YU94791A - Derivati azola - Google Patents
Derivati azolaInfo
- Publication number
- YU94791A YU94791A YU94791A YU94791A YU94791A YU 94791 A YU94791 A YU 94791A YU 94791 A YU94791 A YU 94791A YU 94791 A YU94791 A YU 94791A YU 94791 A YU94791 A YU 94791A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- compounds
- alkyl
- hydrogen
- formula
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DERIVATI AZOLA, pronalazak se odnosi na nova, farmaceutski upotrebljiva jedinjenja sledeće formule I: u kojoj Q označava 5-člani heteroaril, koji opciono ima 1 ili 2 supstituenta nezavisno odabranih iz grupe koju sačinjavaju (1-4C) alkil i halogeno; R1 je vodonik, (1-6C) alkil ili (1-4C)alkanoil); R2 je (kada nije definisan zajedno sa X) vodonik, (3-12C)cikloalkil, (3-6C)alkenil, fenil(3-6C)alkenil, tetrafluorofenil, pentafluorofenil 5- ili 6-člani heteroalkil, opciono supstituisani (1-6C)alkil ili opciono supstituisani fenil; X je oksi, tio, sulfinil, sulfoni ili imino grupa formule -NRa- u kojoj je Ra vodonik, (1-6C)alkil ili zajedno sa R2 i susednim atomom azota čini 4- do 6-člani zasićeni heterociklični prsten; i A je N ili CT gde je T vodonik ili (1-4C)alkil. Pronalazak se takodje odnosi na farmaceutski prihvatljive soli gore navedenih jedinjenja, na postupke za proizvodnju tih jedinjenja i farmaceutske smeše koje sadrže ta jedinjenja. Jedinjenja se primenjuju kao antagonisti adenozina. Pronalazak dalje obezbedjuje nove intermedijate koji se primenjuju u proizvodnji jedinjenja formule I.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909011914A GB9011914D0 (en) | 1990-05-29 | 1990-05-29 | Heterocyclic compounds |
GB909011913A GB9011913D0 (en) | 1990-05-29 | 1990-05-29 | Azole derivatives |
GB919101380A GB9101380D0 (en) | 1991-01-22 | 1991-01-22 | Azole derivatives |
GB919101379A GB9101379D0 (en) | 1991-01-22 | 1991-01-22 | Heterocyclic compounds |
GB919104125A GB9104125D0 (en) | 1991-02-27 | 1991-02-27 | Azole derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
YU94791A true YU94791A (sh) | 1994-06-24 |
YU47812B YU47812B (sr) | 1996-01-09 |
Family
ID=27516979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU94791A YU47812B (sr) | 1990-05-29 | 1991-05-28 | Derivati azola i postupak za njihovo dobijanje |
Country Status (20)
Country | Link |
---|---|
US (1) | US5270311A (sh) |
EP (1) | EP0459702A1 (sh) |
JP (1) | JP2504879B2 (sh) |
KR (1) | KR910020012A (sh) |
CN (1) | CN1056879A (sh) |
AP (1) | AP248A (sh) |
AU (1) | AU642494B2 (sh) |
CA (1) | CA2043424A1 (sh) |
CS (1) | CS159591A3 (sh) |
FI (1) | FI912563A (sh) |
GB (1) | GB2244487B (sh) |
HU (1) | HUT61311A (sh) |
IE (1) | IE911818A1 (sh) |
IL (1) | IL98316A (sh) |
NO (1) | NO178401C (sh) |
NZ (1) | NZ238288A (sh) |
OA (1) | OA09358A (sh) |
PT (1) | PT97776A (sh) |
RO (1) | RO109542B1 (sh) |
YU (1) | YU47812B (sh) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9226735D0 (en) * | 1992-12-22 | 1993-02-17 | Ici Plc | Azole derivatives |
US5356894A (en) * | 1990-05-29 | 1994-10-18 | Rodney Peter W | Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist |
EP0459702A1 (en) * | 1990-05-29 | 1991-12-04 | Zeneca Limited | Azole Derivatives |
GB9111130D0 (en) * | 1991-05-23 | 1991-07-17 | Ici Plc | Azole derivatives |
GB9111131D0 (en) * | 1991-05-23 | 1991-07-17 | Ici Plc | Heterocyclic compounds |
GB9125002D0 (en) * | 1991-11-25 | 1992-01-22 | Ici Plc | Azole derivatives |
GB9124968D0 (en) * | 1991-11-25 | 1992-01-22 | Ici Plc | Chemical process |
GB9125001D0 (en) * | 1991-11-25 | 1992-01-22 | Ici Plc | Heterocyclic compounds |
CA2144330A1 (en) * | 1993-07-27 | 1995-02-09 | Fumio Suzuki | A therapeutic agent for parkinson's disease |
EP0667349B1 (en) * | 1993-09-06 | 2001-01-24 | Kyowa Hakko Kogyo Kabushiki Kaisha | Depression remedy |
CA2284737C (en) * | 1997-03-24 | 2007-03-13 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]triazolo[1,5-c]pyrimidine derivatives |
US6060481A (en) * | 1998-05-28 | 2000-05-09 | The Penn State Research Foundation | Method for improving insulin sensitivity using an adenosine receptor antagonist |
EA200100265A1 (ru) * | 1998-09-22 | 2001-10-22 | Киова Хакко Когио Ко., Лтд. | Производные [1,2,4]триазоло[1,5-c]пиримидина |
CA2500228A1 (en) * | 2002-09-24 | 2004-04-08 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]-triazolo[1,5-c]pyrimidine derivative |
US7329658B2 (en) * | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
WO2004092170A2 (en) * | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists |
EP1633756B1 (en) | 2003-04-09 | 2008-12-24 | Biogen Idec MA Inc. | A2a adenosine receptor antagonists |
EP1618109A2 (en) * | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists |
WO2004110454A1 (ja) * | 2003-06-13 | 2004-12-23 | Ishihara Sangyo Kaisha, Ltd. | アデノシンA2a受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物 |
JP2008527007A (ja) | 2005-01-14 | 2008-07-24 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | Raf−キナーゼ阻害活性を有するシンナミドおよびヒドロシンナミド誘導体 |
US10087715B2 (en) | 2012-12-06 | 2018-10-02 | Siemens Aktiengesellschaft | Arrangement and method for introducing heat into a geological formation by means of electromagnetic induction |
CN106916073A (zh) * | 2017-01-20 | 2017-07-04 | 上海巧坤化工科技有限公司 | 一种大麦芽碱盐酸盐的合成方法 |
WO2019154294A1 (zh) * | 2018-02-06 | 2019-08-15 | 江苏恒瑞医药股份有限公司 | 吡唑并[1,5-a][1,3,5]三嗪-2-胺类衍生物、其制备方法及其在医药上的应用 |
CA3115900A1 (en) * | 2018-06-26 | 2020-01-02 | Zhejiang Vimgreen Pharmaceuticals, Ltd | Triazolotriazine derivatives as a2a receptor antagonists |
CA3103068C (en) * | 2018-06-26 | 2024-06-25 | Zhejiang Vimgreen Pharmaceuticals, Ltd | Triazolotriazine derivatives as a2a receptor antagonists |
BE1026602B1 (fr) | 2018-09-27 | 2020-06-18 | Iteos Therapeutics S A | Inhibiteurs d’a2a ne penetrant pas dans le cerveau et methodes d’utilisation dans le traitement de cancers |
CN111205291B (zh) * | 2018-11-22 | 2022-08-23 | 上海科技大学 | 三唑并环类化合物、其制备方法、中间体和应用 |
CN112479956A (zh) * | 2019-07-30 | 2021-03-12 | 杭州阿诺生物医药科技有限公司 | 一种用于制备腺苷受体抑制剂中间体的方法 |
JP2023508182A (ja) * | 2019-12-26 | 2023-03-01 | チェジン ヴィムグリーン ファーマシューティカルズ リミテッド | トリアゾロトリアジン誘導体の疾患治療への応用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3846423A (en) * | 1972-06-08 | 1974-11-05 | Icn Pharmaceuticals | Pyrazolo (1,5a) 1,3,5-triazines |
ZA743316B (en) * | 1973-05-22 | 1976-01-28 | Sandoz Ltd | Improvements in or relating to organic compounds |
US3995039A (en) * | 1975-05-27 | 1976-11-30 | Merck & Co., Inc. | Pyrazolo [1,5-a] [1,3,5] triazines |
GB1579932A (en) * | 1976-05-12 | 1980-11-26 | Ici Ltd | Herbicidal triazolotriazines |
GB2016002B (en) * | 1978-01-09 | 1982-05-06 | Aron Sa | Amino derivatives of pyrazolo(1,5-a)s triazine |
AU2192683A (en) * | 1982-12-30 | 1984-07-05 | Biomeasure Incorporated | Pyrazolo(1,5-alpha)-1,3,5-triazines |
CA1267143A (en) * | 1985-06-06 | 1990-03-27 | Sun H. Kim | Anti-arthritic 7-phenylpyrazole[1,5-a]-1,3,5- triazine derivatives |
EP0217748B1 (en) * | 1985-09-30 | 1991-02-06 | Ciba-Geigy Ag | 2-Substituted-e-fused-[1,2,4,]triazolo-[1,5-c]pyrimidines pharmaceutical compositions and uses thereof |
DE3781080T2 (de) * | 1986-09-30 | 1992-12-24 | Ciba Geigy Ag | 2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung. |
US4824834A (en) * | 1986-10-31 | 1989-04-25 | Otsuka Pharmaceutical Company, Limited | Pyrazolotriazine compounds |
US4734413A (en) * | 1987-03-02 | 1988-03-29 | Riker Laboratories, Inc. | Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators |
ES2059491T3 (es) * | 1987-06-29 | 1994-11-16 | Duphar Int Res | Derivados de indol con anillos condensados. |
DE3843117A1 (de) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
US4970142A (en) * | 1989-02-16 | 1990-11-13 | Konica Corporation | Silver halide photographic light-sensitive material containing cyan coupler |
EP0459702A1 (en) * | 1990-05-29 | 1991-12-04 | Zeneca Limited | Azole Derivatives |
-
1991
- 1991-05-23 EP EP91304665A patent/EP0459702A1/en not_active Withdrawn
- 1991-05-23 GB GB9111132A patent/GB2244487B/en not_active Expired - Fee Related
- 1991-05-28 CS CS911595A patent/CS159591A3/cs unknown
- 1991-05-28 US US07/708,265 patent/US5270311A/en not_active Expired - Lifetime
- 1991-05-28 NZ NZ238288A patent/NZ238288A/xx unknown
- 1991-05-28 FI FI912563A patent/FI912563A/fi not_active Application Discontinuation
- 1991-05-28 PT PT97776A patent/PT97776A/pt not_active Application Discontinuation
- 1991-05-28 NO NO912051A patent/NO178401C/no unknown
- 1991-05-28 RO RO147639A patent/RO109542B1/ro unknown
- 1991-05-28 AU AU77348/91A patent/AU642494B2/en not_active Ceased
- 1991-05-28 CA CA002043424A patent/CA2043424A1/en not_active Abandoned
- 1991-05-28 IE IE181891A patent/IE911818A1/en unknown
- 1991-05-28 YU YU94791A patent/YU47812B/sh unknown
- 1991-05-28 KR KR1019910008926A patent/KR910020012A/ko not_active Application Discontinuation
- 1991-05-28 AP APAP/P/1991/000266A patent/AP248A/en active
- 1991-05-29 HU HU911789A patent/HUT61311A/hu unknown
- 1991-05-29 OA OA60010A patent/OA09358A/xx unknown
- 1991-05-29 JP JP3235332A patent/JP2504879B2/ja not_active Expired - Fee Related
- 1991-05-29 CN CN91103744A patent/CN1056879A/zh active Pending
- 1991-05-30 IL IL9831691A patent/IL98316A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IE911818A1 (en) | 1991-12-04 |
AP9100266A0 (en) | 1991-07-31 |
HUT61311A (en) | 1992-12-28 |
AU7734891A (en) | 1991-12-05 |
CA2043424A1 (en) | 1991-11-30 |
CN1056879A (zh) | 1991-12-11 |
EP0459702A1 (en) | 1991-12-04 |
GB9111132D0 (en) | 1991-07-17 |
RO109542B1 (ro) | 1995-03-30 |
NO912051D0 (no) | 1991-05-28 |
GB2244487B (en) | 1994-02-02 |
KR910020012A (ko) | 1991-12-19 |
OA09358A (fr) | 1992-09-15 |
GB2244487A (en) | 1991-12-04 |
IL98316A (en) | 1995-05-26 |
IL98316A0 (en) | 1992-06-21 |
US5270311A (en) | 1993-12-14 |
HU911789D0 (en) | 1991-12-30 |
NZ238288A (en) | 1993-07-27 |
CS159591A3 (en) | 1992-01-15 |
YU47812B (sr) | 1996-01-09 |
NO178401B (no) | 1995-12-11 |
AP248A (en) | 1993-03-16 |
PT97776A (pt) | 1992-03-31 |
JP2504879B2 (ja) | 1996-06-05 |
NO178401C (no) | 1996-03-20 |
AU642494B2 (en) | 1993-10-21 |
FI912563A (fi) | 1991-11-30 |
FI912563A0 (fi) | 1991-05-28 |
NO912051L (no) | 1991-12-02 |
JPH0597855A (ja) | 1993-04-20 |
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