HK50296A - Alpha-heterocycle substituted tolunitriles - Google Patents

Alpha-heterocycle substituted tolunitriles

Info

Publication number
HK50296A
HK50296A HK50296A HK50296A HK50296A HK 50296 A HK50296 A HK 50296A HK 50296 A HK50296 A HK 50296A HK 50296 A HK50296 A HK 50296A HK 50296 A HK50296 A HK 50296A
Authority
HK
Hong Kong
Prior art keywords
alkyl
substd
opt
alkylene
alkylthio
Prior art date
Application number
HK50296A
Other languages
English (en)
Inventor
Robert Mathews Bowman
Ronald Edward Steele
Leslie Johnston Browne
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK50296(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of HK50296A publication Critical patent/HK50296A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
HK50296A 1986-03-07 1996-03-21 Alpha-heterocycle substituted tolunitriles HK50296A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (1)

Publication Number Publication Date
HK50296A true HK50296A (en) 1996-03-29

Family

ID=25274596

Family Applications (1)

Application Number Title Priority Date Filing Date
HK50296A HK50296A (en) 1986-03-07 1996-03-21 Alpha-heterocycle substituted tolunitriles

Country Status (36)

Country Link
US (1) US4749713A (xx)
EP (1) EP0236940B3 (xx)
JP (1) JPH0755930B2 (xx)
KR (1) KR910000482B1 (xx)
AT (1) ATE94873T1 (xx)
BG (4) BG45700A3 (xx)
CA (1) CA1316928C (xx)
CY (1) CY1905A (xx)
CZ (3) CZ279028B6 (xx)
DD (1) DD264432A5 (xx)
DE (2) DE3787480T2 (xx)
DK (1) DK172190B1 (xx)
DZ (1) DZ1055A1 (xx)
ES (1) ES2059317T3 (xx)
FI (1) FI91857C (xx)
HK (1) HK50296A (xx)
HU (1) HU202843B (xx)
IE (1) IE61101B1 (xx)
IL (1) IL81746A (xx)
LU (1) LU90128I2 (xx)
LV (1) LV5769B4 (xx)
MA (1) MA20888A1 (xx)
MC (1) MC1805A1 (xx)
MT (1) MTP998B (xx)
MX (1) MX5496A (xx)
MY (1) MY102428A (xx)
NL (1) NL970011I2 (xx)
NO (2) NO170277C (xx)
PH (1) PH24159A (xx)
PL (2) PL152025B1 (xx)
PT (1) PT84410B (xx)
RO (2) RO101532B1 (xx)
SK (3) SK279103B6 (xx)
SU (3) SU1470184A3 (xx)
TN (1) TNSN87033A1 (xx)
ZA (1) ZA871637B (xx)

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US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
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DE59010171D1 (de) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituierte Benzonitrile
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
JP2602456B2 (ja) * 1990-04-12 1997-04-23 雪印乳業株式会社 子宮内膜症治療剤
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
TW210334B (xx) * 1990-12-12 1993-08-01 Ciba Geigy Ag
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
DE4120107A1 (de) * 1991-06-14 1992-12-17 Schering Ag Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
HU220863B1 (en) 1991-09-02 2002-06-29 Yamanouchi Pharma Co Ltd Triazolylated tertiary amines, process for producing them and pharmaceutical compositions containing them
US5223539A (en) * 1991-11-22 1993-06-29 G. D. Searle & Co. N,n-di-alkyl(phenoxy)benzamide derivatives
AU5285593A (en) * 1992-10-21 1994-05-09 Sankyo Company Limited Azole compound
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US5426196A (en) * 1993-12-22 1995-06-20 Glaxo Inc. Synthesis of diaryl methanes
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AU703203B2 (en) * 1996-01-30 1999-03-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU715658B2 (en) * 1996-04-03 2000-02-10 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2250353A1 (en) * 1996-04-03 1997-10-09 Christopher J. Dinsmore Inhibitors of farnesyl-protein transferase
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
SK14042003A3 (sk) 2001-05-16 2004-05-04 Novartis Ag Kombinácia N-{5-[4-metylpiperazinometyl)benzoylamido]-2- metylfenyl}-4-(3-pyridyl)-2-pyrimidínamínu chemoterapeutického činidla a farmaceutický prostriedok, ktorý ju obsahuje
CN1325482C (zh) * 2001-12-11 2007-07-11 埃默里大学 双(氰基苯基)甲基－三唑在预防乳腺癌中的用途
ATE345790T1 (de) * 2002-07-30 2006-12-15 Novartis Pharma Gmbh Kombination von einem aromatasehemmer mit einem bisphosphonat
GB0217636D0 (en) * 2002-07-30 2002-09-11 Novartis Ag Organic compounds
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
AU2003282380A1 (en) * 2003-11-14 2004-06-06 ADIBHATLA, KALI,SATYA, Bhujanga,rao A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer
AR047144A1 (es) * 2003-12-15 2006-01-11 Theramex Derivados de 1-n-fenilamino-1h-imidazol y composiciones farmaceuticas que los contienen
CA2608904A1 (en) * 2005-07-06 2007-09-07 Sicor Inc. Improved process for the preparation of letrozole
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US20090082413A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched letrozole
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
US9150524B2 (en) 2010-08-27 2015-10-06 Generics [Uk] Limited Pure intermediate
BR112014005434B1 (pt) * 2011-09-08 2021-01-05 Novartis Ag Composições farmacêuticas compreendendo inibidor da aromatase 4,4'-[fluoro-(1h-1,2,4triazol-1-il)metilemo]bisbenzonitrila e seu método de preparação
CN104379163A (zh) 2012-06-08 2015-02-25 霍夫曼-拉罗奇有限公司 用于治疗癌症的磷酸肌醇3激酶抑制剂化合物和化疗剂的突变选择性及组合
WO2015022609A1 (en) 2013-08-14 2015-02-19 Novartis Ag Combination therapy for the treatment of cancer
AR104068A1 (es) 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
GB201614179D0 (en) 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
BR112021001233A2 (pt) 2018-07-23 2021-04-20 F. Hoffmann-La Roche Ag método para tratar câncer em um paciente, uso de uma quantidade terapeuticamente eficaz de gdc-0077 e quantidade terapeuticamente eficaz de gdc-0077
JP2022504388A (ja) 2018-10-08 2022-01-13 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｐｉ３ｋアルファ阻害剤およびメトホルミンを用いたがんの処置方法
BR112022010806A2 (pt) 2019-12-03 2022-08-23 Genentech Inc Métodos para tratar câncer de mama, para inibir o crescimento tumoral e para prevenir ou retardar o desenvolvimento de resistência de um câncer de mama
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DE2808086A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Substituierte diphenyl-imidazolyl- methane, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
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US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors

Also Published As

Publication number Publication date
CY1905A (en) 1987-03-05
SK279101B6 (sk) 1998-06-03
EP0236940A3 (en) 1989-10-18
US4749713A (en) 1988-06-07
SU1549478A3 (ru) 1990-03-07
CZ279027B6 (en) 1994-11-16
PT84410A (en) 1987-04-01
DE19775016I2 (de) 2002-02-21
DK117687D0 (da) 1987-03-06
MC1805A1 (fr) 1987-12-22
DD264432A5 (de) 1989-02-01
MTP998B (en) 1987-08-21
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
IE61101B1 (en) 1994-10-05
TNSN87033A1 (fr) 1990-01-01
JPH0755930B2 (ja) 1995-06-14
FI870903A0 (fi) 1987-03-02
LU90128I2 (fr) 1997-10-06
NO170277B (no) 1992-06-22
EP0236940B3 (en) 2011-03-23
PL152025B1 (en) 1990-10-31
IL81746A (en) 1992-02-16
DE3787480T2 (de) 1994-02-24
ATE94873T1 (de) 1993-10-15
MA20888A1 (fr) 1987-10-01
IL81746A0 (en) 1987-10-20
BG61204B2 (bg) 1997-02-28
BG45701A3 (en) 1989-07-14
RO101533B1 (en) 1992-06-25
DE3787480D1 (de) 1993-10-28
FI91857C (fi) 1994-08-25
JPS62212369A (ja) 1987-09-18
IE870575L (en) 1987-09-07
AU6976887A (en) 1987-09-10
CS8707368A2 (en) 1991-02-12
SK151287A3 (en) 1998-06-03
CA1316928C (en) 1993-04-27
CS8701512A2 (en) 1991-02-12
MY102428A (en) 1992-06-30
BG46598A3 (en) 1990-01-15
ZA871637B (en) 1987-10-28
SU1577695A3 (ru) 1990-07-07
SK736887A3 (en) 1998-06-03
DK172190B1 (da) 1997-12-22
AU604011B2 (en) 1990-12-06
NL970011I1 (nl) 1997-05-01
SK279102B6 (sk) 1998-06-03
CZ279026B6 (en) 1994-11-16
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
LV5769A4 (lv) 1996-12-20
SK736787A3 (en) 1998-06-03
PT84410B (pt) 1989-10-04
DZ1055A1 (fr) 2004-09-13
FI870903A (fi) 1987-09-08
DK117687A (da) 1987-09-08
PH24159A (en) 1990-03-22
NO1998010I1 (no) 1998-03-04
MX5496A (es) 1993-12-01
ES2059317T3 (es) 1994-11-16
NO170277C (no) 1992-09-30
NL970011I2 (nl) 1997-09-01
PL264460A1 (en) 1988-07-21
SK279103B6 (sk) 1998-06-03
PL151490B1 (en) 1990-09-28
KR870008851A (ko) 1987-10-21
EP0236940A2 (en) 1987-09-16
CS8707367A2 (en) 1991-02-12
BG45700A3 (en) 1989-07-14
CZ279028B6 (en) 1994-11-16
FI91857B (fi) 1994-05-13
EP0236940B1 (en) 1993-09-22
LV5769B4 (lv) 1997-04-20
RO101532B1 (en) 1992-11-03
KR910000482B1 (ko) 1991-01-25
NO870937L (no) 1987-09-08

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