ES2059317T3 - Tolunitrilos alfa-heterociclo-sustituidos. - Google Patents

Tolunitrilos alfa-heterociclo-sustituidos.

Info

Publication number
ES2059317T3
ES2059317T3 ES87103099T ES87103099T ES2059317T3 ES 2059317 T3 ES2059317 T3 ES 2059317T3 ES 87103099 T ES87103099 T ES 87103099T ES 87103099 T ES87103099 T ES 87103099T ES 2059317 T3 ES2059317 T3 ES 2059317T3
Authority
ES
Spain
Prior art keywords
tolunitrils
heterociclo
alpha
substituted
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87103099T
Other languages
English (en)
Inventor
Robert Mathews Bowman
Ronald Edward Steele
Leslie Johnston Browne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2059317(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2059317T3 publication Critical patent/ES2059317T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) EN LA QUE LOS GRUPOS R,RO,R1,R2, Y W VIENEN DEFINIDOS EN LAS ESPECIFICACIONES. ESTOS COMPUESTOS PRESENTAN PROPIEDADES FARMACOLOGICAS VALIOSAS, ESPECIALMENTE COMO INHIBIDORES DE AROMATASA.
ES87103099T 1986-03-07 1987-03-05 Tolunitrilos alfa-heterociclo-sustituidos. Expired - Lifetime ES2059317T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (1)

Publication Number Publication Date
ES2059317T3 true ES2059317T3 (es) 1994-11-16

Family

ID=25274596

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87103099T Expired - Lifetime ES2059317T3 (es) 1986-03-07 1987-03-05 Tolunitrilos alfa-heterociclo-sustituidos.

Country Status (36)

Country Link
US (1) US4749713A (es)
EP (1) EP0236940B3 (es)
JP (1) JPH0755930B2 (es)
KR (1) KR910000482B1 (es)
AT (1) ATE94873T1 (es)
BG (4) BG45700A3 (es)
CA (1) CA1316928C (es)
CY (1) CY1905A (es)
CZ (3) CZ279027B6 (es)
DD (1) DD264432A5 (es)
DE (2) DE3787480T2 (es)
DK (1) DK172190B1 (es)
DZ (1) DZ1055A1 (es)
ES (1) ES2059317T3 (es)
FI (1) FI91857C (es)
HK (1) HK50296A (es)
HU (1) HU202843B (es)
IE (1) IE61101B1 (es)
IL (1) IL81746A (es)
LU (1) LU90128I2 (es)
LV (1) LV5769B4 (es)
MA (1) MA20888A1 (es)
MC (1) MC1805A1 (es)
MT (1) MTP998B (es)
MX (1) MX5496A (es)
MY (1) MY102428A (es)
NL (1) NL970011I2 (es)
NO (2) NO170277C (es)
PH (1) PH24159A (es)
PL (2) PL152025B1 (es)
PT (1) PT84410B (es)
RO (2) RO101532B1 (es)
SK (3) SK279101B6 (es)
SU (3) SU1470184A3 (es)
TN (1) TNSN87033A1 (es)
ZA (1) ZA871637B (es)

Families Citing this family (46)

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US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
DE3811574A1 (de) * 1988-03-31 1989-10-19 Schering Ag N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE59010171D1 (de) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituierte Benzonitrile
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
JP2602456B2 (ja) * 1990-04-12 1997-04-23 雪印乳業株式会社 子宮内膜症治療剤
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
TW210334B (es) * 1990-12-12 1993-08-01 Ciba Geigy Ag
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
DE4120107A1 (de) * 1991-06-14 1992-12-17 Schering Ag Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
CA2116773C (en) 1991-09-02 2002-12-10 Minoru Okada Triazolylated tertiary amine compound or salt thereof
US5223539A (en) * 1991-11-22 1993-06-29 G. D. Searle & Co. N,n-di-alkyl(phenoxy)benzamide derivatives
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US5426196A (en) * 1993-12-22 1995-06-20 Glaxo Inc. Synthesis of diaryl methanes
JP2000505797A (ja) * 1996-01-30 2000-05-16 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
JP2000504014A (ja) * 1996-01-30 2000-04-04 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
JP2000507585A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシルタンパク質トランスフェラーゼの阻害剤
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
AU715658B2 (en) * 1996-04-03 2000-02-10 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
ATE359790T1 (de) 2001-05-16 2007-05-15 Novartis Pharma Gmbh Kombination von n- 5- 4-(4-methyl-piperazino- methyl)-benzoylamido -2-methylphenyl -4-(3- pyridil)-2pyrimidine-amin mit einem biphosphonat
JP2005515207A (ja) * 2001-12-11 2005-05-26 エモリー ユニバーシティ 乳癌の予防において使用するためのビス（シアノフェニル）メチル−トリアゾール
CN100593401C (zh) * 2002-07-30 2010-03-10 诺瓦提斯公司 芳香酶抑制剂和双膦酸酯的组合
GB0217636D0 (en) * 2002-07-30 2002-09-11 Novartis Ag Organic compounds
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
WO2005047269A1 (en) * 2003-11-14 2005-05-26 Natco Pharma Limited A method for the separation of the letrozole precursor 4-‘1-(1,2,4-triazolyl) methyl!benzonitrile from its 1,3,4-triazolyl isomer
CN1890221B (zh) * 2003-12-15 2014-07-16 沙拉麦斯实验公司 1-n-苯基-氨基-1h-咪唑衍生物和含有它们的医药组合物
JP2008516005A (ja) * 2005-07-06 2008-05-15 シコール インコーポレイティド レトロゾールの改良された調製方法
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US20090082413A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched letrozole
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Also Published As

Publication number Publication date
DK117687A (da) 1987-09-08
SK736887A3 (en) 1998-06-03
CY1905A (en) 1987-03-05
PL152025B1 (en) 1990-10-31
ZA871637B (en) 1987-10-28
SK736787A3 (en) 1998-06-03
CZ279027B6 (en) 1994-11-16
NL970011I1 (nl) 1997-05-01
EP0236940A3 (en) 1989-10-18
CZ279028B6 (en) 1994-11-16
CS8707367A2 (en) 1991-02-12
IL81746A0 (en) 1987-10-20
BG45700A3 (en) 1989-07-14
LV5769A4 (lv) 1996-12-20
FI91857C (fi) 1994-08-25
PT84410A (en) 1987-04-01
MA20888A1 (fr) 1987-10-01
US4749713A (en) 1988-06-07
JPS62212369A (ja) 1987-09-18
CS8701512A2 (en) 1991-02-12
KR910000482B1 (ko) 1991-01-25
NO870937L (no) 1987-09-08
AU604011B2 (en) 1990-12-06
BG45701A3 (en) 1989-07-14
LV5769B4 (lv) 1997-04-20
PH24159A (en) 1990-03-22
PT84410B (pt) 1989-10-04
LU90128I2 (fr) 1997-10-06
SK151287A3 (en) 1998-06-03
RO101533B1 (en) 1992-06-25
PL264460A1 (en) 1988-07-21
CA1316928C (en) 1993-04-27
AU6976887A (en) 1987-09-10
DE3787480D1 (de) 1993-10-28
SU1549478A3 (ru) 1990-03-07
NO1998010I1 (no) 1998-03-04
EP0236940B1 (en) 1993-09-22
FI91857B (fi) 1994-05-13
SK279103B6 (sk) 1998-06-03
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
NL970011I2 (nl) 1997-09-01
ATE94873T1 (de) 1993-10-15
BG46598A3 (en) 1990-01-15
MC1805A1 (fr) 1987-12-22
DE19775016I2 (de) 2002-02-21
EP0236940A2 (en) 1987-09-16
SK279102B6 (sk) 1998-06-03
CS8707368A2 (en) 1991-02-12
NO170277B (no) 1992-06-22
IL81746A (en) 1992-02-16
MTP998B (en) 1987-08-21
RO101532B1 (en) 1992-11-03
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
DK172190B1 (da) 1997-12-22
MX5496A (es) 1993-12-01
PL151490B1 (en) 1990-09-28
IE870575L (en) 1987-09-07
JPH0755930B2 (ja) 1995-06-14
DD264432A5 (de) 1989-02-01
EP0236940B3 (en) 2011-03-23
KR870008851A (ko) 1987-10-21
SK279101B6 (sk) 1998-06-03
IE61101B1 (en) 1994-10-05
CZ279026B6 (en) 1994-11-16
SU1577695A3 (ru) 1990-07-07
DE3787480T2 (de) 1994-02-24
MY102428A (en) 1992-06-30
FI870903A0 (fi) 1987-03-02
HK50296A (en) 1996-03-29
BG61204B2 (bg) 1997-02-28
DZ1055A1 (fr) 2004-09-13
NO170277C (no) 1992-09-30
TNSN87033A1 (fr) 1990-01-01
FI870903A (fi) 1987-09-08
DK117687D0 (da) 1987-03-06

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