HUP0101112A2 - Piperidinil-aminometil-trifluor-metil-ciklikus-éter típusú vegyületek substance P antagonistaként történő felhasználása és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Piperidinil-aminometil-trifluor-metil-ciklikus-éter típusú vegyületek substance P antagonistaként történő felhasználása és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0101112A2 HUP0101112A2 HU0101112A HUP0101112A HUP0101112A2 HU P0101112 A2 HUP0101112 A2 HU P0101112A2 HU 0101112 A HU0101112 A HU 0101112A HU P0101112 A HUP0101112 A HU P0101112A HU P0101112 A2 HUP0101112 A2 HU P0101112A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl group
- compounds
- disorders
- general formula
- hydrogen atom
- Prior art date
Links
- -1 Piperidinylaminomethyl trifluoromethyl cyclic ether compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000003890 substance P antagonist Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 241000590002 Helicobacter pylori Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010042496 Sunburn Diseases 0.000 abstract 1
- 206010046555 Urinary retention Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229940037467 helicobacter pylori Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940124641 pain reliever Drugs 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
- 230000008673 vomiting Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A jelen találmány tárgyát az (I) általános képletű vegyületek és annakgyógyszerészetileg elfogadható sói képezik, ahol az R1 jelentése 1-6szénatomos alkilcsoport; az R2 jelentése hidrogénatom, 1-6 szénatomosalkilcsoport, halogénezett 1-6 szénatomos alkilcsoport, vagyfenilcsoport; az R3 jelentése hidrogénatom, vagy halogénatom; az R4 ésaz R5 jelentése egymástól függetlenül hidrogénatom, 1-6 szénatomosalkilcsoport, vagy halogénezett 1-6 szénatomos alkilcsoport; és az njelentése 1, 2 vagy 3. Ezen vegyületek emlősökben, különösen pedigemberben, mint fájdalomcsillapító vagy gyulladáscsökkentő szerek, vagypéldául az alábbi betegségek, illetve állapotok kezelésérehasználhatók: szív- és érrendszeri megbetegedések, allergiásbetegségek, érképződéssel kapcsolatos rendellenességek,gasztrointesztinális rendellenességek, központi idegrendszeri zavarok,hányás, vizelet-visszatartási zavarok, leégés, a Helicobacter pyloriokozta rendellenességek és kóros állapotok. Ismertetjük továbbá az (I)általános képletű vegyületek előállításához felhasználhatóintermediereket is és az (I) általános képletű vegyületeket tartalmazógyógyszerkészítményeket. Ó
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB9701466 | 1997-11-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0101112A2 true HUP0101112A2 (hu) | 2002-05-29 |
HUP0101112A3 HUP0101112A3 (en) | 2002-06-28 |
Family
ID=11004634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101112A HUP0101112A3 (en) | 1997-11-19 | 1998-10-26 | Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance p antagonists and medicaments containing them |
Country Status (40)
Country | Link |
---|---|
US (2) | US20030208079A1 (hu) |
EP (1) | EP1032571B1 (hu) |
JP (2) | JP3394239B2 (hu) |
KR (1) | KR100366902B1 (hu) |
CN (1) | CN1173974C (hu) |
AP (1) | AP909A (hu) |
AR (1) | AR016422A1 (hu) |
AT (1) | ATE219078T1 (hu) |
AU (1) | AU734218B2 (hu) |
BG (1) | BG63969B1 (hu) |
CA (1) | CA2310627C (hu) |
CO (1) | CO4771153A1 (hu) |
CZ (1) | CZ297315B6 (hu) |
DE (1) | DE69806045T2 (hu) |
DK (1) | DK1032571T3 (hu) |
DZ (1) | DZ2655A1 (hu) |
EA (1) | EA002621B1 (hu) |
ES (1) | ES2177058T3 (hu) |
HK (1) | HK1033313A1 (hu) |
HR (1) | HRP20000313B1 (hu) |
HU (1) | HUP0101112A3 (hu) |
ID (1) | ID24240A (hu) |
IL (1) | IL135631A0 (hu) |
IS (1) | IS2202B (hu) |
MA (1) | MA26567A1 (hu) |
MY (1) | MY120558A (hu) |
NO (2) | NO20002544L (hu) |
NZ (1) | NZ503912A (hu) |
OA (1) | OA11380A (hu) |
PA (1) | PA8463001A1 (hu) |
PE (1) | PE20000021A1 (hu) |
PL (1) | PL193484B1 (hu) |
PT (1) | PT1032571E (hu) |
RS (1) | RS49792B (hu) |
SK (1) | SK283460B6 (hu) |
TN (1) | TNSN98210A1 (hu) |
TR (1) | TR200001463T2 (hu) |
TW (1) | TW426667B (hu) |
UA (1) | UA59417C2 (hu) |
WO (1) | WO1999025714A1 (hu) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9812662D0 (en) * | 1998-06-11 | 1998-08-12 | Merck Sharp & Dohme | Therapeutic use |
GB9812617D0 (en) * | 1998-06-11 | 1998-08-12 | Merck Sharp & Dohme | Therapeutic use |
EA200101050A1 (ru) * | 1999-05-06 | 2002-04-25 | Пфайзер Продактс Инк. | Замещенные бензолактамные соединения |
RS49964B (sr) | 1999-05-17 | 2008-09-29 | Pfizer Products Inc., | Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli |
ATE234832T1 (de) * | 1999-05-21 | 2003-04-15 | Pfizer Prod Inc | 1-trifluorotmethyl-4-hydroxy-7-piperidinyl- aminomethylchroman-derivate |
AU7557000A (en) * | 1999-10-07 | 2001-05-10 | Hisamitsu Pharmaceutical Co. Inc. | Piperidine derivatives |
PT1095939E (pt) * | 1999-10-18 | 2004-04-30 | Pfizer Prod Inc | Processo para a preparacao de eteres ciclicos de compostos com piperidinilaminometilo |
JP2001172178A (ja) * | 1999-10-25 | 2001-06-26 | Pfizer Prod Inc | 偏頭痛治療用のnk−1レセプターアンタゴニスト及びエレトリプタン |
IL142810A0 (en) * | 2000-05-03 | 2002-03-10 | Pfizer Prod Inc | Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles |
US20020049211A1 (en) * | 2000-09-06 | 2002-04-25 | Sobolov-Jaynes Susan Beth | Combination treatment for depression and anxiety |
EP1192952A3 (en) * | 2000-09-28 | 2003-03-26 | Pfizer Products Inc. | Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist |
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
DK1288208T3 (da) | 2001-08-30 | 2006-10-16 | Pfizer Prod Inc | Fremgangsmåde til fremstilling af 2-(4-alkyl-1-piperazinyl)-benzaldehyd- og -benzylidenforbindelser ved nucleofil aromatisk substituering af 2-flourbenzaldehyd med 4-alkyl-1-peperazin i vand som oplösningsmiddel |
US20040001895A1 (en) * | 2002-06-17 | 2004-01-01 | Pfizer Inc. | Combination treatment for depression and anxiety |
AU2003262773A1 (en) * | 2002-08-27 | 2004-03-19 | David T. Harris | Amelioration of effects of cigarette smoke |
US6911544B2 (en) * | 2002-10-23 | 2005-06-28 | Pfizer Inc. | Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine |
US7122700B2 (en) | 2004-07-30 | 2006-10-17 | Xerox Corporation | Arylamine processes |
DE102008000891A1 (de) | 2008-03-31 | 2009-10-01 | Robert Bosch Gmbh | Schutzsystem für Werkzeugmaschinen |
NO2729147T3 (hu) | 2011-07-04 | 2018-02-03 | ||
CN111918647A (zh) | 2018-02-26 | 2020-11-10 | 圣拉斐尔医院有限公司 | 用于治疗眼痛的nk-1拮抗剂 |
US20230134843A1 (en) | 2020-03-11 | 2023-05-04 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9317987D0 (en) * | 1993-08-26 | 1993-10-13 | Glaxo Group Ltd | Chemical compounds |
US5886011A (en) * | 1995-03-27 | 1999-03-23 | Hisamitsu Pharmaceutical Co., Inc. | Piperidine derivatives as substance P antagonists |
TW475930B (en) * | 1995-04-24 | 2002-02-11 | Novartis Ag | Novel compound, its use and pharmaceutical composition comprising it |
DE69612003T2 (de) * | 1995-07-07 | 2001-06-21 | Pfizer | Substituierte benzolaktamverbindungen als substanz-p-antagonisten |
TW340842B (en) * | 1995-08-24 | 1998-09-21 | Pfizer | Substituted benzylaminopiperidine compounds |
US6329396B1 (en) * | 1996-06-10 | 2001-12-11 | Pfizer Inc. | Substituted benzylaminopiperidine compounds |
ATE234832T1 (de) * | 1999-05-21 | 2003-04-15 | Pfizer Prod Inc | 1-trifluorotmethyl-4-hydroxy-7-piperidinyl- aminomethylchroman-derivate |
PT1095939E (pt) * | 1999-10-18 | 2004-04-30 | Pfizer Prod Inc | Processo para a preparacao de eteres ciclicos de compostos com piperidinilaminometilo |
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1998
- 1998-10-21 TW TW087117444A patent/TW426667B/zh not_active IP Right Cessation
- 1998-10-26 CZ CZ20001834A patent/CZ297315B6/cs not_active IP Right Cessation
- 1998-10-26 AU AU94549/98A patent/AU734218B2/en not_active Ceased
- 1998-10-26 DK DK98947726T patent/DK1032571T3/da active
- 1998-10-26 WO PCT/IB1998/001704 patent/WO1999025714A1/en active IP Right Grant
- 1998-10-26 AT AT98947726T patent/ATE219078T1/de not_active IP Right Cessation
- 1998-10-26 TR TR2000/01463T patent/TR200001463T2/xx unknown
- 1998-10-26 EP EP98947726A patent/EP1032571B1/en not_active Expired - Lifetime
- 1998-10-26 UA UA2000042374A patent/UA59417C2/uk unknown
- 1998-10-26 CN CNB988112930A patent/CN1173974C/zh not_active Expired - Fee Related
- 1998-10-26 DE DE69806045T patent/DE69806045T2/de not_active Expired - Fee Related
- 1998-10-26 JP JP2000521096A patent/JP3394239B2/ja not_active Expired - Fee Related
- 1998-10-26 NZ NZ503912A patent/NZ503912A/xx unknown
- 1998-10-26 PT PT98947726T patent/PT1032571E/pt unknown
- 1998-10-26 HU HU0101112A patent/HUP0101112A3/hu unknown
- 1998-10-26 ID IDW20000926A patent/ID24240A/id unknown
- 1998-10-26 RS YUP-294/00A patent/RS49792B/sr unknown
- 1998-10-26 SK SK723-2000A patent/SK283460B6/sk unknown
- 1998-10-26 EA EA200000432A patent/EA002621B1/ru not_active IP Right Cessation
- 1998-10-26 ES ES98947726T patent/ES2177058T3/es not_active Expired - Lifetime
- 1998-10-26 IL IL13563198A patent/IL135631A0/xx not_active IP Right Cessation
- 1998-10-26 CA CA002310627A patent/CA2310627C/en not_active Expired - Fee Related
- 1998-11-11 PA PA19988463001A patent/PA8463001A1/es unknown
- 1998-11-16 PE PE1998001112A patent/PE20000021A1/es not_active Application Discontinuation
- 1998-11-17 MY MYPI98005209A patent/MY120558A/en unknown
- 1998-11-17 MA MA25354A patent/MA26567A1/fr unknown
- 1998-11-17 AR ARP980105829A patent/AR016422A1/es unknown
- 1998-11-18 CO CO98067902A patent/CO4771153A1/es unknown
- 1998-11-18 DZ DZ980265A patent/DZ2655A1/xx active
- 1998-11-18 TN TNTNSN98210A patent/TNSN98210A1/fr unknown
- 1998-11-19 AP APAP/P/1998/001402A patent/AP909A/en active
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2000
- 2000-04-26 IS IS5470A patent/IS2202B/is unknown
- 2000-05-12 OA OA1200000138A patent/OA11380A/en unknown
- 2000-05-15 BG BG104437A patent/BG63969B1/bg unknown
- 2000-05-17 HR HR960576A patent/HRP20000313B1/xx not_active IP Right Cessation
- 2000-05-18 PL PL98340642A patent/PL193484B1/pl unknown
- 2000-05-18 KR KR10-2000-7005431A patent/KR100366902B1/ko not_active IP Right Cessation
- 2000-05-18 NO NO20002544A patent/NO20002544L/no not_active Application Discontinuation
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2001
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2002
- 2002-06-18 JP JP2002177452A patent/JP2003040777A/ja active Pending
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2003
- 2003-04-21 US US10/419,425 patent/US20030208079A1/en not_active Abandoned
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2004
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- 2004-11-18 US US10/991,977 patent/US20050171354A1/en not_active Abandoned
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