NO166129C - Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-9h-pyrido (3,4-b)indoler. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-9h-pyrido (3,4-b)indoler.

Info

Publication number
NO166129C
NO166129C NO883487A NO883487A NO166129C NO 166129 C NO166129 C NO 166129C NO 883487 A NO883487 A NO 883487A NO 883487 A NO883487 A NO 883487A NO 166129 C NO166129 C NO 166129C
Authority
NO
Norway
Prior art keywords
group
denotes
indoles
pyrido
formula
Prior art date
Application number
NO883487A
Other languages
English (en)
Other versions
NO166129B (no
NO883487D0 (no
NO883487L (no
Inventor
Mireille Sevrin
Pascal George
Jacques Menin
Claude Morel
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of NO883487D0 publication Critical patent/NO883487D0/no
Publication of NO883487L publication Critical patent/NO883487L/no
Publication of NO166129B publication Critical patent/NO166129B/no
Publication of NO166129C publication Critical patent/NO166129C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO883487A 1987-08-07 1988-08-05 Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-9h-pyrido (3,4-b)indoler. NO166129C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8711291A FR2619111B1 (fr) 1987-08-07 1987-08-07 Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique

Publications (4)

Publication Number Publication Date
NO883487D0 NO883487D0 (no) 1988-08-05
NO883487L NO883487L (no) 1989-02-08
NO166129B NO166129B (no) 1991-02-25
NO166129C true NO166129C (no) 1991-06-05

Family

ID=9354027

Family Applications (1)

Application Number Title Priority Date Filing Date
NO883487A NO166129C (no) 1987-08-07 1988-08-05 Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-9h-pyrido (3,4-b)indoler.

Country Status (17)

Country Link
US (1) US4977159A (no)
EP (1) EP0302788B1 (no)
JP (1) JPS6466185A (no)
KR (1) KR890003756A (no)
AT (1) ATE72436T1 (no)
AU (1) AU597188B2 (no)
DE (1) DE3868301D1 (no)
DK (1) DK437788A (no)
FI (1) FI883669A7 (no)
FR (1) FR2619111B1 (no)
GR (1) GR3003920T3 (no)
HU (1) HU198931B (no)
IL (1) IL87343A0 (no)
NO (1) NO166129C (no)
NZ (1) NZ225706A (no)
PT (1) PT88206B (no)
ZA (1) ZA885788B (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978669A (en) * 1989-06-08 1990-12-18 Neurex Corporation Method of suppressing appetite by administration of tetrahydro-beta-carboline derivatives
US5102889B1 (en) * 1990-09-27 1993-05-11 2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds
US5229517A (en) * 1990-09-27 1993-07-20 Hoechst-Roussel Pharmaceuticals Incorporated 2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds
US5455254A (en) * 1991-02-15 1995-10-03 Mondadori; Cesare Substituted benzofuranylpiperidine as a nootropic agent
RU2095339C1 (ru) * 1991-10-17 1997-11-10 Циба-Гейги АГ Производные гидрохинона в свободном виде или в виде соли, способы их получения, производные пиперидина и способы их получения
US5693807A (en) * 1992-10-14 1997-12-02 Ciba-Geigy Corporation Substituted hydroquinone derivatives
CN1109880A (zh) * 1994-02-03 1995-10-11 合成实验室公司 3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3，4-二氢-2h-1，4-苯并噁嗪衍生物、制备及其应用
FR2715659B1 (fr) * 1994-02-03 1996-03-22 Synthelabo Dérivés de 3-(2-aminoéthyl)-4-[3-(trifluorométhyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique.
AU3831495A (en) * 1994-10-20 1996-05-15 American Home Products Corporation Indole derivatives useful as serotonergic agents
US6255302B1 (en) 1998-12-17 2001-07-03 American Home Products Corporation 1,4-piperazine derivatives
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
BRPI0014470B1 (pt) 1999-10-08 2016-08-23 Affinium Pharm Inc compostos inibidores de fab i, composição farmacêutica, processo de preparação dos compostos e uso dos compostos para a produção de medicamento para tratamento de infecções bacterianas
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
KR100477818B1 (ko) 1999-12-10 2005-03-22 화이자 프로덕츠 인코포레이티드 피롤로[2,3-ｄ] 피리미딘 화합물
WO2003088897A2 (en) 2001-04-06 2003-10-30 Affinium Pharmaceuticals, Inc. Fab i inhibitors
US7812035B2 (en) * 2001-12-11 2010-10-12 Sepracor Inc. 4-substituted piperidines, and methods of use thereof
RU2309147C9 (ru) * 2002-11-21 2008-03-20 Пфайзер Продактс Инк. Производные 3-аминопиперидина и способы их получения
US7790709B2 (en) 2002-12-06 2010-09-07 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
ATE409485T1 (de) 2003-03-17 2008-10-15 Affinium Pharm Inc Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
JP2006525347A (ja) * 2003-04-29 2006-11-09 オシエント ファーマシューティカルズ 抗生テトラヒドロ−β−カルボリン誘導体
EP2848614A3 (en) 2004-06-04 2015-07-29 Debiopharm International SA Acrylamide derivatives as antibiotic agents
CA2658506C (en) 2006-07-20 2016-01-26 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab 1 inhibitors
US8263613B2 (en) 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
SG11201408100YA (en) 2012-06-19 2015-01-29 Debiopharm Int Sa Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
LT3419628T (lt) 2016-02-26 2021-01-25 Debiopharm International Sa Medikamentas diabetinėms pėdų infekcijoms gydyti
LT3923914T (lt) 2019-02-14 2023-07-25 Debiopharm International S.A. Afabicino kompozicija, jos gamybos būdas
PH12021553086A1 (en) 2019-06-14 2023-08-14 Debiopharm Int Sa Medicament and use thereof for treating bacterial infections involving biofilm

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539407A (en) * 1983-12-13 1985-09-03 American Home Products Corporation β-Carboline anticonvulsants
US4663456A (en) * 1985-09-16 1987-05-05 American Home Products Corporation 2-(substituted piperazinylalkyl)β-carbolines useful in treatment of psychological disorders

Also Published As

Publication number Publication date
FI883669A7 (fi) 1989-02-08
GR3003920T3 (no) 1993-03-16
EP0302788A1 (fr) 1989-02-08
US4977159A (en) 1990-12-11
DE3868301D1 (de) 1992-03-19
ATE72436T1 (de) 1992-02-15
PT88206B (pt) 1995-05-04
HU198931B (en) 1989-12-28
NZ225706A (en) 1990-04-26
KR890003756A (ko) 1989-04-17
AU2044588A (en) 1989-02-09
IL87343A0 (en) 1989-01-31
EP0302788B1 (fr) 1992-02-05
ZA885788B (en) 1989-04-26
FI883669A0 (fi) 1988-08-05
FR2619111B1 (fr) 1991-01-11
DK437788D0 (da) 1988-08-05
FR2619111A1 (fr) 1989-02-10
DK437788A (da) 1989-02-07
AU597188B2 (en) 1990-05-24
JPS6466185A (en) 1989-03-13
HUT48242A (en) 1989-05-29
PT88206A (pt) 1989-06-30
NO166129B (no) 1991-02-25
NO883487D0 (no) 1988-08-05
NO883487L (no) 1989-02-08

Similar Documents

Publication Publication Date Title
NO166129C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-9h-pyrido (3,4-b)indoler.
CO5550421A2 (es) Derivados de indol utiles para el tratamiento de enfermeda- des
NO20025821L (no) 2-aminokarbonyl-9H-purinderivater
EP1288199A4 (en) INHIBITORS OF MMP-12
MXPA00006605A (es) Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
DK0580502T3 (da) 3-(hydroxybenzylidenyl)-indolin-2-oner og farmaceutiske sammensætninger indeholdende disse
DK0594702T3 (da) Substituerede indoler som midler mod AIDS
NO996108L (no) 9-oksinerytromycinderivater
ATE180781T1 (de) Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung
NO172437C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidindionforbindelser
AU2001263278A1 (en) Cyclic gmp-specific phosphodiesterase inhibitors
GB9419318D0 (en) Therapeutic agents
FI970449A0 (fi) N-substituoituja atsabisykloheptaanijohdannaisia, jotka ovat käyttökelpoisia neuroleptisinä aineina
DK0646110T3 (da) N-substituerede 3-azabicyclo(3.2.0) heptanderivater som neuroleptika
CO5180536A1 (es) Inhibidores de proteasas catepsina
ES2128572T3 (es) Utilizacion de los derivados de cefem como agentes antimetastaticos.
ATE170520T1 (de) Eburnan-derivate, verfahren zur ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
TW429147B (en) Pharmaceutical composition for the treatment of CNS disorders
NZ221004A (en) 2,6-piperazinediones and pharamceutical compositions
ES2055155T3 (es) Procedimiento para la obtencion de aciloxiacetidinonas opticamente activas.
DK0514267T3 (da) Hidtil ukendte amidderivater af 1-aminooctahydropyrido(2,1-c)(1,4)oxazin, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem