EA200000432A1 - Соединения пиперидиниламинометил трифторметил циклических эфиров в качестве антагонистов вещества р - Google Patents

Соединения пиперидиниламинометил трифторметил циклических эфиров в качестве антагонистов вещества р

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Publication number
EA200000432A1
EA200000432A1 EA200000432A EA200000432A EA200000432A1 EA 200000432 A1 EA200000432 A1 EA 200000432A1 EA 200000432 A EA200000432 A EA 200000432A EA 200000432 A EA200000432 A EA 200000432A EA 200000432 A1 EA200000432 A1 EA 200000432A1
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Eurasian Patent Office
Prior art keywords
alkyl
compounds
disorders
hydrogen
triftoromethyl
Prior art date
Application number
EA200000432A
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English (en)
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EA002621B1 (ru
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Кунио Сатаке
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Пфайзер Инк.
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Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200000432A1 publication Critical patent/EA200000432A1/ru
Publication of EA002621B1 publication Critical patent/EA002621B1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
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    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Согласно данному изобретению предложено соединение формулы (I) и его фармацевтически приемлемые соли, где Rпредставляет собой C-Cалкил; Rпредставляет собой водород, C-Cалкил, галогеноC-Cалкил или фенил; Rпредставляет собой водород или галогено; Rи Rнезависимо представляют собой водород, C-Cалкил или галогеноC-Cалкил; и n равно единице, двум или трем. Эти соединения являются полезными в качестве аналгетиков или противовоспалительных агентов, либо при лечении у млекопитающего, в особенности у людей, сердечно-сосудистых заболеваний, аллергических расстройств, ангиогенеза, расстройств центральной нервной системы, рвоты, желудочно-кишечных расстройств, солнечной эритемы, недержания мочи или заболеваний, расстройств или неблагоприятных состояний, вызванных Helicobacter pylori или тому подобным. Также описаны промежуточные соединения для получения соединений формулы (I).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000432A 1997-11-19 1998-10-26 Соединения пиперидиниламинометил трифторметил циклических эфиров в качестве антагонистов вещества р EA002621B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9701466 1997-11-19
PCT/IB1998/001704 WO1999025714A1 (en) 1997-11-19 1998-10-26 Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance p antagonists

Publications (2)

Publication Number Publication Date
EA200000432A1 true EA200000432A1 (ru) 2000-12-25
EA002621B1 EA002621B1 (ru) 2002-06-27

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ID=11004634

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Application Number Title Priority Date Filing Date
EA200000432A EA002621B1 (ru) 1997-11-19 1998-10-26 Соединения пиперидиниламинометил трифторметил циклических эфиров в качестве антагонистов вещества р

Country Status (40)

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US (2) US20030208079A1 (ru)
EP (1) EP1032571B1 (ru)
JP (2) JP3394239B2 (ru)
KR (1) KR100366902B1 (ru)
CN (1) CN1173974C (ru)
AP (1) AP909A (ru)
AR (1) AR016422A1 (ru)
AT (1) ATE219078T1 (ru)
AU (1) AU734218B2 (ru)
BG (1) BG63969B1 (ru)
CA (1) CA2310627C (ru)
CO (1) CO4771153A1 (ru)
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DE (1) DE69806045T2 (ru)
DK (1) DK1032571T3 (ru)
DZ (1) DZ2655A1 (ru)
EA (1) EA002621B1 (ru)
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HK (1) HK1033313A1 (ru)
HR (1) HRP20000313B1 (ru)
HU (1) HUP0101112A3 (ru)
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NO (2) NO20002544L (ru)
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GB9812617D0 (en) * 1998-06-11 1998-08-12 Merck Sharp & Dohme Therapeutic use
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IL142810A0 (en) * 2000-05-03 2002-03-10 Pfizer Prod Inc Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
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WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
AU2019223237A1 (en) 2018-02-26 2020-09-03 Ospedale San Raffaele S.R.L. NK-1 antagonists for use in the treatment of ocular pain
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Also Published As

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TR200001463T2 (tr) 2000-12-21
AR016422A1 (es) 2001-07-04
DE69806045D1 (en) 2002-07-18
JP3394239B2 (ja) 2003-04-07
PE20000021A1 (es) 2000-02-25
US20050171354A1 (en) 2005-08-04
WO1999025714A1 (en) 1999-05-27
AU734218B2 (en) 2001-06-07
NO20002544L (no) 2000-07-17
AU9454998A (en) 1999-06-07
DE69806045T2 (de) 2002-11-14
BG63969B1 (bg) 2003-08-29
CO4771153A1 (es) 1999-04-30
BG104437A (en) 2001-02-28
RS49792B (sr) 2008-06-05
JP2003040777A (ja) 2003-02-13
HUP0101112A3 (en) 2002-06-28
KR100366902B1 (ko) 2003-01-09
PL193484B1 (pl) 2007-02-28
CZ20001834A3 (cs) 2001-07-11
EA002621B1 (ru) 2002-06-27
TW426667B (en) 2001-03-21
AP9801402A0 (en) 1998-12-31
NO20042879L (no) 2000-07-17
IS2202B (is) 2007-02-15
ES2177058T3 (es) 2002-12-01
CA2310627C (en) 2005-08-09
EP1032571B1 (en) 2002-06-12
TNSN98210A1 (fr) 2005-03-15
SK283460B6 (sk) 2003-08-05
HRP20000313B1 (en) 2002-04-30
HUP0101112A2 (hu) 2002-05-29
PL340642A1 (en) 2001-02-12
AP909A (en) 2000-12-04
PA8463001A1 (es) 2000-09-29
CA2310627A1 (en) 1999-05-27
HK1033313A1 (en) 2001-08-24
ATE219078T1 (de) 2002-06-15
SK7232000A3 (en) 2001-09-11
ID24240A (id) 2000-07-13
DZ2655A1 (fr) 2003-03-22
EP1032571A1 (en) 2000-09-06
IL135631A0 (en) 2001-05-20
DK1032571T3 (da) 2002-07-15
JP2001523680A (ja) 2001-11-27
CN1279681A (zh) 2001-01-10
US20030208079A1 (en) 2003-11-06
YU29400A (sh) 2003-02-28
CN1173974C (zh) 2004-11-03
NO20002544D0 (no) 2000-05-18
HRP20000313A2 (en) 2000-12-31
IS5470A (is) 2000-04-26
UA59417C2 (ru) 2003-09-15
MY120558A (en) 2005-11-30
PT1032571E (pt) 2002-09-30
OA11380A (en) 2004-01-27
MA26567A1 (fr) 2004-12-20
NZ503912A (en) 2002-09-27
CZ297315B6 (cs) 2006-11-15

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