch Gmbh Schutzsystem für Werkzeugmaschinen
NO2729147T3 (hu) 2011-07-04 2018-02-03
CN111918647A (zh) 2018-02-26 2020-11-10 圣拉斐尔医院有限公司 用于治疗眼痛的nk-1拮抗剂
US20230134843A1 (en) 2020-03-11 2023-05-04 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

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GB9317987D0 (en) * 1993-08-26 1993-10-13 Glaxo Group Ltd Chemical compounds
US5886011A (en) * 1995-03-27 1999-03-23 Hisamitsu Pharmaceutical Co., Inc. Piperidine derivatives as substance P antagonists
TW475930B (en) * 1995-04-24 2002-02-11 Novartis Ag Novel compound, its use and pharmaceutical composition comprising it
DE69612003T2 (de) * 1995-07-07 2001-06-21 Pfizer Substituierte benzolaktamverbindungen als substanz-p-antagonisten
TW340842B (en) * 1995-08-24 1998-09-21 Pfizer Substituted benzylaminopiperidine compounds
US6329396B1 (en) * 1996-06-10 2001-12-11 Pfizer Inc. Substituted benzylaminopiperidine compounds
ATE234832T1 (de) * 1999-05-21 2003-04-15 Pfizer Prod Inc 1-trifluorotmethyl-4-hydroxy-7-piperidinyl- aminomethylchroman-derivate
PT1095939E (pt) * 1999-10-18 2004-04-30 Pfizer Prod Inc Processo para a preparacao de eteres ciclicos de compostos com piperidinilaminometilo

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PL193484B1 (pl) 2007-02-28
DZ2655A1 (fr) 2003-03-22
DK1032571T3 (da) 2002-07-15
ID24240A (id) 2000-07-13
AU9454998A (en) 1999-06-07
JP2003040777A (ja) 2003-02-13
EA200000432A1 (ru) 2000-12-25
EA002621B1 (ru) 2002-06-27
NZ503912A (en) 2002-09-27
HK1033313A1 (en) 2001-08-24
PL340642A1 (en) 2001-02-12
CN1279681A (zh) 2001-01-10
MA26567A1 (fr) 2004-12-20
TR200001463T2 (tr) 2000-12-21
HRP20000313B1 (en) 2002-04-30
IL135631A0 (en) 2001-05-20
CN1173974C (zh) 2004-11-03
SK283460B6 (sk) 2003-08-05
IS2202B (is) 2007-02-15
NO20002544D0 (no) 2000-05-18
SK7232000A3 (en) 2001-09-11
AP9801402A0 (en) 1998-12-31
CZ297315B6 (cs) 2006-11-15
ES2177058T3 (es) 2002-12-01
AR016422A1 (es) 2001-07-04
RS49792B (sr) 2008-06-05
ATE219078T1 (de) 2002-06-15
HUP0101112A3 (en) 2002-06-28
CO4771153A1 (es) 1999-04-30
CA2310627A1 (en) 1999-05-27
NO20002544L (no) 2000-07-17
TW426667B (en) 2001-03-21
UA59417C2 (uk) 2003-09-15
AU734218B2 (en) 2001-06-07
JP2001523680A (ja) 2001-11-27
CA2310627C (en) 2005-08-09
PE20000021A1 (es) 2000-02-25
US20050171354A1 (en) 2005-08-04
CZ20001834A3 (cs) 2001-07-11
NO20042879L (no) 2000-07-17
DE69806045D1 (en) 2002-07-18
WO1999025714A1 (en) 1999-05-27
US20030208079A1 (en) 2003-11-06
KR100366902B1 (ko) 2003-01-09
PT1032571E (pt) 2002-09-30
EP1032571B1 (en) 2002-06-12
HRP20000313A2 (en) 2000-12-31
TNSN98210A1 (fr) 2005-03-15
MY120558A (en) 2005-11-30
EP1032571A1 (en) 2000-09-06
PA8463001A1 (es) 2000-09-29
OA11380A (en) 2004-01-27
JP3394239B2 (ja) 2003-04-07
BG63969B1 (bg) 2003-08-29
AP909A (en) 2000-12-04
DE69806045T2 (de) 2002-11-14
BG104437A (en) 2001-02-28
YU29400A (sh) 2003-02-28
IS5470A (is) 2000-04-26

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