CO5271700A1 - Composicion farmaceutica que comprende acido 3-[2,4-dimetil-5-(2-oxo-1,2-dihidro-indol-3-ilidenmetil)-1h-pirrol-3-il]-propionico, uno o mas compuestos polihidrocarbilo y un vehiculo farmaceuticamente aceptable - Google Patents
Composicion farmaceutica que comprende acido 3-[2,4-dimetil-5-(2-oxo-1,2-dihidro-indol-3-ilidenmetil)-1h-pirrol-3-il]-propionico, uno o mas compuestos polihidrocarbilo y un vehiculo farmaceuticamente aceptableInfo
- Publication number
- CO5271700A1 CO5271700A1 CO00090148A CO00090148A CO5271700A1 CO 5271700 A1 CO5271700 A1 CO 5271700A1 CO 00090148 A CO00090148 A CO 00090148A CO 00090148 A CO00090148 A CO 00090148A CO 5271700 A1 CO5271700 A1 CO 5271700A1
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- compounds
- polyhydrocarbil
- ilidenmetil
- pirrol
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La formulación es adecuada para administración parenteral o administración oral, donde la formulación comprende una indolinona sustituida ionizable, y un vehículo aceptable para uso farmacéutico. El término "indolinona sustituida ionizable" incluye 2-indolinonas sustituidas con pirrol las cuales, además de ser opcionalmente sustituibles en las porciones pirrol y 2-indolinona del compuesto, son necesariamente sustituidas en la porción pirrol con una o más cadenas de hidrocarburos que están a su vez sustituidas con al menos un grupo polar. Las formulaciones y los compuestos en sí son útiles para el tratamiento de trastornos relacionados con la proteína quinasa según se indica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16754499P | 1999-11-24 | 1999-11-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5271700A1 true CO5271700A1 (es) | 2003-04-30 |
Family
ID=22607804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO00090148A CO5271700A1 (es) | 1999-11-24 | 2000-11-24 | Composicion farmaceutica que comprende acido 3-[2,4-dimetil-5-(2-oxo-1,2-dihidro-indol-3-ilidenmetil)-1h-pirrol-3-il]-propionico, uno o mas compuestos polihidrocarbilo y un vehiculo farmaceuticamente aceptable |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1233943B1 (es) |
JP (1) | JP5336686B2 (es) |
AR (1) | AR026593A1 (es) |
AT (1) | ATE514676T1 (es) |
AU (1) | AU1928501A (es) |
CO (1) | CO5271700A1 (es) |
CY (1) | CY1112346T1 (es) |
DK (1) | DK1233943T3 (es) |
ES (1) | ES2367007T3 (es) |
PT (1) | PT1233943E (es) |
TW (1) | TWI265029B (es) |
WO (1) | WO2001037820A2 (es) |
Families Citing this family (85)
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EA005996B1 (ru) * | 2000-02-15 | 2005-08-25 | Сьюджен, Инк. | Пирролзамещенный 2-индолинон, фармацевтическая композиция (варианты), способ модулирования каталитической активности протеинкиназы, способ лечения или профилактики нарушения в организме, связанного с протеинкиназой |
CA2432114A1 (en) * | 2000-12-20 | 2002-07-18 | Sugen, Inc. | 4-(hetero)aryl substituted indolinones |
US8960183B2 (en) | 2001-02-16 | 2015-02-24 | Solar Solutions Llc | Solar water pasteurizer |
US6960572B2 (en) | 2001-06-21 | 2005-11-01 | Ariad Pharmaceuticals, Inc. | Indolinones and uses thereof |
CN100364991C (zh) * | 2001-08-15 | 2008-01-30 | 法玛西雅厄普约翰美国公司 | 2,4-二甲基-1h-吡咯-3-甲酰胺衍生物的苹果酸盐的晶体、其制备方法和其组合物 |
BR0213185A (pt) * | 2001-10-10 | 2004-09-14 | Sugen Inc | Derivados de 3-[4-(heterociclila substituìda)-pirrol-2-ilmetilideno]2-indolinona como inibidores de cinase |
EP1542734A1 (en) * | 2002-08-01 | 2005-06-22 | Pharmacia Italia S.p.A. | Isotopically labelled indolinone derivatives and process for their preparation |
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AR042042A1 (es) * | 2002-11-15 | 2005-06-08 | Sugen Inc | Administracion combinada de una indolinona con un agente quimioterapeutico para trastornos de proliferacion celular |
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CN103880955A (zh) | 2003-07-18 | 2014-06-25 | 安姆根有限公司 | 肝细胞生长因子的特异性结合物 |
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TWI826492B (zh) * | 2018-07-27 | 2023-12-21 | 加拿大商愛彼特生物製藥公司 | 經取代四氫環戊[c]吡咯、經取代二氫吡咯,其類似物及使用其之方法 |
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EP1082305A4 (en) * | 1998-05-29 | 2001-09-26 | Sugen Inc | PYRROL SUBSTITUTED 2-INDOLINONE EFFECTIVE AS A PROTEIN KINASE INHIBITOR |
AU5468499A (en) * | 1998-08-04 | 2000-02-28 | Sugen, Inc. | 3-methylidenyl-2-indolinone modulators of protein kinase |
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BR9916735A (pt) * | 1998-12-31 | 2001-09-25 | Sugen Inc | Compostos de 3-heteroarilidenil-2-indolinona para a modulação da atividade das cinases protéicas e para uso na quimioterapia do cancêr |
AU3770000A (en) * | 1999-03-24 | 2000-10-09 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
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2000
- 2000-11-22 DK DK00982228.9T patent/DK1233943T3/da active
- 2000-11-22 WO PCT/US2000/032277 patent/WO2001037820A2/en active Application Filing
- 2000-11-22 AU AU19285/01A patent/AU1928501A/en not_active Abandoned
- 2000-11-22 JP JP2001539435A patent/JP5336686B2/ja not_active Expired - Fee Related
- 2000-11-22 AT AT00982228T patent/ATE514676T1/de active
- 2000-11-22 ES ES00982228T patent/ES2367007T3/es not_active Expired - Lifetime
- 2000-11-22 EP EP00982228A patent/EP1233943B1/en not_active Expired - Lifetime
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- 2000-11-23 AR ARP000106194A patent/AR026593A1/es not_active Application Discontinuation
- 2000-11-23 TW TW089124929A patent/TWI265029B/zh not_active IP Right Cessation
- 2000-11-24 CO CO00090148A patent/CO5271700A1/es active IP Right Grant
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WO2001037820A2 (en) | 2001-05-31 |
EP1233943A2 (en) | 2002-08-28 |
PT1233943E (pt) | 2011-09-01 |
TWI265029B (en) | 2006-11-01 |
ES2367007T3 (es) | 2011-10-27 |
AR026593A1 (es) | 2003-02-19 |
DK1233943T3 (da) | 2011-08-15 |
WO2001037820A3 (en) | 2001-12-13 |
CY1112346T1 (el) | 2015-12-09 |
AU1928501A (en) | 2001-06-04 |
ATE514676T1 (de) | 2011-07-15 |
JP5336686B2 (ja) | 2013-11-06 |
EP1233943B1 (en) | 2011-06-29 |
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