ES2059491T3 - Derivados de indol con anillos condensados. - Google Patents
Derivados de indol con anillos condensados.Info
- Publication number
- ES2059491T3 ES2059491T3 ES88201253T ES88201253T ES2059491T3 ES 2059491 T3 ES2059491 T3 ES 2059491T3 ES 88201253 T ES88201253 T ES 88201253T ES 88201253 T ES88201253 T ES 88201253T ES 2059491 T3 ES2059491 T3 ES 2059491T3
- Authority
- ES
- Spain
- Prior art keywords
- indol
- derivatives
- condensed rings
- substitutes
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS DERIVADOS DEL INDOL, CON VARIOS ANILLOS, DE FORMULA GENERAL (2) EN LA QUE LOS SUSTITUYENTES TIENEN EL SIGNIFICADO QUE SE DETALLA EN LA INVENCION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8701516 | 1987-06-29 | ||
NL8800643 | 1988-03-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2059491T3 true ES2059491T3 (es) | 1994-11-16 |
Family
ID=26646266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88201253T Expired - Lifetime ES2059491T3 (es) | 1987-06-29 | 1988-06-20 | Derivados de indol con anillos condensados. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4939136A (es) |
EP (1) | EP0297651B1 (es) |
JP (1) | JP2716146B2 (es) |
AU (1) | AU613051B2 (es) |
CA (1) | CA1314879C (es) |
CZ (1) | CZ417991A3 (es) |
DE (1) | DE3885357T2 (es) |
DK (1) | DK174161B1 (es) |
ES (1) | ES2059491T3 (es) |
IE (1) | IE63174B1 (es) |
IL (1) | IL86877A (es) |
NZ (1) | NZ225157A (es) |
SK (1) | SK417991A3 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8802127D0 (en) * | 1988-02-01 | 1988-03-02 | Glaxo Group Ltd | Chemical compounds |
GB8812636D0 (en) * | 1988-05-27 | 1988-06-29 | Glaxo Group Ltd | Chemical compounds |
US5049563A (en) * | 1988-07-07 | 1991-09-17 | Duphar International Research B.V. | Annelated indoleketones with an imidazolylalkyl substituent |
EP0350130A3 (en) * | 1988-07-07 | 1991-07-10 | Duphar International Research B.V | New substituted 1,7-annelated 1h-indazoles |
JPH02180885A (ja) * | 1988-09-01 | 1990-07-13 | Glaxo Group Ltd | ラクタム誘導体 |
US5223625A (en) * | 1988-12-22 | 1993-06-29 | Duphar International Research B.V. | Annelated indolo [3,2,-C]lactams |
NZ233285A (en) * | 1989-04-18 | 1992-06-25 | Duphar Int Res | Imidazole-substituted carbamoyl-indoles and condensed analogues thereof and pharmaceutical compositions |
GB8913646D0 (en) * | 1989-06-14 | 1989-08-02 | Glaxo Group Ltd | Chemical compounds |
CA2030051C (en) * | 1989-11-17 | 2001-08-07 | Haruhiko Kikuchi | Indole derivatives |
EP0459702A1 (en) * | 1990-05-29 | 1991-12-04 | Zeneca Limited | Azole Derivatives |
JP3026845B2 (ja) * | 1991-02-20 | 2000-03-27 | 日清製粉株式会社 | ピペリジン誘導体 |
US5627199A (en) * | 1991-03-28 | 1997-05-06 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz [CD] indoles |
DE4238553A1 (de) * | 1992-11-14 | 1994-05-19 | Kali Chemie Pharma Gmbh | Neue Imidazol-1-yl-Verbindungen enthaltende Arzneimittel |
AU702594B2 (en) * | 1995-10-13 | 1999-02-25 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
US6365743B1 (en) | 1995-10-13 | 2002-04-02 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
HUP9601362A3 (en) * | 1996-05-21 | 1999-04-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing optically active compounds |
DE19813661A1 (de) * | 1997-08-01 | 1999-02-04 | Solvay Pharm Gmbh | Gegen Racemisierung stabilisierte pharmazeutische Zubereitungen von Cilansetron |
TWI222450B (en) * | 1999-07-28 | 2004-10-21 | Upjohn Co | Oxazinocarbazoles for the treatment of CNS diseases |
US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
GB0216027D0 (en) | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
US6932961B1 (en) | 2002-04-16 | 2005-08-23 | Pharmacia & Upjohn Company | Oxazinocarbazoles for the treatment of CNS diseases |
AR041955A1 (es) * | 2002-11-18 | 2005-06-01 | Solvay Pharm Bv | Procedimiento para la preparacion de compuestos de imidazolilo |
US7015333B2 (en) * | 2002-11-18 | 2006-03-21 | Solvay Pharmaceuticals B.V. | Process for preparation of imidazolyl compounds |
EP1424337A1 (en) * | 2002-11-26 | 2004-06-02 | Solvay Pharmaceuticals GmbH | 4-hydroxy derivatives of 5,6,9,10-tetrahydro-10-((2-methyl-1h-imidazol-1-yl)methyl)-4h-pyrido-(3,2,1-jk)-carbazol-11(8h)-one |
JP2006516976A (ja) * | 2003-01-13 | 2006-07-13 | ダイノゲン ファーマシューティカルズ,インコーポレイテッド | 機能性腸障害を処置する方法 |
ES2285407T3 (es) * | 2003-01-13 | 2007-11-16 | Dynogen Pharmaceuticals Inc. | Metodo para el tratamiento de nauseas, vomitos, arcadas o cualquiera de sus combinaciones. |
ES2290741T3 (es) * | 2003-04-04 | 2008-02-16 | Dynogen Pharmaceuticals Inc. | Metodo de tratamiento de trastornos del tracto urinario inferior. |
US7820690B2 (en) | 2004-03-19 | 2010-10-26 | Solvay Pharmaceuticals Gmbh | Method of treating or inhibiting a non-digestive tract derived abdominal disorder associated with pain using a 5-HT, receptor antagonist |
WO2006105117A2 (en) * | 2005-03-28 | 2006-10-05 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
WO2007077111A1 (en) * | 2005-12-30 | 2007-07-12 | F. Hoffmann-La Roche Ag | Compounds and methods for carbazole synthesis |
US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
US7662831B2 (en) | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
WO2009053732A1 (en) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Novel salt |
WO2009053754A2 (en) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Novel crystalline forms |
WO2009053750A2 (en) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Novel crystalline and amorphous forms |
WO2009053733A2 (en) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Novel crystalline forms |
RU2608458C2 (ru) | 2009-05-20 | 2017-01-18 | Инсерм (Энститю Насьональ Де Ля Сантэ Э Де Ля Решерш Медикаль) | Антагонисты серотониновых 5-нт3-рецепторов для применения при лечении вестибулярных нарушений с повреждениями |
EP2253316B1 (en) | 2009-05-20 | 2013-08-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8518743D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
GB8518745D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
-
1988
- 1988-06-20 DE DE88201253T patent/DE3885357T2/de not_active Expired - Lifetime
- 1988-06-20 EP EP88201253A patent/EP0297651B1/en not_active Expired - Lifetime
- 1988-06-20 ES ES88201253T patent/ES2059491T3/es not_active Expired - Lifetime
- 1988-06-24 DK DK198803479A patent/DK174161B1/da not_active IP Right Cessation
- 1988-06-24 IE IE192788A patent/IE63174B1/en not_active IP Right Cessation
- 1988-06-24 CA CA000570420A patent/CA1314879C/en not_active Expired - Lifetime
- 1988-06-24 US US07/210,976 patent/US4939136A/en not_active Expired - Lifetime
- 1988-06-24 NZ NZ225157A patent/NZ225157A/xx unknown
- 1988-06-27 AU AU18414/88A patent/AU613051B2/en not_active Expired
- 1988-06-27 IL IL86877A patent/IL86877A/xx not_active IP Right Cessation
- 1988-06-28 JP JP63158214A patent/JP2716146B2/ja not_active Expired - Lifetime
-
1991
- 1991-12-30 CZ CS914179A patent/CZ417991A3/cs unknown
- 1991-12-30 SK SK4179-91A patent/SK417991A3/sk unknown
Also Published As
Publication number | Publication date |
---|---|
JPS6422870A (en) | 1989-01-25 |
DK347988A (da) | 1988-12-30 |
IL86877A0 (en) | 1988-11-30 |
JP2716146B2 (ja) | 1998-02-18 |
NZ225157A (en) | 1991-01-29 |
IE63174B1 (en) | 1995-03-22 |
CZ417991A3 (en) | 1993-04-14 |
CA1314879C (en) | 1993-03-23 |
DE3885357D1 (de) | 1993-12-09 |
DK347988D0 (da) | 1988-06-24 |
IL86877A (en) | 1992-11-15 |
US4939136A (en) | 1990-07-03 |
SK417991A3 (en) | 2000-10-09 |
AU1841488A (en) | 1989-01-05 |
DK174161B1 (da) | 2002-07-29 |
AU613051B2 (en) | 1991-07-25 |
DE3885357T2 (de) | 1994-03-24 |
IE881927L (en) | 1988-12-29 |
EP0297651B1 (en) | 1993-11-03 |
EP0297651A1 (en) | 1989-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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