FR2970967B1 - Derives de type azaindazole ou diazaindazole comme medicament - Google Patents

Derives de type azaindazole ou diazaindazole comme medicament

Info

Publication number
FR2970967B1
FR2970967B1 FR1150651A FR1150651A FR2970967B1 FR 2970967 B1 FR2970967 B1 FR 2970967B1 FR 1150651 A FR1150651 A FR 1150651A FR 1150651 A FR1150651 A FR 1150651A FR 2970967 B1 FR2970967 B1 FR 2970967B1
Authority
FR
France
Prior art keywords
diazaindazole
azaindazole
derivatives
medicinal product
medicinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1150651A
Other languages
English (en)
Other versions
FR2970967A1 (fr
Inventor
El Bachir Kaloun
Karim Bedjeguelal
Remi Rabot
Anna Kruczynski
Philippe Schmitt
Michel Perez
Nicolas Rahier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR1150651A priority Critical patent/FR2970967B1/fr
Priority to TW101102531A priority patent/TWI546303B/zh
Priority to PL12701884T priority patent/PL2668184T3/pl
Priority to RS20180418A priority patent/RS57101B1/sr
Priority to AU2012210467A priority patent/AU2012210467B2/en
Priority to MYPI2013002799A priority patent/MY180666A/en
Priority to UAA201310425A priority patent/UA109698C2/ru
Priority to KR1020187031264A priority patent/KR20180122028A/ko
Priority to CN201280006671.8A priority patent/CN103339129B/zh
Priority to TR2018/02944T priority patent/TR201802944T4/tr
Priority to RU2013138624/04A priority patent/RU2600976C2/ru
Priority to ARP120100272A priority patent/AR084935A1/es
Priority to MX2013008673A priority patent/MX356411B/es
Priority to DK12701884.4T priority patent/DK2668184T3/en
Priority to EP12701884.4A priority patent/EP2668184B1/fr
Priority to PT127018844T priority patent/PT2668184T/pt
Priority to US13/823,658 priority patent/US20130172360A1/en
Priority to HUE12701884A priority patent/HUE037153T2/hu
Priority to MA36177A priority patent/MA34903B1/fr
Priority to LTEP12701884.4T priority patent/LT2668184T/lt
Priority to SI201231273T priority patent/SI2668184T1/en
Priority to CA2823824A priority patent/CA2823824C/fr
Priority to NZ614432A priority patent/NZ614432B2/en
Priority to JP2013550886A priority patent/JP5931926B2/ja
Priority to ES12701884.4T priority patent/ES2661695T3/es
Priority to KR1020137022330A priority patent/KR101923751B1/ko
Priority to PCT/EP2012/051283 priority patent/WO2012101239A1/fr
Publication of FR2970967A1 publication Critical patent/FR2970967A1/fr
Priority to US13/686,334 priority patent/US8883821B2/en
Application granted granted Critical
Publication of FR2970967B1 publication Critical patent/FR2970967B1/fr
Priority to TNP2013000293A priority patent/TN2013000293A1/fr
Priority to IL227496A priority patent/IL227496B/en
Priority to HK13114261.8A priority patent/HK1186737A1/xx
Priority to IL257748A priority patent/IL257748B/en
Priority to CY20181100338T priority patent/CY1120088T1/el
Priority to HRP20180524TT priority patent/HRP20180524T1/hr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
FR1150651A 2011-01-27 2011-01-27 Derives de type azaindazole ou diazaindazole comme medicament Active FR2970967B1 (fr)

Priority Applications (34)

Application Number Priority Date Filing Date Title
FR1150651A FR2970967B1 (fr) 2011-01-27 2011-01-27 Derives de type azaindazole ou diazaindazole comme medicament
TW101102531A TWI546303B (zh) 2011-01-27 2012-01-20 氮雜吲唑（ａｚａｉｎｄａｚｏｌｅ）或二氮雜吲唑（ｄｉａｚａｉｎｄａｚｏｌｅ）類型之衍生物供作藥物之用途
HUE12701884A HUE037153T2 (hu) 2011-01-27 2012-01-27 Azaindazol vagy diazaindazol típusú származékok mint gyógyszerek
AU2012210467A AU2012210467B2 (en) 2011-01-27 2012-01-27 Derivatives of azaindazole or diazaindazole type as medicament
SI201231273T SI2668184T1 (en) 2011-01-27 2012-01-27 PRODUCTS OF AZAINDAZOL OR DIAZAINDAZOL AS A MEDICINAL PRODUCT
UAA201310425A UA109698C2 (xx) 2011-01-27 2012-01-27 Похідні азаіндазолу або діазаіндазолу як медикамент
KR1020187031264A KR20180122028A (ko) 2011-01-27 2012-01-27 의약으로서의 아자인다졸 또는 디아자인다졸 유형의 유도체
CN201280006671.8A CN103339129B (zh) 2011-01-27 2012-01-27 作为药物的氮杂吲唑或二氮杂吲唑类衍生物
TR2018/02944T TR201802944T4 (tr) 2011-01-27 2012-01-27 İlaç olarak azai̇ndazol veya di̇azai̇ndazol türünün türevleri̇
RU2013138624/04A RU2600976C2 (ru) 2011-01-27 2012-01-27 Производные азаиндазола или диазаиндазола в качестве медикамента
ARP120100272A AR084935A1 (es) 2011-01-27 2012-01-27 Derivados de tipo azaindazol o diazaindazol como medicamentos
MX2013008673A MX356411B (es) 2011-01-27 2012-01-27 Derivados del tipo del azaindazol o diazaindazol como medicamento.
DK12701884.4T DK2668184T3 (en) 2011-01-27 2012-01-27 DERIVATIVES OF AZAINDAZOL OR DIAZAINDAZOL TYPE AS MEDICATION
EP12701884.4A EP2668184B1 (fr) 2011-01-27 2012-01-27 Dérivés de type azaindazole ou diazaindazole utilisés comme médicaments
PT127018844T PT2668184T (pt) 2011-01-27 2012-01-27 Derivados do tipo azaindazole ou diazaindazole utilizados como medicamentos
US13/823,658 US20130172360A1 (en) 2011-01-27 2012-01-27 Derivatives of azaindazole or diazaindazole type as medicament
RS20180418A RS57101B1 (sr) 2011-01-27 2012-01-27 Derivati tipa azaindazola ili diazaindazola kao lek
MA36177A MA34903B1 (fr) 2011-01-27 2012-01-27 Derives de type azaindazole ou diazaindazole utilises comme medicaments
PL12701884T PL2668184T3 (pl) 2011-01-27 2012-01-27 Pochodne typu azaindazolu lub diazaindazolu jako lek
MYPI2013002799A MY180666A (en) 2011-01-27 2012-01-27 Substituted pyrazolo [3,4-b] pyridines as medicaments
CA2823824A CA2823824C (fr) 2011-01-27 2012-01-27 Derives d'azaindazoles et de diazaindazoles et leur utilisation comme medicaments
JP2013550886A JP5931926B2 (ja) 2011-01-27 2012-01-27 医薬としてのアザインダゾールまたはジアザインダゾール型の誘導体
NZ614432A NZ614432B2 (en) 2011-01-27 2012-01-27 Derivatives of azaindazole or diazaindazole type as medicament
ES12701884.4T ES2661695T3 (es) 2011-01-27 2012-01-27 Derivados de tipo azaindazol o diazaindazol como medicamento
KR1020137022330A KR101923751B1 (ko) 2011-01-27 2012-01-27 의약으로서의 아자인다졸 또는 디아자인다졸 유형의 유도체
PCT/EP2012/051283 WO2012101239A1 (fr) 2011-01-27 2012-01-27 Dérivés de type azaindazole ou diazaindazole utilisés comme médicaments
LTEP12701884.4T LT2668184T (lt) 2011-01-27 2012-01-27 Azaindazolo arba diazaindazolo tipo dariniai kaip vaistai
US13/686,334 US8883821B2 (en) 2011-01-27 2012-11-27 Substituted pyrazolo[3,4-b]pyridines as medicaments
TNP2013000293A TN2013000293A1 (en) 2011-01-27 2013-07-11 Derivatives of azaindazole or diazaindazole type as medicament
IL227496A IL227496B (en) 2011-01-27 2013-07-16 Pyrazolo[4,3–b]pyridines are converted as drugs
HK13114261.8A HK1186737A1 (en) 2011-01-27 2013-12-24 Derivatives of azaindazole or diazaindazole type as medicament
IL257748A IL257748B (en) 2011-01-27 2018-02-26 Derivatives of pyrazole [4,3-b]pyridine, pyrazolo[4,3-b]pyridine and pyrazolo[4,3-b]pyrazine for use in the treatment of cancer, inflammatory diseases and neurodegenerative diseases,
CY20181100338T CY1120088T1 (el) 2011-01-27 2018-03-26 Παραγωγα τυπου αζαϊνδαζολιου ή διαζαϊνδαζολιου ως φαρμακo
HRP20180524TT HRP20180524T1 (hr) 2011-01-27 2018-03-29 Derivati tipa azaindazola ili diazaindazola kao lijek

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1150651A FR2970967B1 (fr) 2011-01-27 2011-01-27 Derives de type azaindazole ou diazaindazole comme medicament

Publications (2)

Publication Number Publication Date
FR2970967A1 FR2970967A1 (fr) 2012-08-03
FR2970967B1 true FR2970967B1 (fr) 2013-02-15

Family

ID=44318089

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1150651A Active FR2970967B1 (fr) 2011-01-27 2011-01-27 Derives de type azaindazole ou diazaindazole comme medicament

Country Status (30)

Country Link
US (2) US20130172360A1 (fr)
EP (1) EP2668184B1 (fr)
JP (1) JP5931926B2 (fr)
KR (2) KR20180122028A (fr)
CN (1) CN103339129B (fr)
AR (1) AR084935A1 (fr)
AU (1) AU2012210467B2 (fr)
CA (1) CA2823824C (fr)
CY (1) CY1120088T1 (fr)
DK (1) DK2668184T3 (fr)
ES (1) ES2661695T3 (fr)
FR (1) FR2970967B1 (fr)
HK (1) HK1186737A1 (fr)
HR (1) HRP20180524T1 (fr)
HU (1) HUE037153T2 (fr)
IL (2) IL227496B (fr)
LT (1) LT2668184T (fr)
MA (1) MA34903B1 (fr)
MX (1) MX356411B (fr)
MY (1) MY180666A (fr)
PL (1) PL2668184T3 (fr)
PT (1) PT2668184T (fr)
RS (1) RS57101B1 (fr)
RU (1) RU2600976C2 (fr)
SI (1) SI2668184T1 (fr)
TN (1) TN2013000293A1 (fr)
TR (1) TR201802944T4 (fr)
TW (1) TWI546303B (fr)
UA (1) UA109698C2 (fr)
WO (1) WO2012101239A1 (fr)

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EP2689778A1 (fr) * 2012-07-27 2014-01-29 Pierre Fabre Medicament Dérivés de type azaindazole ou diazaindazole pour le traitement de la douleur
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
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US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016096709A1 (fr) 2014-12-16 2016-06-23 Eudendron S.R.L. Dérivés hétérocycliques modulant l'activité de certaines protéines kinases
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN113004278B (zh) 2015-02-20 2023-07-21 因赛特控股公司 作为fgfr抑制剂的双环杂环
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US10211205B2 (en) * 2016-04-27 2019-02-19 International Business Machines Corporation Field effect transistor structure for reducing contact resistance
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AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
AU2019262195A1 (en) 2018-05-04 2020-12-24 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
AU2019262579A1 (en) 2018-05-04 2020-12-24 Incyte Corporation Salts of an FGFR inhibitor
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
EP3725777A1 (fr) * 2019-04-17 2020-10-21 Rottapharm Biotech S.r.l. Benzo- et pyrido-pyrazoles en tant qu`inhibiteurs de protéine kinase
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
BR112022007163A2 (pt) 2019-10-14 2022-08-23 Incyte Corp Heterociclos bicíclicos como inibidores de fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
KR20220131900A (ko) 2019-12-04 2022-09-29 인사이트 코포레이션 Fgfr 억제제의 유도체
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Also Published As

Publication number Publication date
DK2668184T3 (en) 2018-03-12
SI2668184T1 (en) 2018-06-29
RS57101B1 (sr) 2018-06-29
MY180666A (en) 2020-12-04
RU2013138624A (ru) 2015-03-10
AU2012210467A1 (en) 2013-09-12
TN2013000293A1 (en) 2015-01-20
TWI546303B (zh) 2016-08-21
AR084935A1 (es) 2013-07-10
HRP20180524T1 (hr) 2018-05-04
US20130172360A1 (en) 2013-07-04
PL2668184T3 (pl) 2018-06-29
MA34903B1 (fr) 2014-02-01
UA109698C2 (xx) 2015-09-25
KR20180122028A (ko) 2018-11-09
EP2668184A1 (fr) 2013-12-04
KR20140014147A (ko) 2014-02-05
IL227496A0 (en) 2013-09-30
IL257748A (en) 2018-04-30
TW201247664A (en) 2012-12-01
IL257748B (en) 2020-06-30
CN103339129A (zh) 2013-10-02
CA2823824C (fr) 2018-12-11
MX2013008673A (es) 2013-12-02
IL227496B (en) 2019-02-28
WO2012101239A1 (fr) 2012-08-02
TR201802944T4 (tr) 2018-03-21
CY1120088T1 (el) 2018-12-12
JP2014503574A (ja) 2014-02-13
US20130085144A1 (en) 2013-04-04
CN103339129B (zh) 2015-07-29
HK1186737A1 (en) 2014-03-21
KR101923751B1 (ko) 2018-11-29
NZ614432A (en) 2015-03-27
MX356411B (es) 2018-05-24
EP2668184B1 (fr) 2018-01-10
HUE037153T2 (hu) 2018-08-28
RU2600976C2 (ru) 2016-10-27
US8883821B2 (en) 2014-11-11
PT2668184T (pt) 2018-03-13
JP5931926B2 (ja) 2016-06-08
AU2012210467B2 (en) 2016-07-07
LT2668184T (lt) 2018-04-10
CA2823824A1 (fr) 2012-08-02
FR2970967A1 (fr) 2012-08-03
ES2661695T3 (es) 2018-04-03

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