AR028740A1 - Procedimiento para la preparacion de pirazolopirimidinonas - Google Patents

Procedimiento para la preparacion de pirazolopirimidinonas

Info

Publication number
AR028740A1
AR028740A1 ARP010102935A ARP010102935A AR028740A1 AR 028740 A1 AR028740 A1 AR 028740A1 AR P010102935 A ARP010102935 A AR P010102935A AR P010102935 A ARP010102935 A AR P010102935A AR 028740 A1 AR028740 A1 AR 028740A1
Authority
AR
Argentina
Prior art keywords
compound
pirazolopirimidinones
procedure
preparation
formula
Prior art date
Application number
ARP010102935A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26244540&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR028740(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0015472A external-priority patent/GB0015472D0/en
Priority claimed from GB0105857A external-priority patent/GB0105857D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of AR028740A1 publication Critical patent/AR028740A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Se proporciona un procedimiento para la produccion de un compuesto de formula general 1 en la que A, R1, R2, R3 y R4 tienen los significados dados en la descripcion, procedimiento que comprende la reaccion de un compuesto de formula 2 en la que R2 es un grupo sustituible por un aminopirazol, con un compuesto de formula 3 donde los sustituyentes de los compuestos formulas 2 y 3 poseen los significados dados en la descripcion. Se proporcionan también el compuesto intermediario 2 segun lo antes mencionado.
ARP010102935A 2000-06-22 2001-06-20 Procedimiento para la preparacion de pirazolopirimidinonas AR028740A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0015472A GB0015472D0 (en) 2000-06-22 2000-06-22 Novel process for the preparation of pyrazolopyrimidinones
GB0105857A GB0105857D0 (en) 2001-03-09 2001-03-09 Novel process for the preparation of pyrazolopyrimidinones

Publications (1)

Publication Number Publication Date
AR028740A1 true AR028740A1 (es) 2003-05-21

Family

ID=26244540

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010102935A AR028740A1 (es) 2000-06-22 2001-06-20 Procedimiento para la preparacion de pirazolopirimidinonas

Country Status (29)

Country Link
EP (1) EP1292586B1 (es)
JP (1) JP2004501142A (es)
KR (1) KR100525698B1 (es)
CN (1) CN100338047C (es)
AP (1) AP2001002194A0 (es)
AR (1) AR028740A1 (es)
AT (1) ATE272626T1 (es)
AU (2) AU2001262597B2 (es)
BR (1) BR0111581A (es)
CA (1) CA2411961C (es)
CZ (1) CZ20024176A3 (es)
DE (1) DE60104691T2 (es)
DK (1) DK1292586T3 (es)
DO (1) DOP2001000190A (es)
ES (1) ES2223863T3 (es)
HK (1) HK1054926A1 (es)
HU (1) HUP0301183A3 (es)
IL (1) IL153532A0 (es)
MX (1) MXPA02012884A (es)
MY (1) MY124903A (es)
PA (1) PA8519801A1 (es)
PE (1) PE20020105A1 (es)
PL (1) PL359651A1 (es)
PT (1) PT1292586E (es)
SV (1) SV2002000503A (es)
TN (1) TNSN01093A1 (es)
TR (1) TR200401983T4 (es)
WO (1) WO2001098284A1 (es)
YU (1) YU93902A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2310144B1 (es) 2007-06-15 2010-01-12 Galenicum Health, S.L. Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5.
US8410098B2 (en) 2007-12-28 2013-04-02 Topharman Shanghai Co., Ltd. N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-OXO-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof
CN101747282A (zh) * 2008-12-10 2010-06-23 上海特化医药科技有限公司 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途
AU2010280358A1 (en) 2009-08-07 2012-03-08 Ranbaxy Laboratories Limited Processes for the preparation of vardenafil
WO2011088192A1 (en) 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Compounds and methods
MX2010006227A (es) 2010-06-07 2011-12-14 World Trade Imp Exp Wtie Ag Nuevos derivados 1,4-diazepanos, inhibidores de pde-5.
FR2970967B1 (fr) 2011-01-27 2013-02-15 Pf Medicament Derives de type azaindazole ou diazaindazole comme medicament
EP2689779A1 (en) 2012-07-27 2014-01-29 Pierre Fabre Medicament Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing trk
EP2689778A1 (en) 2012-07-27 2014-01-29 Pierre Fabre Medicament Derivatives of azaindoles or diazaindoles for treating pain
BR112019006490B1 (pt) * 2016-10-24 2023-11-28 Fmc Corporation Composto, composições fungicidas e métodos para o controle das doenças dos vegetais

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822238D0 (en) * 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
EP1002798A1 (en) * 1998-11-20 2000-05-24 Orchid Chemicals & Pharmaceuticals Ltd. An improved process for preparing a therapeutically active pyrazolopyrimidinone derivative

Also Published As

Publication number Publication date
PT1292586E (pt) 2004-11-30
MY124903A (en) 2006-07-31
PE20020105A1 (es) 2002-02-21
ATE272626T1 (de) 2004-08-15
DOP2001000190A (es) 2002-05-15
PA8519801A1 (es) 2002-04-25
HUP0301183A3 (en) 2006-02-28
CA2411961A1 (en) 2001-12-27
CA2411961C (en) 2007-02-06
DK1292586T3 (da) 2004-08-30
WO2001098284A1 (en) 2001-12-27
PL359651A1 (en) 2004-08-23
TNSN01093A1 (fr) 2005-11-10
ES2223863T3 (es) 2005-03-01
AU2001262597B2 (en) 2005-10-20
CN1437589A (zh) 2003-08-20
YU93902A (sh) 2005-11-28
EP1292586A1 (en) 2003-03-19
CZ20024176A3 (cs) 2004-01-14
SV2002000503A (es) 2002-07-03
KR20030031912A (ko) 2003-04-23
EP1292586B1 (en) 2004-08-04
MXPA02012884A (es) 2003-05-14
DE60104691D1 (de) 2004-09-09
JP2004501142A (ja) 2004-01-15
AP2001002194A0 (en) 2002-12-21
HUP0301183A2 (hu) 2003-08-28
TR200401983T4 (tr) 2004-09-21
AU6259701A (en) 2002-01-02
BR0111581A (pt) 2003-03-25
DE60104691T2 (de) 2005-01-13
HK1054926A1 (en) 2003-12-19
KR100525698B1 (ko) 2005-11-03
CN100338047C (zh) 2007-09-19
IL153532A0 (en) 2003-07-06

Similar Documents

Publication Publication Date Title
ATE517663T1 (de) Photostabile organische sonnenschutzverbindungen mit antioxidationseigenschaften und daraus gewonnene zusammensetzungen
WO2000023446A8 (de) Kernerweiterte perylenbisimide und ihre verwendung als fluoreszenzfarbstoffe
UY27522A1 (es) Inhibidores de pde9 para tratamiento de trastornos cardiovasculares
MEP7808A (en) Process for preparing 4-trifluoromethylsulphinylpyrazole derivative
MXPA05006908A (es) Compuestos diazoicos cationicos particulares, composiciones que los contienen como colorante directo, procedimiento de coloracion de fibras queratinicas y dispositivo.
PE20020476A1 (es) Derivados de glucopiranosiloxibencilbenceno y composiciones farmaceuticas que comprenden los mismos
ID17851A (id) Persenyawaan heterosiklis, produksi dan pemakaiannya
BG108174A (en) 5-phenylpyrimidines, methods and intermediate products for the production thereof and use of the same for controlling pathogenic fungi
AR057088A1 (es) Compuestos quimicos
AR028740A1 (es) Procedimiento para la preparacion de pirazolopirimidinonas
AR036000A1 (es) Proceso para la preparacion de derivados de indol y novedosos intermediarios
BR0307008A (pt) N-aril-4,5-dia-minopirazóis e agentes de tingimento que contêm esses compostos
DE60115080D1 (de) Verfahren zur herstellung von bis-benzazolyl verbindungen
EA200400323A1 (ru) Аралкилтетрагидропиридины, их получение и содержащие их фармацевтические композиции
EA200300458A1 (ru) Новые соединения аминотриазолона, способ их получения и фармацевтические композиции, содержащие их
AR029767A1 (es) Procedimiento para la preparacion de compuestos de pirazolo (4, 3-d) pirimidin-7-onas-3-piridilsulfonilo y compuestos intermediarios utiles en dicho procedimiento.
CY1107515T1 (el) Συνθεση ενδιαμεσων χρησιμων στην παρασκευη τρικυκλικων ενωσεων
EA200101204A1 (ru) Новые бициклические соединения аминопиразинона, способ их получения и содержащие их фармацевтические композиции
EE200300090A (et) Asendatud imidasopüridiinühendite valmistamise meetod
UY26784A1 (es) Nuevo procedimiento para la preparación de pirazolopirimidinonas
ES2183500T3 (es) Nuevos compuestos y composiciones farmaceuticas que los contienen.
AR008526A1 (es) Procedimiento para preparar eteres bencilicos.
DE69204480D1 (de) Anilinderivate und Verfahren zu ihrer Herstellung.
AU7851201A (en) Method for the production of imidazo-(1,2-c)(2,3)-benzodiazepines and intermediates in the production thereof
AR036680A1 (es) Procedimiento para preparar derivados de heterocicloalquilsulfonilpirazol y compuestos utiles en su preparacion

Legal Events

Date Code Title Description
FG Grant, registration