ES2081111T3 - Derivados de n-hidroxiurea que inhiben la lipoxigenasa. - Google Patents

Derivados de n-hidroxiurea que inhiben la lipoxigenasa.

Info

Publication number
ES2081111T3
ES2081111T3 ES92911441T ES92911441T ES2081111T3 ES 2081111 T3 ES2081111 T3 ES 2081111T3 ES 92911441 T ES92911441 T ES 92911441T ES 92911441 T ES92911441 T ES 92911441T ES 2081111 T3 ES2081111 T3 ES 2081111T3
Authority
ES
Spain
Prior art keywords
alkyl
lipoxigenase
compounds
inhibit
alcoxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92911441T
Other languages
English (en)
Inventor
Kazuo Ando
Takafumi Ikeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2081111T3 publication Critical patent/ES2081111T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (A) EN LA QUE X ES -CH2-, -OO -S-, M VALE ENTRE 1 Y 3, N VALE 1 O 2, Y R1 ES HIDROGENO, ALQUIL C1-C4, ARIL O ARIL SUSTITUIDO CON UNO O MAS SUSTITUYENTES SELECCIONADOS INDEPENDIENTEMENTE ENTRE EL GRUPO QUE CONSTA DE HALOGENO, NITRO, CIANO, ALQUIL C1-C10, ALQUIL C1-C10 SUSTITUIDO CON HALO, ALCOXIDO C1-C10, ALCOXICARBONIL QUE TENGA ENTRE 1 Y 10 ATOMOS DE CARBONO EN LA MOLECULA DE ALCOXIDO, AMINOCARBONIL, ALQUILAMINOCARBONIL QUE TENGA ENTRE 1 Y 10 ATOMOS DE CARBONO EN LA MOLECULA DE ALQUIL Y DIALQUILAMINOCARBONIL QUE TENGA ENTRE 1 Y 10 ATOMOS DE CARBONO EN CADA UNA DE LAS MOLECULAS DE ALQUIL, ASIMISMO SE PRESENTAN LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS COMPUESTOS, ESTOS COMPUESTOS INHIBEN LA LIPOXIGENASA DE LAS ENZIMAS Y SON UTILES EN EL TRATAMIENTO DE ALERGIAS Y ENFERMEDADES INFLAMATORIOS Y CARDIOVASCULARES PARA LAS CUALES SE IMPLICA LA ACCION DE LA LIPOXIGENASA. ESTOS COMPUESTOS FORMAN EL INGREDIENTE ACTIVO EN COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE TALES ENFERMEDADES.
ES92911441T 1991-06-13 1992-05-21 Derivados de n-hidroxiurea que inhiben la lipoxigenasa. Expired - Lifetime ES2081111T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3142123A JPH07100687B2 (ja) 1991-06-13 1991-06-13 新規なｎ−ヒドロキシ尿素化合物および組成物

Publications (1)

Publication Number Publication Date
ES2081111T3 true ES2081111T3 (es) 1996-02-16

Family

ID=15307927

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92911441T Expired - Lifetime ES2081111T3 (es) 1991-06-13 1992-05-21 Derivados de n-hidroxiurea que inhiben la lipoxigenasa.

Country Status (13)

Country Link
US (1) US5384320A (es)
EP (1) EP0588850B1 (es)
JP (1) JPH07100687B2 (es)
AT (1) ATE131162T1 (es)
CA (1) CA2109800C (es)
DE (1) DE69206616T2 (es)
DK (1) DK0588850T3 (es)
ES (1) ES2081111T3 (es)
FI (1) FI935552A7 (es)
GR (1) GR3018321T3 (es)
IE (1) IE69369B1 (es)
PT (1) PT100582A (es)
WO (1) WO1992022543A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3179286B2 (ja) * 1994-05-19 2001-06-25 ファイザー製薬株式会社 Ｎ−ヒドロキシ尿素系抗炎症剤
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU201300B (en) * 1985-03-16 1990-10-28 Wellcome Found Process for production of derivatives of aryl and medical compositions containing them as active substance
CA1336099C (en) * 1987-04-24 1995-06-27 James B. Summers, Jr. Urea based lipoxygenase compounds
US5068251A (en) * 1988-12-16 1991-11-26 Abbott Laboratories Lipoxygenase inhibiting compounds
US4981865A (en) * 1989-05-26 1991-01-01 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents

Also Published As

Publication number Publication date
EP0588850B1 (en) 1995-12-06
ATE131162T1 (de) 1995-12-15
FI935552L (fi) 1993-12-10
CA2109800C (en) 1996-03-19
JPH04368366A (ja) 1992-12-21
GR3018321T3 (en) 1996-03-31
DE69206616T2 (de) 1996-04-25
EP0588850A1 (en) 1994-03-30
JPH07100687B2 (ja) 1995-11-01
IE69369B1 (en) 1996-09-04
WO1992022543A1 (en) 1992-12-23
PT100582A (pt) 1993-08-31
DK0588850T3 (da) 1996-01-08
IE921902A1 (en) 1992-12-16
FI935552A0 (fi) 1993-12-10
DE69206616D1 (de) 1996-01-18
US5384320A (en) 1995-01-24
FI935552A7 (fi) 1993-12-10
CA2109800A1 (en) 1992-12-23

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