AR001767A1 - Derivados de ciclolignanos utiles como inmunosupresores composiciones farmaceuticas que los contienen y procedimiento para preparar dichos derivados - Google Patents

Derivados de ciclolignanos utiles como inmunosupresores composiciones farmaceuticas que los contienen y procedimiento para preparar dichos derivados

Info

Publication number
AR001767A1
AR001767A1 AR33423295A AR33423295A AR001767A1 AR 001767 A1 AR001767 A1 AR 001767A1 AR 33423295 A AR33423295 A AR 33423295A AR 33423295 A AR33423295 A AR 33423295A AR 001767 A1 AR001767 A1 AR 001767A1
Authority
AR
Argentina
Prior art keywords
derivatives
alkyl
immunosuppressants
preparing
pharmaceutical compositions
Prior art date
Application number
AR33423295A
Other languages
English (en)
Original Assignee
Univ Salamanca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Salamanca filed Critical Univ Salamanca
Publication of AR001767A1 publication Critical patent/AR001767A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se trata de derivados de ciclolignante o de fórmula (I) o de la fórmula (II), donde: R1 es hidrógeno, hidroxi, alcoxi: (C1-C6),R2 y R3 son hidrógeno,alquilo (C1-C6), acilo (C1-C6) o juntos R2 y R3 forman un grupo -CHR4, donde R4 es:hidrógeno, alquilo (C1-C6), alquenilo (C3-C6), hidroxialquilo (C1-C6),polihalo-alquilo (C1-C6), arilo, aciloxi (C1-C20)alquilo (C1-C6), alcoxi (C1-C6),carboxi-alquilo (C1-C6), alcoxi(C1-C6) carbonilo, carbamoilo, R5,cuandoestá presente, eshidrógeno, al quilo(C1-C6), alquenilo, (C3-C6) arilo, (poli) haloalquilo, (C1-C6)acilo, (C1-C20)carbamoilo, o tiocarbamoilo; R6 es alquilo,(C1-C6)hidroxialquilo, (C1-C6)haloalquilo, (C1-C6) acilo, (C1-C20) aciloxi (C1-C20)alquilo (C1-C6),carboxi, o alcoxi ( C1-C6) carbonilo. Ar es 3,4,5-trialcoxi(C1-C6)fenilo o 4-hidroxi-3,5-dialcoxi(C1-C6)fenilo; X es nitrógeno u oxígeno. Dichos compuestos son útiles como inmunosupresores. Se proponentambién composiciones farmacéuticasformuladas con dichos derivados y un proceso para prepararlos.
AR33423295A 1994-11-14 1995-11-14 Derivados de ciclolignanos utiles como inmunosupresores composiciones farmaceuticas que los contienen y procedimiento para preparar dichos derivados AR001767A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9422947A GB9422947D0 (en) 1994-11-14 1994-11-14 Immunosuppressive cyclolignan derivatives

Publications (1)

Publication Number Publication Date
AR001767A1 true AR001767A1 (es) 1997-12-10

Family

ID=10764358

Family Applications (1)

Application Number Title Priority Date Filing Date
AR33423295A AR001767A1 (es) 1994-11-14 1995-11-14 Derivados de ciclolignanos utiles como inmunosupresores composiciones farmaceuticas que los contienen y procedimiento para preparar dichos derivados

Country Status (13)

Country Link
US (1) US5739114A (es)
EP (1) EP0711765B9 (es)
JP (1) JPH08225534A (es)
AR (1) AR001767A1 (es)
AU (1) AU3784695A (es)
BR (1) BR9505178A (es)
CA (1) CA2162760A1 (es)
DE (1) DE69531586T2 (es)
ES (1) ES2206481T3 (es)
GB (1) GB9422947D0 (es)
IL (1) IL115982A (es)
NZ (1) NZ280455A (es)
ZA (1) ZA959665B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
KR100433679B1 (ko) * 2000-11-20 2004-06-09 김송배 신규의 4'-데메틸-4'-ｏ-치환-1-데옥시포도필로톡신유도체 및 그의 기하 이성체, 그의 제조방법 및 그를포함하는 항암제
SE0102168D0 (sv) 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds
WO2009100349A1 (en) * 2008-02-09 2009-08-13 The Trustees Of Columbia University In The City Of New York Analogues of (-)-picropodophyllin, synthesis and uses thereof
KR20110044947A (ko) * 2008-06-23 2011-05-03 악셀라르 아베 과잉활성 면역계 치료를 위한 사이클로리그난의 용도
WO2014183055A1 (en) 2013-05-10 2014-11-13 M. Alphabet 2, L.L.C. Methods of treating skin conditions using cyclolignan compounds
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPH0720966B2 (ja) * 1984-12-28 1995-03-08 コンプハルム・エイビ− 製薬学的に活性な化合物を含有する病気治療剤
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof

Also Published As

Publication number Publication date
DE69531586T2 (de) 2004-06-24
EP0711765A1 (en) 1996-05-15
IL115982A0 (en) 1996-01-31
IL115982A (en) 1999-10-28
CA2162760A1 (en) 1996-05-15
NZ280455A (en) 1998-09-24
GB9422947D0 (en) 1995-01-04
DE69531586D1 (de) 2003-10-02
BR9505178A (pt) 1997-10-28
AU3784695A (en) 1996-05-23
ZA959665B (en) 1996-05-29
EP0711765B9 (en) 2004-03-03
EP0711765B1 (en) 2003-08-27
ES2206481T3 (es) 2004-05-16
US5739114A (en) 1998-04-14
JPH08225534A (ja) 1996-09-03

Similar Documents

Publication Publication Date Title
ATE14579T1 (de) Pharmazeutische heterocyclische verbindungen, verfahren zu ihrer herstellung und sie enthaltende zusammensetzungen.
DE69615002T2 (de) Durch hetero-aromatische ring substituierte phenyloxazolidinone als antimikrobielles mittel
ATE25251T1 (de) Anti srs-a carbonsaeure-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische formulierungen.
CA2304713A1 (en) Biphenyl-5-alkanoic acid derivatives and use thereof
KR940019701A (ko) N-헤테로아릴-n'-페닐우레아 유도체, 그의 제조방법 및 용도
ES2187025T3 (es) Nuevos agentes quelantes de hierro (iii) activos via oral.
AR001767A1 (es) Derivados de ciclolignanos utiles como inmunosupresores composiciones farmaceuticas que los contienen y procedimiento para preparar dichos derivados
DE69214784D1 (de) Verfahren zur herstellung von cephalosporinzwischenverbindungen
KR950702529A (ko) 신규한 비타민 D 동족체(Novel vitamin D analogues)
ATE199909T1 (de) Derivate der phosphonsäure, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten
ES2016017A6 (es) Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
HUP0204430A2 (en) Method for the enzymatic resolution of the racemates of aminomethyl-aryl-cyclohexanol derivatives, the obtained new compounds and pharmaceutical compositions containing thereof
DE69939106D1 (de) Verfahren zur Herstellung von ED-71
ES8105319A1 (es) Procedimiento de preparacion de derivados pirazolo (1,5-c) quinazolinos y de sus sales de adicion acidas
BR9608929A (pt) Derivados de hidroxilamina anti-isquêmicos e composições farmacêuticas
DK0504290T3 (da) Inhibitorer af dihydrofylatreduktase fra Pneumocystis carinii
HUP0000298A2 (hu) Eljárás aril-béta-diketon-, aril-pirimidin-keton-származékok és növényvédőszerek közbenső termékeinek előállítására
BG100704A (en) New piperazine derivatives and methods for their preparation as well as of the compounds containing them
DE69327092T2 (de) Optisch aktives 1-phenylpyrrolidonderivat und dessen herstellung
FI941300A0 (fi) Bentseenijohdannaiset
KR910020176A (ko) 알도스 환원효소 저해제