CO5370679A1 - Inhibidores fab 1 - Google Patents
Inhibidores fab 1Info
- Publication number
- CO5370679A1 CO5370679A1 CO00039765A CO00039765A CO5370679A1 CO 5370679 A1 CO5370679 A1 CO 5370679A1 CO 00039765 A CO00039765 A CO 00039765A CO 00039765 A CO00039765 A CO 00039765A CO 5370679 A1 CO5370679 A1 CO 5370679A1
- Authority
- CO
- Colombia
- Prior art keywords
- pyrido
- indole
- tetrahydro
- methyl
- benzoyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Un compuesto según la fórmula (I): <EMI FILE="00039765_1" ID="1" IMF=JPEG >en la cual:R1 es Ar o Het;R2 es H, alquilo C1-6 o Ar-alquilo C0-6;X es H, alquilo C1-4, ORAND#39, SRAND#39, alquil C1-4-sulfonilo, alquil C1-4-sulfoxilo, CN, N(RAND#39)2, CH2N(RAND#39)2, NO2, CF3, CO2RAND#39,CON(RAND#39)2, CORAND#39, NRAND#39C(O)RAND#39, F, Cl, Br, I o CF3S(O)r-;RAND#39 es H, alquilo C1-6 o Ar-alquilo C0-6; yr es 0, 1 ó 2;o una sal farmacéuticamente aceptable del mismo.Un compuesto según la reivindicación 1, que es:2-benzoil-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-benzoil-9-metil-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol; 2-benzoil-9-[(4-benciloxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-benzoil-9-[(4-hidroxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(3,4-metilendioxi)benzoil-9-[(4-hidroxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(2-hidroxi)benzoil-9-[(4-hidroxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(3-imidazo)benzoil-9-[(4-hidroxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(6-hidroxi)nicotinoil-9-[(4-hidroxifenil)metil-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(6-amino)nicotinoil-9-[(4-hidroxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(3-amino)benzoil-9-metil-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(4-hidroxi)benzoil-9-[(4-hidroxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(4-metilamino)benzoil-9-[(4-hidroxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(4-amino)benzoil-9-[(4-hidroxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(4-cloro)benzoil-9-[(4-hidroxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(4-hidroxi)benzoil-9-[(4-trifluorometilfenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol;2-(3,5-dicloro-4-hidroxi)benzoil-9-[(4-hidroxifenil)metil]-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13700499P | 1999-06-01 | 1999-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5370679A1 true CO5370679A1 (es) | 2004-02-27 |
Family
ID=22475391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00039765A CO5370679A1 (es) | 1999-06-01 | 2000-05-30 | Inhibidores fab 1 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6573272B1 (es) |
| EP (1) | EP1180030B1 (es) |
| JP (1) | JP4733836B2 (es) |
| KR (1) | KR20020005767A (es) |
| CN (1) | CN1365280A (es) |
| AR (1) | AR024158A1 (es) |
| AT (1) | ATE283049T1 (es) |
| AU (1) | AU773550B2 (es) |
| BR (1) | BR0011121A (es) |
| CA (1) | CA2375630A1 (es) |
| CO (1) | CO5370679A1 (es) |
| CZ (1) | CZ20014290A3 (es) |
| DE (1) | DE60016198T2 (es) |
| HK (1) | HK1045644A1 (es) |
| HU (1) | HUP0201206A3 (es) |
| IL (1) | IL146514A0 (es) |
| MX (1) | MXPA01012326A (es) |
| NO (1) | NO20015722D0 (es) |
| NZ (1) | NZ515611A (es) |
| PL (1) | PL351959A1 (es) |
| TR (1) | TR200103485T2 (es) |
| WO (1) | WO2000072846A1 (es) |
| ZA (1) | ZA200109733B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| CO5370679A1 (es) | 1999-06-01 | 2004-02-27 | Smithkline Beecham Corp | Inhibidores fab 1 |
| US6730684B1 (en) * | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| CO5251397A1 (es) * | 1999-10-08 | 2003-02-28 | Smithkline Beecham Corp | Inhibidores de fab i |
| EP1226138B1 (en) | 1999-10-08 | 2004-12-29 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| US6762201B1 (en) | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| ES2241902T3 (es) | 2000-12-08 | 2005-11-01 | Smithkline Beecham Corporation | Compuestos antibacterianos. |
| AU3773102A (en) * | 2000-12-21 | 2002-07-01 | Rima Mcleod | Fab i and inhibition of apicomplexan parasites |
| US7022856B2 (en) * | 2001-02-12 | 2006-04-04 | Lilly Icos Llc. | Carboline derivatives |
| WO2003088897A2 (en) * | 2001-04-06 | 2003-10-30 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| EP1575951B1 (en) * | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterocyclic compounds, methods of making them and their use in therapy |
| CA2519429C (en) * | 2003-03-17 | 2013-08-06 | Affinium Pharmaceuticals, Inc. | Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics |
| EP1628977B1 (en) * | 2003-04-29 | 2008-11-12 | Oscient Pharmaceuticals | ANTIBIOTIC TETRAHYDRO-b-CARBOLINE DERIVATIVES |
| PT1828167E (pt) * | 2004-06-04 | 2014-10-08 | Debiopharm Int Sa | Derivados de acrilamida como agentes antibióticos |
| EP1973902A2 (en) * | 2005-12-05 | 2008-10-01 | Affinium Pharmaceuticals, Inc. | 3-heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ， インク． | Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 |
| US7854963B2 (en) * | 2006-10-13 | 2010-12-21 | Solopower, Inc. | Method and apparatus for controlling composition profile of copper indium gallium chalcogenide layers |
| WO2008098374A1 (en) | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| JP2011505373A (ja) | 2007-11-30 | 2011-02-24 | ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド | 抗菌剤としての２環式ｐｐａｔ阻害剤 |
| KR101135179B1 (ko) * | 2009-02-20 | 2012-04-16 | 한국생명공학연구원 | ＦａｂＩ 저해 물질 비나산손을 포함하는 항균용 조성물 |
| JP6107650B2 (ja) | 2011-03-18 | 2017-04-05 | 小野薬品工業株式会社 | テトラヒドロカルボリン誘導体 |
| BR112014031635B1 (pt) | 2012-06-19 | 2022-01-11 | Debiopharm International Sa | Derivados de pró-fármaco de (e)-n-metil-n-( (3-metilbenzofuran-2-il) metil)-3-(7-oxo-5,6,7,8- tetraidro- 1, 8- naftirindin-3-il) acrilamida |
| CN108778286A (zh) | 2016-02-26 | 2018-11-09 | 德彪药业国际股份公司 | 用于治疗糖尿病足感染的药物 |
| US20210163479A1 (en) * | 2018-08-16 | 2021-06-03 | Recreo Pharmaceuticals Llc | 1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indole derivative compounds and uses thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3828068A (en) | 1971-05-10 | 1974-08-06 | Tenneco Chem | ((substituted indazolyl)-n1-methyl)carbamates |
| US4154943A (en) | 1977-12-29 | 1979-05-15 | University Of Vermont | Preparation of vincadifformine |
| US4267330A (en) * | 1978-08-24 | 1981-05-12 | Omnium Chimique Societe Anonyme | Process for the synthesis of vincadifformine and related derivatives |
| FR2619111B1 (fr) * | 1987-08-07 | 1991-01-11 | Synthelabo | Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique |
| FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| US5416193A (en) * | 1993-04-30 | 1995-05-16 | Pfizer Inc. | Coupling reagent and method |
| MA23420A1 (fr) | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
| US5614551A (en) | 1994-01-24 | 1997-03-25 | The Johns Hopkins University | Inhibitors of fatty acid synthesis as antimicrobial agents |
| CN1156995A (zh) | 1994-06-29 | 1997-08-13 | 史密丝克莱恩比彻姆公司 | 玻璃体结合蛋白受体拮抗剂 |
| US6451816B1 (en) | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
| DE19624659A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| JPH10310582A (ja) * | 1997-03-13 | 1998-11-24 | Sankyo Co Ltd | ピペリジン環縮合カルバペネム化合物 |
| AU6870098A (en) | 1997-03-31 | 1998-10-22 | Du Pont Merck Pharmaceutical Company, The | Indazoles of cyclic ureas useful as hiv protease inhibitors |
| US6207679B1 (en) | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| US5932743A (en) | 1997-08-21 | 1999-08-03 | American Home Products Corporation | Methods for the solid phase synthesis of substituted indole compounds |
| SI1042287T1 (en) * | 1997-12-24 | 2005-10-31 | Aventis Pharma Deutschland Gmbh | Indole derivatives as inhibitors of factor xa |
| EA200100255A1 (ru) * | 1998-08-20 | 2002-02-28 | Агурон Фармасьютикалз, Инк. | НЕПЕПТИДНЫЕ СРЕДСТВА GnRH, СПОСОБЫ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ИХ ПОЛУЧЕНИЯ |
| GT199900167A (es) * | 1998-10-01 | 2001-03-21 | Nuevos bis-benzimidazoles. | |
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| AR024077A1 (es) | 1999-05-25 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| CO5370679A1 (es) | 1999-06-01 | 2004-02-27 | Smithkline Beecham Corp | Inhibidores fab 1 |
| CO5180605A1 (es) | 1999-06-23 | 2002-07-30 | Smithkline Beecham Corp | Compuestos de indol |
| US6346391B1 (en) | 1999-07-22 | 2002-02-12 | Trustees Of Tufts College | Methods of reducing microbial resistance to drugs |
| EP1225895B1 (en) | 1999-10-08 | 2005-05-04 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| EP1226138B1 (en) | 1999-10-08 | 2004-12-29 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| CO5251397A1 (es) | 1999-10-08 | 2003-02-28 | Smithkline Beecham Corp | Inhibidores de fab i |
| US6503908B1 (en) | 1999-10-11 | 2003-01-07 | Pfizer Inc | Pharmaceutically active compounds |
| US6656703B1 (en) | 1999-12-29 | 2003-12-02 | Millennium Pharamaceuticals, Inc. | High throughput screen for inhibitors of fatty acid biosynthesis in bacteria |
| US6372752B1 (en) | 2000-02-07 | 2002-04-16 | Genzyme Corporation | Inha inhibitors and methods of use thereof |
| US6642252B2 (en) | 2000-11-07 | 2003-11-04 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
| US20020107266A1 (en) | 2000-12-12 | 2002-08-08 | Marguerita Lim-Wilby | Compounds, compositions and methods for treatment of parasitic infections |
-
2000
- 2000-05-30 CO CO00039765A patent/CO5370679A1/es unknown
- 2000-05-30 AR ARP000102666A patent/AR024158A1/es not_active Application Discontinuation
- 2000-06-01 CN CN00810964A patent/CN1365280A/zh active Pending
- 2000-06-01 WO PCT/US2000/015154 patent/WO2000072846A1/en not_active Application Discontinuation
- 2000-06-01 KR KR1020017015412A patent/KR20020005767A/ko not_active Application Discontinuation
- 2000-06-01 BR BR0011121-0A patent/BR0011121A/pt not_active Withdrawn
- 2000-06-01 CZ CZ20014290A patent/CZ20014290A3/cs unknown
- 2000-06-01 EP EP00936459A patent/EP1180030B1/en not_active Expired - Lifetime
- 2000-06-01 AT AT00936459T patent/ATE283049T1/de not_active IP Right Cessation
- 2000-06-01 TR TR2001/03485T patent/TR200103485T2/xx unknown
- 2000-06-01 HU HU0201206A patent/HUP0201206A3/hu unknown
- 2000-06-01 CA CA002375630A patent/CA2375630A1/en not_active Abandoned
- 2000-06-01 IL IL14651400A patent/IL146514A0/xx unknown
- 2000-06-01 MX MXPA01012326A patent/MXPA01012326A/es active IP Right Grant
- 2000-06-01 PL PL00351959A patent/PL351959A1/xx not_active Application Discontinuation
- 2000-06-01 JP JP2000620958A patent/JP4733836B2/ja not_active Expired - Fee Related
- 2000-06-01 US US09/980,369 patent/US6573272B1/en not_active Expired - Fee Related
- 2000-06-01 AU AU51774/00A patent/AU773550B2/en not_active Ceased
- 2000-06-01 NZ NZ515611A patent/NZ515611A/en not_active IP Right Cessation
- 2000-06-01 DE DE60016198T patent/DE60016198T2/de not_active Expired - Lifetime
-
2001
- 2001-11-23 NO NO20015722A patent/NO20015722D0/no not_active Application Discontinuation
- 2001-11-27 ZA ZA200109733A patent/ZA200109733B/en unknown
-
2002
- 2002-07-19 HK HK02105376.1A patent/HK1045644A1/zh unknown
-
2003
- 2003-05-05 US US10/429,923 patent/US6964970B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1180030A4 (en) | 2002-09-25 |
| JP2003500448A (ja) | 2003-01-07 |
| EP1180030B1 (en) | 2004-11-24 |
| HUP0201206A2 (en) | 2002-08-28 |
| WO2000072846A1 (en) | 2000-12-07 |
| DE60016198T2 (de) | 2005-12-01 |
| US6573272B1 (en) | 2003-06-03 |
| NO20015722L (no) | 2001-11-23 |
| JP4733836B2 (ja) | 2011-07-27 |
| US20030232850A1 (en) | 2003-12-18 |
| TR200103485T2 (tr) | 2002-04-22 |
| CZ20014290A3 (cs) | 2002-05-15 |
| CA2375630A1 (en) | 2000-12-07 |
| EP1180030A1 (en) | 2002-02-20 |
| KR20020005767A (ko) | 2002-01-17 |
| ZA200109733B (en) | 2002-09-11 |
| BR0011121A (pt) | 2002-02-26 |
| NZ515611A (en) | 2004-05-28 |
| AU773550B2 (en) | 2004-05-27 |
| HUP0201206A3 (en) | 2003-07-28 |
| ATE283049T1 (de) | 2004-12-15 |
| IL146514A0 (en) | 2002-07-25 |
| CN1365280A (zh) | 2002-08-21 |
| DE60016198D1 (de) | 2004-12-30 |
| MXPA01012326A (es) | 2002-07-30 |
| AU5177400A (en) | 2000-12-18 |
| PL351959A1 (en) | 2003-07-14 |
| NO20015722D0 (no) | 2001-11-23 |
| US6964970B2 (en) | 2005-11-15 |
| HK1045644A1 (zh) | 2002-12-06 |
| AR024158A1 (es) | 2002-09-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO5370679A1 (es) | Inhibidores fab 1 | |
| AR054021A1 (es) | Derivados de ciclopentapiridina y tetrahidroquinolina | |
| AR031627A1 (es) | Activadores heteroaromaticos fusionados de la glucoquinasa | |
| RU2009128966A (ru) | Новые производные аминопиримидина в качестве ингибиторов plr1 | |
| PE20130239A1 (es) | Compuestos heteroaril-aril-ureas como inhibidores de la quinasa | |
| CO5200783A1 (es) | Compuestos terapeuticos | |
| CO5210884A1 (es) | DERIVADOS DE 5H-TIAZOLO[3,2-a] PIRIMIDINA | |
| TW200621709A (en) | Indoline compound and process for producing the same | |
| JP2007507551A5 (es) | ||
| DK1897546T3 (da) | Kombinerede sammensætninger omfattende (E)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3r,5s]-3,5-dihydroxyhept-6-enoinsyre | |
| ZA200205331B (en) | Crystalline salts of 7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid. | |
| IS2217B (is) | Tatrat sölt af 5,8,14,-tríasatetrasýkló[10.3.1.02,11.04,9]-hexadeka-2(11),3,5,7,8,-pentaeni. | |
| CR7439A (es) | Pirazolilcarboxanilidas disubstituidas | |
| TR200102839T2 (tr) | LH agonistleri olarak faydalı bisiklik heteroaromatik bileşikler. | |
| NO20042578L (no) | Kjemokinreseptor-bindende heterosykliske forbindelser med forsterket effektivitet | |
| WO2003106428A8 (fr) | Derives d'arylsulfonamides et leur utilisation en tant que antagonistes au recepteur b1 de la bradykinine | |
| PE20010641A1 (es) | Derivados de piperazina como antagonistas del receptor de serotonina 5-ht1b | |
| PE20011114A1 (es) | Decahidro-isoquinolinas | |
| PE20061378A1 (es) | INHIBIDORES DE LA ACTIVIDAD DE Akt | |
| CA2239603A1 (en) | Quinolines and quinazolines useful in therapy | |
| PL376728A1 (pl) | Indole użyteczne do leczenia chorób związanych z receptorem androgenowym | |
| BR0115609A (pt) | Agentes serotonérgicos | |
| PE20060632A1 (es) | Derivados de arilsulfonilestilbeno como antagonistas de los receptores 5-ht2a | |
| DE60112306D1 (de) | Kondensierte pyrazindionderivate als pde5 inhibitore | |
| PE20060734A1 (es) | Derivado de pirrol sustituido como antagonistas del receptor de androgenos |