YU94791A - Derivati azola - Google Patents

Derivati azola

Info

Publication number
YU94791A
YU94791A YU94791A YU94791A YU94791A YU 94791 A YU94791 A YU 94791A YU 94791 A YU94791 A YU 94791A YU 94791 A YU94791 A YU 94791A YU 94791 A YU94791 A YU 94791A
Authority
YU
Yugoslavia
Prior art keywords
compounds
alkyl
hydrogen
formula
alkenyl
Prior art date
Application number
YU94791A
Other languages
English (en)
Serbian (sr)
Other versions
YU47812B (sr
Inventor
P.W. Caulkett
G. Jones
M.G. Collis
S.M. Poucher
Original Assignee
Imperial Chemical Industries Plc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909011913A external-priority patent/GB9011913D0/en
Priority claimed from GB909011914A external-priority patent/GB9011914D0/en
Priority claimed from GB919101379A external-priority patent/GB9101379D0/en
Priority claimed from GB919101380A external-priority patent/GB9101380D0/en
Priority claimed from GB919104125A external-priority patent/GB9104125D0/en
Application filed by Imperial Chemical Industries Plc. filed Critical Imperial Chemical Industries Plc.
Publication of YU94791A publication Critical patent/YU94791A/sh
Publication of YU47812B publication Critical patent/YU47812B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVATI AZOLA, pronalazak se odnosi na nova, farmaceutski upotrebljiva jedinjenja sledeće formule I: u kojoj Q označava 5-člani heteroaril, koji opciono ima 1 ili 2 supstituenta nezavisno odabranih iz grupe koju sačinjavaju (1-4C) alkil i halogeno; R1 je vodonik, (1-6C) alkil ili (1-4C)alkanoil); R2 je (kada nije definisan zajedno sa X) vodonik, (3-12C)cikloalkil, (3-6C)alkenil, fenil(3-6C)alkenil, tetrafluorofenil, pentafluorofenil 5- ili 6-člani heteroalkil, opciono supstituisani (1-6C)alkil ili opciono supstituisani fenil; X je oksi, tio, sulfinil, sulfoni ili imino grupa formule -NRa- u kojoj je Ra vodonik, (1-6C)alkil ili zajedno sa R2 i susednim atomom azota čini 4- do 6-člani zasićeni heterociklični prsten; i A je N ili CT gde je T vodonik ili (1-4C)alkil. Pronalazak se takodje odnosi na farmaceutski prihvatljive soli gore navedenih jedinjenja, na postupke za proizvodnju tih jedinjenja i farmaceutske smeše koje sadrže ta jedinjenja. Jedinjenja se primenjuju kao antagonisti adenozina. Pronalazak dalje obezbedjuje nove intermedijate koji se primenjuju u proizvodnji jedinjenja formule I.
YU94791A 1990-05-29 1991-05-28 Derivati azola i postupak za njihovo dobijanje YU47812B (sr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB909011913A GB9011913D0 (en) 1990-05-29 1990-05-29 Azole derivatives
GB909011914A GB9011914D0 (en) 1990-05-29 1990-05-29 Heterocyclic compounds
GB919101379A GB9101379D0 (en) 1991-01-22 1991-01-22 Heterocyclic compounds
GB919101380A GB9101380D0 (en) 1991-01-22 1991-01-22 Azole derivatives
GB919104125A GB9104125D0 (en) 1991-02-27 1991-02-27 Azole derivatives

Publications (2)

Publication Number Publication Date
YU94791A true YU94791A (sh) 1994-06-24
YU47812B YU47812B (sr) 1996-01-09

Family

ID=27516979

Family Applications (1)

Application Number Title Priority Date Filing Date
YU94791A YU47812B (sr) 1990-05-29 1991-05-28 Derivati azola i postupak za njihovo dobijanje

Country Status (20)

Country Link
US (1) US5270311A (sh)
EP (1) EP0459702A1 (sh)
JP (1) JP2504879B2 (sh)
KR (1) KR910020012A (sh)
CN (1) CN1056879A (sh)
AP (1) AP248A (sh)
AU (1) AU642494B2 (sh)
CA (1) CA2043424A1 (sh)
CS (1) CS159591A3 (sh)
FI (1) FI912563A (sh)
GB (1) GB2244487B (sh)
HU (1) HUT61311A (sh)
IE (1) IE911818A1 (sh)
IL (1) IL98316A (sh)
NO (1) NO178401C (sh)
NZ (1) NZ238288A (sh)
OA (1) OA09358A (sh)
PT (1) PT97776A (sh)
RO (1) RO109542B1 (sh)
YU (1) YU47812B (sh)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226735D0 (en) * 1992-12-22 1993-02-17 Ici Plc Azole derivatives
EP0459702A1 (en) * 1990-05-29 1991-12-04 Zeneca Limited Azole Derivatives
US5356894A (en) * 1990-05-29 1994-10-18 Rodney Peter W Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
GB9124968D0 (en) * 1991-11-25 1992-01-22 Ici Plc Chemical process
GB9125001D0 (en) * 1991-11-25 1992-01-22 Ici Plc Heterocyclic compounds
GB9125002D0 (en) * 1991-11-25 1992-01-22 Ici Plc Azole derivatives
US5565460A (en) * 1993-07-27 1996-10-15 Kyowa Hakko Koygo Co., Ltd. Therapeutic purine agents for parkinson's disease
AU7546794A (en) * 1993-09-06 1995-03-27 Kyowa Hakko Kogyo Co. Ltd. Depression remedy
EP0976753B1 (en) * 1997-03-24 2004-01-02 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
US6060481A (en) * 1998-05-28 2000-05-09 The Penn State Research Foundation Method for improving insulin sensitivity using an adenosine receptor antagonist
EP1116722B1 (en) * 1998-09-22 2005-01-12 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
US20060058320A1 (en) * 2002-09-24 2006-03-16 Kyowa Hakko Kogyo Co., Ltd. [1,2,4] Triazolo[1,5-c]pyrimidine derivatives
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
WO2004092172A2 (en) * 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosin e receptor antagonists
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
US7285550B2 (en) 2003-04-09 2007-10-23 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines and methods of making and using the same
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
CA2594860A1 (en) 2005-01-14 2006-07-20 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
RU2015126797A (ru) 2012-12-06 2017-01-12 Сименс Акциенгезелльшафт Система и способ введения тепла в геологическую формацию при помощи электромагнитной индукции
CN106916073A (zh) * 2017-01-20 2017-07-04 上海巧坤化工科技有限公司 一种大麦芽碱盐酸盐的合成方法
TWI701251B (zh) * 2018-02-06 2020-08-11 大陸商江蘇恒瑞醫藥股份有限公司 吡唑并[1,5-a][1,3,5]三-2-胺類衍生物、其製備方法及其在醫藥上的應用
JP7197206B2 (ja) * 2018-06-26 2022-12-27 チョーチヤン ビムグリーン ファーマシューティカルズ、リミテッド Ａ２ａ受容体拮抗薬として用いられるトリアゾロトリアジン誘導体
JP7175034B2 (ja) * 2018-06-26 2022-11-18 チョーチヤン ビムグリーン ファーマシューティカルズ、リミテッド Ａ２ａ受容体拮抗薬として用いられるトリアゾロトリアジン誘導体
BE1026602B1 (fr) 2018-09-27 2020-06-18 Iteos Therapeutics S A Inhibiteurs d’a2a ne penetrant pas dans le cerveau et methodes d’utilisation dans le traitement de cancers
WO2020103939A1 (zh) * 2018-11-22 2020-05-28 上海科技大学 三唑并环类化合物、其制备方法、中间体和应用
CN112592346B (zh) * 2019-07-30 2022-04-26 厦门宝太生物科技股份有限公司 一种a2a和/或a2b抑制剂中间体的制备方法
JP2023508182A (ja) * 2019-12-26 2023-03-01 チェジン ヴィムグリーン ファーマシューティカルズ リミテッド トリアゾロトリアジン誘導体の疾患治療への応用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846423A (en) * 1972-06-08 1974-11-05 Icn Pharmaceuticals Pyrazolo (1,5a) 1,3,5-triazines
BE815405A (en) * 1973-05-22 1974-11-22 Pyrazolo(1,5-a)-s-triazines - and their salts, with bronchospasmolytic activity
US3995039A (en) * 1975-05-27 1976-11-30 Merck & Co., Inc. Pyrazolo [1,5-a] [1,3,5] triazines
GB1579932A (en) * 1976-05-12 1980-11-26 Ici Ltd Herbicidal triazolotriazines
GB2016002B (en) * 1978-01-09 1982-05-06 Aron Sa Amino derivatives of pyrazolo(1,5-a)s triazine
AU2192683A (en) * 1982-12-30 1984-07-05 Biomeasure Incorporated Pyrazolo(1,5-alpha)-1,3,5-triazines
CA1267143A (en) * 1985-06-06 1990-03-27 Sun H. Kim Anti-arthritic 7-phenylpyrazole[1,5-a]-1,3,5- triazine derivatives
US4824834A (en) * 1986-10-31 1989-04-25 Otsuka Pharmaceutical Company, Limited Pyrazolotriazine compounds
US4734413A (en) * 1987-03-02 1988-03-29 Riker Laboratories, Inc. Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators
EP0297651B1 (en) * 1987-06-29 1993-11-03 Duphar International Research B.V Anellated indole derivatives
US4970142A (en) * 1989-02-16 1990-11-13 Konica Corporation Silver halide photographic light-sensitive material containing cyan coupler
EP0459702A1 (en) * 1990-05-29 1991-12-04 Zeneca Limited Azole Derivatives

Also Published As

Publication number Publication date
NZ238288A (en) 1993-07-27
CN1056879A (zh) 1991-12-11
FI912563A (fi) 1991-11-30
GB2244487B (en) 1994-02-02
HUT61311A (en) 1992-12-28
IL98316A (en) 1995-05-26
IE911818A1 (en) 1991-12-04
NO912051L (no) 1991-12-02
US5270311A (en) 1993-12-14
RO109542B1 (ro) 1995-03-30
JPH0597855A (ja) 1993-04-20
KR910020012A (ko) 1991-12-19
OA09358A (fr) 1992-09-15
NO912051D0 (no) 1991-05-28
YU47812B (sr) 1996-01-09
GB2244487A (en) 1991-12-04
AP248A (en) 1993-03-16
GB9111132D0 (en) 1991-07-17
NO178401B (no) 1995-12-11
FI912563A0 (fi) 1991-05-28
CA2043424A1 (en) 1991-11-30
CS159591A3 (en) 1992-01-15
IL98316A0 (en) 1992-06-21
PT97776A (pt) 1992-03-31
EP0459702A1 (en) 1991-12-04
AP9100266A0 (en) 1991-07-31
JP2504879B2 (ja) 1996-06-05
HU911789D0 (en) 1991-12-30
AU7734891A (en) 1991-12-05
AU642494B2 (en) 1993-10-21
NO178401C (no) 1996-03-20

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