PE20030532A1 - Procedimiento para preparar derivados de heterocicloalquilsulfonilpirazol - Google Patents

Procedimiento para preparar derivados de heterocicloalquilsulfonilpirazol

Info

Publication number
PE20030532A1
PE20030532A1 PE2002000951A PE2002000951A PE20030532A1 PE 20030532 A1 PE20030532 A1 PE 20030532A1 PE 2002000951 A PE2002000951 A PE 2002000951A PE 2002000951 A PE2002000951 A PE 2002000951A PE 20030532 A1 PE20030532 A1 PE 20030532A1
Authority
PE
Peru
Prior art keywords
heterocloalkylsulfonylpirazole
procedure
halo
refers
formula
Prior art date
Application number
PE2002000951A
Other languages
English (en)
Inventor
Michael James Castaldi
Dennis Ernest Bourassa
David Harold Brown Ripin
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20030532A1 publication Critical patent/PE20030532A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A PROCEDIMIENTOS PARA PREPARAR DERIVADOS DE HETEROCICLOALQUILSULFONILPIRAZOL DE FORMULA I QUE COMPRENDE LA COMBINACION DE R1-C0-CH2(R2)-CO-R3; ALQUILSULFONILPIRIDINA; ACIDOS; DISOLVENTES ORGANICOS MISCIBLES EN AGUA TAL COMO ALCOHOLES; AGUA; R1 ES FENILO OPCIONALMENTE SUSTITUIDO POR HALO, HIDROXILO, CIANO, MERCAPTO, ENTRE OTROS; R2 ES H, HALO, ALQUILO; R3 ES ALQUILO OPCIONALMENTE SUSTITUIDO CON HALOATOMOS; R4 ES ALQUILO. TAMBIEN SE REFIERE A UN COMPUESTO DE FORMULA 4. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO O MITIGACION DE INFLAMACION COMO ARTRITIS, NEURODEGENERACION, CANCER DE COLON
PE2002000951A 2001-09-28 2002-09-26 Procedimiento para preparar derivados de heterocicloalquilsulfonilpirazol PE20030532A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32564701P 2001-09-28 2001-09-28

Publications (1)

Publication Number Publication Date
PE20030532A1 true PE20030532A1 (es) 2003-06-18

Family

ID=23268786

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000951A PE20030532A1 (es) 2001-09-28 2002-09-26 Procedimiento para preparar derivados de heterocicloalquilsulfonilpirazol

Country Status (20)

Country Link
US (2) US6646128B2 (es)
EP (1) EP1430046A1 (es)
JP (1) JP2005504127A (es)
KR (1) KR20040039424A (es)
CN (1) CN1561339A (es)
AR (1) AR036680A1 (es)
BR (1) BR0212860A (es)
CA (1) CA2457798A1 (es)
CZ (1) CZ2004414A3 (es)
GT (1) GT200200183A (es)
HU (1) HUP0401914A3 (es)
IL (1) IL160369A0 (es)
MX (1) MXPA04002879A (es)
PA (1) PA8555601A1 (es)
PE (1) PE20030532A1 (es)
PL (1) PL370110A1 (es)
RU (1) RU2004109148A (es)
UY (1) UY27453A1 (es)
WO (1) WO2003029244A1 (es)
ZA (1) ZA200401043B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008534505A (ja) * 2005-03-25 2008-08-28 メルク エンド カムパニー インコーポレーテッド テストステロンサプリメントおよび５アルファ−レダクターゼインヒビターによる男性の治療方法
PL2557520T3 (pl) * 2007-07-23 2021-10-11 The Chinese University Of Hong Kong Określanie zaburzenia równowagi sekwencji kwasu nukleinowego

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
IL104311A (en) 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5401765A (en) 1993-11-30 1995-03-28 G. D. Searle 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders
US5434178A (en) 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
ATE212985T1 (de) 1993-11-30 2002-02-15 Searle & Co Tricyclische,substituierte pyrazolyl- benzolsulfonamide und ihre verwendung als cyclooxygenase ii inhibitoren
US5475018A (en) 1993-11-30 1995-12-12 G. D. Searle & Co. 1,5-diphenyl pyrazole compounds for treatment of inflammation
CA2195847A1 (en) 1994-07-27 1996-02-08 John J. Talley Substituted thiazoles for the treatment of inflammation
US5620999A (en) 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5585504A (en) 1994-09-16 1996-12-17 Merck & Co., Inc. Process of making cox-2 inhibitors having a lactone bridge
CA2206978A1 (en) 1994-12-21 1996-06-27 Merck Frosst Canada Inc. Diaryl-2-(5h)-furanones as cox-2 inhibitors
US5691374A (en) 1995-05-18 1997-11-25 Merck Frosst Canada Inc. Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors
US5756529A (en) 1995-09-29 1998-05-26 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
GB9520584D0 (en) 1995-10-09 1995-12-13 Fujisawa Pharmaceutical Co Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
UA57002C2 (uk) 1995-10-13 2003-06-16 Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування
EP0904269B1 (en) 1995-10-30 2002-01-23 Merck Frosst Canada & Co. 3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors
DE60018792T2 (de) * 1999-12-03 2006-01-26 Pfizer Products Inc., Groton Heterocyclo-alkylsulfonylpyrazolderivate zur verwendung als anti-imflammatorische oder analgetische verbindungen
TR200302047T4 (tr) 1999-12-03 2004-01-21 Pfizer Products Inc. Anti-iltihabik / analjezik maddeler olarak heteroaril fenil pirazol bileşikleri.
EP1104758B1 (en) * 1999-12-03 2003-07-23 Pfizer Products Inc. Acetylene derivatives as anti-inflammatory/analgesic agents

Also Published As

Publication number Publication date
CZ2004414A3 (cs) 2004-12-15
JP2005504127A (ja) 2005-02-10
AR036680A1 (es) 2004-09-29
WO2003029244A8 (en) 2003-09-04
BR0212860A (pt) 2004-10-13
UY27453A1 (es) 2003-04-30
PA8555601A1 (es) 2003-09-17
ZA200401043B (en) 2005-04-15
WO2003029244A1 (en) 2003-04-10
CA2457798A1 (en) 2003-04-10
US20030100765A1 (en) 2003-05-29
MXPA04002879A (es) 2004-07-15
US6846930B2 (en) 2005-01-25
US6646128B2 (en) 2003-11-11
EP1430046A1 (en) 2004-06-23
RU2004109148A (ru) 2005-08-20
CN1561339A (zh) 2005-01-05
HUP0401914A2 (hu) 2005-01-28
IL160369A0 (en) 2004-07-25
PL370110A1 (en) 2005-05-16
US20040044042A1 (en) 2004-03-04
KR20040039424A (ko) 2004-05-10
HUP0401914A3 (en) 2006-04-28
GT200200183A (es) 2003-05-23

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