AR024158A1 - Compuestos antibacterianos - Google Patents

Compuestos antibacterianos

Info

Publication number
AR024158A1
AR024158A1 ARP000102666A ARP000102666A AR024158A1 AR 024158 A1 AR024158 A1 AR 024158A1 AR P000102666 A ARP000102666 A AR P000102666A AR P000102666 A ARP000102666 A AR P000102666A AR 024158 A1 AR024158 A1 AR 024158A1
Authority
AR
Argentina
Prior art keywords
alkyl
antibacterial compounds
compounds
cf3s
sulfoxyl
Prior art date
Application number
ARP000102666A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR024158A1 publication Critical patent/AR024158A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen compuestos de formula (1) que son inhibidores de Fab I y son utiles en el tratamiento de infecciones bacterianas en la cual R1 es Ar o Het; R2es H, alquilo C1-6 o Ar-alquilo C0-6; X es H, alquilo C1-4, OR. SR, alquilo C1-4-sulfonilo, alquilo C1-4-sulfoxilo, CN, N(R)2, NO2, CF3, CO2R, CON(R)2,COR, NRC(O)R, F, Cl, Br, I o CF3S(O)r; R es H,alquilo C1-6 o Ar-alquilo C0-6; y r es 0, 1 o 2; o una sal farmacéuticamente aceptable de los mismos.
ARP000102666A 1999-06-01 2000-05-30 Compuestos antibacterianos AR024158A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13700499P 1999-06-01 1999-06-01

Publications (1)

Publication Number Publication Date
AR024158A1 true AR024158A1 (es) 2002-09-04

Family

ID=22475391

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000102666A AR024158A1 (es) 1999-06-01 2000-05-30 Compuestos antibacterianos

Country Status (23)

Country Link
US (2) US6573272B1 (es)
EP (1) EP1180030B1 (es)
JP (1) JP4733836B2 (es)
KR (1) KR20020005767A (es)
CN (1) CN1365280A (es)
AR (1) AR024158A1 (es)
AT (1) ATE283049T1 (es)
AU (1) AU773550B2 (es)
BR (1) BR0011121A (es)
CA (1) CA2375630A1 (es)
CO (1) CO5370679A1 (es)
CZ (1) CZ20014290A3 (es)
DE (1) DE60016198T2 (es)
HK (1) HK1045644A1 (es)
HU (1) HUP0201206A3 (es)
IL (1) IL146514A0 (es)
MX (1) MXPA01012326A (es)
NO (1) NO20015722D0 (es)
NZ (1) NZ515611A (es)
PL (1) PL351959A1 (es)
TR (1) TR200103485T2 (es)
WO (1) WO2000072846A1 (es)
ZA (1) ZA200109733B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
DE60029235T2 (de) * 1999-10-08 2007-06-14 Affinium Pharmaceuticals, Inc., Toronto Fab-i-hemmer
US6730684B1 (en) * 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
CA2387016C (en) * 1999-10-08 2010-09-28 William H. Miller Acrylamide derivatives as fab i inhibitors
US6987115B2 (en) 2000-12-08 2006-01-17 Smithkline Beecham Corporation Antibacterial compounds
CA2432992A1 (en) * 2000-12-21 2002-06-27 Rima Mcleod Fab i and inhibition of apicomplexan parasites
EP1360185B1 (en) * 2001-02-12 2005-08-24 Lilly Icos LLC Carboline derivatives
DK1560584T3 (da) * 2001-04-06 2009-05-18 Affinium Pharm Inc Fab I inhibitorer
JP4859460B2 (ja) * 2002-12-06 2012-01-25 アフィニウム ファーマシューティカルズ， インク． ヘテロ環化合物、その製造方法および治療におけるその使用
CA2519429C (en) * 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
CA2524125A1 (en) * 2003-04-29 2004-11-11 Oscient Pharmaceuticals Antibiotic tetrahydro-.beta.-carboline derivatives
DK1828167T3 (da) * 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
EP2054422B1 (en) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
US7854963B2 (en) * 2006-10-13 2010-12-21 Solopower, Inc. Method and apparatus for controlling composition profile of copper indium gallium chalcogenide layers
EP2125802A4 (en) * 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
EP2225250A2 (en) 2007-11-30 2010-09-08 Biota Scientific Management Pty Ltd Bicyclic ppat inhibitors as antibacterial agents
KR101135179B1 (ko) * 2009-02-20 2012-04-16 한국생명공학연구원 ＦａｂＩ 저해 물질 비나산손을 포함하는 항균용 조성물
TW201309698A (zh) 2011-03-18 2013-03-01 Ono Pharmaceutical Co 四氫咔啉衍生物
IN2014KN02915A (es) 2012-06-19 2015-05-08 Debiopharm Int Sa
TN2018000293A1 (en) 2016-02-26 2020-01-16 Debiopharm Int Sa Medicament for treatment of diabetic foot infections
WO2020037155A1 (en) * 2018-08-16 2020-02-20 Recreo Pharmaceuticals Llc 1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indole derivative compounds and uses thereof

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US4154943A (en) * 1977-12-29 1979-05-15 University Of Vermont Preparation of vincadifformine
US4267330A (en) * 1978-08-24 1981-05-12 Omnium Chimique Societe Anonyme Process for the synthesis of vincadifformine and related derivatives
FR2619111B1 (fr) * 1987-08-07 1991-01-11 Synthelabo Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5416193A (en) 1993-04-30 1995-05-16 Pfizer Inc. Coupling reagent and method
MA23420A1 (fr) 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US5614551A (en) 1994-01-24 1997-03-25 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents
CA2193966A1 (en) 1994-06-29 1996-01-11 Fadia El-Fehail Ali Vitronectin receptor antagonists
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
JPH10310582A (ja) * 1997-03-13 1998-11-24 Sankyo Co Ltd ピペリジン環縮合カルバペネム化合物
JP2001518094A (ja) 1997-03-31 2001-10-09 デュポン ファーマシューティカルズ カンパニー Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素
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WO1999033800A1 (en) * 1997-12-24 1999-07-08 Aventis Pharma Deutschland Gmbh Indole derivatives as inhibitors or factor xa
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CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024077A1 (es) 1999-05-25 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
CO5180605A1 (es) 1999-06-23 2002-07-30 Smithkline Beecham Corp Compuestos de indol
US6346391B1 (en) 1999-07-22 2002-02-12 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
CA2387016C (en) 1999-10-08 2010-09-28 William H. Miller Acrylamide derivatives as fab i inhibitors
DE60029235T2 (de) 1999-10-08 2007-06-14 Affinium Pharmaceuticals, Inc., Toronto Fab-i-hemmer
WO2001026654A1 (en) 1999-10-08 2001-04-19 Smithkline Beecham Corporation Fab i inhibitors
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Also Published As

Publication number Publication date
JP4733836B2 (ja) 2011-07-27
BR0011121A (pt) 2002-02-26
WO2000072846A1 (en) 2000-12-07
IL146514A0 (en) 2002-07-25
DE60016198T2 (de) 2005-12-01
JP2003500448A (ja) 2003-01-07
PL351959A1 (en) 2003-07-14
CA2375630A1 (en) 2000-12-07
NO20015722L (no) 2001-11-23
CO5370679A1 (es) 2004-02-27
DE60016198D1 (de) 2004-12-30
EP1180030A1 (en) 2002-02-20
US6964970B2 (en) 2005-11-15
NZ515611A (en) 2004-05-28
HUP0201206A2 (en) 2002-08-28
AU5177400A (en) 2000-12-18
AU773550B2 (en) 2004-05-27
MXPA01012326A (es) 2002-07-30
US20030232850A1 (en) 2003-12-18
EP1180030B1 (en) 2004-11-24
KR20020005767A (ko) 2002-01-17
NO20015722D0 (no) 2001-11-23
EP1180030A4 (en) 2002-09-25
CZ20014290A3 (cs) 2002-05-15
ATE283049T1 (de) 2004-12-15
ZA200109733B (en) 2002-09-11
US6573272B1 (en) 2003-06-03
HUP0201206A3 (en) 2003-07-28
TR200103485T2 (tr) 2002-04-22
HK1045644A1 (zh) 2002-12-06
CN1365280A (zh) 2002-08-21

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