LV5769B4 - Tolunitrili ar heterociklisku aizvietotaju alfa-stavokli - Google Patents

Tolunitrili ar heterociklisku aizvietotaju alfa-stavokli

Info

Publication number
LV5769B4
LV5769B4 LV960274A LV960274A LV5769B4 LV 5769 B4 LV5769 B4 LV 5769B4 LV 960274 A LV960274 A LV 960274A LV 960274 A LV960274 A LV 960274A LV 5769 B4 LV5769 B4 LV 5769B4
Authority
LV
Latvia
Prior art keywords
alkyl
substd
opt
alkylene
alkylthio
Prior art date
Application number
LV960274A
Other languages
English (en)
Latvian (lv)
Other versions
LV5769A4 (lv
Inventor
Robert Mathews Bowman
Ronald Edward Steele
Leslie Johnston Browne
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV5769(B4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of LV5769A4 publication Critical patent/LV5769A4/xx
Publication of LV5769B4 publication Critical patent/LV5769B4/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
LV960274A 1986-03-07 1996-07-18 Tolunitrili ar heterociklisku aizvietotaju alfa-stavokli LV5769B4 (lv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles
EP87103099A EP0236940B3 (en) 1986-03-07 1987-03-05 Alpha-heterocycle substituted tolunitriles

Publications (2)

Publication Number Publication Date
LV5769A4 LV5769A4 (lv) 1996-12-20
LV5769B4 true LV5769B4 (lv) 1997-04-20

Family

ID=25274596

Family Applications (1)

Application Number Title Priority Date Filing Date
LV960274A LV5769B4 (lv) 1986-03-07 1996-07-18 Tolunitrili ar heterociklisku aizvietotaju alfa-stavokli

Country Status (36)

Country Link
US (1) US4749713A (xx)
EP (1) EP0236940B3 (xx)
JP (1) JPH0755930B2 (xx)
KR (1) KR910000482B1 (xx)
AT (1) ATE94873T1 (xx)
BG (4) BG45701A3 (xx)
CA (1) CA1316928C (xx)
CY (1) CY1905A (xx)
CZ (3) CZ279028B6 (xx)
DD (1) DD264432A5 (xx)
DE (2) DE3787480T2 (xx)
DK (1) DK172190B1 (xx)
DZ (1) DZ1055A1 (xx)
ES (1) ES2059317T3 (xx)
FI (1) FI91857C (xx)
HK (1) HK50296A (xx)
HU (1) HU202843B (xx)
IE (1) IE61101B1 (xx)
IL (1) IL81746A (xx)
LU (1) LU90128I2 (xx)
LV (1) LV5769B4 (xx)
MA (1) MA20888A1 (xx)
MC (1) MC1805A1 (xx)
MT (1) MTP998B (xx)
MX (1) MX5496A (xx)
MY (1) MY102428A (xx)
NL (1) NL970011I2 (xx)
NO (2) NO170277C (xx)
PH (1) PH24159A (xx)
PL (2) PL152025B1 (xx)
PT (1) PT84410B (xx)
RO (2) RO101533B1 (xx)
SK (3) SK279102B6 (xx)
SU (3) SU1470184A3 (xx)
TN (1) TNSN87033A1 (xx)
ZA (1) ZA871637B (xx)

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US5112845A (en) * 1986-03-07 1992-05-12 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
DE3811574A1 (de) * 1988-03-31 1989-10-19 Schering Ag N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
ES2084687T3 (es) * 1989-07-14 1996-05-16 Ciba Geigy Ag Benzonitrilos substituidos.
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
JP2602456B2 (ja) * 1990-04-12 1997-04-23 雪印乳業株式会社 子宮内膜症治療剤
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
TW210334B (xx) * 1990-12-12 1993-08-01 Ciba Geigy Ag
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
DE4120107A1 (de) * 1991-06-14 1992-12-17 Schering Ag Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
RO114129B1 (ro) 1991-09-02 1999-01-29 Yamanouchi Pharmaceutical Co., Ltd. Derivaţi aminici terţiari substituiţi cu triazolil
US5223539A (en) * 1991-11-22 1993-06-29 G. D. Searle & Co. N,n-di-alkyl(phenoxy)benzamide derivatives
AU5285593A (en) * 1992-10-21 1994-05-09 Sankyo Company Limited Azole compound
GB2273704B (en) * 1992-12-16 1997-01-22 Orion Yhtymae Oy Triazolyl diaryl selective aromatase inhibiting compounds
US5426196A (en) * 1993-12-22 1995-06-20 Glaxo Inc. Synthesis of diaryl methanes
JP2000504014A (ja) * 1996-01-30 2000-04-04 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
EP0877610A4 (en) * 1996-01-30 1999-09-15 Merck & Co Inc FARNESYL-PROTEIN TRANSFERASE INHIBITORS
AU715603B2 (en) * 1996-04-03 2000-02-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2249615A1 (en) * 1996-04-03 1997-10-09 Robert Gomez Inhibitors of farnesyl-protein transferase
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
BR0209647A (pt) 2001-05-16 2004-07-27 Novartis Ag Combinação que compreende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metil fenil}-4-(3-piridil)-2-pirimidina-amina e um agente quimioterapêutico
AU2002366587A1 (en) * 2001-12-11 2003-06-23 Emory University Bis(cyanophenyl)methyl-triazole for use in prevention of breast cancer
GB0217636D0 (en) * 2002-07-30 2002-09-11 Novartis Ag Organic compounds
EP1534265B1 (en) * 2002-07-30 2006-11-22 Novartis AG Combination of an aromatase inhibitor with a bisphosphonate
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
AU2003282380A1 (en) * 2003-11-14 2004-06-06 ADIBHATLA, KALI,SATYA, Bhujanga,rao A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer
OA13336A (en) * 2003-12-15 2006-04-13 Theramex 1-N-phenyl-amino-1H-imidazole derivatives and pharmaceutical compositions containing them.
JP2008516005A (ja) * 2005-07-06 2008-05-15 シコール インコーポレイティド レトロゾールの改良された調製方法
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US20090082413A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched letrozole
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
EP2609087A2 (en) 2010-08-27 2013-07-03 Generics [UK] Limited Pure intermediate
CA2845929C (en) 2011-09-08 2018-06-19 Novartis Ag Use of an aromatase inhibitor for the treatment of hypogonadism and related diseases
MX2014014831A (es) 2012-06-08 2015-02-12 Hoffmann La Roche Selectividad de mutante y combinaciones de un compuesto inhibidor de fosfoinositida 3 cinasa y agentes quimioterapeuticos para el tratamiento de cancer.
DK3033086T3 (da) 2013-08-14 2022-01-03 Novartis Ag Kombinationsterapi til behandling af cancer
AR104068A1 (es) 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
GB201614179D0 (en) 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
BR112021001233A2 (pt) 2018-07-23 2021-04-20 F. Hoffmann-La Roche Ag método para tratar câncer em um paciente, uso de uma quantidade terapeuticamente eficaz de gdc-0077 e quantidade terapeuticamente eficaz de gdc-0077
EP3863618A1 (en) 2018-10-08 2021-08-18 F. Hoffmann-La Roche AG Methods of treating cancer with pi3k alpha inhibitors and metformin
BR112022010806A2 (pt) 2019-12-03 2022-08-23 Genentech Inc Métodos para tratar câncer de mama, para inibir o crescimento tumoral e para prevenir ou retardar o desenvolvimento de resistência de um câncer de mama
AU2021395248A1 (en) 2020-12-11 2023-07-06 F. Hoffmann-La Roche Ag Combination therapies for treatment of her2 cancer

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US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors

Also Published As

Publication number Publication date
RO101532B1 (en) 1992-11-03
PL264460A1 (en) 1988-07-21
LV5769A4 (lv) 1996-12-20
CA1316928C (en) 1993-04-27
CS8707368A2 (en) 1991-02-12
NO870937L (no) 1987-09-08
NO170277B (no) 1992-06-22
NL970011I2 (nl) 1997-09-01
FI91857C (fi) 1994-08-25
IE870575L (en) 1987-09-07
CS8701512A2 (en) 1991-02-12
BG46598A3 (en) 1990-01-15
EP0236940B3 (en) 2011-03-23
HK50296A (en) 1996-03-29
MC1805A1 (fr) 1987-12-22
IE61101B1 (en) 1994-10-05
KR910000482B1 (ko) 1991-01-25
MA20888A1 (fr) 1987-10-01
FI870903A0 (fi) 1987-03-02
AU604011B2 (en) 1990-12-06
BG45700A3 (en) 1989-07-14
SK151287A3 (en) 1998-06-03
RO101533B1 (en) 1992-06-25
CY1905A (en) 1987-03-05
DE3787480D1 (de) 1993-10-28
EP0236940A3 (en) 1989-10-18
JPS62212369A (ja) 1987-09-18
PT84410A (en) 1987-04-01
DK117687A (da) 1987-09-08
US4749713A (en) 1988-06-07
ES2059317T3 (es) 1994-11-16
NL970011I1 (nl) 1997-05-01
CZ279028B6 (en) 1994-11-16
BG61204B2 (bg) 1997-02-28
MY102428A (en) 1992-06-30
EP0236940A2 (en) 1987-09-16
PL152025B1 (en) 1990-10-31
ZA871637B (en) 1987-10-28
CZ279026B6 (en) 1994-11-16
IL81746A0 (en) 1987-10-20
IL81746A (en) 1992-02-16
DK117687D0 (da) 1987-03-06
ATE94873T1 (de) 1993-10-15
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
MX5496A (es) 1993-12-01
AU6976887A (en) 1987-09-10
DD264432A5 (de) 1989-02-01
SK736887A3 (en) 1998-06-03
DZ1055A1 (fr) 2004-09-13
CZ279027B6 (en) 1994-11-16
EP0236940B1 (en) 1993-09-22
DE19775016I2 (de) 2002-02-21
DK172190B1 (da) 1997-12-22
NO170277C (no) 1992-09-30
TNSN87033A1 (fr) 1990-01-01
MTP998B (en) 1987-08-21
SU1577695A3 (ru) 1990-07-07
PT84410B (pt) 1989-10-04
DE3787480T2 (de) 1994-02-24
LU90128I2 (fr) 1997-10-06
JPH0755930B2 (ja) 1995-06-14
SK279101B6 (sk) 1998-06-03
NO1998010I1 (no) 1998-03-04
SU1549478A3 (ru) 1990-03-07
SK736787A3 (en) 1998-06-03
CS8707367A2 (en) 1991-02-12
PH24159A (en) 1990-03-22
SK279103B6 (sk) 1998-06-03
PL151490B1 (en) 1990-09-28
BG45701A3 (en) 1989-07-14
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
KR870008851A (ko) 1987-10-21
SK279102B6 (sk) 1998-06-03
FI91857B (fi) 1994-05-13
FI870903A (fi) 1987-09-08

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