ES2081111T3 - Derivados de n-hidroxiurea que inhiben la lipoxigenasa. - Google Patents
Derivados de n-hidroxiurea que inhiben la lipoxigenasa.Info
- Publication number
- ES2081111T3 ES2081111T3 ES92911441T ES92911441T ES2081111T3 ES 2081111 T3 ES2081111 T3 ES 2081111T3 ES 92911441 T ES92911441 T ES 92911441T ES 92911441 T ES92911441 T ES 92911441T ES 2081111 T3 ES2081111 T3 ES 2081111T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- lipoxigenase
- compounds
- inhibit
- alcoxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Lubricants (AREA)
- Cleaning Or Clearing Of The Surface Of Open Water (AREA)
Abstract
SE PRESENTAN COMPUESTOS DE LA FORMULA (A) EN LA QUE X ES -CH2-, -OO -S-, M VALE ENTRE 1 Y 3, N VALE 1 O 2, Y R1 ES HIDROGENO, ALQUIL C1-C4, ARIL O ARIL SUSTITUIDO CON UNO O MAS SUSTITUYENTES SELECCIONADOS INDEPENDIENTEMENTE ENTRE EL GRUPO QUE CONSTA DE HALOGENO, NITRO, CIANO, ALQUIL C1-C10, ALQUIL C1-C10 SUSTITUIDO CON HALO, ALCOXIDO C1-C10, ALCOXICARBONIL QUE TENGA ENTRE 1 Y 10 ATOMOS DE CARBONO EN LA MOLECULA DE ALCOXIDO, AMINOCARBONIL, ALQUILAMINOCARBONIL QUE TENGA ENTRE 1 Y 10 ATOMOS DE CARBONO EN LA MOLECULA DE ALQUIL Y DIALQUILAMINOCARBONIL QUE TENGA ENTRE 1 Y 10 ATOMOS DE CARBONO EN CADA UNA DE LAS MOLECULAS DE ALQUIL, ASIMISMO SE PRESENTAN LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS COMPUESTOS, ESTOS COMPUESTOS INHIBEN LA LIPOXIGENASA DE LAS ENZIMAS Y SON UTILES EN EL TRATAMIENTO DE ALERGIAS Y ENFERMEDADES INFLAMATORIOS Y CARDIOVASCULARES PARA LAS CUALES SE IMPLICA LA ACCION DE LA LIPOXIGENASA. ESTOS COMPUESTOS FORMAN EL INGREDIENTE ACTIVO EN COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE TALES ENFERMEDADES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3142123A JPH07100687B2 (ja) | 1991-06-13 | 1991-06-13 | 新規なn−ヒドロキシ尿素化合物および組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2081111T3 true ES2081111T3 (es) | 1996-02-16 |
Family
ID=15307927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92911441T Expired - Lifetime ES2081111T3 (es) | 1991-06-13 | 1992-05-21 | Derivados de n-hidroxiurea que inhiben la lipoxigenasa. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5384320A (es) |
EP (1) | EP0588850B1 (es) |
JP (1) | JPH07100687B2 (es) |
AT (1) | ATE131162T1 (es) |
CA (1) | CA2109800C (es) |
DE (1) | DE69206616T2 (es) |
DK (1) | DK0588850T3 (es) |
ES (1) | ES2081111T3 (es) |
FI (1) | FI935552A (es) |
GR (1) | GR3018321T3 (es) |
IE (1) | IE69369B1 (es) |
PT (1) | PT100582A (es) |
WO (1) | WO1992022543A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3179286B2 (ja) * | 1994-05-19 | 2001-06-25 | ファイザー製薬株式会社 | N−ヒドロキシ尿素系抗炎症剤 |
EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THERE |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU201300B (en) * | 1985-03-16 | 1990-10-28 | Wellcome Found | Process for production of derivatives of aryl and medical compositions containing them as active substance |
ES2053609T3 (es) * | 1987-04-24 | 1994-08-01 | Abbott Lab | Derivados de urea inhibidores de lipoxigenasa. |
US5068251A (en) * | 1988-12-16 | 1991-11-26 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
US4981865A (en) * | 1989-05-26 | 1991-01-01 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
-
1991
- 1991-06-13 JP JP3142123A patent/JPH07100687B2/ja not_active Expired - Lifetime
-
1992
- 1992-05-21 DE DE69206616T patent/DE69206616T2/de not_active Expired - Fee Related
- 1992-05-21 EP EP92911441A patent/EP0588850B1/en not_active Expired - Lifetime
- 1992-05-21 CA CA002109800A patent/CA2109800C/en not_active Expired - Fee Related
- 1992-05-21 DK DK92911441.1T patent/DK0588850T3/da active
- 1992-05-21 ES ES92911441T patent/ES2081111T3/es not_active Expired - Lifetime
- 1992-05-21 WO PCT/US1992/004007 patent/WO1992022543A1/en active IP Right Grant
- 1992-05-21 AT AT92911441T patent/ATE131162T1/de not_active IP Right Cessation
- 1992-06-11 PT PT100582A patent/PT100582A/pt not_active Application Discontinuation
- 1992-07-01 IE IE921902A patent/IE69369B1/en not_active IP Right Cessation
-
1993
- 1993-12-10 US US08/162,104 patent/US5384320A/en not_active Expired - Fee Related
- 1993-12-10 FI FI935552A patent/FI935552A/fi not_active Application Discontinuation
-
1995
- 1995-12-07 GR GR950403281T patent/GR3018321T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0588850B1 (en) | 1995-12-06 |
CA2109800C (en) | 1996-03-19 |
IE921902A1 (en) | 1992-12-16 |
CA2109800A1 (en) | 1992-12-23 |
DK0588850T3 (da) | 1996-01-08 |
DE69206616D1 (de) | 1996-01-18 |
JPH07100687B2 (ja) | 1995-11-01 |
PT100582A (pt) | 1993-08-31 |
FI935552A0 (fi) | 1993-12-10 |
DE69206616T2 (de) | 1996-04-25 |
FI935552A (fi) | 1993-12-10 |
WO1992022543A1 (en) | 1992-12-23 |
US5384320A (en) | 1995-01-24 |
IE69369B1 (en) | 1996-09-04 |
EP0588850A1 (en) | 1994-03-30 |
JPH04368366A (ja) | 1992-12-21 |
GR3018321T3 (en) | 1996-03-31 |
ATE131162T1 (de) | 1995-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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