MX9700003A - Proceso para la reparacion de derivados de ??cido-clorometil-fenilglioxilico. - Google Patents

Proceso para la reparacion de derivados de ??cido-clorometil-fenilglioxilico.

Info

Publication number
MX9700003A
MX9700003A MX9700003A MX9700003A MX9700003A MX 9700003 A MX9700003 A MX 9700003A MX 9700003 A MX9700003 A MX 9700003A MX 9700003 A MX9700003 A MX 9700003A MX 9700003 A MX9700003 A MX 9700003A
Authority
MX
Mexico
Prior art keywords
compound
formula
preparation
chloromethyl
acid derivatives
Prior art date
Application number
MX9700003A
Other languages
English (en)
Inventor
Jean-Marie Assercq
Hans-Dieter Schneider
Albert Pfiffner
Werner Pfaff
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27171705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9700003(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX9700003A publication Critical patent/MX9700003A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/52—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Se describe un proceso para la preparacion de un compuesto de la formula I. En cuyo proceso: a) un compuesto de la formula II: se hace reaccionar con un compuesto de litio orgánico de la formula III: Li-R7 b) el complejo de litio resultante se hace reaccionar con un compuesto de la formula IV: Y1CO-CO-Y1 para formar un compuesto de la formula V: C) ese compuesto, en cualquier orden, c1) se axioma con amina o-metilhidroxílica; o se axioma con amina hidroxílica, y luego se metila o se fluorometila o se difluorometila; c2) se hace reaccionar con un éster de ácido cloroformico. X, m, Y, R1 a R3 y R7, son como se definen en la descripcion.
MX9700003A 1996-01-03 1997-01-07 Proceso para la reparacion de derivados de ??cido-clorometil-fenilglioxilico. MX9700003A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH196 1996-01-03
CH111296 1996-05-02
CH187496 1996-07-26

Publications (1)

Publication Number Publication Date
MX9700003A true MX9700003A (es) 1997-12-31

Family

ID=27171705

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700003A MX9700003A (es) 1996-01-03 1997-01-07 Proceso para la reparacion de derivados de ??cido-clorometil-fenilglioxilico.

Country Status (23)

Country Link
US (2) US5756811A (es)
EP (1) EP0782982B1 (es)
JP (1) JP4621308B2 (es)
KR (2) KR100540153B1 (es)
CN (3) CN1073554C (es)
AR (1) AR005362A1 (es)
AT (1) ATE193010T1 (es)
AU (1) AU714429B2 (es)
BR (1) BR9700009A (es)
CA (1) CA2194203C (es)
CZ (1) CZ290146B6 (es)
DE (1) DE59605241D1 (es)
DK (1) DK0782982T3 (es)
ES (1) ES2147357T3 (es)
GR (1) GR3033714T3 (es)
HK (2) HK1048982A1 (es)
HU (1) HUP9603547A1 (es)
IL (1) IL119922A (es)
MX (1) MX9700003A (es)
PL (1) PL184464B1 (es)
PT (1) PT782982E (es)
SK (1) SK168996A3 (es)
TW (1) TW477785B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990036612A (ko) * 1997-10-08 1999-05-25 고사이 아끼오 벤질 브로마이드 유도체의 제조 방법
GB9908530D0 (en) * 1999-04-14 1999-06-09 Novartis Ag Organic compounds
WO2008125592A1 (en) * 2007-04-12 2008-10-23 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Improved process for preparing o-chloromethylphenylglyoxylic esters, improved process for preparing (e)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters, and novel intermediates for their preparation
WO2009037230A2 (en) * 2007-09-17 2009-03-26 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Improved process for preparing (e)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters
CN108358797A (zh) * 2018-04-20 2018-08-03 南京农业大学 一种烷基甘氨酸的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ213630A (en) 1984-10-19 1990-02-26 Ici Plc Acrylic acid derivatives and fungicidal compositions
GB8617648D0 (en) 1986-07-18 1986-08-28 Ici Plc Fungicides
DE3835028A1 (de) * 1988-10-14 1990-04-19 Basf Ag Oximether-derivate, verfahren zu ihrer herstellung und diese enthaltende fungizide
DE3843439A1 (de) * 1988-12-23 1990-06-28 Basf Ag Schwefelhaltige oximether und diese enthaltende fungizide
DE3932542A1 (de) * 1989-09-29 1991-04-11 Basf Ag Neue anilinderivate und diese enthaltende fungizide
DE59304268D1 (de) * 1992-08-29 1996-11-28 Basf Ag N-Methylamide, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie Verfahren zur Bekämpfung von Schädlingen
DE4305502A1 (de) * 1993-02-23 1994-08-25 Basf Ag Ortho-substituierte 2-Methoxyiminophenylessigsäuremethylamide
SK88096A3 (en) 1994-01-05 1996-12-04 Ciba Geigy Ag Pesticidal compounds, preparation method thereof and intermediate products at this method and pesticidal agents containing them
NZ278587A (en) * 1994-02-04 1998-08-26 Basf Ag Oxime-substituted phenylacetic acid derivatives; biocides
HU219195B (en) * 1994-06-10 2001-03-28 Basf Ag Method of preparing alpha-methoxyiminocarboxylic acid methylamides
US5583249A (en) * 1994-08-19 1996-12-10 Ciba-Geigy Corporation Pesticides

Also Published As

Publication number Publication date
CN1167756A (zh) 1997-12-17
CZ397A3 (cs) 1998-07-15
SK168996A3 (en) 1998-02-04
US5756811A (en) 1998-05-26
KR970059162A (ko) 1997-08-12
CN1073554C (zh) 2001-10-24
PL184464B1 (pl) 2002-11-29
CN1185208C (zh) 2005-01-19
AR005362A1 (es) 1999-04-28
AU714429B2 (en) 2000-01-06
IL119922A0 (en) 1997-03-18
KR100540153B1 (ko) 2006-04-20
IL119922A (en) 2004-07-25
PL317751A1 (en) 1997-07-07
PT782982E (pt) 2000-10-31
DK0782982T3 (da) 2000-10-09
HUP9603547A1 (hu) 1998-01-28
CZ290146B6 (cs) 2002-06-12
AU1000397A (en) 1997-07-10
HU9603547D0 (en) 1997-02-28
JPH09227486A (ja) 1997-09-02
KR100540148B1 (ko) 2005-12-29
US6124493A (en) 2000-09-26
EP0782982A1 (de) 1997-07-09
ATE193010T1 (de) 2000-06-15
CN1368497A (zh) 2002-09-11
ES2147357T3 (es) 2000-09-01
CN1185209C (zh) 2005-01-19
GR3033714T3 (en) 2000-10-31
CA2194203A1 (en) 1997-07-04
DE59605241D1 (de) 2000-06-21
EP0782982B1 (de) 2000-05-17
HK1048982A1 (zh) 2003-04-25
CN1368498A (zh) 2002-09-11
JP4621308B2 (ja) 2011-01-26
TW477785B (en) 2002-03-01
HK1048983A1 (zh) 2003-04-25
BR9700009A (pt) 1998-11-10
CA2194203C (en) 2005-04-26

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