DE69838146D1 - Androgene steroidderivate und ein verfahren zur herstellung und verwendung derselben - Google Patents

Androgene steroidderivate und ein verfahren zur herstellung und verwendung derselben

Info

Publication number
DE69838146D1
DE69838146D1 DE69838146T DE69838146T DE69838146D1 DE 69838146 D1 DE69838146 D1 DE 69838146D1 DE 69838146 T DE69838146 T DE 69838146T DE 69838146 T DE69838146 T DE 69838146T DE 69838146 D1 DE69838146 D1 DE 69838146D1
Authority
DE
Germany
Prior art keywords
preparation
steroid derivatives
androgenic steroid
androgenic
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69838146T
Other languages
English (en)
Inventor
Edgar C Cook
John A Kepler
Yue-Wei Lee
Mansukh C Wani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Triangle Institute
Original Assignee
Research Triangle Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Triangle Institute filed Critical Research Triangle Institute
Application granted granted Critical
Publication of DE69838146D1 publication Critical patent/DE69838146D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0077—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Neurology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69838146T 1997-11-26 1998-11-23 Androgene steroidderivate und ein verfahren zur herstellung und verwendung derselben Expired - Lifetime DE69838146D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/979,369 US5952319A (en) 1997-11-26 1997-11-26 Androgenic steroid compounds and a method of making and using the same
PCT/US1998/024527 WO1999026962A1 (en) 1997-11-26 1998-11-23 Androgenic steroid compounds and a method of making and using the same

Publications (1)

Publication Number Publication Date
DE69838146D1 true DE69838146D1 (de) 2007-09-06

Family

ID=25526867

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69838146T Expired - Lifetime DE69838146D1 (de) 1997-11-26 1998-11-23 Androgene steroidderivate und ein verfahren zur herstellung und verwendung derselben

Country Status (11)

Country Link
US (4) US5952319A (de)
EP (1) EP1042352B1 (de)
JP (1) JP2001524487A (de)
KR (1) KR100577129B1 (de)
CN (1) CN1257181C (de)
AT (1) ATE368050T1 (de)
AU (1) AU750663B2 (de)
CA (1) CA2311448A1 (de)
DE (1) DE69838146D1 (de)
NO (1) NO317879B1 (de)
WO (1) WO1999026962A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
US5952319A (en) * 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
HUP0200871A3 (en) * 1999-05-04 2004-04-28 Strakan Int Ltd Androgen glycosides and androgenic activity thereof
US6740645B1 (en) 1999-09-03 2004-05-25 Research Triangle Institute 17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
US20030069215A1 (en) * 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate
EP1272196B1 (de) * 2000-03-31 2006-08-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Verfahren zur herstellung von den trans-4-n-butylcyclohexanoicsaüre- und undecanoicsaüreestern von (7-alpha,11-beta)-dimethyl-17 beta -hydroxy-4-estren-3-one und deren medizynische anwendung
CA2409647C (en) * 2000-05-26 2012-07-03 Harry Fisch Methods of treating androgen deficiency in men using selective antiestrogens
GB0025221D0 (en) * 2000-10-14 2000-11-29 Astrazeneca Ab New process
BR0116127A (pt) * 2000-12-15 2003-11-04 Akzo Nobel Nv Composto, composição farmacêutica, uso de um composto, e, conjunto para a contracepção masculina
DE10104327A1 (de) * 2001-01-24 2002-07-25 Schering Ag 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate
CA2459943A1 (en) * 2001-09-21 2003-04-03 Merck & Co., Inc. Androstanes as androgen receptor modulators
DE10234525A1 (de) * 2002-07-25 2004-02-05 Schering Ag Zusammensetzung, enthaltend ein androgenes 11ß-Halogensteroid und ein Gestagen sowie männliches Kontrazeptivum auf Basis dieser Zusammensetzung
US20040010138A1 (en) * 2002-03-21 2004-01-15 Schering Ag Process for the production of 7alpha-methyl steroids
PL373808A1 (en) 2002-07-24 2005-09-19 Schering Aktiengesellschaft Microbiological method for the production of 7 alpha-substituted 11 alpha-hydroxysteroids
DE10233723A1 (de) * 2002-07-24 2004-02-12 Schering Ag Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene
CN1671394A (zh) * 2002-07-25 2005-09-21 舍林股份公司 包含雄激素性11β－卤素甾体和孕激素的组合物以及基于该组合物的雄性避孕药
EP2298315A1 (de) 2002-08-28 2011-03-23 Harbor BioSciences, Inc. Therapeutische Behandlungsmethoden
US8445469B2 (en) * 2004-12-30 2013-05-21 Bayer Intellectual Property Gmbh 18-methyl-19-nor-17-pregn-4-ene-21,17-carbolactones, as well as pharmaceutical preparations that contain the latter
ATE426610T1 (de) * 2005-02-04 2009-04-15 Us Gov Health & Human Serv Nandrolon-17ss-carbonate
EP2688901B1 (de) * 2011-03-25 2019-05-08 Université Laval Hemmer von 17-beta-hsd1, 17-beta-hsd3 und 17-beta-hsd10
WO2021252761A2 (en) * 2020-06-11 2021-12-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monomeric and oligomeric compound embodiments as contraceptives and therapies and methods of making and using the same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB912036A (en) * 1960-06-23 1962-12-05 British Drug Houses Ltd 11-methylene-5ª--steroids
GB912037A (en) * 1960-06-27 1962-12-05 British Drug Houses Ltd 11-methylene steroids
GB912038A (en) * 1960-06-30 1962-12-05 British Drug Houses Ltd 11ª--methyl-5ª--steroids
US3846456A (en) * 1965-04-07 1974-11-05 Upjohn Co Organic compounds
US3325520A (en) * 1965-12-08 1967-06-13 Searle & Co (optionally 17-hydrocarbon-substituted) 11, 13beta-dialkylgon-4-en-3-ones and esters corresponding
US3652606A (en) * 1970-08-07 1972-03-28 Searle & Co 3-oxygenated 11beta-methylestr-4-en-17beta-ol and esters thereof
FI54128C (fi) * 1972-12-09 1978-10-10 Akzo Nv Foerfarande foer framstaellning av nya 11,11-alkylidensteroider ur oestran- och 19-norpregnanserien med foerbaettrad hormonell verkan
US4412993A (en) * 1980-01-25 1983-11-01 The Upjohn Company Method of treating pseudopregnancy, galactorrhea and mastitis in mammals
DE3909770A1 (de) * 1989-03-21 1990-09-27 Schering Ag Verfahren zur herstellung von 3-desoxy-4-en-steroiden
WO1993013122A1 (de) * 1991-12-22 1993-07-08 Schering Aktiengesellschaft 3-methylsulfonylhydrazono- und 3-oxyimino-steroide, ein verfahren zu deren herstellung, diese steroide enthaltende pharmazeutische präparate sowie ihre verwendung zur herstellung von arzneimitteln
US5733565A (en) * 1996-02-23 1998-03-31 The Population Council, Center For Biomedical Research Male contraceptive implant
US5952319A (en) * 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
EP1272196B1 (de) 2000-03-31 2006-08-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Verfahren zur herstellung von den trans-4-n-butylcyclohexanoicsaüre- und undecanoicsaüreestern von (7-alpha,11-beta)-dimethyl-17 beta -hydroxy-4-estren-3-one und deren medizynische anwendung
US20030069215A1 (en) * 2001-03-30 2003-04-10 The Government Of The United States Of America, Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate

Also Published As

Publication number Publication date
US20020103177A1 (en) 2002-08-01
US6864248B2 (en) 2005-03-08
KR100577129B1 (ko) 2006-05-09
AU750663B2 (en) 2002-07-25
NO20002676D0 (no) 2000-05-25
KR20010032449A (ko) 2001-04-25
NO20002676L (no) 2000-05-25
EP1042352B1 (de) 2007-07-25
US20020002156A1 (en) 2002-01-03
AU1589199A (en) 1999-06-15
JP2001524487A (ja) 2001-12-04
EP1042352A1 (de) 2000-10-11
CN1283200A (zh) 2001-02-07
ATE368050T1 (de) 2007-08-15
US20040097477A1 (en) 2004-05-20
NO317879B1 (no) 2004-12-27
CA2311448A1 (en) 1999-06-03
US6670352B2 (en) 2003-12-30
US6369047B2 (en) 2002-04-09
US5952319A (en) 1999-09-14
WO1999026962A1 (en) 1999-06-03
EP1042352A4 (de) 2004-12-22
CN1257181C (zh) 2006-05-24

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Legal Events

Date Code Title Description
8332 No legal effect for de