DE69939106D1 - Verfahren zur Herstellung von ED-71 - Google Patents

Verfahren zur Herstellung von ED-71

Info

Publication number
DE69939106D1
DE69939106D1 DE69939106T DE69939106T DE69939106D1 DE 69939106 D1 DE69939106 D1 DE 69939106D1 DE 69939106 T DE69939106 T DE 69939106T DE 69939106 T DE69939106 T DE 69939106T DE 69939106 D1 DE69939106 D1 DE 69939106D1
Authority
DE
Germany
Prior art keywords
vitamin
derivatives
protective group
represents hydrogen
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939106T
Other languages
English (en)
Inventor
Susumi Hatakeyama
Hiroyoshi Watanabe
Akira Kawase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69939106D1 publication Critical patent/DE69939106D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/44—Halogenated unsaturated alcohols containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69939106T 1998-02-24 1999-02-23 Verfahren zur Herstellung von ED-71 Expired - Lifetime DE69939106D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4229598 1998-02-24
PCT/JP1999/000796 WO1999043645A1 (fr) 1998-02-24 1999-02-23 Derives de 24-hydroxyvitamine d

Publications (1)

Publication Number Publication Date
DE69939106D1 true DE69939106D1 (de) 2008-08-28

Family

ID=12632059

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939106T Expired - Lifetime DE69939106D1 (de) 1998-02-24 1999-02-23 Verfahren zur Herstellung von ED-71

Country Status (6)

Country Link
EP (1) EP1061070B1 (de)
JP (2) JP4357114B2 (de)
AT (1) ATE401303T1 (de)
AU (1) AU2549099A (de)
DE (1) DE69939106D1 (de)
WO (1) WO1999043645A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE341533T1 (de) * 1998-02-27 2006-10-15 Chugai Pharmaceutical Co Ltd Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position
CA2586679A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US8168157B2 (en) 2006-11-22 2012-05-01 Shiseido Company Ltd. Production method of fine particle zinc oxide powder and cosmetics containing the same
CN102099297B (zh) 2008-07-18 2015-02-25 巴斯夫欧洲公司 改性氧化锌颗粒
US9006220B2 (en) * 2010-10-25 2015-04-14 Teijin Pharma Limited 23-yne-vitamin D3 derivative
WO2013162047A1 (ja) * 2012-04-24 2013-10-31 帝人ファーマ株式会社 二次性副甲状腺機能亢進症治療剤
CN113853378A (zh) * 2019-05-13 2021-12-28 费斯制药股份有限公司 用于制备艾地骨化醇的方法和中间体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51108048A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidokishikorekarushifuerooruno seizoho
JPS5846507B2 (ja) * 1978-12-26 1983-10-17 帝人株式会社 １α，２４（Ｒ），２５↓−トリヒドロキシコレカルシフエロ−ルの製造法
JPS58208223A (ja) * 1982-05-28 1983-12-03 Kureha Chem Ind Co Ltd 抗腫瘍剤
US4666634A (en) * 1984-12-05 1987-05-19 Chugai Seiyaku Kabushiki Kaisha vitamin D3 derivatives having a substituent at 2-position
JPH0780773B2 (ja) * 1986-06-05 1995-08-30 中外製薬株式会社 新規ビタミンｄ▲下３▼誘導体を有効成分とする医薬
CA2166898C (en) * 1993-07-09 2004-09-07 Roger Bouillon Novel structural analogues of vitamin d
JP3712077B2 (ja) * 1995-05-12 2005-11-02 株式会社クラレ ヒドロインダン−４−オール誘導体およびその製造方法
JPH11130711A (ja) * 1997-10-24 1999-05-18 Teijin Ltd １α，２４，２５−トリヒドロキシビタミンＤ３類の合成中間体およびその製造法
ATE341533T1 (de) * 1998-02-27 2006-10-15 Chugai Pharmaceutical Co Ltd Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position

Also Published As

Publication number Publication date
WO1999043645A1 (fr) 1999-09-02
JP2009256361A (ja) 2009-11-05
ATE401303T1 (de) 2008-08-15
AU2549099A (en) 1999-09-15
EP1061070B1 (de) 2008-07-16
JP4357114B2 (ja) 2009-11-04
JP4990937B2 (ja) 2012-08-01
EP1061070A1 (de) 2000-12-20
EP1061070A4 (de) 2005-03-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition