ATE341533T1 - Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position - Google Patents

Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position

Info

Publication number
ATE341533T1
ATE341533T1 AT99906474T AT99906474T ATE341533T1 AT E341533 T1 ATE341533 T1 AT E341533T1 AT 99906474 T AT99906474 T AT 99906474T AT 99906474 T AT99906474 T AT 99906474T AT E341533 T1 ATE341533 T1 AT E341533T1
Authority
AT
Austria
Prior art keywords
vitamin
substituent
derivatives
ring part
synthesis
Prior art date
Application number
AT99906474T
Other languages
English (en)
Inventor
Kunio Ogasawara
Michiyasu Takahashi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE341533T1 publication Critical patent/ATE341533T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1787—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings and having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99906474T 1998-02-27 1999-02-25 Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position ATE341533T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4712098 1998-02-27

Publications (1)

Publication Number Publication Date
ATE341533T1 true ATE341533T1 (de) 2006-10-15

Family

ID=12766310

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99906474T ATE341533T1 (de) 1998-02-27 1999-02-25 Intermediat für die synthese des a-ringteils von vitamin d derivaten mit einem substituenten in der 2-position

Country Status (7)

Country Link
US (1) US6335458B1 (de)
EP (1) EP1072582B1 (de)
JP (1) JP4366013B2 (de)
AT (1) ATE341533T1 (de)
AU (1) AU2639999A (de)
DE (1) DE69933441T2 (de)
WO (1) WO1999043641A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69939106D1 (de) * 1998-02-24 2008-08-28 Chugai Pharmaceutical Co Ltd Verfahren zur Herstellung von ED-71
CN104558013B (zh) * 2015-01-29 2017-03-22 上海皓元生物医药科技有限公司 一种(z)‑2‑((3r,4r,5r)‑3,5‑双羟基‑4‑(3‑羟基‑丙氧基)‑2‑亚甲基环己基)乙醇的衍生物a的制备方法
CA3137236A1 (en) 2019-05-13 2020-11-19 Gonzalo Hernandez Herrero Process and intermediates for the preparation of eldecalcitol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3030157B2 (ja) * 1991-03-13 2000-04-10 株式会社クラレ シクロヘキサントリオール誘導体
WO1996001811A1 (en) * 1994-07-11 1996-01-25 The Johns-Hopkins University 2-substituted 1,25-dihydroxyvitamin d3 derivatives
JP3986606B2 (ja) 1997-03-07 2007-10-03 中外製薬株式会社 ビタミンｄ誘導体のａ環部分の合成に有用な合成中間体、その製造方法およびその使用方法
DE69939106D1 (de) * 1998-02-24 2008-08-28 Chugai Pharmaceutical Co Ltd Verfahren zur Herstellung von ED-71

Also Published As

Publication number Publication date
US6335458B1 (en) 2002-01-01
EP1072582A1 (de) 2001-01-31
AU2639999A (en) 1999-09-15
DE69933441D1 (de) 2006-11-16
JP4366013B2 (ja) 2009-11-18
DE69933441T2 (de) 2007-08-23
EP1072582A4 (de) 2005-02-02
EP1072582B1 (de) 2006-10-04
WO1999043641A1 (fr) 1999-09-02

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties