ES2180693T3 - 3-((bencil 5-sustituido)amino)-2-fenilpiperidinas como antagonistas de la sustancia p. - Google Patents

3-((bencil 5-sustituido)amino)-2-fenilpiperidinas como antagonistas de la sustancia p.

Info

Publication number
ES2180693T3
ES2180693T3 ES96203560T ES96203560T ES2180693T3 ES 2180693 T3 ES2180693 T3 ES 2180693T3 ES 96203560 T ES96203560 T ES 96203560T ES 96203560 T ES96203560 T ES 96203560T ES 2180693 T3 ES2180693 T3 ES 2180693T3
Authority
ES
Spain
Prior art keywords
sub
sup
rent
halo
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96203560T
Other languages
English (en)
Inventor
Hiroaki Wakabayashi
Yuji Shishido
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2180693T3 publication Critical patent/ES2180693T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION PROPORCIONA UN COMPUESTO DE FORMULA: Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE R{SUP,1} ES ALQUILO C{SUB,1}-C{SUB,6}, CICLOALQUILO C{SUB,3}C{SUB,6}, HALO C{SUB,1}-C{SUB,6} ALQUILO O TETRAHIDROPIRANILO, QUE TIENE UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE CIANO, 1,3TIAZOLILO, COOR{SUP,2}, COR{SUP,2}, OCOR{SUP,2}, CONR{SUP,3}R{SUP,4}, NR{SUP,3}R{SUP,4}, NR{SUP,5}COR{SUP,3} Y C*CR{SUP,6}; DONDE R{SUP,2} ES HIDROGENO O ALQUILO C{SUB,1}C{SUB,4}; R{SUP,3} Y R{SUP,4} SON, INDEPENDIENTEMENTE, HIDROGENO, ALQUILO C{SUB,1}-C{SUB,4} O CICLOALQUILO C{SUB,3}-C{SUB,6}; R{SUP,5} ES ALQUILO C{SUB,1}-C{SUB,4} O CICLOALQUILO C{SUB,3}C{SUB,6} Y R{SUP,6} ES HIDROGENO, HALO, CIANO, ALQUILO C{SUB,1}C{SUB,6}, COOH, COO(ALQUILO C{SUB,1}-C{SUB,4}) O FENILO; X ES ALCOXI C{SUB,1}-C{SUB,6} O HALO C{SUB,1}-C{SUB,6} ALCOXI; Y AR ES FENILO OPCIONALMENTE SUSTITUIDO CON HALO. DICHOS COMPUESTO SON UTILES PARA EL TRATAMIENTO DE AFECCIONES ALERGICAS, ANGIOGENESIS, ALTERACIONES GASTROINTESTINALES, ALTERACIONES DEL SISTEMA NERVIOSO CENTRAL, ENFERMEDADES INFLAMATORIAS, VOMITO, INCONTINENCIA URINARIA, DOLOR, MIGRAÑA, QUEMADURAS SOLARES, Y ENFERMEDADES, ALTERACIONES, Y CONDICIONES ADVERSAS PRODUCIDAS POR HELICOBACTER PYLORI, EN UN MAMIFERO.
ES96203560T 1995-12-21 1996-12-16 3-((bencil 5-sustituido)amino)-2-fenilpiperidinas como antagonistas de la sustancia p. Expired - Lifetime ES2180693T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9501148 1995-12-21

Publications (1)

Publication Number Publication Date
ES2180693T3 true ES2180693T3 (es) 2003-02-16

Family

ID=11004393

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96203560T Expired - Lifetime ES2180693T3 (es) 1995-12-21 1996-12-16 3-((bencil 5-sustituido)amino)-2-fenilpiperidinas como antagonistas de la sustancia p.

Country Status (8)

Country Link
US (1) US5789423A (es)
EP (1) EP0780375B1 (es)
AT (1) ATE223896T1 (es)
CA (1) CA2193468C (es)
DE (1) DE69623580T2 (es)
DK (1) DK0780375T3 (es)
ES (1) ES2180693T3 (es)
PT (1) PT780375E (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW340842B (en) * 1995-08-24 1998-09-21 Pfizer Substituted benzylaminopiperidine compounds
EP0991622A1 (en) * 1997-06-27 2000-04-12 MERCK SHARP & DOHME LTD. Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents
AU3572800A (en) * 1999-05-06 2000-11-21 Pfizer Products Inc. Substituted benzolactam compounds
AU9223601A (en) * 2000-09-26 2002-04-08 Tanabe Seiyaku Co 5-phenylbenzylamine compounds, process for their production and intermediates for their synthesis
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
US10227360B2 (en) 2014-02-19 2019-03-12 Piramal Enterprises Limited Compounds for use as GPR120 agonists
US10273230B2 (en) 2014-07-25 2019-04-30 Piramal Enterprises Limited Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof
WO2016038540A1 (en) 2014-09-11 2016-03-17 Piramal Enterprises Limited Fused heterocyclic compounds as gpr120 agonists

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680283A (en) 1984-09-26 1987-07-14 Merck & Co., Inc. Analogs of substance P and eledoisin
DE3602169A1 (de) 1986-01-22 1987-07-23 Schering Ag Neue alkan- und alkoxyalkanderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende insektizide und akarizide mittel
UA41251C2 (uk) 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
US5232929A (en) * 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
US5364943A (en) 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
BR9205807A (pt) * 1991-03-26 1994-06-28 Pfizer Preparação estéreo-seletiva de piperidinas substituidas
BR9206161A (pt) 1991-06-20 1995-10-31 Pfizer Derivados fluoroalcoxibenzilamino de heterociclos contendo nitrogénio
EP1114823A3 (en) * 1992-08-19 2001-07-18 Pfizer Inc. Substituted benzylamino nitrogen containing non-aromatic heterocycles
GB9305718D0 (en) * 1993-03-19 1993-05-05 Glaxo Group Ltd Medicaments
IL109646A0 (en) 1993-05-19 1994-08-26 Pfizer Heteroatom substituted alkyl benzylamino-quinuclidines

Also Published As

Publication number Publication date
CA2193468A1 (en) 1997-06-22
PT780375E (pt) 2002-12-31
US5789423A (en) 1998-08-04
EP0780375A1 (en) 1997-06-25
DE69623580T2 (de) 2003-01-09
CA2193468C (en) 2001-04-24
DK0780375T3 (da) 2002-10-07
EP0780375B1 (en) 2002-09-11
ATE223896T1 (de) 2002-09-15
DE69623580D1 (de) 2002-10-17

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