PT780375E - 3-¬(benzilo substituido em 5)amino|-2-phenilpiperidinas como antagonistas da substancia p - Google Patents
3-¬(benzilo substituido em 5)amino|-2-phenilpiperidinas como antagonistas da substancia pInfo
- Publication number
- PT780375E PT780375E PT96203560T PT96203560T PT780375E PT 780375 E PT780375 E PT 780375E PT 96203560 T PT96203560 T PT 96203560T PT 96203560 T PT96203560 T PT 96203560T PT 780375 E PT780375 E PT 780375E
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- halo
- disorders
- cycloalkyl
- hydrogen
- Prior art date
Links
- -1 AMINO Chemical class 0.000 title abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 241000590002 Helicobacter pylori Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010042496 Sunburn Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 229940037467 helicobacter pylori Drugs 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB9501148 | 1995-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT780375E true PT780375E (pt) | 2002-12-31 |
Family
ID=11004393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96203560T PT780375E (pt) | 1995-12-21 | 1996-12-16 | 3-¬(benzilo substituido em 5)amino|-2-phenilpiperidinas como antagonistas da substancia p |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5789423A (pt) |
| EP (1) | EP0780375B1 (pt) |
| AT (1) | ATE223896T1 (pt) |
| CA (1) | CA2193468C (pt) |
| DE (1) | DE69623580T2 (pt) |
| DK (1) | DK0780375T3 (pt) |
| ES (1) | ES2180693T3 (pt) |
| PT (1) | PT780375E (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW340842B (en) * | 1995-08-24 | 1998-09-21 | Pfizer | Substituted benzylaminopiperidine compounds |
| EP0991622A1 (en) * | 1997-06-27 | 2000-04-12 | MERCK SHARP & DOHME LTD. | Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents |
| AU3572800A (en) * | 1999-05-06 | 2000-11-21 | Pfizer Products Inc. | Substituted benzolactam compounds |
| AU9223601A (en) * | 2000-09-26 | 2002-04-08 | Tanabe Seiyaku Co | 5-phenylbenzylamine compounds, process for their production and intermediates for their synthesis |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| US10227360B2 (en) | 2014-02-19 | 2019-03-12 | Piramal Enterprises Limited | Compounds for use as GPR120 agonists |
| US10273230B2 (en) | 2014-07-25 | 2019-04-30 | Piramal Enterprises Limited | Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof |
| WO2016038540A1 (en) | 2014-09-11 | 2016-03-17 | Piramal Enterprises Limited | Fused heterocyclic compounds as gpr120 agonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680283A (en) | 1984-09-26 | 1987-07-14 | Merck & Co., Inc. | Analogs of substance P and eledoisin |
| DE3602169A1 (de) | 1986-01-22 | 1987-07-23 | Schering Ag | Neue alkan- und alkoxyalkanderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende insektizide und akarizide mittel |
| UA41251C2 (uk) | 1990-01-04 | 2001-09-17 | Пфайзер, Інк. | Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі |
| US5232929A (en) * | 1990-11-28 | 1993-08-03 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use |
| US5364943A (en) | 1991-11-27 | 1994-11-15 | Pfizer Inc. | Preparation of substituted piperidines |
| BR9205807A (pt) * | 1991-03-26 | 1994-06-28 | Pfizer | Preparação estéreo-seletiva de piperidinas substituidas |
| BR9206161A (pt) | 1991-06-20 | 1995-10-31 | Pfizer | Derivados fluoroalcoxibenzilamino de heterociclos contendo nitrogénio |
| EP1114823A3 (en) * | 1992-08-19 | 2001-07-18 | Pfizer Inc. | Substituted benzylamino nitrogen containing non-aromatic heterocycles |
| GB9305718D0 (en) * | 1993-03-19 | 1993-05-05 | Glaxo Group Ltd | Medicaments |
| IL109646A0 (en) | 1993-05-19 | 1994-08-26 | Pfizer | Heteroatom substituted alkyl benzylamino-quinuclidines |
-
1996
- 1996-12-16 ES ES96203560T patent/ES2180693T3/es not_active Expired - Lifetime
- 1996-12-16 DE DE69623580T patent/DE69623580T2/de not_active Expired - Fee Related
- 1996-12-16 DK DK96203560T patent/DK0780375T3/da active
- 1996-12-16 AT AT96203560T patent/ATE223896T1/de not_active IP Right Cessation
- 1996-12-16 EP EP96203560A patent/EP0780375B1/en not_active Expired - Lifetime
- 1996-12-16 PT PT96203560T patent/PT780375E/pt unknown
- 1996-12-17 US US08/767,985 patent/US5789423A/en not_active Expired - Fee Related
- 1996-12-19 CA CA002193468A patent/CA2193468C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2193468A1 (en) | 1997-06-22 |
| US5789423A (en) | 1998-08-04 |
| EP0780375A1 (en) | 1997-06-25 |
| DE69623580T2 (de) | 2003-01-09 |
| CA2193468C (en) | 2001-04-24 |
| DK0780375T3 (da) | 2002-10-07 |
| EP0780375B1 (en) | 2002-09-11 |
| ES2180693T3 (es) | 2003-02-16 |
| ATE223896T1 (de) | 2002-09-15 |
| DE69623580D1 (de) | 2002-10-17 |
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