DE69820481D1 - Verfahren zur herstellung von cholecalciferol-derivaten und zwischenverbindungen - Google Patents
Verfahren zur herstellung von cholecalciferol-derivaten und zwischenverbindungenInfo
- Publication number
- DE69820481D1 DE69820481D1 DE69820481T DE69820481T DE69820481D1 DE 69820481 D1 DE69820481 D1 DE 69820481D1 DE 69820481 T DE69820481 T DE 69820481T DE 69820481 T DE69820481 T DE 69820481T DE 69820481 D1 DE69820481 D1 DE 69820481D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- hydroxyl protecting
- intermediate compounds
- cholecalciferol derivatives
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 150000003704 vitamin D3 derivatives Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 2
- BJYLYJCXYAMOFT-RRXOBRNQSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCC(O)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C BJYLYJCXYAMOFT-RRXOBRNQSA-N 0.000 abstract 1
- REYZXWIIUPKFTI-UHFFFAOYSA-N 2-propan-2-yloxirane Chemical compound CC(C)C1CO1 REYZXWIIUPKFTI-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL32427498 | 1998-01-14 | ||
| PL98324274A PL188697B1 (pl) | 1998-01-14 | 1998-01-14 | Sposób otrzymywania pochodnych cholekalcyferolu oraz nowe związki pośrednie |
| PCT/PL1998/000051 WO1999036400A1 (en) | 1998-01-14 | 1998-12-29 | Method of preparation of cholecalciferol derivatives and new intermediate compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69820481D1 true DE69820481D1 (de) | 2004-01-22 |
| DE69820481T2 DE69820481T2 (de) | 2004-10-14 |
Family
ID=20071356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69820481T Expired - Lifetime DE69820481T2 (de) | 1998-01-14 | 1998-12-29 | Verfahren zur herstellung von cholecalciferol-derivaten und zwischenverbindungen |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1047671B1 (de) |
| AT (1) | ATE256108T1 (de) |
| DE (1) | DE69820481T2 (de) |
| ES (1) | ES2214756T3 (de) |
| PL (1) | PL188697B1 (de) |
| WO (1) | WO1999036400A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1497264A2 (de) * | 2002-04-11 | 2005-01-19 | Instytut Farmaceutyczny | Verfahren zur herstellung von 24-alkyl-analoga von cholecalciferol und nicht racemischen verbindungen |
| PL208188B1 (pl) * | 2007-07-12 | 2011-03-31 | Inst Farmaceutyczny | Sposób otrzymywania kalcypotriolu |
| PL216135B1 (pl) | 2009-08-07 | 2014-03-31 | Inst Farmaceutyczny | Nowe syntony i ich zastosowanie do otrzymywania pochodnych 19-nor witamin D |
| CN103122009B (zh) * | 2013-01-09 | 2015-11-25 | 江苏吉贝尔药业股份有限公司 | 两种用于合成他卡西醇支链的重要中间体化合物 |
| CN103012463B (zh) * | 2013-01-17 | 2016-02-10 | 南京理工大学 | (s)-3-甲基-2-(叔丁基二甲基硅氧基)-1-溴丁烷的合成方法 |
| CN105439927A (zh) * | 2014-09-29 | 2016-03-30 | 南京理工大学 | 一种对映选择性合成他卡西醇的制备方法 |
| CN104496871B (zh) * | 2014-12-22 | 2016-03-09 | 上海皓元生物医药科技有限公司 | 一种他卡西醇的制备方法 |
| CN108663441B (zh) * | 2017-12-30 | 2021-03-30 | 南京海融制药有限公司 | 一种他卡西醇软膏剂有关物质检查方法 |
| CN108017567A (zh) * | 2017-12-30 | 2018-05-11 | 南京海融制药有限公司 | 一种他卡西醇的异构体杂质py2及其制备方法和用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77668A (en) * | 1986-01-21 | 1989-03-31 | Teva Pharma | Production of cholecalciferol derivatives and novel intermediates used therefor |
| EP0377743B1 (de) * | 1988-07-05 | 1995-06-28 | Kuraray Co., Ltd. | Steroid-verbindungen |
-
1998
- 1998-01-14 PL PL98324274A patent/PL188697B1/pl unknown
- 1998-12-29 EP EP98960122A patent/EP1047671B1/de not_active Expired - Lifetime
- 1998-12-29 WO PCT/PL1998/000051 patent/WO1999036400A1/en active IP Right Grant
- 1998-12-29 ES ES98960122T patent/ES2214756T3/es not_active Expired - Lifetime
- 1998-12-29 DE DE69820481T patent/DE69820481T2/de not_active Expired - Lifetime
- 1998-12-29 AT AT98960122T patent/ATE256108T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1047671B1 (de) | 2003-12-10 |
| PL324274A1 (en) | 1999-07-19 |
| PL188697B1 (pl) | 2005-03-31 |
| EP1047671A1 (de) | 2000-11-02 |
| ES2214756T3 (es) | 2004-09-16 |
| WO1999036400A1 (en) | 1999-07-22 |
| ATE256108T1 (de) | 2003-12-15 |
| DE69820481T2 (de) | 2004-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KOENIG, B., DIPL.-PHYS. DR.RER.NAT., PAT.-ANW., 80 |