ATE256108T1 - Verfahren zur herstellung von cholecalciferol- derivaten und zwischenverbindungen - Google Patents

Verfahren zur herstellung von cholecalciferol- derivaten und zwischenverbindungen

Info

Publication number
ATE256108T1
ATE256108T1 AT98960122T AT98960122T ATE256108T1 AT E256108 T1 ATE256108 T1 AT E256108T1 AT 98960122 T AT98960122 T AT 98960122T AT 98960122 T AT98960122 T AT 98960122T AT E256108 T1 ATE256108 T1 AT E256108T1
Authority
AT
Austria
Prior art keywords
formula
hydroxyl protecting
intermediate compounds
cholecalciferol derivatives
producing
Prior art date
Application number
AT98960122T
Other languages
English (en)
Inventor
Andrzej Kutner
Micha Chodynski
Wies Szelejewski
Ma Odrzywolska
Hanna Fitak
Original Assignee
Inst Farmaceutyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Farmaceutyczny filed Critical Inst Farmaceutyczny
Application granted granted Critical
Publication of ATE256108T1 publication Critical patent/ATE256108T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AT98960122T 1998-01-14 1998-12-29 Verfahren zur herstellung von cholecalciferol- derivaten und zwischenverbindungen ATE256108T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL98324274A PL188697B1 (pl) 1998-01-14 1998-01-14 Sposób otrzymywania pochodnych cholekalcyferolu oraz nowe związki pośrednie
PCT/PL1998/000051 WO1999036400A1 (en) 1998-01-14 1998-12-29 Method of preparation of cholecalciferol derivatives and new intermediate compounds

Publications (1)

Publication Number Publication Date
ATE256108T1 true ATE256108T1 (de) 2003-12-15

Family

ID=20071356

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98960122T ATE256108T1 (de) 1998-01-14 1998-12-29 Verfahren zur herstellung von cholecalciferol- derivaten und zwischenverbindungen

Country Status (6)

Country Link
EP (1) EP1047671B1 (de)
AT (1) ATE256108T1 (de)
DE (1) DE69820481T2 (de)
ES (1) ES2214756T3 (de)
PL (1) PL188697B1 (de)
WO (1) WO1999036400A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003087048A2 (en) * 2002-04-11 2003-10-23 Instytut Farmaceutyczny Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds
PL208188B1 (pl) * 2007-07-12 2011-03-31 Inst Farmaceutyczny Sposób otrzymywania kalcypotriolu
PL216135B1 (pl) 2009-08-07 2014-03-31 Inst Farmaceutyczny Nowe syntony i ich zastosowanie do otrzymywania pochodnych 19-nor witamin D
CN103122009B (zh) * 2013-01-09 2015-11-25 江苏吉贝尔药业股份有限公司 两种用于合成他卡西醇支链的重要中间体化合物
CN103012463B (zh) * 2013-01-17 2016-02-10 南京理工大学 (s)-3-甲基-2-(叔丁基二甲基硅氧基)-1-溴丁烷的合成方法
CN105439927A (zh) * 2014-09-29 2016-03-30 南京理工大学 一种对映选择性合成他卡西醇的制备方法
CN104496871B (zh) * 2014-12-22 2016-03-09 上海皓元生物医药科技有限公司 一种他卡西醇的制备方法
CN108017567A (zh) * 2017-12-30 2018-05-11 南京海融制药有限公司 一种他卡西醇的异构体杂质py2及其制备方法和用途
CN108663441B (zh) * 2017-12-30 2021-03-30 南京海融制药有限公司 一种他卡西醇软膏剂有关物质检查方法
GB202016614D0 (en) 2020-10-20 2020-12-02 King S College London Compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77668A (en) * 1986-01-21 1989-03-31 Teva Pharma Production of cholecalciferol derivatives and novel intermediates used therefor
WO1990000560A1 (en) * 1988-07-05 1990-01-25 Kuraray Co., Ltd. Steroid compounds

Also Published As

Publication number Publication date
DE69820481T2 (de) 2004-10-14
EP1047671B1 (de) 2003-12-10
ES2214756T3 (es) 2004-09-16
EP1047671A1 (de) 2000-11-02
PL188697B1 (pl) 2005-03-31
WO1999036400A1 (en) 1999-07-22
DE69820481D1 (de) 2004-01-22
PL324274A1 (en) 1999-07-19

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