BR0011121A - Compostos antibacterianos - Google Patents

Compostos antibacterianos

Info

Publication number
BR0011121A
BR0011121A BR0011121-0A BR0011121A BR0011121A BR 0011121 A BR0011121 A BR 0011121A BR 0011121 A BR0011121 A BR 0011121A BR 0011121 A BR0011121 A BR 0011121A
Authority
BR
Brazil
Prior art keywords
alkyl
antibacterial compounds
compounds
antibacterial
alkylsulfoxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
BR0011121-0A
Other languages
English (en)
Inventor
William H Miller
Kenneth A Newlander
Mark Seefeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smithkline Beecham Corp
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR0011121A publication Critical patent/BR0011121A/pt
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTOS ANTIBACTERIANOS". Compostos de fórmula (I) são descritos, os quais são inibidores de Fab I e são úteis no tratamento de infecções bacterianas, em que: R^ 1^ é Ar ou Het; R^ 2^ é H, alquila C~ 1-6~ ou Ar-alquila C~ 0-6~; X é H, alquila C~ 1-4~, OR', SR', alquilsulfonila C~ 1-4~, alquilsulfoxila C~ 1-4~, CN, N(R')~ 2~, CH~ 2~N(R')~ 2~, NO~ 2~, CF~ 3~, CO~ 2~R', CON(R')~ 2~, COR', NR'C(O)R', F, Cl, Br, I, ou CF~ 3~S (0)~ r~-; R' é H, alquila C~ 1-6~ ou Ar-alquila C~ 0-5~; e r é 0, 1 ou 2; ou um sal farmaceuticamente aceitável destes.
BR0011121-0A 1999-06-01 2000-06-01 Compostos antibacterianos Withdrawn BR0011121A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13700499P 1999-06-01 1999-06-01
PCT/US2000/015154 WO2000072846A1 (en) 1999-06-01 2000-06-01 Antibacterial compounds

Publications (1)

Publication Number Publication Date
BR0011121A true BR0011121A (pt) 2002-02-26

Family

ID=22475391

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011121-0A Withdrawn BR0011121A (pt) 1999-06-01 2000-06-01 Compostos antibacterianos

Country Status (23)

Country Link
US (2) US6573272B1 (pt)
EP (1) EP1180030B1 (pt)
JP (1) JP4733836B2 (pt)
KR (1) KR20020005767A (pt)
CN (1) CN1365280A (pt)
AR (1) AR024158A1 (pt)
AT (1) ATE283049T1 (pt)
AU (1) AU773550B2 (pt)
BR (1) BR0011121A (pt)
CA (1) CA2375630A1 (pt)
CO (1) CO5370679A1 (pt)
CZ (1) CZ20014290A3 (pt)
DE (1) DE60016198T2 (pt)
HK (1) HK1045644A1 (pt)
HU (1) HUP0201206A3 (pt)
IL (1) IL146514A0 (pt)
MX (1) MXPA01012326A (pt)
NO (1) NO20015722L (pt)
NZ (1) NZ515611A (pt)
PL (1) PL351959A1 (pt)
TR (1) TR200103485T2 (pt)
WO (1) WO2000072846A1 (pt)
ZA (1) ZA200109733B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
JP4803935B2 (ja) * 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
US6730684B1 (en) * 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
DE60029235T2 (de) * 1999-10-08 2007-06-14 Affinium Pharmaceuticals, Inc., Toronto Fab-i-hemmer
US6987115B2 (en) 2000-12-08 2006-01-17 Smithkline Beecham Corporation Antibacterial compounds
CA2432992A1 (en) * 2000-12-21 2002-06-27 Rima Mcleod Fab i and inhibition of apicomplexan parasites
DE60112974T2 (de) * 2001-02-12 2006-02-16 Lilly Icos Llc, Wilmington Carbolinderivate
ATE420640T1 (de) * 2001-04-06 2009-01-15 Affinium Pharm Inc Fab-i-inhibitoren
US7790709B2 (en) * 2002-12-06 2010-09-07 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
CA2519429C (en) * 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
ATE414082T1 (de) * 2003-04-29 2008-11-15 Oscient Pharmaceuticals Antibiotische tetrahydro-b-carbolinderivative
DK1828167T3 (da) * 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
CA2658506C (en) * 2006-07-20 2016-01-26 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab 1 inhibitors
US7854963B2 (en) * 2006-10-13 2010-12-21 Solopower, Inc. Method and apparatus for controlling composition profile of copper indium gallium chalcogenide layers
US8263613B2 (en) * 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
EP2225250A2 (en) 2007-11-30 2010-09-08 Biota Scientific Management Pty Ltd Bicyclic ppat inhibitors as antibacterial agents
KR101135179B1 (ko) * 2009-02-20 2012-04-16 한국생명공학연구원 ＦａｂＩ 저해 물질 비나산손을 포함하는 항균용 조성물
EP2687531B1 (en) 2011-03-18 2016-07-13 ONO Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
NZ702695A (en) 2012-06-19 2015-10-30 Debiopharm Int Sa Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
PT3419628T (pt) 2016-02-26 2021-01-05 Debiopharm Int Sa Medicamento para o tratamento de infeções do pé diabético
EP3836919A4 (en) * 2018-08-16 2022-05-18 Recreo Pharmaceuticals Inc. 1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOLE DERIVATIVE COMPOUNDS AND USES THEREOF

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3828068A (en) 1971-05-10 1974-08-06 Tenneco Chem ((substituted indazolyl)-n1-methyl)carbamates
US4154943A (en) 1977-12-29 1979-05-15 University Of Vermont Preparation of vincadifformine
US4267330A (en) * 1978-08-24 1981-05-12 Omnium Chimique Societe Anonyme Process for the synthesis of vincadifformine and related derivatives
FR2619111B1 (fr) * 1987-08-07 1991-01-11 Synthelabo Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5416193A (en) * 1993-04-30 1995-05-16 Pfizer Inc. Coupling reagent and method
MA23420A1 (fr) 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US5614551A (en) 1994-01-24 1997-03-25 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents
JPH10504808A (ja) 1994-06-29 1998-05-12 スミスクライン・ビーチャム・コーポレイション ビトロネクチン受容体拮抗物質
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
JPH10310582A (ja) * 1997-03-13 1998-11-24 Sankyo Co Ltd ピペリジン環縮合カルバペネム化合物
JP2001518094A (ja) 1997-03-31 2001-10-09 デュポン ファーマシューティカルズ カンパニー Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
US5932743A (en) 1997-08-21 1999-08-03 American Home Products Corporation Methods for the solid phase synthesis of substituted indole compounds
JP4589529B2 (ja) * 1997-12-24 2010-12-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｘａ因子阻害剤としてのインドール誘導体
TR200100631T2 (tr) * 1998-08-20 2002-08-21 Agouron Pharmaceuticals,Inc. Peptit-olmayan GnRH maddeleri
GT199900167A (es) * 1998-10-01 2001-03-21 Nuevos bis-benzimidazoles.
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024077A1 (es) 1999-05-25 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
CO5180605A1 (es) 1999-06-23 2002-07-30 Smithkline Beecham Corp Compuestos de indol
US6346391B1 (en) 1999-07-22 2002-02-12 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
DE60029235T2 (de) 1999-10-08 2007-06-14 Affinium Pharmaceuticals, Inc., Toronto Fab-i-hemmer
JP4961084B2 (ja) 1999-10-08 2012-06-27 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
JP4803935B2 (ja) 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
US6503908B1 (en) 1999-10-11 2003-01-07 Pfizer Inc Pharmaceutically active compounds
US6656703B1 (en) 1999-12-29 2003-12-02 Millennium Pharamaceuticals, Inc. High throughput screen for inhibitors of fatty acid biosynthesis in bacteria
US6372752B1 (en) 2000-02-07 2002-04-16 Genzyme Corporation Inha inhibitors and methods of use thereof
EP1332131A2 (en) 2000-11-07 2003-08-06 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
US20020107266A1 (en) 2000-12-12 2002-08-08 Marguerita Lim-Wilby Compounds, compositions and methods for treatment of parasitic infections

Also Published As

Publication number Publication date
ATE283049T1 (de) 2004-12-15
AU773550B2 (en) 2004-05-27
ZA200109733B (en) 2002-09-11
NO20015722D0 (no) 2001-11-23
TR200103485T2 (tr) 2002-04-22
IL146514A0 (en) 2002-07-25
AU5177400A (en) 2000-12-18
MXPA01012326A (es) 2002-07-30
DE60016198D1 (de) 2004-12-30
EP1180030A1 (en) 2002-02-20
CZ20014290A3 (cs) 2002-05-15
JP4733836B2 (ja) 2011-07-27
EP1180030B1 (en) 2004-11-24
JP2003500448A (ja) 2003-01-07
DE60016198T2 (de) 2005-12-01
NO20015722L (no) 2001-11-23
US20030232850A1 (en) 2003-12-18
US6573272B1 (en) 2003-06-03
AR024158A1 (es) 2002-09-04
EP1180030A4 (en) 2002-09-25
NZ515611A (en) 2004-05-28
PL351959A1 (en) 2003-07-14
WO2000072846A1 (en) 2000-12-07
KR20020005767A (ko) 2002-01-17
CO5370679A1 (es) 2004-02-27
CN1365280A (zh) 2002-08-21
HUP0201206A2 (en) 2002-08-28
CA2375630A1 (en) 2000-12-07
HK1045644A1 (zh) 2002-12-06
US6964970B2 (en) 2005-11-15
HUP0201206A3 (en) 2003-07-28

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: AFFINIUM PHARMACEUTICALS, INC. (CA)

Free format text: TRANSFERIDO DE: SMITHKLINE BEECHAM CORPORATION

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.

B15K Others concerning applications: alteration of classification

Ipc: C07D 471/04 (2006.01), A61P 31/04 (2006.01)