CY1107515T1 - Συνθεση ενδιαμεσων χρησιμων στην παρασκευη τρικυκλικων ενωσεων - Google Patents

Συνθεση ενδιαμεσων χρησιμων στην παρασκευη τρικυκλικων ενωσεων

Info

Publication number
CY1107515T1
CY1107515T1 CY20071100293T CY071100293T CY1107515T1 CY 1107515 T1 CY1107515 T1 CY 1107515T1 CY 20071100293 T CY20071100293 T CY 20071100293T CY 071100293 T CY071100293 T CY 071100293T CY 1107515 T1 CY1107515 T1 CY 1107515T1
Authority
CY
Cyprus
Prior art keywords
preparation
composition
tricyclic compounds
intermediate use
tricyclic
Prior art date
Application number
CY20071100293T
Other languages
English (en)
Inventor
Marc Poirier
Yee-Shing Wong
George G Wu
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of CY1107515T1 publication Critical patent/CY1107515T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Παρέχεται μια μέθοδος για την παρασκευή μιας ένωσης που έχει τον τύπο (I) η οποία περιλαμβάνει: (α) την αντίδραση μιας ένωσης που έχει τον τύπο (II) με έναν ισοκυανικό εστέρα που έχει τον τύπο R1NCO για να παραχθεί μια ένωση που έχει τον τύπο (III), (β) προαιρετικώς την υδρόλυση της ένωσης του τύπου (III) για να σχηματιστεί ένα αμίδιο που έχει τον τύπο (IV), (γ) την αντίδραση της ένωσης του τύπου (III) ή του αμιδίου του τύπου (IV) με μια ένωση που έχει τον τύπο (V) παρουσία μιας ισχυρής βάσης για να παραχθεί μια ένωση που έχει τον τύπο (VI), και (δ) την κυκλοποίηση της ένωσης του τύπου (VI) για να ληφθεί η ένωση του τύπου (I), όπου το R είναι Η ή Cl, το Μ επιλέγεται από την ομάδα που αποτελείται από Li, Na, Κ, MgX, ZnRA και Al(RA)2, το RA είναι αλκύλιο, το Χ είναι αλογόνο, το R1 επιλέγεται από την ομάδα που αποτελείται από αλκύλιο, αρύλιο, αραλκύλιο, ετεροαρύλιο, ετεροαραλκύλιο, κυκλοαλκύλιο, κυκλοαλκυλαλκύλιο, ετεροκυκλοαλκύλιο και ετεροκυκλοαλκυλαλκύλιο, και το L είναι μια απομακρυνόμενη ομάδα. Επίσης παρέχεται μια μέθοδος παρασκευής μιας ένωσης που έχει τον τύπο (VIII) η οποία περιλαμβάνει την αντίδραση μιας ένωσης που έχει τον τύπο (II) με CO2 και ένα μέσον πρωτονίωσης για να ληφθεί η ένωση του τύπου (VIII), όπου το Μ επιλέγεται από την ομάδα που αποτελείται από Li, Na, Κ, MgX, ZnRA και AI(RA)2, όπου το RΑ είναι αλκύλιο και το Χ είναι αλογόνο.
CY20071100293T 2000-04-18 2007-03-01 Συνθεση ενδιαμεσων χρησιμων στην παρασκευη τρικυκλικων ενωσεων CY1107515T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19834100P 2000-04-18 2000-04-18
EP01927122A EP1274688B1 (en) 2000-04-18 2001-04-17 Synthesis of intermediates useful in preparing tricyclic compounds

Publications (1)

Publication Number Publication Date
CY1107515T1 true CY1107515T1 (el) 2013-03-13

Family

ID=22732984

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100293T CY1107515T1 (el) 2000-04-18 2007-03-01 Συνθεση ενδιαμεσων χρησιμων στην παρασκευη τρικυκλικων ενωσεων

Country Status (15)

Country Link
US (2) US6492519B2 (el)
EP (1) EP1274688B1 (el)
JP (1) JP2004501081A (el)
CN (2) CN1636982A (el)
AT (1) ATE348815T1 (el)
AU (1) AU2001253602A1 (el)
CA (1) CA2406384C (el)
CY (1) CY1107515T1 (el)
DE (1) DE60125343T2 (el)
DK (1) DK1274688T3 (el)
ES (1) ES2273832T3 (el)
HK (1) HK1048630B (el)
MX (1) MXPA02010274A (el)
PT (1) PT1274688E (el)
WO (1) WO2001079175A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1421068B1 (en) 2001-08-21 2008-07-09 Schering Corporation A process of synthesis of a tricyclic ketone intermediate
US8044291B2 (en) * 2006-05-18 2011-10-25 Adobe Systems Incorporated Selection of visually displayed audio data for editing
CN102731383A (zh) * 2012-07-07 2012-10-17 盛世泰科生物医药技术(苏州)有限公司 一种3-甲基-6-氯-2-甲酸甲酯吡啶的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282233B1 (en) 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
US5089496A (en) 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
CA2284646C (en) * 1997-03-25 2004-04-06 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US5998620A (en) * 1997-03-25 1999-12-07 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
WO2000005215A1 (en) * 1998-07-24 2000-02-03 Russinsky Limited A process for preparing benzocycloheptapyridin-11-ones
WO2000030589A2 (en) * 1998-11-20 2000-06-02 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds

Also Published As

Publication number Publication date
DE60125343D1 (de) 2007-02-01
EP1274688A1 (en) 2003-01-15
US6750347B2 (en) 2004-06-15
PT1274688E (pt) 2007-03-30
DK1274688T3 (da) 2007-02-05
HK1048630B (zh) 2007-02-09
CA2406384A1 (en) 2001-10-25
DE60125343T2 (de) 2007-06-14
MXPA02010274A (es) 2003-04-25
CN1217937C (zh) 2005-09-07
CA2406384C (en) 2010-02-09
CN1636982A (zh) 2005-07-13
EP1274688B1 (en) 2006-12-20
ES2273832T3 (es) 2007-05-16
US20020035261A1 (en) 2002-03-21
HK1048630A1 (en) 2003-04-11
WO2001079175A1 (en) 2001-10-25
AU2001253602A1 (en) 2001-10-30
US6492519B2 (en) 2002-12-10
JP2004501081A (ja) 2004-01-15
ATE348815T1 (de) 2007-01-15
CN1425006A (zh) 2003-06-18
US20030050319A1 (en) 2003-03-13

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