ATE132867T1 - 20,21-dinoreburnaminderivate, substituiert in position 15, verfahren zu deren herstellung und die auf diese weise erhaltenen zwischenverbindungen, deren anwendung als arzneimittel und diese enthaltende zusammensetzungen - Google Patents
20,21-dinoreburnaminderivate, substituiert in position 15, verfahren zu deren herstellung und die auf diese weise erhaltenen zwischenverbindungen, deren anwendung als arzneimittel und diese enthaltende zusammensetzungenInfo
- Publication number
- ATE132867T1 ATE132867T1 AT90402898T AT90402898T ATE132867T1 AT E132867 T1 ATE132867 T1 AT E132867T1 AT 90402898 T AT90402898 T AT 90402898T AT 90402898 T AT90402898 T AT 90402898T AT E132867 T1 ATE132867 T1 AT E132867T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- radical
- carbon atoms
- alkenyl
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-M oxidooxomethyl Chemical compound [O-][C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-M 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8913544A FR2653124B1 (fr) | 1989-10-17 | 1989-10-17 | Nouveaux derives substitues en 15 de la 20, 21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE132867T1 true ATE132867T1 (de) | 1996-01-15 |
Family
ID=9386471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90402898T ATE132867T1 (de) | 1989-10-17 | 1990-10-16 | 20,21-dinoreburnaminderivate, substituiert in position 15, verfahren zu deren herstellung und die auf diese weise erhaltenen zwischenverbindungen, deren anwendung als arzneimittel und diese enthaltende zusammensetzungen |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6534515B2 (de) |
| EP (1) | EP0424248B1 (de) |
| JP (1) | JPH03133981A (de) |
| KR (1) | KR0180706B1 (de) |
| CN (1) | CN1040000C (de) |
| AT (1) | ATE132867T1 (de) |
| AU (1) | AU646817B2 (de) |
| CA (1) | CA2027724A1 (de) |
| DE (1) | DE69024745T2 (de) |
| DK (1) | DK0424248T3 (de) |
| ES (1) | ES2081957T3 (de) |
| FR (1) | FR2653124B1 (de) |
| GR (1) | GR3018736T3 (de) |
| HU (1) | HU218937B (de) |
| IE (1) | IE71209B1 (de) |
| MX (1) | MX22863A (de) |
| PT (1) | PT95600B (de) |
| RU (1) | RU2069663C1 (de) |
| ZA (1) | ZA907832B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2865650B1 (fr) * | 2004-01-30 | 2008-06-13 | Biocortech | Utilisation du 14,15 dihydro 20,21-dinoreburnamenin14-ol pour traiter et/ou prevenir les depressions majeures et les desordres du cycle veille-sommeil |
| FR2865649A1 (fr) * | 2004-01-30 | 2005-08-05 | Biocortech | Utilisation du 14,15-dihydro 20,21-dinoreburnamenin14-ol pour traiter et/ou prevenir les depressions majeures |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR22021E (fr) * | 1919-12-30 | 1921-04-21 | Dujardin Et Cie | Perfectionnements aux frappeurs pneumatiques |
| AU532001B2 (en) * | 1978-11-20 | 1983-09-15 | Sumitomo Chemical Company, Limited | Polycyclic indole derivatives |
| FR2514357A1 (fr) * | 1981-10-08 | 1983-04-15 | Roussel Uclaf | Nouveaux derives de 20,21-dinoreburnamenine eventuellement substitues sur le cycle e, procede de preparation et application comme medicaments |
| FR2623501B1 (fr) * | 1987-11-19 | 1990-03-16 | Roussel Uclaf | Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| FR2623503B1 (de) * | 1987-11-19 | 1991-04-05 | Roussel Uclaf |
-
1989
- 1989-10-17 FR FR8913544A patent/FR2653124B1/fr not_active Expired - Fee Related
-
1990
- 1990-10-01 ZA ZA907832A patent/ZA907832B/xx unknown
- 1990-10-16 EP EP90402898A patent/EP0424248B1/de not_active Expired - Lifetime
- 1990-10-16 MX MX2286390A patent/MX22863A/es unknown
- 1990-10-16 IE IE370290A patent/IE71209B1/en not_active IP Right Cessation
- 1990-10-16 DE DE69024745T patent/DE69024745T2/de not_active Expired - Fee Related
- 1990-10-16 CA CA002027724A patent/CA2027724A1/fr not_active Abandoned
- 1990-10-16 PT PT95600A patent/PT95600B/pt not_active IP Right Cessation
- 1990-10-16 AT AT90402898T patent/ATE132867T1/de not_active IP Right Cessation
- 1990-10-16 HU HU462/90A patent/HU218937B/hu not_active IP Right Cessation
- 1990-10-16 DK DK90402898.2T patent/DK0424248T3/da active
- 1990-10-16 ES ES90402898T patent/ES2081957T3/es not_active Expired - Lifetime
- 1990-10-17 JP JP2276590A patent/JPH03133981A/ja active Pending
- 1990-10-17 CN CN90108428A patent/CN1040000C/zh not_active Expired - Fee Related
- 1990-10-17 KR KR1019900016818A patent/KR0180706B1/ko not_active Expired - Fee Related
- 1990-10-17 AU AU64668/90A patent/AU646817B2/en not_active Ceased
-
1992
- 1992-01-22 RU SU5010658/04A patent/RU2069663C1/ru not_active IP Right Cessation
-
1994
- 1994-04-15 US US08/228,300 patent/US6534515B2/en not_active Expired - Fee Related
-
1996
- 1996-01-19 GR GR950401768T patent/GR3018736T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2653124A1 (fr) | 1991-04-19 |
| CN1040000C (zh) | 1998-09-30 |
| ES2081957T3 (es) | 1996-03-16 |
| FR2653124B1 (fr) | 1992-01-17 |
| CA2027724A1 (fr) | 1991-04-18 |
| EP0424248B1 (de) | 1996-01-10 |
| EP0424248A2 (de) | 1991-04-24 |
| DE69024745D1 (de) | 1996-02-22 |
| HUT55013A (en) | 1991-04-29 |
| IE903702A1 (en) | 1991-04-24 |
| GR3018736T3 (en) | 1996-04-30 |
| CN1051042A (zh) | 1991-05-01 |
| KR910007930A (ko) | 1991-05-30 |
| PT95600A (pt) | 1991-09-13 |
| ZA907832B (en) | 1991-12-24 |
| MX22863A (es) | 1993-11-01 |
| RU2069663C1 (ru) | 1996-11-27 |
| IE71209B1 (en) | 1997-02-12 |
| US20020045637A1 (en) | 2002-04-18 |
| AU646817B2 (en) | 1994-03-10 |
| HU218937B (hu) | 2001-01-29 |
| AU6466890A (en) | 1991-04-26 |
| JPH03133981A (ja) | 1991-06-07 |
| DE69024745T2 (de) | 1996-11-14 |
| DK0424248T3 (da) | 1996-03-04 |
| HU906462D0 (en) | 1991-04-29 |
| US6534515B2 (en) | 2003-03-18 |
| KR0180706B1 (ko) | 1999-03-20 |
| PT95600B (pt) | 1997-08-29 |
| EP0424248A3 (en) | 1992-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |