DE69803982D1 - Verfahren zur herstellung von 2-alkoxyestradiolen - Google Patents

Verfahren zur herstellung von 2-alkoxyestradiolen

Info

Publication number
DE69803982D1
DE69803982D1 DE69803982T DE69803982T DE69803982D1 DE 69803982 D1 DE69803982 D1 DE 69803982D1 DE 69803982 T DE69803982 T DE 69803982T DE 69803982 T DE69803982 T DE 69803982T DE 69803982 D1 DE69803982 D1 DE 69803982D1
Authority
DE
Germany
Prior art keywords
alkoxyestradiols
producing
compound represented
structural formula
following structural
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69803982T
Other languages
English (en)
Inventor
Yesh Sachdeva
Siya Ram
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson Matthey Pharmaceutical Materials Inc
Original Assignee
Pharm Eco Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharm Eco Laboratories Inc filed Critical Pharm Eco Laboratories Inc
Application granted granted Critical
Publication of DE69803982D1 publication Critical patent/DE69803982D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0077—Ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69803982T 1997-03-13 1998-03-13 Verfahren zur herstellung von 2-alkoxyestradiolen Expired - Lifetime DE69803982D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/816,558 US6051726A (en) 1997-03-13 1997-03-13 Synthesis of 2-alkoxyestradiols
PCT/US1998/005026 WO1998040398A1 (en) 1997-03-13 1998-03-13 Synthesis of 2-alkoxyestradiols

Publications (1)

Publication Number Publication Date
DE69803982D1 true DE69803982D1 (de) 2002-04-04

Family

ID=25220965

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69803982T Expired - Lifetime DE69803982D1 (de) 1997-03-13 1998-03-13 Verfahren zur herstellung von 2-alkoxyestradiolen

Country Status (10)

Country Link
US (2) US6051726A (de)
EP (1) EP0984979B1 (de)
JP (1) JP2001514666A (de)
AT (1) ATE213740T1 (de)
AU (1) AU6464998A (de)
BR (1) BR9808330A (de)
CA (1) CA2283436A1 (de)
DE (1) DE69803982D1 (de)
IL (1) IL131754A0 (de)
WO (1) WO1998040398A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504074A (en) 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
US6908910B2 (en) 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
US20040214807A1 (en) * 1993-08-06 2004-10-28 D'amato Robert J. Estrogenic compounds as anti-mitotic agents
US6346510B1 (en) * 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
DE69922684T2 (de) 1998-08-11 2005-10-06 Entremed, Inc. Verwendung von 2-methoxyestradiol als fungizide
JP5317381B2 (ja) * 1999-08-23 2013-10-16 エントレメッド インコーポレイテッド 高純度２−メトキシエストラジオールの生成方法
US7087592B1 (en) 1999-08-23 2006-08-08 Entre Med, Inc. Compositions comprising purified 2-methoxyestradiol and methods of producing same
AU2007234536B2 (en) * 1999-08-23 2011-03-03 Entremed, Inc. Compositions comprising purified 2-methoxyestradiol and methods of producing same
AUPQ342599A0 (en) * 1999-10-14 1999-11-04 University Of Melbourne, The Conjugates and uses thereof
US20020035098A1 (en) * 2000-03-17 2002-03-21 Oncology Sciences Corporation Agents and methods for the prevention of initial onset and recurrence of existing cancers
US20050192258A1 (en) * 2000-08-18 2005-09-01 Agoston Gregory E. Antiangiogenic agents
US6995278B2 (en) * 2000-08-18 2006-02-07 Entre Med, Inc. Antiangiogenic agents
US7135581B2 (en) * 2000-08-18 2006-11-14 Entremed, Inc. Antiangiogenic agents
WO2002062347A1 (en) * 2001-02-05 2002-08-15 Oncology Sciences Corporation Method and composition of novel compounds for the therapy and targeting of the primary modalities of cancer cell proliferation and homeostasis
US6593321B2 (en) 2001-06-11 2003-07-15 Southwest Foundation For Biomedical Research 2-alkoxyestradiol analogs with antiproliferative and antimitotic activity
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
US20030236439A1 (en) * 2002-01-30 2003-12-25 Gregory Agoston Non-steroidal analogs of 2-methoxyestradiol
EP1633367A2 (de) * 2003-05-28 2006-03-15 EntreMed, Inc. Antiangiogene mittel
US7498322B2 (en) * 2004-03-12 2009-03-03 Entremed, Inc. Antiangiogenic agents
US20070004689A1 (en) * 2004-03-12 2007-01-04 Agoston Gregory E Antiangiogenic agents
TW200611909A (en) * 2004-08-04 2006-04-16 Akzo Nobel Nv Process for the preparation 2-substituted-derivatives of estrone and estradiol
TW200613316A (en) * 2004-08-26 2006-05-01 Akzo Nobel Nv Process for the preparation of estrone and/or estradiol-derivates
AU2005309455A1 (en) * 2004-11-29 2006-06-01 Entremed, Inc. A method of administering anti-angiogenic agents and a method of treating disease using same
US20070185069A1 (en) * 2005-11-14 2007-08-09 Plum Stacy M Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
US20070176403A1 (en) * 2006-02-01 2007-08-02 Dennis Calderone Air adjustable seat
CA2646065C (en) * 2006-03-20 2014-01-14 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol
US20080234243A1 (en) * 2007-01-31 2008-09-25 Lavallee Theresa M Method of treating amyloidosis mediated diseases
US8012952B2 (en) 2007-02-13 2011-09-06 Council Of Scientific & Industrial Research Cationic 17 α-substituted-estradiol derivatives useful as anti-cancer agent
WO2008137599A2 (en) * 2007-05-01 2008-11-13 Evestra, Inc. 2-alkoxyestradiol analogs and pharmaceutical preparations
CN101723813A (zh) 2008-10-15 2010-06-09 上海华理生物医药有限公司 一种乙氧基二苯乙烷衍生物及其制备方法和用途
US7901904B2 (en) 2008-10-16 2011-03-08 Naxospharma S.R.L. Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds
US20120225849A1 (en) * 2011-03-01 2012-09-06 The University Of Kansas 2-Methoxyestradiol (2-ME2) Prodrug with Enhanced Bioavailability for Prophylaxis or Treatment of Cancerous or Non-Cancerous Condition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2078804C (en) * 1991-10-01 2003-02-25 Takehiko Suzuki Manufacture and use of novel glycosides of catechol estrogens

Also Published As

Publication number Publication date
ATE213740T1 (de) 2002-03-15
BR9808330A (pt) 2000-05-16
EP0984979A1 (de) 2000-03-15
IL131754A0 (en) 2001-03-19
JP2001514666A (ja) 2001-09-11
US6051726A (en) 2000-04-18
WO1998040398A1 (en) 1998-09-17
US6054598A (en) 2000-04-25
EP0984979B1 (de) 2002-02-27
CA2283436A1 (en) 1998-09-17
AU6464998A (en) 1998-09-29

Similar Documents

Publication Publication Date Title
ATE213740T1 (de) Verfahren zur herstellung von 2-alkoxyestradiolen
ATE205824T1 (de) Verfahren zur herstellung von citalopram
EP0738703A3 (de) Acryl-Säure-Derivate, Verfahren zur Herstellung von Acryl-Säure-Derivaten und Acryl-Säure-Polymere
ATE153332T1 (de) Verfahren zur herstellung von oxetanonen
ATE282020T1 (de) Verfahren zur herstellung von 2-aminomalonsäure- derivaten
DE69821622D1 (de) Verfahren zur herstellung von phosphinverbindungen
DE3768319D1 (de) Verfahren zur herstellung von o-substituierten hydroxylaminen.
DE69106003D1 (de) Verfahren und zwischenprodukte zur herstellung von azabicyclo[2.2.2]octan-3-iminen.
ATE256108T1 (de) Verfahren zur herstellung von cholecalciferol- derivaten und zwischenverbindungen
ATE14428T1 (de) Verfahren zur herstellung von bromhaltigen 1,3dioxolen-2-ones.
ATE55382T1 (de) Verfahren zur herstellung von optisch aktiven hydrochinonderivaten sowie von d-alphatocopherol.
DE69937988D1 (de) Verfahren zur herstellung von 3-cephemderivaten
ATE240286T1 (de) Verfahren zur herstellung von 1-aryl-3- cyclopropyl-1,3-propandionen
ATE271057T1 (de) Verfahren zur herstellung von alendron-säure
ATE229000T1 (de) Verfahren zur herstellung von alpha-aminoketonen
ATE165824T1 (de) Verfahren zur herstellung von 2-perfluoroalkyl-3- oxazolin-5-one
DE59803194D1 (de) Verfahren zur herstellung von 1,3-disubstituierten 2-nitroguanidinen
DE3762845D1 (de) Verfahren zur herstellung von optisch aktiven hydrochinonderivaten, sowie von d-alpha-tocopherol.
MX9700003A (es) Proceso para la reparacion de derivados de ??cido-clorometil-fenilglioxilico.
ATE245149T1 (de) Verfahren zur herstellung von alkoxytriazolinonen
DE60007848D1 (de) Herstellung von 2'-substitutierter rns
DE69733716D1 (de) Verfahren zur herstellung von imidazolderivaten
DE69821763D1 (de) Verfahren zur herstellung von 2-alkylthio-substituierten benzoesäurederivaten
ATE244228T1 (de) Verfahren zur herstellung von chloroacetylaminothiazoleaceticsäure derivate
ATE67194T1 (de) Thiadiazolylacetamid-derivate, verfahren zu ihrer herstellung und ihre verwendung.

Legal Events

Date Code Title Description
8332 No legal effect for de