NO20062761L - Ny fremgangsmate for fremstilling av 3-fluorinterte quinoliner - Google Patents

Ny fremgangsmate for fremstilling av 3-fluorinterte quinoliner

Info

Publication number
NO20062761L
NO20062761L NO20062761A NO20062761A NO20062761L NO 20062761 L NO20062761 L NO 20062761L NO 20062761 A NO20062761 A NO 20062761A NO 20062761 A NO20062761 A NO 20062761A NO 20062761 L NO20062761 L NO 20062761L
Authority
NO
Norway
Prior art keywords
alkyl
quinolines
preparation
optionally substituted
protecting group
Prior art date
Application number
NO20062761A
Other languages
English (en)
Inventor
Serge Mignani
Jean-Pierre Leconte
Michel Tabart
Youssef El Ahmad
Stephane Mutti
Joel Malpart
Original Assignee
Novexel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novexel filed Critical Novexel
Publication of NO20062761L publication Critical patent/NO20062761L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Foreliggende oppfinnelse gjelder en ny fremgangsmåte for fremstilling av 3-fluorerte kinoliner med formel (I) Oppfinnelsen særpreges ved at en forbindelse med den generelle formel (IV) utsettes for Hofmann-degradering for dannelse av en forbindelse med den generelle formel (III), som behandles under betingelser som fører til dannelse av diazoniumsaltet med den generelle formel (II), som i sin tur oppvarmes i et inert organisk løsemiddel.
NO20062761A 2003-11-17 2006-06-13 Ny fremgangsmate for fremstilling av 3-fluorinterte quinoliner NO20062761L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0313384A FR2862301B1 (fr) 2003-11-17 2003-11-17 Nouveau procede de preparation de quinoleines 3-fluorees
PCT/FR2004/002910 WO2005049575A1 (fr) 2003-11-17 2004-11-15 Nouveau procede de preparation de quinoleines 3-fluorees

Publications (1)

Publication Number Publication Date
NO20062761L true NO20062761L (no) 2006-08-17

Family

ID=34508487

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062761A NO20062761L (no) 2003-11-17 2006-06-13 Ny fremgangsmate for fremstilling av 3-fluorinterte quinoliner

Country Status (18)

Country Link
EP (1) EP1687276B1 (no)
JP (1) JP4751333B2 (no)
KR (1) KR20060123161A (no)
CN (1) CN100537540C (no)
AT (1) ATE445605T1 (no)
AU (1) AU2004291376A1 (no)
CA (1) CA2542796C (no)
DE (1) DE602004023640D1 (no)
ES (1) ES2334796T3 (no)
FR (1) FR2862301B1 (no)
HK (1) HK1099020A1 (no)
HR (1) HRP20060168A2 (no)
IL (1) IL175649A (no)
IS (1) IS8423A (no)
MX (1) MXPA06005599A (no)
NO (1) NO20062761L (no)
RU (1) RU2351591C2 (no)
WO (1) WO2005049575A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7396934B2 (en) 2003-11-17 2008-07-08 Youssef El-Ahmad Process for preparing 3-fluoroquinolines
CN102361863B (zh) 2009-01-21 2014-12-03 巴斯利尔药物股份公司 新的二环抗生素
CN104672131B (zh) * 2013-11-27 2017-03-15 中国科学院大连化学物理研究所 一种合成3‑氟喹啉衍生物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA801526B (en) * 1979-03-26 1981-08-26 Robins Co Inc A H 4-amino-3-quinolinecarboxylic acids and esters-antisecretory, anti-ulcer compounds
DE3620856A1 (de) * 1986-06-21 1987-12-23 Basf Ag 3-cyanchinolinderivate
DK273689A (da) * 1988-06-06 1989-12-07 Sanofi Sa 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler
JPH06287187A (ja) * 1993-04-02 1994-10-11 Nippon Soda Co Ltd 新規なピラゾ−ル誘導体及びその農園芸用殺菌剤
SE0004056D0 (sv) * 2000-11-06 2000-11-06 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain
FR2816618B1 (fr) * 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
FR2822154B1 (fr) * 2001-03-13 2005-10-21 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
TWI275390B (en) * 2002-04-30 2007-03-11 Wyeth Corp Process for the preparation of 7-substituted-3- quinolinecarbonitriles

Also Published As

Publication number Publication date
IS8423A (is) 2006-04-21
CN1894216A (zh) 2007-01-10
JP2007511490A (ja) 2007-05-10
IL175649A (en) 2011-01-31
JP4751333B2 (ja) 2011-08-17
CA2542796C (fr) 2011-08-02
RU2351591C2 (ru) 2009-04-10
ES2334796T3 (es) 2010-03-16
HRP20060168A2 (en) 2006-09-30
RU2006120275A (ru) 2008-01-10
AU2004291376A1 (en) 2005-06-02
WO2005049575A1 (fr) 2005-06-02
EP1687276B1 (fr) 2009-10-14
MXPA06005599A (es) 2007-01-26
ATE445605T1 (de) 2009-10-15
DE602004023640D1 (de) 2009-11-26
KR20060123161A (ko) 2006-12-01
FR2862301B1 (fr) 2007-12-21
CN100537540C (zh) 2009-09-09
FR2862301A1 (fr) 2005-05-20
IL175649A0 (en) 2006-09-05
CA2542796A1 (fr) 2005-06-02
EP1687276A1 (fr) 2006-08-09
HK1099020A1 (en) 2007-08-03

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application