AR024158A1 - Compuestos antibacterianos - Google Patents

Compuestos antibacterianos

Info

Publication number
AR024158A1
AR024158A1 ARP000102666A ARP000102666A AR024158A1 AR 024158 A1 AR024158 A1 AR 024158A1 AR P000102666 A ARP000102666 A AR P000102666A AR P000102666 A ARP000102666 A AR P000102666A AR 024158 A1 AR024158 A1 AR 024158A1
Authority
AR
Argentina
Prior art keywords
alkyl
antibacterial compounds
compounds
cf3s
sulfoxyl
Prior art date
Application number
ARP000102666A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR024158A1 publication Critical patent/AR024158A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen compuestos de formula (1) que son inhibidores de Fab I y son utiles en el tratamiento de infecciones bacterianas en la cual R1 es Ar o Het; R2es H, alquilo C1-6 o Ar-alquilo C0-6; X es H, alquilo C1-4, OR. SR, alquilo C1-4-sulfonilo, alquilo C1-4-sulfoxilo, CN, N(R)2, NO2, CF3, CO2R, CON(R)2,COR, NRC(O)R, F, Cl, Br, I o CF3S(O)r; R es H,alquilo C1-6 o Ar-alquilo C0-6; y r es 0, 1 o 2; o una sal farmacéuticamente aceptable de los mismos.
ARP000102666A 1999-06-01 2000-05-30 Compuestos antibacterianos AR024158A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13700499P 1999-06-01 1999-06-01

Publications (1)

Publication Number Publication Date
AR024158A1 true AR024158A1 (es) 2002-09-04

Family

ID=22475391

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000102666A AR024158A1 (es) 1999-06-01 2000-05-30 Compuestos antibacterianos

Country Status (23)

Country Link
US (2) US6573272B1 (es)
EP (1) EP1180030B1 (es)
JP (1) JP4733836B2 (es)
KR (1) KR20020005767A (es)
CN (1) CN1365280A (es)
AR (1) AR024158A1 (es)
AT (1) ATE283049T1 (es)
AU (1) AU773550B2 (es)
BR (1) BR0011121A (es)
CA (1) CA2375630A1 (es)
CO (1) CO5370679A1 (es)
CZ (1) CZ20014290A3 (es)
DE (1) DE60016198T2 (es)
HK (1) HK1045644A1 (es)
HU (1) HUP0201206A3 (es)
IL (1) IL146514A0 (es)
MX (1) MXPA01012326A (es)
NO (1) NO20015722D0 (es)
NZ (1) NZ515611A (es)
PL (1) PL351959A1 (es)
TR (1) TR200103485T2 (es)
WO (1) WO2000072846A1 (es)
ZA (1) ZA200109733B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
DE60029235T2 (de) * 1999-10-08 2007-06-14 Affinium Pharmaceuticals, Inc., Toronto Fab-i-hemmer
US6730684B1 (en) * 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
ECSP003699A (es) 1999-10-08 2002-04-23 Smithkline Beecham Corp Inhibidores de fab i
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
WO2002062339A1 (en) 2000-12-08 2002-08-15 Smithkline Beecham Corporation Antibacterial compounds
DE60135157D1 (de) * 2000-12-21 2008-09-11 Rima W Mcleod Fab i und hemmung von apicomplexan-parasiten
JP4220779B2 (ja) * 2001-02-12 2009-02-04 リリー アイコス リミテッド ライアビリティ カンパニー 化学化合物
DE60230934D1 (de) * 2001-04-06 2009-03-05 Affinium Pharm Inc Fab-i-inhibitoren
EP1575951B1 (en) * 2002-12-06 2014-06-25 Debiopharm International SA Heterocyclic compounds, methods of making them and their use in therapy
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
DE602004017714D1 (de) * 2003-04-29 2008-12-24 Oscient Pharmaceuticals ANTIBIOTISCHE TETRAHYDRO-b-CARBOLINDERIVATIVE
US8450307B2 (en) * 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
CA2632476A1 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
EP2687533B1 (en) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
US7854963B2 (en) * 2006-10-13 2010-12-21 Solopower, Inc. Method and apparatus for controlling composition profile of copper indium gallium chalcogenide layers
WO2008098374A1 (en) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
JP2011505373A (ja) * 2007-11-30 2011-02-24 ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド 抗菌剤としての２環式ｐｐａｔ阻害剤
KR101135179B1 (ko) * 2009-02-20 2012-04-16 한국생명공학연구원 ＦａｂＩ 저해 물질 비나산손을 포함하는 항균용 조성물
TW201309698A (zh) 2011-03-18 2013-03-01 Ono Pharmaceutical Co 四氫咔啉衍生物
KR101720885B1 (ko) 2012-06-19 2017-03-28 데비오팜 인터네셔날 에스 에이 (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체
RS61312B1 (sr) 2016-02-26 2021-02-26 Debiopharm Int Sa Lek za lečenje infekcija dijabetskog stopala
WO2020037155A1 (en) * 2018-08-16 2020-02-20 Recreo Pharmaceuticals Llc 1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indole derivative compounds and uses thereof
MY203711A (en) 2019-02-14 2024-07-15 Debiopharm Int Sa Afabicin formulation, method for making the same and uses thereof
JP7418475B2 (ja) 2019-06-14 2024-01-19 デバイオファーム インターナショナル エス．エー． バイオフィルムが関与する細菌感染症を治療するための医薬及びその使用

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US4154943A (en) * 1977-12-29 1979-05-15 University Of Vermont Preparation of vincadifformine
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FR2619111B1 (fr) * 1987-08-07 1991-01-11 Synthelabo Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
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MA23420A1 (fr) 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US5614551A (en) 1994-01-24 1997-03-25 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents
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CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024077A1 (es) 1999-05-25 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
CO5180605A1 (es) 1999-06-23 2002-07-30 Smithkline Beecham Corp Compuestos de indol
US6346391B1 (en) 1999-07-22 2002-02-12 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
DE60029235T2 (de) 1999-10-08 2007-06-14 Affinium Pharmaceuticals, Inc., Toronto Fab-i-hemmer
DE60019954T2 (de) 1999-10-08 2006-02-23 Affinium Pharmaceuticals, Inc., Toronto Fab i hemmer
ECSP003699A (es) 1999-10-08 2002-04-23 Smithkline Beecham Corp Inhibidores de fab i
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US6656703B1 (en) 1999-12-29 2003-12-02 Millennium Pharamaceuticals, Inc. High throughput screen for inhibitors of fatty acid biosynthesis in bacteria
US6372752B1 (en) 2000-02-07 2002-04-16 Genzyme Corporation Inha inhibitors and methods of use thereof
HUP0400651A2 (hu) 2000-11-07 2004-06-28 Bristol-Myers Squibb Company Szerin proteáz inhibitorokként alkalmazható savszármazékok és ezeket tartalmazó gyógyszerkészítmények
WO2002048097A1 (en) 2000-12-12 2002-06-20 Corvas International, Inc. Compounds, compositions and methods for treatment of parasitic infections

Also Published As

Publication number Publication date
US6573272B1 (en) 2003-06-03
NO20015722L (no) 2001-11-23
HK1045644A1 (zh) 2002-12-06
CN1365280A (zh) 2002-08-21
US6964970B2 (en) 2005-11-15
WO2000072846A1 (en) 2000-12-07
ZA200109733B (en) 2002-09-11
JP4733836B2 (ja) 2011-07-27
DE60016198D1 (de) 2004-12-30
EP1180030A1 (en) 2002-02-20
AU773550B2 (en) 2004-05-27
MXPA01012326A (es) 2002-07-30
ATE283049T1 (de) 2004-12-15
AU5177400A (en) 2000-12-18
NZ515611A (en) 2004-05-28
KR20020005767A (ko) 2002-01-17
TR200103485T2 (tr) 2002-04-22
PL351959A1 (en) 2003-07-14
HUP0201206A2 (en) 2002-08-28
CO5370679A1 (es) 2004-02-27
CZ20014290A3 (cs) 2002-05-15
JP2003500448A (ja) 2003-01-07
BR0011121A (pt) 2002-02-26
NO20015722D0 (no) 2001-11-23
DE60016198T2 (de) 2005-12-01
EP1180030B1 (en) 2004-11-24
US20030232850A1 (en) 2003-12-18
HUP0201206A3 (en) 2003-07-28
IL146514A0 (en) 2002-07-25
EP1180030A4 (en) 2002-09-25
CA2375630A1 (en) 2000-12-07

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