ATE401303T1 - Verfahren zur herstellung von ed-71 - Google Patents

Verfahren zur herstellung von ed-71

Info

Publication number
ATE401303T1
ATE401303T1 AT99905280T AT99905280T ATE401303T1 AT E401303 T1 ATE401303 T1 AT E401303T1 AT 99905280 T AT99905280 T AT 99905280T AT 99905280 T AT99905280 T AT 99905280T AT E401303 T1 ATE401303 T1 AT E401303T1
Authority
AT
Austria
Prior art keywords
vitamin
derivatives
protective group
represents hydrogen
producing
Prior art date
Application number
AT99905280T
Other languages
English (en)
Inventor
Susumi Hatakeyama
Hiroyoshi Watanabe
Akira Kawase
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE401303T1 publication Critical patent/ATE401303T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/44—Halogenated unsaturated alcohols containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT99905280T 1998-02-24 1999-02-23 Verfahren zur herstellung von ed-71 ATE401303T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4229598 1998-02-24

Publications (1)

Publication Number Publication Date
ATE401303T1 true ATE401303T1 (de) 2008-08-15

Family

ID=12632059

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99905280T ATE401303T1 (de) 1998-02-24 1999-02-23 Verfahren zur herstellung von ed-71

Country Status (6)

Country Link
EP (1) EP1061070B1 (de)
JP (2) JP4357114B2 (de)
AT (1) ATE401303T1 (de)
AU (1) AU2549099A (de)
DE (1) DE69939106D1 (de)
WO (1) WO1999043645A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE341533T1 (de) * 1998-02-27 2006-10-15 Chugai Pharmaceutical Co Ltd Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position
US20080293647A1 (en) 2004-11-12 2008-11-27 Luciano Adorini Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer
JPWO2008062871A1 (ja) 2006-11-22 2010-03-04 株式会社資生堂 微粒子酸化亜鉛粉体の製造方法及びこれを配合した化粧料
WO2010007039A1 (de) 2008-07-18 2010-01-21 Basf Se Modifizierte zinkoxid-teilchen
US9006220B2 (en) * 2010-10-25 2015-04-14 Teijin Pharma Limited 23-yne-vitamin D3 derivative
WO2013162047A1 (ja) * 2012-04-24 2013-10-31 帝人ファーマ株式会社 二次性副甲状腺機能亢進症治療剤
BR112021022555A2 (pt) 2019-05-13 2021-12-28 Faes Farma Sa Processo e intermediários para a preparação de eldecalcitol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51108048A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidokishikorekarushifuerooruno seizoho
JPS5846507B2 (ja) * 1978-12-26 1983-10-17 帝人株式会社 １α，２４（Ｒ），２５↓−トリヒドロキシコレカルシフエロ−ルの製造法
JPS58208223A (ja) * 1982-05-28 1983-12-03 Kureha Chem Ind Co Ltd 抗腫瘍剤
US4666634A (en) * 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
JPH0780773B2 (ja) * 1986-06-05 1995-08-30 中外製薬株式会社 新規ビタミンｄ▲下３▼誘導体を有効成分とする医薬
CA2166898C (en) * 1993-07-09 2004-09-07 Roger Bouillon Novel structural analogues of vitamin d
JP3712077B2 (ja) * 1995-05-12 2005-11-02 株式会社クラレ ヒドロインダン−４−オール誘導体およびその製造方法
JPH11130711A (ja) * 1997-10-24 1999-05-18 Teijin Ltd １α，２４，２５−トリヒドロキシビタミンＤ３類の合成中間体およびその製造法
ATE341533T1 (de) * 1998-02-27 2006-10-15 Chugai Pharmaceutical Co Ltd Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position

Also Published As

Publication number Publication date
EP1061070B1 (de) 2008-07-16
EP1061070A4 (de) 2005-03-30
JP4990937B2 (ja) 2012-08-01
AU2549099A (en) 1999-09-15
JP4357114B2 (ja) 2009-11-04
WO1999043645A1 (fr) 1999-09-02
DE69939106D1 (de) 2008-08-28
JP2009256361A (ja) 2009-11-05
EP1061070A1 (de) 2000-12-20

Similar Documents

Publication Publication Date Title
ATE267822T1 (de) Verfahren zur herstellung von luteolin und luteolin-derivaten
ATE132145T1 (de) Verfahren zur herstellung von bacchatin iii und von desacetyl-10-bacchatin iii derivate
ATE181074T1 (de) Vinylen-azaindolderivate und verfahren zu ihrer herstellung
ATE246196T1 (de) Sulphostinanaloga und verfahren zur herstellung von sulphostin und analoga davon
DE69838146D1 (de) Androgene steroidderivate und ein verfahren zur herstellung und verwendung derselben
ATE234304T1 (de) Zwischenprodukte zur herstellung von duocarmycin sa und dessen derivaten sowie ein verfahren zur herstellung der zwischenprodukte
MY145819A (en) Process and intermediates useful in the preparation of pharmaceutical compounds as fulvestrant
ATE211474T1 (de) Galanthamin derivate, verfahren zu ihrer herstellung und ihre verwendung als medikamente
ATE134623T1 (de) Salicyl(thio)etherderivate, verfahren und zwischenprodukte zu ihrer herstellung
ATE401303T1 (de) Verfahren zur herstellung von ed-71
DE60235365D1 (de) Verfahren zur herstellung von 7-amino-syn-3,5-dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung
ATE152118T1 (de) Kardioaktive 17b-(3-furyl) und 17b-(4- pyridazinyl)-5beta, 14beta-androstan derivate, verfahren zu ihrer herstellung und pharmazeutische präparate davon
MX9708735A (es) Benzotiazoles y benzoxazoles, composiciones farmaceuticas que contienen estos compuestos y su uso y proceso para prepararlos.
HK1028028A1 (en) Substituted heterocyclic compounds, method for preparing and compositions containing same
DE69612568T2 (de) 17-seitenkette-alknyl- und 20-oxopregna-derivate von vitamin d, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon
ATE229006T1 (de) Verfahren zur herstellung von schwefelhaltigen imidazolderivaten und erhaltene zwischenprodukte
ATE170520T1 (de) Eburnan-derivate, verfahren zur ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
AU8777991A (en) New imidazole compounds, a process for the preparation thereof, and pharmaceutical compositions containing them
ATE292962T1 (de) Verwendung einer zusammensetzung zur herstellung eines arzneimittels zur vorbeugung und behandlung von parodontitis
AR001767A1 (es) Derivados de ciclolignanos utiles como inmunosupresores composiciones farmaceuticas que los contienen y procedimiento para preparar dichos derivados
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
ATE300534T1 (de) Verfahren und zwischenverbindungen zur herstellung von imidazopyridinen
DE69327906T2 (de) Vitamin-d-derivat und verfahren zu seiner herstellung
CA2027542A1 (en) Uv-absorbing cyclic enaminoketones
ATE111093T1 (de) Verfahren zur herstellung von enantiomeren von 3- aminchromanderivaten.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties