AR036680A1 - Procedimiento para preparar derivados de heterocicloalquilsulfonilpirazol y compuestos utiles en su preparacion - Google Patents

Procedimiento para preparar derivados de heterocicloalquilsulfonilpirazol y compuestos utiles en su preparacion

Info

Publication number
AR036680A1
AR036680A1 ARP020103634A ARP020103634A AR036680A1 AR 036680 A1 AR036680 A1 AR 036680A1 AR P020103634 A ARP020103634 A AR P020103634A AR P020103634 A ARP020103634 A AR P020103634A AR 036680 A1 AR036680 A1 AR 036680A1
Authority
AR
Argentina
Prior art keywords
alkyl
formula
halo
amino
optionally substituted
Prior art date
Application number
ARP020103634A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR036680A1 publication Critical patent/AR036680A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Abstract

Un procedimiento para preparar un compuesto de la fórmula (1) que comprende la combinación de: (a) un compuesto de la fórmula (2); (b) un compuesto de la fórmula (3); (c) uno o más ácidos; (d) uno o más disolventes orgánicos miscibles en agua; y (e) agua; en la que: R1 es fenilo opcionalmente sustituido por 1-3 sustituyentes independientemente seleccionados del grupo formado por: halo-hidroxilo, ciano, mercapto, alquilo C1-6, alquenilo C2-6, alcoxi C1-6, -OCF3, alquilo C1-6-S-, alquilo C1-6-S(=O)-, alquilo C1-6-SO2-, amino, alquilamino C1-6, di[alquil C1-6]amino, H2N-(C=O)-, alquil C1-6-NH-(C=O)- y formilo; R2 es hidrógeno, halo- ó alquilo C1-6; R3 alquilo C1-6 opcionalmente sustituido por uno a tres haloátomos; y R4 es alquilo C1-6. Se describen también compuestos de fórmula (4) en el que R1 es fenilo opcionalmente sustituido por 1-3 sustituyentes independientemente seleccionados del grupo formado por: halo-hidroxilo, ciano, mercapto, alquilo C1-6, alquenilo C2-6, alcoxi C1-6, -OCF3, alquilo C1-6-S-, alquilo C1-6-S(=O)-, alquilo C1-6-SO2-, amino, alquilamino C1-6, di[alquil C1-6]amino, H2N-(C=O)-, alquil C1-6-NH-(C=O)- y formilo; R2 es hidrógeno, halo- ó alquilo C1-6; R3 es alquilo C1-6 opcionalmente sustituido por uno a tres haloátomos; y R4 es alquilo C1-6, útiles en la fabricación de los mismos. Los compuestos de fórmula (1) son útiles en el tratamiento o mitigación de la inflamación y otros trastornos asociados con la inflamación.
ARP020103634A 2001-09-28 2002-09-26 Procedimiento para preparar derivados de heterocicloalquilsulfonilpirazol y compuestos utiles en su preparacion AR036680A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32564701P 2001-09-28 2001-09-28

Publications (1)

Publication Number Publication Date
AR036680A1 true AR036680A1 (es) 2004-09-29

Family

ID=23268786

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020103634A AR036680A1 (es) 2001-09-28 2002-09-26 Procedimiento para preparar derivados de heterocicloalquilsulfonilpirazol y compuestos utiles en su preparacion

Country Status (20)

Country Link
US (2) US6646128B2 (es)
EP (1) EP1430046A1 (es)
JP (1) JP2005504127A (es)
KR (1) KR20040039424A (es)
CN (1) CN1561339A (es)
AR (1) AR036680A1 (es)
BR (1) BR0212860A (es)
CA (1) CA2457798A1 (es)
CZ (1) CZ2004414A3 (es)
GT (1) GT200200183A (es)
HU (1) HUP0401914A3 (es)
IL (1) IL160369A0 (es)
MX (1) MXPA04002879A (es)
PA (1) PA8555601A1 (es)
PE (1) PE20030532A1 (es)
PL (1) PL370110A1 (es)
RU (1) RU2004109148A (es)
UY (1) UY27453A1 (es)
WO (1) WO2003029244A1 (es)
ZA (1) ZA200401043B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1865955A4 (en) * 2005-03-25 2009-04-15 Merck & Co Inc TREATMENT OF MALE-HUMAN HUMANS BY TESTOSTERONE SUPPLEMENTATION ASSOCIATED WITH 5ALPHA-REDUCTASE INHIBITOR
US20090029377A1 (en) * 2007-07-23 2009-01-29 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
IL104311A (en) 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
CA2276945C (en) 1993-11-30 2006-08-01 G.D. Searle & Co. Tricyclic-substituted pyrazolyl benzenesulfonamides and pharmaceutical compositions thereof
US5401765A (en) 1993-11-30 1995-03-28 G. D. Searle 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders
US5434178A (en) 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
US5475018A (en) 1993-11-30 1995-12-12 G. D. Searle & Co. 1,5-diphenyl pyrazole compounds for treatment of inflammation
EP1125932A3 (en) 1994-07-27 2001-08-29 G.D. Searle & Co. Substituted thiazoles for the treatment of inflammation
US5620999A (en) 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5585504A (en) 1994-09-16 1996-12-17 Merck & Co., Inc. Process of making cox-2 inhibitors having a lactone bridge
JPH10511089A (ja) 1994-12-21 1998-10-27 メルク フロスト カナダ インコーポレーテツド Ｃｏｘ−２阻害剤としてのジアリール−２−（５ｈ）−フラノン
US5691374A (en) 1995-05-18 1997-11-25 Merck Frosst Canada Inc. Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors
US5756529A (en) 1995-09-29 1998-05-26 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
GB9520584D0 (en) 1995-10-09 1995-12-13 Fujisawa Pharmaceutical Co Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
UA57002C2 (uk) 1995-10-13 2003-06-16 Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування
EP0904269B1 (en) 1995-10-30 2002-01-23 Merck Frosst Canada & Co. 3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors
JP2003517475A (ja) * 1999-12-03 2003-05-27 ファイザー・プロダクツ・インク 抗炎症／鎮痛薬としてのヘテロシクロ−アルキルスルホニルピラゾール誘導体
DK1104758T3 (da) * 1999-12-03 2003-10-20 Pfizer Prod Inc Acetylenderivativer som anti-inflammatoriske/analgesiske lægemidler
ATE252576T1 (de) 1999-12-03 2003-11-15 Pfizer Prod Inc Heteroarylphenylpyrazolverbindungen zur verwendung als analgetisches/entzündungshemmendes mittel

Also Published As

Publication number Publication date
CZ2004414A3 (cs) 2004-12-15
BR0212860A (pt) 2004-10-13
JP2005504127A (ja) 2005-02-10
WO2003029244A1 (en) 2003-04-10
GT200200183A (es) 2003-05-23
MXPA04002879A (es) 2004-07-15
ZA200401043B (en) 2005-04-15
HUP0401914A3 (en) 2006-04-28
CA2457798A1 (en) 2003-04-10
EP1430046A1 (en) 2004-06-23
PL370110A1 (en) 2005-05-16
US20030100765A1 (en) 2003-05-29
RU2004109148A (ru) 2005-08-20
IL160369A0 (en) 2004-07-25
CN1561339A (zh) 2005-01-05
PE20030532A1 (es) 2003-06-18
UY27453A1 (es) 2003-04-30
HUP0401914A2 (hu) 2005-01-28
KR20040039424A (ko) 2004-05-10
WO2003029244A8 (en) 2003-09-04
US6646128B2 (en) 2003-11-11
PA8555601A1 (es) 2003-09-17
US20040044042A1 (en) 2004-03-04
US6846930B2 (en) 2005-01-25

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